SI3050576T1 - Spojine pegiliranega rekombinantnega humanega rastnega hormona - Google Patents
Spojine pegiliranega rekombinantnega humanega rastnega hormonaInfo
- Publication number
- SI3050576T1 SI3050576T1 SI200932127T SI200932127T SI3050576T1 SI 3050576 T1 SI3050576 T1 SI 3050576T1 SI 200932127 T SI200932127 T SI 200932127T SI 200932127 T SI200932127 T SI 200932127T SI 3050576 T1 SI3050576 T1 SI 3050576T1
- Authority
- SI
- Slovenia
- Prior art keywords
- growth hormone
- recombinant human
- human growth
- pegylated recombinant
- hormone compounds
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08155408A EP2113256A1 (en) | 2008-04-29 | 2008-04-29 | PEGylated rhGH compounds |
EP08162865 | 2008-08-22 | ||
EP08167289 | 2008-10-22 | ||
EP16156852.2A EP3050576B1 (en) | 2008-04-29 | 2009-04-29 | Pegylated recombinant human growth hormone compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3050576T1 true SI3050576T1 (sl) | 2021-08-31 |
Family
ID=40872078
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200932127T SI3050576T1 (sl) | 2008-04-29 | 2009-04-29 | Spojine pegiliranega rekombinantnega humanega rastnega hormona |
SI200931492A SI2279007T1 (sl) | 2008-04-29 | 2009-04-29 | Spojine pegiliranega rekombinantnega humanega rastnega hormona |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200931492A SI2279007T1 (sl) | 2008-04-29 | 2009-04-29 | Spojine pegiliranega rekombinantnega humanega rastnega hormona |
Country Status (19)
Country | Link |
---|---|
US (4) | US9272048B2 (sl) |
EP (3) | EP3050576B1 (sl) |
JP (5) | JP6112766B2 (sl) |
CN (2) | CN102014965B (sl) |
CA (3) | CA2721947C (sl) |
CY (2) | CY1117882T1 (sl) |
DK (2) | DK3050576T3 (sl) |
ES (2) | ES2875426T3 (sl) |
HK (2) | HK1152239A1 (sl) |
HR (2) | HRP20161040T1 (sl) |
HU (2) | HUE029926T2 (sl) |
IL (2) | IL208833A (sl) |
LT (2) | LT3050576T (sl) |
MX (2) | MX2010011800A (sl) |
PL (2) | PL3050576T3 (sl) |
PT (2) | PT3050576T (sl) |
RU (1) | RU2689336C2 (sl) |
SI (2) | SI3050576T1 (sl) |
WO (1) | WO2009133137A2 (sl) |
Families Citing this family (38)
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HUE045882T2 (hu) * | 2004-03-23 | 2020-01-28 | Ascendis Pharma Gmbh | Polimer prodrug önmagát lehasító linkerrel |
DK3050576T3 (da) * | 2008-04-29 | 2021-06-07 | Ascendis Pharma Endocrinology Div A/S | Pegylerede rekombinante forbindelser af humant væksthormon |
CN102076331B (zh) * | 2008-06-26 | 2013-12-18 | 普罗林科斯有限责任公司 | 具有可控的药物释放速率的前药和药物-大分子轭合物 |
MX345226B (es) | 2008-10-29 | 2017-01-20 | Ablynx Nv | Formulaciones de moleculas de union a antigeno de dominio sencillo. |
CA2739352C (en) | 2008-10-29 | 2021-07-13 | Wyeth Llc | Methods for purification of single domain antigen binding molecules |
KR101759499B1 (ko) | 2009-07-31 | 2017-07-19 | 사노피-아벤티스 도이칠란트 게엠베하 | 지속형 인슐린 조성물 |
SG178193A1 (en) | 2009-07-31 | 2012-03-29 | Sanofi Aventis Deutschland | Prodrugs comprising an insulin linker conjugate |
EP2485712A1 (en) | 2009-10-06 | 2012-08-15 | Ascendis Pharma A/S | Subcutaneous paliperidone composition |
US8986609B2 (en) | 2009-10-29 | 2015-03-24 | Ascendis Pharma A/S | Sterilization of biodegradable hydrogels |
JP2013513647A (ja) * | 2009-12-15 | 2013-04-22 | アセンディス ファーマ エー/エス | ポリマー担体に一時的に連結された乾燥成長ホルモン組成物 |
WO2011089216A1 (en) | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
WO2011089215A1 (en) | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aromatic amine-containing drugs |
EP2525831B1 (en) | 2010-01-22 | 2019-05-15 | Ascendis Pharma A/S | Carrier-linked carbamate prodrug linkers |
CN103119062A (zh) * | 2010-07-16 | 2013-05-22 | 埃博灵克斯股份有限公司 | 修饰的单结构域抗原结合分子及其应用 |
EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
AU2012296954B2 (en) | 2011-08-12 | 2016-09-15 | Ascendis Pharma A/S | Carrier-linked treprostinil prodrugs |
AU2012296953B2 (en) | 2011-08-12 | 2016-10-20 | Ascendis Pharma A/S | Sustained release composition of prostacyclin |
WO2013082667A1 (en) * | 2011-12-09 | 2013-06-13 | Metabolic Pharmaceuticals Pty Ltd | Use of growth hormone fragments |
KR101365849B1 (ko) * | 2012-03-28 | 2014-02-24 | 경동제약 주식회사 | 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체 |
EP2841109A1 (en) | 2012-04-25 | 2015-03-04 | Ascendis Pharma A/S | Prodrugs of hydroxyl-comprising drugs |
CN104755104A (zh) | 2012-10-11 | 2015-07-01 | 阿森迪斯药物股份有限公司 | 诊断、预防和治疗关节疾病 |
CA2891949C (en) | 2012-12-07 | 2021-03-23 | Ascendis Pharma A/S | Carrier-linked prostanoid prodrugs |
CN103976982A (zh) * | 2014-06-03 | 2014-08-13 | 长春理工大学 | 一种包载重组人生长激素缓释药物微囊 |
IL307773A (en) * | 2014-11-18 | 2023-12-01 | Ascendis Pharma Endocrinology Div A/S | Novel polymeric human growth hormone drug matrices |
PL3220892T3 (pl) | 2014-11-21 | 2022-01-31 | Ascendis Pharma Endocrinology Division A/S | Postacie dawkowane długo działającego hormonu wzrostu |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
RU2747316C2 (ru) | 2016-03-01 | 2021-05-04 | Асцендис Фарма Боун Дизизис А/С | Пролекарства pth |
LT3518960T (lt) | 2016-09-29 | 2023-09-11 | Ascendis Pharma Bone Diseases A/S | Kontroliuojamo išsiskyrimo pth junginio dozavimo režimas |
KR102611820B1 (ko) | 2016-09-29 | 2023-12-07 | 아센디스 파마 본 디지즈 에이/에스 | 낮은 피크 대 트로프 비를 가진 pth 화합물 |
CN109789221B (zh) * | 2016-09-29 | 2022-11-01 | 阿森迪斯药物骨疾病股份有限公司 | 控释pth的药物组合物 |
AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
KR20200139730A (ko) * | 2018-03-28 | 2020-12-14 | 아센디스 파마 온콜로지 디비전 에이/에스 | Il-2 접합체 |
TW202015735A (zh) | 2018-05-30 | 2020-05-01 | 法商賽諾菲公司 | 包含glp-1/升糖素/gip三重受體促效劑、連接子及透明質酸之接合物 |
EP3934625A1 (en) | 2019-03-04 | 2022-01-12 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone dosage forms with superior efficacy to daily somatropin |
JP2023527919A (ja) | 2020-06-03 | 2023-06-30 | アセンディス ファーマ オンコロジー ディヴィジョン エー/エス | Il-2配列及びその使用 |
BR112023003476A2 (pt) | 2020-08-28 | 2023-04-11 | Ascendis Pharma Oncology Div A/S | Proteínas il-2 glicosiladas e usos das mesmas |
CN112362643A (zh) * | 2020-11-09 | 2021-02-12 | 长春金赛药业有限责任公司 | 一种基于镧系元素化学发光法长效生长激素免疫定量检测试剂盒及其方法 |
CN114539384A (zh) * | 2020-11-19 | 2022-05-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇化长效生长激素及其制备方法和医药应用 |
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