HRP20180387T1 - Oralne formulacije deferasiroksa - Google Patents

Oralne formulacije deferasiroksa Download PDF

Info

Publication number
HRP20180387T1
HRP20180387T1 HRP20180387TT HRP20180387T HRP20180387T1 HR P20180387 T1 HRP20180387 T1 HR P20180387T1 HR P20180387T T HRP20180387T T HR P20180387TT HR P20180387 T HRP20180387 T HR P20180387T HR P20180387 T1 HRP20180387 T1 HR P20180387T1
Authority
HR
Croatia
Prior art keywords
tablet
deferasirox
film
oral administration
administration according
Prior art date
Application number
HRP20180387TT
Other languages
English (en)
Inventor
Indrajit Ghosh
Jia-Ai Zhang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50288212&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20180387(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HRP20180387T1 publication Critical patent/HRP20180387T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Claims (9)

1. Filmom obložena tableta za oralnu primjenu, naznačena time, da ona obuhvaća deferasiroks ili njegovu farmaceutski prihvatljivu sol, koji/koja je prisutan/prisutna u količini od 45 do 60 masenih postotaka na osnovi ukupne mase tablete, te time, da tableta sadrži 90 mg, 180 mg ili 360 mg deferasiroksa ili njegove farmaceutski prihvatljive soli, pri čemu tableta nadalje obuhvaća sljedeće: (i) najmanje jedno punilo u ukupnoj količini od 10 do 40 masenih postotaka na osnovi ukupne mase tablete, gdje to punilo je mikrokristalna celuloza; (ii) najmanje jedan dezintegrator u ukupnoj količini od jednoga do 10 masenih postotaka na osnovi ukupne mase tablete, gdje taj dezintegrator je unakrsno povezani polivinilpirolidon (krospovidon); (iii) najmanje jedno vezivo u ukupnoj količini od jednoga do 5 masenih postotaka na osnovi ukupne mase tablete, gdje to vezivo je polivinilpirolidon (PVP); (iv) prema potrebi, najmanje jedan tenzid u ukupnoj količini od 0,0 do dva masena postotka na osnovi ukupne mase tablete, gdje taj tenzid je poloksamer; (v) najmanje jedno klizno sredstvo u ukupnoj količini od 0,1 do jednog masenog postotka na osnovi ukupne mase tablete, gdje to klizno sredstvo je koloidni silicijev dioksid; (vi) najmanje jedan lubrikant u ukupnoj količini od manje od 0,1 do dva masena postotka na osnovi ukupne mase tablete, gdje taj lubrikant je magnezijev stearat; i (vii) obloga.
2. Filmom obložena tableta za oralnu primjenu prema zahtjevu 1, naznačena time, da tableta obuhvaća 90 mg deferasiroksa ili njegove farmaceutski prihvatljive soli.
3. Filmom obložena tableta za oralnu primjenu prema zahtjevu 1, naznačena time, da tableta obuhvaća 180 mg deferasiroksa ili njegove farmaceutski prihvatljive soli.
4. Filmom obložena tableta za oralnu primjenu prema zahtjevu 1, naznačena time, da tableta obuhvaća 360 mg deferasiroksa ili njegove farmaceutski prihvatljive soli.
5. Filmom obložena tableta za oralnu primjenu prema bilo kojem od prethodnih zahtjeva, naznačena time, da tableta pokazuje vrijeme dezintegracije u trajanju od 5-10 minuta kada se mjeri standardnim USP testom dezintegracije.
6. Filmom obložena tableta za oralnu primjenu prema zahtjevu 1, naznačena time, da se ona sastoji od: 90 mg deferasiroksa; 53,61 mg mikrokristalne celuloze; 3,65 mg polivinilpirolidona; 11,34 mg krospovidona; 0,16 mg poloksamera 188; 0,81 mg koloidnog silicijevog dioksida; 2,43 mg magnezijevog stearata; i 4,86 mg obloge.
7. Filmom obložena tableta za oralnu primjenu prema zahtjevu 1, naznačena time, da se ona sastoji od: 180 mg deferasiroksa; 107,23 mg mikrokristalne celuloze; 7,29 mg polivinilpirolidona; 22,68 mg krospovidona; 0,32 mg poloksamera 188; 1,62 mg koloidnog silicijevog dioksida; 4,86 mg magnezijevog stearata; i 9,72 mg obloge.
8. Filmom obložena tableta za oralnu primjenu prema zahtjevu 1, naznačena time, da se ona sastoji od: 360 mg deferasiroksa; 215,45 mg mikrokristalne celuloze; 14,58 mg polivinilpirolidona; 45,36 mg krospovidona; 0,65 mg poloksamera 188; 3,24 mg koloidnog silicijevog dioksida; 9,72 mg magnezijevog stearata; i 19,44 mg obloge.
9. Filmom obložena tableta za oralnu primjenu prema zahtjevu 1, naznačena time, da ona obuhvaća sljedeće: [image]
HRP20180387TT 2013-03-08 2018-03-06 Oralne formulacije deferasiroksa HRP20180387T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361774893P 2013-03-08 2013-03-08
US201361824435P 2013-05-17 2013-05-17
EP16188627.0A EP3124018B2 (en) 2013-03-08 2014-03-06 Oral formulations of deferasirox

Publications (1)

Publication Number Publication Date
HRP20180387T1 true HRP20180387T1 (hr) 2018-04-20

Family

ID=50288212

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20180387TT HRP20180387T1 (hr) 2013-03-08 2018-03-06 Oralne formulacije deferasiroksa
HRP20190173TT HRP20190173T1 (hr) 2013-03-08 2019-01-25 Oralne formulacije deferasiroksa

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20190173TT HRP20190173T1 (hr) 2013-03-08 2019-01-25 Oralne formulacije deferasiroksa

Country Status (42)

Country Link
US (4) US9283209B2 (hr)
EP (2) EP3124018B2 (hr)
JP (3) JP6434429B2 (hr)
KR (2) KR20170045391A (hr)
CN (1) CN105025886B (hr)
AP (1) AP2015008668A0 (hr)
AU (2) AU2014224198B2 (hr)
BR (1) BR112015021254A2 (hr)
CA (1) CA2890465A1 (hr)
CL (1) CL2015002495A1 (hr)
CR (1) CR20150467A (hr)
CU (1) CU24348B1 (hr)
CY (2) CY1120021T1 (hr)
DK (2) DK3124018T3 (hr)
DO (1) DOP2015000220A (hr)
EA (1) EA031719B1 (hr)
EC (1) ECSP15042897A (hr)
ES (2) ES2708955T5 (hr)
HK (1) HK1212242A1 (hr)
HR (2) HRP20180387T1 (hr)
HU (2) HUE041224T2 (hr)
IL (1) IL240797B (hr)
JO (1) JO3570B1 (hr)
LT (2) LT3124018T (hr)
ME (1) ME03297B (hr)
MX (1) MX361055B (hr)
MY (1) MY170303A (hr)
NI (1) NI201500126A (hr)
NZ (1) NZ711179A (hr)
PE (1) PE20151600A1 (hr)
PH (1) PH12015501981A1 (hr)
PL (2) PL3124018T3 (hr)
PT (2) PT3124018T (hr)
RS (2) RS58317B1 (hr)
SA (1) SA515360425B1 (hr)
SG (2) SG10201807204YA (hr)
SI (2) SI2964202T1 (hr)
TN (1) TN2015000393A1 (hr)
TW (2) TWI625136B (hr)
UY (1) UY35367A (hr)
WO (1) WO2014136079A1 (hr)
ZA (1) ZA201506060B (hr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3570B1 (ar) 2013-03-08 2020-07-05 Novartis Ag صيغ للإعطاء بالفم من ديفيرازيروكس
US9866684B2 (en) * 2015-02-16 2018-01-09 Microsoft Technology Licensing, Llc Process for real-time data exchange between users on a phone call
WO2016167729A1 (en) * 2015-04-16 2016-10-20 Öğün Yusuf Toktamiş Dispersible tablets comprising deferasirox
EP3310354A4 (en) 2015-06-17 2018-12-12 Dispersol Technologies, LLC Improved formulations of deferasirox and methods of making the same
WO2017158559A1 (en) 2016-03-17 2017-09-21 Lupin Limited Compositions of deferasirox
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
EP3481390A4 (en) * 2016-07-05 2020-03-04 Jubilant Generics Limited PHARMACEUTICAL COMPOSITION WITH IMMEDIATE RELEASE OF IRON CHELATE IMAGERS
WO2018059922A1 (en) 2016-09-30 2018-04-05 Synthon B.V. Pharmaceutical composition comprising deferasirox
CZ2017255A3 (cs) * 2017-05-04 2018-11-14 Zentiva, K.S. Filmem potažené tablety Deferasiroxu
TR201707764A2 (tr) * 2017-05-29 2018-12-21 Biofarma Ilac Sanayi Ve Ticaret Anonim Sirketi Deferasiroksun bölünebilir tablet formları.
WO2019108156A1 (en) * 2017-11-28 2019-06-06 Biofarma Ilac Sanayi Ve Ticaret A.S. A scored tablet formulation comprising deferasirox in a film tablet form
KR20200113116A (ko) 2019-03-22 2020-10-06 주식회사 한국팜비오 데페라시록스를 포함하는 필름코팅정제
EP4052698A1 (en) * 2021-03-05 2022-09-07 Sanovel Ilac Sanayi Ve Ticaret A.S. Film coated tablet comprising deferasirox
CN115154428B (zh) * 2022-09-06 2023-01-10 上海奥科达医药科技股份有限公司 一种地拉罗司药物组合物及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW533205B (en) 1996-06-25 2003-05-21 Novartis Ag Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition
GB0223978D0 (en) * 2002-10-15 2002-11-20 Novartis Ag Organic compound
GB0408078D0 (en) * 2004-04-08 2004-05-12 Novartis Ag Organic compounds
KR20070022243A (ko) * 2004-04-08 2007-02-26 노파르티스 아게 데페라시록스 분산성 정제
WO2007045445A1 (en) * 2005-10-19 2007-04-26 Novartis Ag Dispersible tablets comprising deferasirox
US20090142395A1 (en) * 2007-11-19 2009-06-04 Uri Zadok Deferasirox pharmaceutical compositions
WO2009106824A2 (en) 2008-02-25 2009-09-03 Cipla Limited Pharmaceutical formulations
US20110097413A1 (en) 2008-04-21 2011-04-28 Actavis Group Ptc Ehf Solid state forms of deferasirox salts and process for the preparation thereof
WO2010035282A1 (en) 2008-09-24 2010-04-01 Matrix Laboratories Limited Pharmaceutical compositions comprising deferasirox
WO2010143006A1 (en) * 2009-06-10 2010-12-16 Carlo Ghisalberti Orally bioavailable iron chelators in the treatment of an inflammatory bowel disease
US8703203B2 (en) * 2010-07-08 2014-04-22 Ratiopharm Gmbh Oral dosage form of deferasirox
RU2589842C2 (ru) * 2010-10-01 2016-07-10 Сипла Лимитед Фармацевтическая композиция
JO3570B1 (ar) 2013-03-08 2020-07-05 Novartis Ag صيغ للإعطاء بالفم من ديفيرازيروكس
WO2017158559A1 (en) 2016-03-17 2017-09-21 Lupin Limited Compositions of deferasirox

Also Published As

Publication number Publication date
CU20150110A7 (es) 2016-04-25
SI2964202T1 (sl) 2019-02-28
TWI625136B (zh) 2018-06-01
NZ711179A (en) 2018-07-27
HK1212242A1 (en) 2016-06-10
TW201838623A (zh) 2018-11-01
EP3124018A1 (en) 2017-02-01
AP2015008668A0 (en) 2015-08-31
KR20150126900A (ko) 2015-11-13
CR20150467A (es) 2015-10-27
DK2964202T3 (en) 2019-02-25
IL240797A0 (en) 2015-10-29
ME03297B (me) 2019-07-20
JP2020180123A (ja) 2020-11-05
US20160220493A1 (en) 2016-08-04
BR112015021254A2 (pt) 2017-07-18
JP6739470B2 (ja) 2020-08-12
CY1120021T1 (el) 2018-12-12
CY1121315T1 (el) 2020-05-29
PT2964202T (pt) 2019-02-06
HUE036921T2 (hu) 2018-08-28
CU24348B1 (es) 2018-05-08
EP3124018B1 (en) 2017-12-20
EA201591665A1 (ru) 2015-12-30
EP2964202B2 (en) 2023-05-31
TWI686215B (zh) 2020-03-01
JP6434429B2 (ja) 2018-12-05
SG10201807204YA (en) 2018-09-27
LT2964202T (lt) 2019-02-11
AU2014224198A1 (en) 2015-09-10
US9283209B2 (en) 2016-03-15
IL240797B (en) 2022-01-01
RS56890B1 (sr) 2018-04-30
WO2014136079A1 (en) 2014-09-12
SI3124018T1 (en) 2018-04-30
CN105025886A (zh) 2015-11-04
AU2014224198B2 (en) 2017-06-15
UY35367A (es) 2014-10-31
ECSP15042897A (es) 2019-03-29
NI201500126A (es) 2015-11-18
KR20170045391A (ko) 2017-04-26
PH12015501981B1 (en) 2016-01-11
EP2964202B1 (en) 2018-10-31
EP3124018B2 (en) 2024-04-24
ES2708955T5 (es) 2023-11-10
US20180221285A1 (en) 2018-08-09
HRP20190173T1 (hr) 2019-03-22
CA2890465A1 (en) 2014-09-12
US20150017241A1 (en) 2015-01-15
KR101925671B1 (ko) 2019-02-27
PE20151600A1 (es) 2015-11-26
PL3124018T3 (pl) 2018-05-30
US20170290811A1 (en) 2017-10-12
ES2708955T3 (es) 2019-04-12
JP2018162255A (ja) 2018-10-18
DOP2015000220A (es) 2015-11-30
LT3124018T (lt) 2018-03-12
ES2663135T3 (es) 2018-04-11
PH12015501981A1 (en) 2016-01-11
EA031719B1 (ru) 2019-02-28
MY170303A (en) 2019-07-17
JO3570B1 (ar) 2020-07-05
EP2964202A1 (en) 2016-01-13
TN2015000393A1 (en) 2017-01-03
MX361055B (es) 2018-11-26
PL2964202T3 (pl) 2019-04-30
ZA201506060B (en) 2016-12-21
SA515360425B1 (ar) 2018-01-21
MX2015011962A (es) 2016-07-07
AU2017203897B2 (en) 2019-02-14
PT3124018T (pt) 2018-03-22
AU2017203897A1 (en) 2017-06-29
CL2015002495A1 (es) 2016-03-04
SG11201506491RA (en) 2015-09-29
HUE041224T2 (hu) 2019-05-28
DK3124018T3 (en) 2018-03-26
JP2016510068A (ja) 2016-04-04
CN105025886B (zh) 2019-01-15
TW201442742A (zh) 2014-11-16
RS58317B1 (sr) 2019-03-29

Similar Documents

Publication Publication Date Title
HRP20180387T1 (hr) Oralne formulacije deferasiroksa
IL273300B1 (en) High dose valbenazine formulation and related preparations, methods and kits
HRP20192026T1 (hr) Formulacija tableta od neratinib maleata
HRP20160880T4 (hr) Formulacija obložene tablete i postupak
WO2009034541A3 (en) Controlled release pharmaceutical dosage forms of trimetazidine
NZ602075A (en) Abuse-resistant formulations
JP2011098964A5 (hr)
HRP20211862T1 (hr) Pripravci za i postupci liječenja anemije
RS51330B (en) STABLE PHARMACEUTICAL FORMULATIONS OF MONTELUKAST SODIUM
CO6400186A2 (es) Tabletas de acetato de ulipristal
RU2011152105A (ru) Составы таблеток 3-цианохинолина и их применение
NZ604055A (en) Pharmaceutical compositions comprising 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactate monohydrate
MX354416B (es) Formulaciones a base de nalbufina y sus usos.
WO2011147026A3 (en) A stable pharmaceutical formulation comprising telmisartan and hydrochlorothiazide
WO2016210003A3 (en) 17-hydroxyprogesterone ester-containing oral compositions and related methods
HRP20230616T1 (hr) Disperzivni pripravci
BR112013017750A2 (pt) nanocápsulas com envoltório polimérico
BR112014009438A2 (pt) composição farmacêutica para administração oral, e, método de preparação da composição farmacêutica para administração oral
HRP20192227T1 (hr) Dvojna uporaba oralnog farmaceutskog pripravka tableta sulfatnih soli i metode njihove uporabe
CO6150126A2 (es) Formulaciones de comprimidos de liberacion inmediata de un antagonista del receptor de trombina
WO2019059953A3 (en) Dry powder compositions with magnesium stearate
BR112015001640A2 (pt) formulações e métodos de produção de formulações para uso em evacuação colônica
CA2797458A1 (en) Tablet formulation of ezatiostat
RU2019109695A (ru) Лекарственная форма для пролонгированного ослабления симптомов
BR112015014430A2 (pt) composição em comprimido, e, granulado adequado para a fabricação de uma composição em comprimido