SI2432467T1 - Antagonist receptorja serotonina 5-ht3 za uporabo pri zdravljenju lezijskih vestibularnih motenj - Google Patents

Antagonist receptorja serotonina 5-ht3 za uporabo pri zdravljenju lezijskih vestibularnih motenj Download PDF

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SI2432467T1
SI2432467T1 SI201031661T SI201031661T SI2432467T1 SI 2432467 T1 SI2432467 T1 SI 2432467T1 SI 201031661 T SI201031661 T SI 201031661T SI 201031661 T SI201031661 T SI 201031661T SI 2432467 T1 SI2432467 T1 SI 2432467T1
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serotonin
receptor antagonist
use according
antagonist
receptor
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SI201031661T
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English (en)
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Christian Chabbert
Frederic Venail
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Inserm (Institut National De La Sante Et De La Recherche Medicale)
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Priority claimed from EP09305464.1A external-priority patent/EP2253316B1/en
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Publication of SI2432467T1 publication Critical patent/SI2432467T1/sl

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Claims (9)

  1. ANTAGONIST RECEPTORJA SEROTONINA 5-HT3 ZA UPORABO PRI ZDRAVLJENJU LEZIJSKIH VESTIBULARNIH MOTENJ EP2432467 Patentni zahtevki
    1. Antagonist receptoma serotonina 5-HT3 za uporabo pri zdravljenju lezijske vestibulame motnje pri subjektu, ki to potrebuje, pri čemer je omenjeni antagonist receptoma serotonina 5-HT3 izbran iz skupine, ki jo sestavljajo azasetron, tropisetron, palonosetron, lerisetron, alosetron, granisetron, dolasetron, bemesetron, ramosetron, itasetron, zacoprid in cilansetron.
  2. 2. Antagonist receptorja serotonina 5-HT3 za uporabo po zahtevku 1, pri čemer je omenjeni antagonist receptorja serotonina 5-HT3 azasetron.
  3. 3. Antagonist receptorja serotonina 5-HT3 za uporabo po zahtevku 1, pri čemer je antagonist receptorjev serotonina 5-HT3 tropisetron.
  4. 4. Antagonist receptorja serotonina 5-HT3 za uporabo po kateremkoli izmed zahtevkov 1 do 3, pri čemer je omenjena lezijska vestibulama motnja izbrana iz skupine, ki jo sestavljajo vestibulami nevritis, virusni nevronitis, labirintitis, virusni endolimfatski labirintitis, z zdravili inducirana ototoksičnost, Menieijeva bolezen, endolimfatični hidrops, travma glave z lezijskimi vestibulamimi deficiti, labirintna krvavitev, kronična ali akutna labirintna okužba, serumski labirintitis, barotraumatizem, avtoimunska bolezen notranjega ušesa, kronična Menierjeva bolezen, prezbivestibulija in toksične vestibulame okvare.
  5. 5. Antagonist receptorja serotonina 5-HT3 za uporabo po kateremkoli od zahtevkov 1 do 4, pri čemer je omenjeni antagonist receptorja serotonina 5-HT3 potrebno administrirati oralno ali parenteralno.
  6. 6. Antagonist receptorja serotonina 5-HT3 za uporabo po kateremkoli od zahtevkov 1 do 4, pri čemer je omenjeni antagonist receptorja serotonina 5-HT3 potrebno administrirati neposredno v notranjem ušesu skozi timpansko membrano.
  7. 7. Antagonist receptoija serotonina 5-HT3 za uporabo po kateremkoli od zahtevkov 1 do 4, pri čemer je omenjeni antagonist receptorja serotonina 5-HT3 potrebno administrirati po nazalni poti.
  8. 8. Antagonist receptorja serotonina 5-HT3 za uporabo po kateremkoli od zahtevkov 1 do 4 ali 7, pri čemer je omenjeni antagonist receptorja serotonina 5-HT3 formuliran v napravi za nazalno administracijo.
  9. 9. Antagonist receptoija serotonina 5-HT3 za uporabo po kateremkoli od zahtevkov 1 do 8, pri čemer je subjekt človek.
SI201031661T 2009-05-20 2010-05-20 Antagonist receptorja serotonina 5-ht3 za uporabo pri zdravljenju lezijskih vestibularnih motenj SI2432467T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09305464.1A EP2253316B1 (en) 2009-05-20 2009-05-20 Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
EP09305996 2009-10-21
PCT/EP2010/056953 WO2010133663A1 (en) 2009-05-20 2010-05-20 Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
EP10723060.9A EP2432467B1 (en) 2009-05-20 2010-05-20 Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders

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SI2432467T1 true SI2432467T1 (sl) 2018-06-29

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SI201031661T SI2432467T1 (sl) 2009-05-20 2010-05-20 Antagonist receptorja serotonina 5-ht3 za uporabo pri zdravljenju lezijskih vestibularnih motenj

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US (1) US8580730B2 (sl)
EP (1) EP2432467B1 (sl)
JP (2) JP5955767B2 (sl)
KR (1) KR101779991B1 (sl)
CN (1) CN102458400B (sl)
CA (1) CA2761762C (sl)
CY (1) CY1120661T1 (sl)
DK (1) DK2432467T3 (sl)
ES (1) ES2664599T3 (sl)
HR (1) HRP20180531T1 (sl)
HU (1) HUE037300T2 (sl)
IL (1) IL216258A (sl)
LT (1) LT2432467T (sl)
PL (1) PL2432467T3 (sl)
PT (1) PT2432467T (sl)
RU (1) RU2608458C2 (sl)
SI (1) SI2432467T1 (sl)
WO (1) WO2010133663A1 (sl)

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Publication number Priority date Publication date Assignee Title
WO2015073789A1 (en) * 2013-11-14 2015-05-21 Insys Pharma, Inc. Ondansetron sublingual spray formulation
US11464838B2 (en) 2015-04-01 2022-10-11 Colorado State University Research Foundation Optimized cancer stem cell vaccines
PL3297628T3 (pl) * 2015-05-18 2021-12-06 Sensorion Azasetron do stosowania w leczeniu niedosłuchu
US10172833B2 (en) 2015-08-11 2019-01-08 Insys Development Company, Inc. Sublingual ondansetron spray
US11612605B2 (en) * 2016-04-14 2023-03-28 Sensorion (+)-azasetron for use in the treatment of ear disorders
WO2017178645A1 (en) 2016-04-14 2017-10-19 Sensorion (+)-azasetron for use in the treatment of ear disorders
JP2019210240A (ja) * 2018-06-04 2019-12-12 学校法人慶應義塾 衝動抑制薬のスクリーニング方法、及び衝動抑制薬
KR102514860B1 (ko) 2020-12-01 2023-03-29 한국과학기술연구원 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물
US11986464B2 (en) * 2021-04-30 2024-05-21 University Of Kentucky Research Foundation 5HT3R antagonist for use in treating aneurysms and cardiovascular risk
WO2023190707A1 (ja) * 2022-03-30 2023-10-05 国立大学法人大阪大学 感音難聴の予防または治療用組成物

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919292A1 (de) 1979-05-12 1980-11-20 Bayer Ag Substituierte harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als pflanzenbakterizide
GB2100259B (en) 1981-06-13 1984-10-31 Merrell Toraude & Co Treatment of migraine with tropyl benzoate derivatives
NL8202031A (nl) 1982-05-17 1983-12-16 Stork Pmt Inrichting voor het verwijderen der ingewanden van geslacht gevogelte.
FI74707C (fi) 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
FR2529548A1 (fr) 1982-07-02 1984-01-06 Delalande Sa Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
JPS5936675A (ja) 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4695578A (en) 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
IE57809B1 (en) 1984-01-25 1993-04-21 Glaxo Group Ltd 1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4 one derivatives
US4808624A (en) 1984-06-28 1989-02-28 Bristol-Myers Company Pharmacologically active substituted benzamides
EP0200444B1 (en) 1985-04-27 1992-11-11 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-ht antagonist activity
DE3687980T2 (de) 1986-01-07 1993-06-17 Beecham Group Plc Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
DE3771376D1 (de) 1986-03-17 1991-08-22 Glaxo Group Ltd Indol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4772459A (en) 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
ZA878096B (en) 1986-11-03 1988-04-26 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds
US4906755A (en) 1986-11-03 1990-03-06 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds
GR871809B (en) 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
EP0297651B1 (en) 1987-06-29 1993-11-03 Duphar International Research B.V Anellated indole derivatives
GB8718345D0 (en) 1987-08-03 1987-09-09 Fordonal Sa N-substituted benzamides
US5360800A (en) 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
NZ226032A (en) 1987-09-03 1991-12-23 Glaxo Group Ltd 2-(imidazolylmethyl)-pyrido or-azepino(4,3-b)indole-1(2h)-one derivatives; preparatory processes and pharmaceutical compositions
ZA886585B (en) 1987-09-08 1990-05-30 Lilly Co Eli Specific 5-ht,antagonists
IT1231413B (it) 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
CA1304082C (en) 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
GB8808433D0 (en) 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
US4863921A (en) 1988-04-27 1989-09-05 Rorer Pharmaceutical Corporation Dibenzofurancarboxamides and their pharmaceutical compositions and methods
US5017573A (en) 1988-07-29 1991-05-21 Dainippon Pharmaceutical Co., Ltd. Indazole-3-carboxylic acid derivatives
DE68926553T2 (de) 1988-08-02 1996-10-17 Glaxo Group Ltd., London Lactamderivate
US5008272A (en) 1988-08-15 1991-04-16 Glaxo Group Limited Lactam derivatives
AU626980B2 (en) 1989-02-02 1992-08-13 Astellas Pharma Inc. Tetrahydrobenzimidazole derivatives
US4963689A (en) 1989-05-19 1990-10-16 Pfizer Inc. Heterocyclicguanidines as 5HT3 antagonists
US4914207A (en) 1989-05-09 1990-04-03 Pfizer Inc. Arylthiazolylimidazoles
ZA909529B (en) 1989-11-28 1992-08-26 Syntex Inc New tricyclic compounds
US5225407A (en) 1990-02-22 1993-07-06 Glaxo Group Limited 5-HT3 receptor antagonists for the treatment of autism
US5256665A (en) 1991-05-10 1993-10-26 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. Process for preparing new 2-piperazinylbenzimidazole
WO1995009167A1 (fr) 1993-09-30 1995-04-06 Tokyo Tanabe Company Limited Derive d'indoline et antagoniste du recepteur 5-ht3 contenant ce derive et utilise comme ingredient actif
GB9423511D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
JP3702318B2 (ja) 1996-02-09 2005-10-05 日本電池株式会社 非水電解質電池用電極及びその電極を用いた非水電解質電池
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6566131B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of Smad6 expression
US6410323B1 (en) 1999-08-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense modulation of human Rho family gene expression
US6107091A (en) 1998-12-03 2000-08-22 Isis Pharmaceuticals Inc. Antisense inhibition of G-alpha-16 expression
US5981732A (en) 1998-12-04 1999-11-09 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-13 expression
US6046321A (en) 1999-04-09 2000-04-04 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-i1 expression
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
JP2003526367A (ja) 2000-03-16 2003-09-09 ジェネティカ インコーポレイテッド Ｒｎａ干渉の方法とｒｎａ干渉組成物
GB0009914D0 (en) * 2000-04-20 2000-06-07 Metris Therapeutics Limited Device
US6365354B1 (en) 2000-07-31 2002-04-02 Isis Pharmaceuticals, Inc. Antisense modulation of lysophospholipase I expression
US6566135B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression
US20030044356A1 (en) * 2001-04-20 2003-03-06 Jin Auh Composition for nasal solution sprays having effective component of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one)
WO2003061657A1 (en) 2002-01-18 2003-07-31 Aryx Therapeutics 5-ht3 receptor antagonists and methods of use
GB0213869D0 (en) * 2002-06-17 2002-07-31 Arakis Ltd The treatment of pain
CN1498613A (zh) * 2002-11-07 2004-05-26 北京东方凯恩医药科技有限公司 5－ht3受体拮抗剂鼻粘膜喷雾给药组合物及其用途
DE602004005814T2 (de) * 2003-01-13 2008-01-10 Dynogen Pharmaceuticals Inc., Waltham Verfahren zur behandlung von übelkeit, erbrechen, würgereiz oder jede kombination daraus
MY143789A (en) 2003-02-18 2011-07-15 Helsinn Healthcare Sa Use of palonosetron treating post- operative nausea and vomiting
US20040204466A1 (en) * 2003-04-14 2004-10-14 Orchid Chemicals And Pharmaceuticals Ltd. Treatment of bronchial asthma using 5-HT3 receptor antagonists
US20070259933A1 (en) 2006-05-04 2007-11-08 Xenoport, Inc. Compositions, dosage forms and methods of treating emesis
US20070265329A1 (en) 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
EP2725035A1 (en) * 2007-10-02 2014-04-30 Avaxia Biologics, Inc. Antibody therapy for use in the digestive tract

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