SI9210305A - Indole derivatives, processes for their preparation and medicaments containing them - Google Patents

Indole derivatives, processes for their preparation and medicaments containing them Download PDF

Info

Publication number
SI9210305A
SI9210305A SI9210305A SI9210305A SI9210305A SI 9210305 A SI9210305 A SI 9210305A SI 9210305 A SI9210305 A SI 9210305A SI 9210305 A SI9210305 A SI 9210305A SI 9210305 A SI9210305 A SI 9210305A
Authority
SI
Slovenia
Prior art keywords
phenyl
indolyl
urea
methyl
diisopropyl
Prior art date
Application number
SI9210305A
Other languages
English (en)
Slovenian (sl)
Inventor
Didier Festal
Denid Descours
Robert Bellemin
Jacques Decerprit
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of SI9210305A publication Critical patent/SI9210305A/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
SI9210305A 1991-03-26 1992-03-26 Indole derivatives, processes for their preparation and medicaments containing them SI9210305A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9103618A FR2674522B1 (fr) 1991-03-26 1991-03-26 Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
YU30592A YU30592A (sh) 1991-03-26 1992-03-26 Novi derivati indola i postupci dobijanja

Publications (1)

Publication Number Publication Date
SI9210305A true SI9210305A (en) 1996-02-29

Family

ID=9411107

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9210305A SI9210305A (en) 1991-03-26 1992-03-26 Indole derivatives, processes for their preparation and medicaments containing them

Country Status (25)

Country Link
US (1) US5219859A (de)
EP (1) EP0506532B1 (de)
JP (1) JPH0597802A (de)
KR (1) KR950007753B1 (de)
AT (1) ATE111078T1 (de)
AU (1) AU658609B2 (de)
CA (1) CA2063170A1 (de)
CS (1) CS89592A3 (de)
DE (1) DE69200378T2 (de)
DK (1) DK0506532T3 (de)
ES (1) ES2064149T3 (de)
FR (1) FR2674522B1 (de)
HU (1) HUT65489A (de)
IE (1) IE65366B1 (de)
IL (1) IL101248A (de)
MA (1) MA22474A1 (de)
MX (1) MX9201365A (de)
NO (1) NO178260C (de)
NZ (1) NZ242078A (de)
OA (1) OA09573A (de)
RU (1) RU2074179C1 (de)
SI (1) SI9210305A (de)
TN (1) TNSN92022A1 (de)
YU (1) YU30592A (de)
ZA (1) ZA922163B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
CA2134359C (en) * 1992-05-28 1997-07-01 Ernest S. Hamanaka New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
NZ250916A (en) * 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
IL109568A0 (en) * 1993-05-19 1994-08-26 Fujisawa Pharmaceutical Co Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
JP3720395B2 (ja) * 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
US6107329A (en) * 1995-06-06 2000-08-22 Pfizer, Inc. Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors
US6297269B1 (en) 1995-06-06 2001-10-02 Pfizer Inc. Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors
KR100241643B1 (ko) * 1995-06-06 2000-03-02 디. 제이. 우드 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체
NZ299242A (en) * 1995-09-11 1997-12-19 Nihon Nohyaku Co Ltd N-phenyl-n'-(phenyl substituted imidazol-5-yl, -oxazol-4-yl, and -thiazol-4-yl)urea derivatives
HUP9900617A3 (en) * 1995-10-05 2001-12-28 Kyoto Pharma Ind Novel indole-, indoline- or tetrahydrokinoline derivatives as acat and lipid peroxidation inhibitors, use thereof, pharmaceutical compositions containing these compounds
EP0773218A1 (de) * 1995-11-13 1997-05-14 Mitsubishi Chemical Corporation N-(Piperazinylalkoxyphenyl)-N'-phenylalkylharnstoffderivate als ACAT-Hemmer zur Atherosklerosebehandlung
FR2763334A1 (fr) * 1997-05-13 1998-11-20 Lipha Derives anthraniliques
CN1210268C (zh) * 1997-12-16 2005-07-13 沃尼尔·朗伯公司 ((环)烷基取代的)－γ－氨基丁酸衍生物(=GABA类似物),其制备和在治疗神经病中的用途
AU759392B2 (en) * 1997-12-16 2003-04-10 Warner-Lambert Company 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
PL341291A1 (en) * 1997-12-16 2001-04-09 Warner Lambert Co 1-substituted derivatives of 1-aminomethyl-ccycloalkanes (gabapentin analogues), their production and application of them in treating neurological disorders
SK282727B6 (sk) 1997-12-19 2002-11-06 Slovakofarma, A. S. 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
ATE406371T1 (de) 2000-11-02 2008-09-15 Us Gov Health & Human Serv Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung
EP1501800A1 (de) * 2002-05-03 2005-02-02 Warner-Lambert Company LLC Bombesin antagonisten
RS20050127A (en) * 2002-07-17 2007-06-04 Kyoto Pharmaceutical Industries Ltd., Novel indoline compound and medicinal use thereof
WO2004094394A1 (en) * 2003-04-01 2004-11-04 Eli Lilly And Company Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
BRPI0619263A2 (pt) 2005-11-30 2011-09-27 Hoffmann La Roche indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis
EP1957488B1 (de) 2005-11-30 2009-09-09 F.Hoffmann-La Roche Ag 3-amino-2-arylpropylazaindole und anwendungen davon
RU2361581C2 (ru) * 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
SK287385B6 (sk) 2007-11-27 2010-08-09 Hameln-Rds, A. S. 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia
CN104628621A (zh) * 2015-01-22 2015-05-20 湖南华腾制药有限公司 一种氟取代吲哚衍生物的制备方法
CR20200033A (es) 2017-06-26 2020-03-05 Lunella Biotech Inc Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas
SG11202109111VA (en) 2019-02-27 2021-09-29 Univ California Azepino-indoles and other heterocycles for treating brain disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151505A (en) * 1979-05-14 1980-11-26 Kuraray Co Ltd Indole agricultural and horticultural fungicide
CA1299174C (en) * 1987-02-02 1992-04-21 Michael Edward Flaugh Alkylmelatonins
EP0375133A1 (de) * 1988-11-14 1990-06-27 The Upjohn Company Alpha-amino-indol-3-essigsäure, verwendbar als antidiabetische, antifettleibige und antiarteriosklerotische Agenten
IE903206A1 (en) * 1989-09-07 1991-03-13 Abbott Lab Indole-, benzofuran-, and benzothiophene-containing¹lipoxygenase-inhibiting compounds
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
DK0471296T3 (da) * 1990-08-13 1996-03-11 Hoechst Roussel Pharma 1-(Pyridinylalkyl)-1H-indoler, -indoliner og beslægtede analoge
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase

Also Published As

Publication number Publication date
NO178260B (no) 1995-11-13
DK0506532T3 (da) 1995-02-20
EP0506532B1 (de) 1994-09-07
US5219859A (en) 1993-06-15
HUT65489A (en) 1994-06-28
FR2674522A1 (fr) 1992-10-02
MA22474A1 (fr) 1992-10-01
IE65366B1 (en) 1995-10-18
MX9201365A (es) 1992-10-01
NO921141D0 (no) 1992-03-24
NZ242078A (en) 1994-10-26
AU658609B2 (en) 1995-04-27
NO178260C (no) 1996-02-21
YU30592A (sh) 1994-12-28
IL101248A (en) 1996-12-05
RU2074179C1 (ru) 1997-02-27
HU9200997D0 (en) 1992-05-28
DE69200378D1 (de) 1994-10-13
JPH0597802A (ja) 1993-04-20
CS89592A3 (en) 1992-10-14
IL101248A0 (en) 1992-11-15
KR950007753B1 (ko) 1995-07-14
EP0506532A1 (de) 1992-09-30
ES2064149T3 (es) 1995-01-16
KR920018022A (ko) 1992-10-21
NO921141L (no) 1992-09-28
IE920937A1 (en) 1992-10-07
ZA922163B (en) 1993-09-27
DE69200378T2 (de) 1995-03-09
CA2063170A1 (en) 1992-09-27
AU1309492A (en) 1992-10-01
FR2674522B1 (fr) 1993-07-16
TNSN92022A1 (fr) 1993-06-08
ATE111078T1 (de) 1994-09-15
OA09573A (fr) 1993-01-31

Similar Documents

Publication Publication Date Title
SI9210305A (en) Indole derivatives, processes for their preparation and medicaments containing them
JP4395076B2 (ja) 三環式ステロイドホルモン核内受容体モジュレーター
SI9300076A (en) New azaindoles, preparation processes and medical products containing them
HUT66319A (en) Benzanilide derivatives and pharmaceutical compositions containing them
FR2500450A1 (fr) Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
FR2639636A1 (fr) Nouveaux composes heterocycliques a activite anticonvulsivante, procede de preparation et compositions therapeutiques les contenant
US5834471A (en) Amide derivatives as 5HT1D receptor antagonists
FR2581993A1 (fr) Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
JPS6253504B2 (de)
US5110831A (en) Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors
US20090182025A1 (en) Substituted carboxamides
FI77224B (fi) Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara aminopropanolderivat av 2-hydroxi- -fenylpropiofenoner.
IE63709B1 (en) Novel 1,3-dicarbonyl compounds and their use
FR2595695A1 (fr) Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
BE1004906A3 (fr) Nouveaux derives substitues du styrene, leur procede de preparation et compositions pharmaceutiques les contenant.
NO180195B (no) Analogifremgangsmåte ved fremstilling av heksahydroazepinderivater
KR100248643B1 (ko) 아릴 및 헤테로아릴 알콕시나프탈렌 유도체
US5130487A (en) Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same
FR2460294A1 (fr) Nouveaux oxime-ethers, leur procede de preparation et compositions pharmaceutiques les contenant
DK159435B (da) Analogifremgangsmaade til fremstilling af 2-hydroxy-5-(1-hydroxy-2-piperazinylethyl)benzoesyrederivater eller et farmaceutisk acceptabelt syreadditionssalt deraf
FR2637596A1 (fr) Methyl-4 ((aryl-4 piperazinyl-1)-2 ethyl)-5 thiazole et ses derives, leur procede de preparation et les medicaments en contenant
NO154391B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-amino-naftalen-derivater.
Rani et al. Isoxazolinyl derivatives of anthranilic acid as antiinflammatory agents
CA2045849A1 (fr) Derives d'oxazolo pyridines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US4663334A (en) Heteroaromatic acetylenes useful as antihypertensive agents