SI9010455B - Novi kompleksi oziroma kelati antibiotikov z dvovalentnimi in/ali trovalentnimi kovinami in postopki za njihovo pripravo - Google Patents

Novi kompleksi oziroma kelati antibiotikov z dvovalentnimi in/ali trovalentnimi kovinami in postopki za njihovo pripravo Download PDF

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Publication number
SI9010455B
SI9010455B SI9010455A SI9010455A SI9010455B SI 9010455 B SI9010455 B SI 9010455B SI 9010455 A SI9010455 A SI 9010455A SI 9010455 A SI9010455 A SI 9010455A SI 9010455 B SI9010455 B SI 9010455B
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Slovenia
Prior art keywords
azithromycin
chelates
complexes
complex
valent
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SI9010455A
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English (en)
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SI9010455A (en
Inventor
Slobodan D�oki�
Zlatko Vajtner
Hrvoje Krnjevi�
Nevenka Lopotar
Babi� Lidija Kola�ny
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Pliva
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Publication of SI9010455A publication Critical patent/SI9010455A/sl
Publication of SI9010455B publication Critical patent/SI9010455B/sl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Description

(54) NOVI KOMPLEKSI OZIROMA KELATI ANTIBIOTIKOV Z DVOVALENTNIMI IN/ALI TROVALENTNIMI KOVINAMI IN POSTOPKI ZA NJIHOVO PRIPRAVO

Claims (10)

1. Kompleksi ali kelati azitromicina z dvovalentnimi in/ali trivalentnimi kovinami izbranimi izmed Mg2+, Al3+, Fe3+, Rh3+ in La3+.
2. Kompleksi ali kelati azitromicina z dvovalentnimi in/ali trivalentnimi kovinami izbranimi izmed Mg2+, Al3+, Fe3+, Rh3+ in La3+ v razmerju 1:1 do 1:4.
3. Kompleksi ali kelati azitromicina z dvovalentnimi in/ali trivalentnimi kovinami izbranimi izmed Mg2+, Al3+, Fe3+, Rh3+ in La3+v razmerju 2:1.
4. Kompleks azitromicina z Mg .
5. Kompleks azitromicina z Al3+.
6. Kompleks azitromicina z Fe3+.
7. Kompleks azitromicina z Rh3+.
8. Kompleks azitromicina z La3+.
9. Kelat azitromicina z Al(OH)3-MgCO3 v obliki gela.
10. Kelat azitromicina s sukralfatom v obliki gela.
44 · Postopek za pripravo kompleksov oz. kelatov antibiotikov z dvovalentnimi in/ ali trivalentnimi kovinami, označen s tem, da azitromicin kot prosta baza ali v obliki hidroklorida reagira s solmi kovin iz skupine Mg+2, Al+^> Fe+3, Rh+3 in La+3 kot so kloridi, v molarnem razmerju 2:1, v vodni raztopini ali v zmesi alkohol-voda, pri sobni temperaturi in vzdrževanju konstantnega pH od 8.0 do 11.0 oz. s kovinskimi hidroksidi in/ali karbonati, subsalicilati ali njihovimi geli, kot so gel iz aluminijevega hidroksida/magnezijevega karbonata in sukralfat, v razmerju 1:1 do 1:4, pri sobni temperaturi v alkoholu, kot je metanol ali etanol.
Za:
SI9010455A 1990-03-07 1990-03-28 Novi kompleksi oziroma kelati antibiotikov z dvovalentnimi in/ali trovalentnimi kovinami in postopki za njihovo pripravo SI9010455B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU45590A YU45590A (sh) 1990-03-07 1990-03-07 Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje

Publications (2)

Publication Number Publication Date
SI9010455A SI9010455A (en) 1997-08-31
SI9010455B true SI9010455B (sl) 2000-04-30

Family

ID=25550003

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9010455A SI9010455B (sl) 1990-03-07 1990-03-28 Novi kompleksi oziroma kelati antibiotikov z dvovalentnimi in/ali trovalentnimi kovinami in postopki za njihovo pripravo

Country Status (20)

Country Link
US (1) US5498699A (sl)
EP (1) EP0445743B1 (sl)
JP (1) JP2731636B2 (sl)
CN (2) CN1041166C (sl)
AT (1) ATE143266T1 (sl)
BG (1) BG61230B1 (sl)
CA (1) CA2037663C (sl)
CZ (1) CZ280181B6 (sl)
DE (1) DE69122282T2 (sl)
DK (1) DK0445743T3 (sl)
ES (1) ES2094763T3 (sl)
GR (1) GR3021947T3 (sl)
HR (1) HRP940256B1 (sl)
HU (2) HU209455B (sl)
PL (1) PL166279B1 (sl)
RO (1) RO107660B1 (sl)
RU (2) RU2039060C1 (sl)
SI (1) SI9010455B (sl)
SK (1) SK279278B6 (sl)
YU (1) YU45590A (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
GB9120131D0 (en) * 1991-09-20 1991-11-06 Glaxo Group Ltd Medicaments
TW271400B (sl) * 1992-07-30 1996-03-01 Pfizer
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
CN1177357A (zh) * 1995-01-26 1998-03-25 耐克麦德英梅金公司 铋化合物
US5900410A (en) * 1996-08-27 1999-05-04 Hartmann; John F. Monotherapy of peptic ulcers and gastritis
US6861411B1 (en) * 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
EP1671979B1 (en) 2001-05-22 2008-08-13 Pfizer Products Inc. New Cristal Form of Azithromycin
EA200400214A1 (ru) * 2001-08-21 2004-06-24 Пфайзер Продактс Инк. Азитромицин в виде разовой дозы
US20060046970A1 (en) * 2004-08-31 2006-03-02 Insite Vision Incorporated Topical otic compositions and methods of topical treatment of prevention of otic infections
EP1805134B1 (en) 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
CN104892694A (zh) * 2015-05-24 2015-09-09 广西师范学院 蔗糖硫酸酯铜类化合物及其制作方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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US3862225A (en) * 1961-08-18 1975-01-21 Pfizer D-ring substituted tetracyclines
US3622627A (en) * 1967-09-13 1971-11-23 Pfizer 4-dedimethylaminatetracycline and 5a, 6-anhydro derivatives thereof
HU167946B (sl) * 1973-04-16 1976-01-28
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
SG72632A1 (en) * 1985-04-18 2000-05-23 Procter & Gamble Treatment of non-ulcer dyspepsia with bismuth salts
DE3650504T2 (de) * 1985-06-13 1996-10-31 Marshall Barry James Verfahren und Zusammensetzungen zur Behandlung von gastrointestinalen Störungen
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina
YU44599B (en) * 1986-09-12 1990-10-31 Pliva Pharm & Chem Works Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals
DE3860503D1 (de) * 1987-09-03 1990-10-04 Pliva Pharm & Chem Works 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
DE3887353T2 (de) * 1987-10-12 1994-05-05 Capability Services Pty Ltd Behandlungsverfahren für magen-darm-krankheiten.
US5246708A (en) * 1987-10-28 1993-09-21 Pro-Neuron, Inc. Methods for promoting wound healing with deoxyribonucleosides
EP0391005B1 (en) * 1989-04-03 1991-10-16 Ranbaxy Laboratories, Ltd. Process for the production of alpha-6-deoxytetracyclines
US5348946A (en) * 1991-02-28 1994-09-20 Biochem Immunosystems, Inc. Heteroanthracycline antitumor analogs
MA28714B1 (fr) * 2005-12-15 2007-07-02 Green Technlology Sarl Une arabinogalactane proteine ayant la propriete d'absorber les graisses et le procede d'obtention de cette arabinogalactane proteine

Also Published As

Publication number Publication date
ES2094763T3 (es) 1997-02-01
CA2037663C (en) 1999-01-19
CN1054534A (zh) 1991-09-18
RO107660B1 (ro) 1993-12-30
BG61230B1 (bg) 1997-03-31
CS9100587A2 (en) 1991-10-15
EP0445743B1 (en) 1996-09-25
CN1168891A (zh) 1997-12-31
SK279278B6 (sk) 1998-09-09
RU2039061C1 (ru) 1995-07-09
HRP940256B1 (en) 1998-10-31
JPH06184186A (ja) 1994-07-05
CZ280181B6 (cs) 1995-11-15
RU2039060C1 (ru) 1995-07-09
DE69122282T2 (de) 1997-04-24
HU211475A9 (en) 1995-11-28
GR3021947T3 (en) 1997-03-31
SI9010455A (en) 1997-08-31
EP0445743A3 (en) 1992-10-07
JP2731636B2 (ja) 1998-03-25
HUT56849A (en) 1991-10-28
CN1041166C (zh) 1998-12-16
DE69122282D1 (de) 1996-10-31
BG93995A (bg) 1993-12-24
HRP940256A2 (en) 1997-06-30
HU209455B (en) 1994-06-28
ATE143266T1 (de) 1996-10-15
EP0445743A2 (en) 1991-09-11
CA2037663A1 (en) 1991-09-08
CN1051560C (zh) 2000-04-19
DK0445743T3 (sl) 1997-02-17
US5498699A (en) 1996-03-12
YU45590A (sh) 1992-07-20
HU910740D0 (en) 1991-09-30
PL166279B1 (pl) 1995-04-28

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