SI3124018T1 - Oral formulations of deferasirox - Google Patents

Oral formulations of deferasirox Download PDF

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Publication number
SI3124018T1
SI3124018T1 SI201430621T SI201430621T SI3124018T1 SI 3124018 T1 SI3124018 T1 SI 3124018T1 SI 201430621 T SI201430621 T SI 201430621T SI 201430621 T SI201430621 T SI 201430621T SI 3124018 T1 SI3124018 T1 SI 3124018T1
Authority
SI
Slovenia
Prior art keywords
tablet
deferasirox
film
oral administration
administration according
Prior art date
Application number
SI201430621T
Other languages
English (en)
Slovenian (sl)
Inventor
Indrajit Ghosh
Jia-Ai Zhang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50288212&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3124018(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI3124018T1 publication Critical patent/SI3124018T1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846Poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125Camphor; Nuclear substituted derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/148Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893Tablet coating processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/04Chelating agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201430621T 2013-03-08 2014-03-06 Oral formulations of deferasirox SI3124018T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361774893P 2013-03-08 2013-03-08
US201361824435P 2013-05-17 2013-05-17
EP16188627.0A EP3124018B2 (en) 2013-03-08 2014-03-06 Oral formulations of deferasirox

Publications (1)

Publication Number Publication Date
SI3124018T1 true SI3124018T1 (en) 2018-04-30

Family

ID=50288212

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201430621T SI3124018T1 (en) 2013-03-08 2014-03-06 Oral formulations of deferasirox
SI201431064T SI2964202T1 (sl) 2013-03-08 2014-03-06 Peroralne formulacije deferasiroksa

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201431064T SI2964202T1 (sl) 2013-03-08 2014-03-06 Peroralne formulacije deferasiroksa

Country Status (41)

Country Link
US (4) US9283209B2 (enExample)
EP (2) EP3124018B2 (enExample)
JP (3) JP6434429B2 (enExample)
KR (2) KR20170045391A (enExample)
CN (1) CN105025886B (enExample)
AP (1) AP2015008668A0 (enExample)
AU (2) AU2014224198B2 (enExample)
BR (1) BR112015021254A2 (enExample)
CA (1) CA2890465A1 (enExample)
CL (1) CL2015002495A1 (enExample)
CR (1) CR20150467A (enExample)
CU (1) CU24348B1 (enExample)
CY (2) CY1120021T1 (enExample)
DK (2) DK2964202T3 (enExample)
DO (1) DOP2015000220A (enExample)
EA (1) EA031719B1 (enExample)
EC (1) ECSP15042897A (enExample)
ES (2) ES2708955T5 (enExample)
HR (2) HRP20190173T1 (enExample)
HU (2) HUE036921T2 (enExample)
IL (1) IL240797B (enExample)
JO (1) JO3570B1 (enExample)
LT (2) LT2964202T (enExample)
ME (1) ME03297B (enExample)
MX (1) MX361055B (enExample)
MY (1) MY170303A (enExample)
NI (1) NI201500126A (enExample)
NZ (1) NZ711179A (enExample)
PE (1) PE20151600A1 (enExample)
PH (1) PH12015501981A1 (enExample)
PL (2) PL2964202T3 (enExample)
PT (2) PT3124018T (enExample)
RS (2) RS56890B1 (enExample)
SA (1) SA515360425B1 (enExample)
SG (2) SG10201807204YA (enExample)
SI (2) SI3124018T1 (enExample)
TN (1) TN2015000393A1 (enExample)
TW (2) TWI625136B (enExample)
UY (1) UY35367A (enExample)
WO (1) WO2014136079A1 (enExample)
ZA (1) ZA201506060B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS56890B1 (sr) 2013-03-08 2018-04-30 Novartis Ag Formulacije deferasiroksa za oralnu upotrebu
US9866684B2 (en) * 2015-02-16 2018-01-09 Microsoft Technology Licensing, Llc Process for real-time data exchange between users on a phone call
WO2016167729A1 (en) * 2015-04-16 2016-10-20 Öğün Yusuf Toktamiş Dispersible tablets comprising deferasirox
EP3310354A4 (en) 2015-06-17 2018-12-12 Dispersol Technologies, LLC Improved formulations of deferasirox and methods of making the same
WO2017158559A1 (en) 2016-03-17 2017-09-21 Lupin Limited Compositions of deferasirox
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
CA3029543C (en) * 2016-07-05 2021-11-23 Jubilant Generics Limited Immediate release pharmaceutical composition of iron chelating agents
EP3518904A1 (en) 2016-09-30 2019-08-07 Synthon B.V. Pharmaceutical composition comprising deferasirox
CZ2017255A3 (cs) 2017-05-04 2018-11-14 Zentiva, K.S. Filmem potažené tablety Deferasiroxu
TR201707764A2 (tr) * 2017-05-29 2018-12-21 Biofarma Ilac Sanayi Ve Ticaret Anonim Sirketi Deferasiroksun bölünebilir tablet formları.
WO2019108156A1 (en) * 2017-11-28 2019-06-06 Biofarma Ilac Sanayi Ve Ticaret A.S. A scored tablet formulation comprising deferasirox in a film tablet form
KR20200113116A (ko) 2019-03-22 2020-10-06 주식회사 한국팜비오 데페라시록스를 포함하는 필름코팅정제
EP3854385A1 (en) * 2020-01-27 2021-07-28 ROS Therapeutics ApS Methotrexate dosage form
EP4052698A1 (en) * 2021-03-05 2022-09-07 Sanovel Ilac Sanayi Ve Ticaret A.S. Film coated tablet comprising deferasirox
CN115154428B (zh) * 2022-09-06 2023-01-10 上海奥科达医药科技股份有限公司 一种地拉罗司药物组合物及其制备方法
WO2025242589A1 (en) 2024-05-21 2025-11-27 Chiesi Farmaceutici S.P.A. Pharmaceutical dosage forms for deferiprone and deferasirox combined therapy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW533205B (en) * 1996-06-25 2003-05-21 Novartis Ag Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition
GB0223978D0 (en) 2002-10-15 2002-11-20 Novartis Ag Organic compound
KR20070022243A (ko) * 2004-04-08 2007-02-26 노파르티스 아게 데페라시록스 분산성 정제
GB0408078D0 (en) * 2004-04-08 2004-05-12 Novartis Ag Organic compounds
CA2625112A1 (en) 2005-10-19 2007-04-26 Novartis Ag Dispersible tablets comprising deferasirox
WO2009067557A1 (en) 2007-11-19 2009-05-28 Teva Pharmaceutical Industries Ltd. Deferasirox pharmaceutical compositions
WO2009106824A2 (en) 2008-02-25 2009-09-03 Cipla Limited Pharmaceutical formulations
WO2009130604A2 (en) * 2008-04-21 2009-10-29 Actavis Group Ptc Ehf Solid state forms of deferasirox salts and process for the preparation thereof
WO2010035282A1 (en) 2008-09-24 2010-04-01 Matrix Laboratories Limited Pharmaceutical compositions comprising deferasirox
WO2010143006A1 (en) 2009-06-10 2010-12-16 Carlo Ghisalberti Orally bioavailable iron chelators in the treatment of an inflammatory bowel disease
ES2543427T3 (es) * 2010-07-08 2015-08-19 Ratiopharm Gmbh Forma farmacéutica oral de deferasirox
KR20140011300A (ko) 2010-10-01 2014-01-28 시플라 리미티드 데페라시록스를 포함하는 약학 조성물
RS56890B1 (sr) 2013-03-08 2018-04-30 Novartis Ag Formulacije deferasiroksa za oralnu upotrebu
WO2017158559A1 (en) 2016-03-17 2017-09-21 Lupin Limited Compositions of deferasirox

Also Published As

Publication number Publication date
AU2017203897A1 (en) 2017-06-29
PL3124018T3 (pl) 2018-05-30
LT2964202T (lt) 2019-02-11
ES2708955T5 (es) 2023-11-10
DK3124018T3 (en) 2018-03-26
ES2663135T3 (es) 2018-04-11
JP2018162255A (ja) 2018-10-18
CA2890465A1 (en) 2014-09-12
SA515360425B1 (ar) 2018-01-21
EP2964202B2 (en) 2023-05-31
AU2014224198B2 (en) 2017-06-15
US9283209B2 (en) 2016-03-15
ES2708955T3 (es) 2019-04-12
ES2663135T5 (en) 2024-12-16
EP3124018A1 (en) 2017-02-01
ECSP15042897A (es) 2019-03-29
AU2017203897B2 (en) 2019-02-14
PL2964202T3 (pl) 2019-04-30
IL240797A0 (en) 2015-10-29
UY35367A (es) 2014-10-31
EA201591665A1 (ru) 2015-12-30
MY170303A (en) 2019-07-17
PH12015501981B1 (en) 2016-01-11
KR20170045391A (ko) 2017-04-26
RS58317B1 (sr) 2019-03-29
JP2016510068A (ja) 2016-04-04
HUE036921T2 (hu) 2018-08-28
US20170290811A1 (en) 2017-10-12
ZA201506060B (en) 2016-12-21
TWI686215B (zh) 2020-03-01
RS56890B1 (sr) 2018-04-30
TW201442742A (zh) 2014-11-16
AU2014224198A1 (en) 2015-09-10
US20160220493A1 (en) 2016-08-04
SG11201506491RA (en) 2015-09-29
PT2964202T (pt) 2019-02-06
CY1121315T1 (el) 2020-05-29
HRP20180387T1 (hr) 2018-04-20
CU20150110A7 (es) 2016-04-25
AP2015008668A0 (en) 2015-08-31
SI2964202T1 (sl) 2019-02-28
IL240797B (en) 2022-01-01
CL2015002495A1 (es) 2016-03-04
DOP2015000220A (es) 2015-11-30
LT3124018T (lt) 2018-03-12
PT3124018T (pt) 2018-03-22
TW201838623A (zh) 2018-11-01
EP2964202A1 (en) 2016-01-13
EP2964202B1 (en) 2018-10-31
HUE041224T2 (hu) 2019-05-28
TN2015000393A1 (en) 2017-01-03
CN105025886B (zh) 2019-01-15
HRP20190173T1 (hr) 2019-03-22
ME03297B (me) 2019-07-20
US20180221285A1 (en) 2018-08-09
BR112015021254A2 (pt) 2017-07-18
NI201500126A (es) 2015-11-18
JP2020180123A (ja) 2020-11-05
KR101925671B1 (ko) 2019-02-27
EA031719B1 (ru) 2019-02-28
JP6739470B2 (ja) 2020-08-12
WO2014136079A1 (en) 2014-09-12
CR20150467A (es) 2015-10-27
DK2964202T3 (en) 2019-02-25
EP3124018B1 (en) 2017-12-20
SG10201807204YA (en) 2018-09-27
PE20151600A1 (es) 2015-11-26
TWI625136B (zh) 2018-06-01
JO3570B1 (ar) 2020-07-05
MX2015011962A (es) 2016-07-07
EP3124018B2 (en) 2024-04-24
CY1120021T1 (el) 2018-12-12
JP6434429B2 (ja) 2018-12-05
CU24348B1 (es) 2018-05-08
CN105025886A (zh) 2015-11-04
HK1212242A1 (en) 2016-06-10
US20150017241A1 (en) 2015-01-15
KR20150126900A (ko) 2015-11-13
MX361055B (es) 2018-11-26
NZ711179A (en) 2018-07-27
PH12015501981A1 (en) 2016-01-11

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