SI2729474T1 - (TIENO (2,3-b) (1,5) BENZOXAZEPIN-4-YL) PIPERAZINE-1-IL COMPOUNDS AS TWO ACTIVE H1 INVERTIVE AGENTS / 5-HT2A ANTAGONISTS - Google Patents
(TIENO (2,3-b) (1,5) BENZOXAZEPIN-4-YL) PIPERAZINE-1-IL COMPOUNDS AS TWO ACTIVE H1 INVERTIVE AGENTS / 5-HT2A ANTAGONISTS Download PDFInfo
- Publication number
- SI2729474T1 SI2729474T1 SI201231263T SI201231263T SI2729474T1 SI 2729474 T1 SI2729474 T1 SI 2729474T1 SI 201231263 T SI201231263 T SI 201231263T SI 201231263 T SI201231263 T SI 201231263T SI 2729474 T1 SI2729474 T1 SI 2729474T1
- Authority
- SI
- Slovenia
- Prior art keywords
- compound
- pharmaceutically acceptable
- benzoxazepin
- piperazin
- compounds
- Prior art date
Links
- -1 (THIENO(2,3-b)(1,5)BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS Chemical class 0.000 title claims 2
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 title claims 2
- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 title claims 2
- 239000005557 antagonist Substances 0.000 title claims 2
- 230000009977 dual effect Effects 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- 238000003874 inverse correlation nuclear magnetic resonance spectroscopy Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 206010022437 insomnia Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000000938 histamine H1 antagonist Substances 0.000 abstract 1
- 239000002400 serotonin 2A antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505685P | 2011-07-08 | 2011-07-08 | |
| PCT/US2012/045254 WO2013009517A1 (en) | 2011-07-08 | 2012-07-02 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS |
| EP12735409.0A EP2729474B1 (en) | 2011-07-08 | 2012-07-02 | (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2729474T1 true SI2729474T1 (en) | 2018-04-30 |
Family
ID=46513872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231263T SI2729474T1 (en) | 2011-07-08 | 2012-07-02 | (TIENO (2,3-b) (1,5) BENZOXAZEPIN-4-YL) PIPERAZINE-1-IL COMPOUNDS AS TWO ACTIVE H1 INVERTIVE AGENTS / 5-HT2A ANTAGONISTS |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9481688B2 (enExample) |
| EP (1) | EP2729474B1 (enExample) |
| JP (1) | JP6050813B2 (enExample) |
| KR (1) | KR101582429B1 (enExample) |
| CN (1) | CN103703008B (enExample) |
| AU (1) | AU2012283035B2 (enExample) |
| BR (1) | BR112014000379A2 (enExample) |
| CA (1) | CA2840217C (enExample) |
| DK (1) | DK2729474T3 (enExample) |
| EA (1) | EA023460B1 (enExample) |
| ES (1) | ES2665035T3 (enExample) |
| HR (1) | HRP20180475T1 (enExample) |
| HU (1) | HUE037649T2 (enExample) |
| IN (1) | IN2014MN00144A (enExample) |
| LT (1) | LT2729474T (enExample) |
| MX (1) | MX341132B (enExample) |
| NO (1) | NO2729474T3 (enExample) |
| PL (1) | PL2729474T3 (enExample) |
| PT (1) | PT2729474T (enExample) |
| RS (1) | RS57207B1 (enExample) |
| SI (1) | SI2729474T1 (enExample) |
| WO (1) | WO2013009517A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2943498T3 (pl) * | 2013-01-14 | 2018-01-31 | Lilly Co Eli | Związki (tieno[2,3-b][1,5]benzoksazepin-4-ylo)piperazyn-1-ylowe jako odwrotni agoniści h1 / antagoniści 5-ht2a o podwójnej aktywności |
| TW201625644A (zh) | 2014-04-29 | 2016-07-16 | 美國禮來大藥廠 | 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物 |
| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| CN108371660B (zh) * | 2017-12-14 | 2020-03-10 | 五邑大学 | 一种四氢环戊二烯并吡咯化合物及其衍生物的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602124A (en) * | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
| AU775299B2 (en) * | 1999-09-29 | 2004-07-29 | Eli Lilly And Company | Piperidine derivatives as reuptake inhibitors |
| HU226410B1 (en) * | 2003-04-22 | 2008-11-28 | Egis Gyogyszergyar Nyilvanosan | Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them |
| US7807828B2 (en) * | 2005-08-11 | 2010-10-05 | Hypnion, Inc. | Olanzapine analogs and methods of use thereof |
| BRPI0808828A8 (pt) * | 2007-03-15 | 2017-11-28 | Aryx Therapeutics Inc | Compostos de dibenzo[b,f][1,4]oxazapina |
| JP6106361B2 (ja) * | 2008-05-27 | 2017-03-29 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 睡眠障害および他の障害のための方法および組成物 |
| GB0910009D0 (en) * | 2009-06-10 | 2009-07-22 | Glaxo Group Ltd | Novel compounds |
| AR084867A1 (es) * | 2011-02-07 | 2013-07-10 | Lilly Co Eli | Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual |
| AU2012300451B2 (en) * | 2011-08-30 | 2016-10-13 | Eli Lilly And Company | (thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT 2A antagonists |
-
2012
- 2012-07-02 DK DK12735409.0T patent/DK2729474T3/en active
- 2012-07-02 JP JP2014519227A patent/JP6050813B2/ja active Active
- 2012-07-02 LT LTEP12735409.0T patent/LT2729474T/lt unknown
- 2012-07-02 WO PCT/US2012/045254 patent/WO2013009517A1/en not_active Ceased
- 2012-07-02 PT PT127354090T patent/PT2729474T/pt unknown
- 2012-07-02 CA CA2840217A patent/CA2840217C/en not_active Expired - Fee Related
- 2012-07-02 US US14/125,320 patent/US9481688B2/en active Active
- 2012-07-02 AU AU2012283035A patent/AU2012283035B2/en not_active Ceased
- 2012-07-02 HR HRP20180475TT patent/HRP20180475T1/hr unknown
- 2012-07-02 KR KR1020147000119A patent/KR101582429B1/ko not_active Expired - Fee Related
- 2012-07-02 MX MX2014000337A patent/MX341132B/es active IP Right Grant
- 2012-07-02 PL PL12735409T patent/PL2729474T3/pl unknown
- 2012-07-02 HU HUE12735409A patent/HUE037649T2/hu unknown
- 2012-07-02 BR BR112014000379A patent/BR112014000379A2/pt not_active IP Right Cessation
- 2012-07-02 EA EA201391706A patent/EA023460B1/ru not_active IP Right Cessation
- 2012-07-02 CN CN201280031201.7A patent/CN103703008B/zh active Active
- 2012-07-02 RS RS20180568A patent/RS57207B1/sr unknown
- 2012-07-02 EP EP12735409.0A patent/EP2729474B1/en active Active
- 2012-07-02 NO NO12735409A patent/NO2729474T3/no unknown
- 2012-07-02 ES ES12735409.0T patent/ES2665035T3/es active Active
- 2012-07-02 SI SI201231263T patent/SI2729474T1/en unknown
-
2014
- 2014-01-23 IN IN144MUN2014 patent/IN2014MN00144A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2729474B1 (en) | 2018-03-14 |
| ES2665035T3 (es) | 2018-04-24 |
| PT2729474T (pt) | 2018-06-05 |
| EP2729474A1 (en) | 2014-05-14 |
| NO2729474T3 (enExample) | 2018-08-11 |
| JP6050813B2 (ja) | 2016-12-21 |
| PL2729474T3 (pl) | 2018-08-31 |
| CA2840217A1 (en) | 2013-01-17 |
| MX2014000337A (es) | 2014-11-13 |
| EA023460B1 (ru) | 2016-06-30 |
| RS57207B1 (sr) | 2018-07-31 |
| CA2840217C (en) | 2016-03-22 |
| LT2729474T (lt) | 2018-05-10 |
| CN103703008A (zh) | 2014-04-02 |
| KR20140029512A (ko) | 2014-03-10 |
| KR101582429B1 (ko) | 2016-01-04 |
| HUE037649T2 (hu) | 2018-09-28 |
| JP2014518280A (ja) | 2014-07-28 |
| MX341132B (es) | 2016-08-09 |
| US20140121199A1 (en) | 2014-05-01 |
| HRP20180475T1 (hr) | 2018-06-15 |
| WO2013009517A1 (en) | 2013-01-17 |
| AU2012283035B2 (en) | 2015-07-30 |
| EA201391706A1 (ru) | 2014-04-30 |
| US9481688B2 (en) | 2016-11-01 |
| IN2014MN00144A (enExample) | 2015-06-19 |
| AU2012283035A1 (en) | 2014-01-16 |
| DK2729474T3 (en) | 2018-05-22 |
| BR112014000379A2 (pt) | 2017-01-10 |
| CN103703008B (zh) | 2015-11-25 |
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