SI9200139A - New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them - Google Patents

New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them Download PDF

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Publication number
SI9200139A
SI9200139A SI9200139A SI9200139A SI9200139A SI 9200139 A SI9200139 A SI 9200139A SI 9200139 A SI9200139 A SI 9200139A SI 9200139 A SI9200139 A SI 9200139A SI 9200139 A SI9200139 A SI 9200139A
Authority
SI
Slovenia
Prior art keywords
clavulanic acid
hydrophobic
heptaxis
derivatives
alkali
Prior art date
Application number
SI9200139A
Other languages
English (en)
Slovenian (sl)
Inventor
Janko Zmitek
Darja Fercej-Temeljotov
Katarina Verhnjak
Sonja Kotnik
Mateja Kovacic
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Priority to SI9200139A priority Critical patent/SI9200139A/sl
Priority to HU9301968A priority patent/HUT64961A/hu
Priority to KR1019930012769A priority patent/KR970001653B1/ko
Priority to EP93110883A priority patent/EP0578231A1/fr
Priority to AU41824/93A priority patent/AU662986B2/en
Priority to CA002100045A priority patent/CA2100045A1/fr
Priority to FI933113A priority patent/FI933113A/fi
Priority to JP5169361A priority patent/JPH072905A/ja
Publication of SI9200139A publication Critical patent/SI9200139A/sl
Priority to US08/369,301 priority patent/US5498788A/en
Priority to US08/469,870 priority patent/US5608052A/en
Priority to US08/470,267 priority patent/US5614199A/en
Priority to KR96041583A priority patent/KR970001654B1/ko

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
SI9200139A 1992-07-08 1992-07-08 New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them SI9200139A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
SI9200139A SI9200139A (en) 1992-07-08 1992-07-08 New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
CA002100045A CA2100045A1 (fr) 1992-07-08 1993-07-07 Complexes d'inclusion d'acide clavulanique et de ses sels alcalins avec des derives hydrophiles et hydrophobes de .beta.-cyclodextrine, leur procede de fabrication et leur utilisation
KR1019930012769A KR970001653B1 (ko) 1992-07-08 1993-07-07 클라부란산 및 그들의 알카리염과 친수성과 소수성 β-싸이클로덱스트린 유도체의 신규 포접복합체와 그들의 제법과 그 용도
EP93110883A EP0578231A1 (fr) 1992-07-08 1993-07-07 Complexes d'inclusion de l'acide clavulanic et ses sels d'alcalin avec des beta-cyclodextrines
AU41824/93A AU662986B2 (en) 1992-07-08 1993-07-07 Novel inclusion complexes of clavulanic acid and of alkali salts thereof with hydrophilic and hydrophobic beta-cyclodextrin derivatives, a process for the preparation thereof and the use thereof
HU9301968A HUT64961A (en) 1992-07-08 1993-07-07 Inclusion complexes of clavulanic acid with hydrophylic and hydrophobic beta-cyclodextrin derivatives and method for producint them
FI933113A FI933113A (fi) 1992-07-08 1993-07-07 Nya inklusionskomplexer av clavulanisk syra och dess alkalisalter med hydrofilisk och hydrofobisk b-cyclodextrinfoereningar, foerfarande foer dess framstaellning och anvaendning daerav
JP5169361A JPH072905A (ja) 1992-07-08 1993-07-08 包接複合体、その製造方法及びクラブラン酸アルカリの製造方法及び包接複合体を含有する安定なガレン製剤
US08/369,301 US5498788A (en) 1992-07-08 1995-01-06 Inclusion complexes of clavulanic acid and of potassium salts thereof with hydrophobic β-cyclodextrin derivatives a process for the preparation thereof
US08/469,870 US5608052A (en) 1992-07-08 1995-06-06 Inclusioin complexes of clavulanic acid and of alkali salts thereof with hydrophilic and hydrophobic beta-cyclodextrin derivatives, a process for the preparation thereof and the use thereof
US08/470,267 US5614199A (en) 1992-07-08 1995-06-06 Inclusion complexes of clavulanic acid and of alkali salts thereof with hydrophilic and hydrophobic β-cyclodextrin derivatives, a process for the preparation thereof and the use thereof
KR96041583A KR970001654B1 (en) 1992-07-08 1996-09-23 Inclusion complexes of clavulanic acid with hydrophylic and hydrophobic beta-cyclodextrin derivatives and method for producing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9200139A SI9200139A (en) 1992-07-08 1992-07-08 New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them

Publications (1)

Publication Number Publication Date
SI9200139A true SI9200139A (en) 1994-03-31

Family

ID=20430975

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9200139A SI9200139A (en) 1992-07-08 1992-07-08 New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them

Country Status (9)

Country Link
US (3) US5498788A (fr)
EP (1) EP0578231A1 (fr)
JP (1) JPH072905A (fr)
KR (1) KR970001653B1 (fr)
AU (1) AU662986B2 (fr)
CA (1) CA2100045A1 (fr)
FI (1) FI933113A (fr)
HU (1) HUT64961A (fr)
SI (1) SI9200139A (fr)

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AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ES2142641T3 (es) 1997-03-24 2000-04-16 Cipan Comp Ind Prod Procedimiento para aislar una sal alcalino-metalica farmaceuticamente aceptable del acido clavulanico.
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US8557291B2 (en) 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
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CA2569958C (fr) 2004-06-12 2016-03-22 Jane C. Hirsh Formulations de prevention des abus
US7695479B1 (en) 2005-04-12 2010-04-13 Biomet Manufacturing Corp. Femoral sizer
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Also Published As

Publication number Publication date
KR970001653B1 (ko) 1997-02-13
JPH072905A (ja) 1995-01-06
HU9301968D0 (en) 1993-09-28
HUT64961A (en) 1994-03-28
AU4182493A (en) 1994-01-13
CA2100045A1 (fr) 1994-01-09
FI933113A (fi) 1994-01-09
US5498788A (en) 1996-03-12
AU662986B2 (en) 1995-09-21
EP0578231A1 (fr) 1994-01-12
US5608052A (en) 1997-03-04
FI933113A0 (fi) 1993-07-07
US5614199A (en) 1997-03-25

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