SI2419428T1 - Imidazo (1,2-a) piridin derivati kot FGFR kinaza inhibitorji za uporabo v terapiji - Google Patents
Imidazo (1,2-a) piridin derivati kot FGFR kinaza inhibitorji za uporabo v terapijiInfo
- Publication number
- SI2419428T1 SI2419428T1 SI201030994T SI201030994T SI2419428T1 SI 2419428 T1 SI2419428 T1 SI 2419428T1 SI 201030994 T SI201030994 T SI 201030994T SI 201030994 T SI201030994 T SI 201030994T SI 2419428 T1 SI2419428 T1 SI 2419428T1
- Authority
- SI
- Slovenia
- Prior art keywords
- imidazo
- therapy
- kinase inhibitors
- pyridine derivatives
- fgfr kinase
- Prior art date
Links
- 150000005234 imidazo[1,2-a]pyridines Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16950309P | 2009-04-15 | 2009-04-15 | |
| GBGB0906470.0A GB0906470D0 (en) | 2009-04-15 | 2009-04-15 | New compounds |
| EP20100718660 EP2419428B1 (en) | 2009-04-15 | 2010-04-15 | Imidazo[1,2-a]pyridine derivatives as fgfr kinase inhibitors for use in therapy |
| PCT/GB2010/050618 WO2010119285A1 (en) | 2009-04-15 | 2010-04-15 | Imidazo [1,2-a]pyridine derivatives as fgfr kinase inhibitors for use in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2419428T1 true SI2419428T1 (sl) | 2015-10-30 |
Family
ID=40750626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201030994T SI2419428T1 (sl) | 2009-04-15 | 2010-04-15 | Imidazo (1,2-a) piridin derivati kot FGFR kinaza inhibitorji za uporabo v terapiji |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8722687B2 (https=) |
| EP (1) | EP2419428B1 (https=) |
| JP (1) | JP5646598B2 (https=) |
| AU (1) | AU2010238290B2 (https=) |
| CA (1) | CA2757326C (https=) |
| DK (1) | DK2419428T3 (https=) |
| ES (1) | ES2545215T3 (https=) |
| GB (1) | GB0906470D0 (https=) |
| HR (1) | HRP20150825T1 (https=) |
| HU (1) | HUE027494T2 (https=) |
| PL (1) | PL2419428T3 (https=) |
| PT (1) | PT2419428E (https=) |
| RS (1) | RS54166B1 (https=) |
| SI (1) | SI2419428T1 (https=) |
| SM (1) | SMT201500200B (https=) |
| WO (1) | WO2010119285A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8513276B2 (en) | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
| HRP20150642T1 (hr) | 2006-12-22 | 2015-08-14 | Astex Therapeutics Limited | BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| UA111382C2 (uk) | 2011-10-10 | 2016-04-25 | Оріон Корпорейшн | Інгібітори протеїнкінази |
| WO2013138341A1 (en) * | 2012-03-15 | 2013-09-19 | Regents Of The University Of Minnesota | Topk inhibiting compounds |
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| CN102786543B (zh) * | 2012-07-24 | 2016-04-27 | 上海瑞博化学有限公司 | 咪唑并[1,2-a]吡啶-6-硼酸频哪醇酯及其衍生物的制备方法 |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| JP6430383B2 (ja) * | 2012-09-28 | 2018-11-28 | ヴァンダービルト ユニバーシティーVanderbilt University | 選択的bmp阻害剤としての縮合複素環化合物 |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| KR102344105B1 (ko) | 2014-08-18 | 2021-12-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모노시클릭 피리딘 유도체의 염 및 이의 결정 |
| JP6585167B2 (ja) * | 2014-10-03 | 2019-10-02 | ノバルティス アーゲー | Fgfr4阻害剤としての縮環二環式ピリジル誘導体の使用 |
| WO2016060937A1 (en) * | 2014-10-13 | 2016-04-21 | R4 Ventures Llc | Real time individual electronic enclosure cooling system |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| EP3275442B1 (en) | 2015-03-25 | 2021-07-28 | National Cancer Center | Therapeutic agent for bile duct cancer |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| SG10201913990RA (en) | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| CN108367000A (zh) | 2015-12-17 | 2018-08-03 | 卫材R&D管理有限公司 | 用于乳腺癌的治疗剂 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| WO2019178383A1 (en) | 2018-03-14 | 2019-09-19 | Vanderbilt University | Inhibition of bmp signaling, compounds, compositions and uses thereof |
| US11219619B2 (en) | 2018-03-28 | 2022-01-11 | Eisai R&D Management Co., Ltd. | Therapeutic agent for hepatocellular carcinoma |
| AU2019262579B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Salts of an FGFR inhibitor |
| HRP20241288T1 (hr) | 2018-05-04 | 2024-12-06 | Incyte Corporation | Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4006027B1 (en) | 2019-07-26 | 2025-10-01 | CGeneTech (Suzhou, China) Co., Ltd. | Pyridine derivative as fgfr and vegfr dual inhibitors for the treatment of cancer |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3157361A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| JP7832891B2 (ja) | 2019-12-04 | 2026-03-18 | インサイト・コーポレイション | Fgfr阻害剤の誘導体 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR102537615B1 (ko) * | 2020-02-25 | 2023-05-30 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| KR102537616B1 (ko) | 2020-02-25 | 2023-05-26 | 주식회사 종근당 | 히스톤 탈아세틸화 효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| CA3206502A1 (en) * | 2021-01-26 | 2022-08-04 | Zhengxia CHEN | Crystal form of methylpyrazole-substituted pyridoimidazole compound and preparation method therefor |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| CA3220155A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
| TW202432120A (zh) * | 2023-02-01 | 2024-08-16 | 韓商安康尼克治療有限公司 | 注射用組合物、包含其之醫藥調配物以及製備該組合物之方法 |
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-
2009
- 2009-04-15 GB GBGB0906470.0A patent/GB0906470D0/en not_active Ceased
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2010
- 2010-04-15 HU HUE10718660A patent/HUE027494T2/en unknown
- 2010-04-15 JP JP2012505239A patent/JP5646598B2/ja not_active Expired - Fee Related
- 2010-04-15 CA CA2757326A patent/CA2757326C/en active Active
- 2010-04-15 PT PT107186603T patent/PT2419428E/pt unknown
- 2010-04-15 SI SI201030994T patent/SI2419428T1/sl unknown
- 2010-04-15 US US13/264,596 patent/US8722687B2/en active Active
- 2010-04-15 RS RS20150533A patent/RS54166B1/sr unknown
- 2010-04-15 AU AU2010238290A patent/AU2010238290B2/en not_active Ceased
- 2010-04-15 PL PL10718660T patent/PL2419428T3/pl unknown
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- 2010-04-15 ES ES10718660.3T patent/ES2545215T3/es active Active
- 2010-04-15 DK DK10718660.3T patent/DK2419428T3/en active
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2545215T3 (es) | 2015-09-09 |
| JP5646598B2 (ja) | 2014-12-24 |
| DK2419428T3 (en) | 2015-08-10 |
| GB0906470D0 (en) | 2009-05-20 |
| PT2419428E (pt) | 2015-09-21 |
| AU2010238290B2 (en) | 2015-12-17 |
| PL2419428T3 (pl) | 2015-10-30 |
| HUE027494T2 (en) | 2016-10-28 |
| RS54166B1 (sr) | 2015-12-31 |
| SMT201500200B (it) | 2015-10-30 |
| CA2757326A1 (en) | 2010-10-21 |
| AU2010238290A1 (en) | 2011-12-08 |
| HRP20150825T1 (hr) | 2015-09-11 |
| WO2010119285A1 (en) | 2010-10-21 |
| US8722687B2 (en) | 2014-05-13 |
| CA2757326C (en) | 2018-06-12 |
| JP2012524056A (ja) | 2012-10-11 |
| US20120041000A1 (en) | 2012-02-16 |
| EP2419428B1 (en) | 2015-05-13 |
| EP2419428A1 (en) | 2012-02-22 |
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