SI2213652T1 - Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov - Google Patents

Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov

Info

Publication number
SI2213652T1
SI2213652T1 SI200531929T SI200531929T SI2213652T1 SI 2213652 T1 SI2213652 T1 SI 2213652T1 SI 200531929 T SI200531929 T SI 200531929T SI 200531929 T SI200531929 T SI 200531929T SI 2213652 T1 SI2213652 T1 SI 2213652T1
Authority
SI
Slovenia
Prior art keywords
binding
amyloid plaques
stilbene derivatives
imaging amyloid
imaging
Prior art date
Application number
SI200531929T
Other languages
English (en)
Slovenian (sl)
Inventor
Hank F. Kung
Mei-Ping Kung
Zhi-Ping Zhuang
Original Assignee
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Publication of SI2213652T1 publication Critical patent/SI2213652T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200531929T 2004-12-17 2005-12-19 Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov SI2213652T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US68639505P 2005-06-02 2005-06-02
EP10161604.3A EP2213652B1 (en) 2004-12-17 2005-12-19 Stilbene derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
SI2213652T1 true SI2213652T1 (sl) 2015-03-31

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200531929T SI2213652T1 (sl) 2004-12-17 2005-12-19 Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov

Country Status (25)

Country Link
US (2) US7807135B2 (enExample)
EP (3) EP1838298A4 (enExample)
JP (1) JP5128956B2 (enExample)
KR (1) KR101321619B1 (enExample)
AU (1) AU2005316421B2 (enExample)
BE (1) BE2015C015I2 (enExample)
BR (1) BRPI0516408B8 (enExample)
CA (1) CA2591534C (enExample)
DK (1) DK2213652T3 (enExample)
EA (1) EA012334B1 (enExample)
ES (1) ES2526655T3 (enExample)
FR (1) FR15C0012I2 (enExample)
HU (1) HUS1500014I1 (enExample)
IL (2) IL183946A (enExample)
LT (1) LTC2213652I2 (enExample)
LU (1) LU92647I2 (enExample)
MX (1) MX2007007380A (enExample)
NL (1) NL300719I1 (enExample)
NO (1) NO339195B1 (enExample)
NZ (1) NZ555942A (enExample)
PL (1) PL2213652T3 (enExample)
PT (1) PT2213652E (enExample)
SG (1) SG194363A1 (enExample)
SI (1) SI2213652T1 (enExample)
WO (1) WO2006066104A2 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002323417B2 (en) * 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
CA2591534C (en) * 2004-12-17 2013-08-06 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US20070031328A1 (en) * 2005-06-24 2007-02-08 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
PL1999109T3 (pl) 2006-03-30 2012-05-31 Univ Pennsylvania Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
WO2009001046A2 (en) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use
CA2699965A1 (en) * 2007-07-04 2009-01-08 Tohoku University Pet probe having an alkoxy group substituted by fluorine and hydroxy group
US8779002B2 (en) * 2007-10-15 2014-07-15 Salk Institute For Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
EP2599763A1 (en) * 2008-02-14 2013-06-05 Siemens Molecular Imaging, Inc. Novel imaging agents for detecting neurological dysfunction
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
AU2009219406A1 (en) * 2008-02-27 2009-09-03 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled A-beta binding compounds
US8557222B2 (en) * 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
WO2010056900A1 (en) * 2008-11-13 2010-05-20 Avid Radiopharmaceuticals, Inc. Histogram-based analysis method for the detection and diagnosis of neurodegenerative diseases
CN102292461A (zh) * 2008-12-22 2011-12-21 拜耳先灵医药股份有限公司 使用交换树脂合成放射性核素标记的化合物的方法
AU2009335049B2 (en) * 2008-12-31 2015-07-16 Avid Radiopharmaceuticals, Inc. Synthesis of 18F-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
US8968701B2 (en) 2009-07-10 2015-03-03 Piramal Imaging Sa Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
AU2010334929B2 (en) * 2009-12-23 2015-04-23 Lantheus Biosciences Ltd. Formulations suitable for pet imaging with hydrophobic pet agents
CA2801530C (en) 2010-06-04 2017-09-12 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
BR112012030946A2 (pt) * 2010-06-04 2016-11-01 Piramal Imaging Sa método para a produção de ligante para amiloide beta marcado com f-18
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
EA201201647A1 (ru) 2010-06-04 2013-05-30 Пирамаль Имэджинг Са Способ получения f-18 меченных лигандов бета-амилоида
EP3263136A1 (en) * 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Imaging of meningiomas using stilbene, or biphenylalkyne derivatives
WO2012145169A2 (en) 2011-04-21 2012-10-26 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
MY183997A (en) 2011-06-21 2021-03-17 Life Molecular Imaging Sa Formulations of fluorinated stilbene suitable for pet imaging
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
CA2852840A1 (en) 2011-10-19 2013-04-25 Piramal Imaging Sa Improved method for production of f-18 labeled a.beta. ligands
CA2869398C (en) 2012-04-10 2019-10-22 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) * 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
US10675365B2 (en) 2016-09-29 2020-06-09 Korea Atomic Energy Research Institute Curcumin derivative, method for producing same, and photo-acoustic imaging agent comprising same for detecting beta-amyloid plaque
TWI752098B (zh) 2016-10-10 2022-01-11 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500507A (en) * 1981-10-30 1985-02-19 Wong Dennis W Diagnostic composition for radiologic imaging of neoplasms in the body and method of preparation
JPS60247244A (ja) 1984-05-22 1985-12-06 Mitsubishi Paper Mills Ltd 電子写真感光体
DD231432A1 (de) 1984-11-01 1985-12-24 Univ Leipzig Material zur silberfreien bildaufzeichnung
DD234666A1 (de) 1984-11-01 1986-04-09 Univ Leipzig Verfahren zur herstellung von einfachen und substituierten 4-dimethylamino-alpha-halogenstilbenen
JPH06329566A (ja) 1993-05-21 1994-11-29 Asahi Glass Co Ltd ジフルオロスチルベン誘導体化合物およびそれを含有する液晶組成物
TW325458B (en) * 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5601801A (en) * 1994-08-02 1997-02-11 Merck Frosst Canada, Inc. Radiolabelled angiotensin converting enzyme inhibitors
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
JP4022951B2 (ja) 1997-08-06 2007-12-19 大日本インキ化学工業株式会社 ジフルオロスチルベン誘導体の製造方法
WO2001084937A1 (en) * 2000-05-08 2001-11-15 Novozymes A/S Oxidoreductase mediated antimicrobial activity
AU2002323417B2 (en) * 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
CA2591534C (en) * 2004-12-17 2013-08-06 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US20070031328A1 (en) * 2005-06-24 2007-02-08 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents

Also Published As

Publication number Publication date
IL183946A0 (en) 2007-10-31
EA012334B1 (ru) 2009-08-28
PL2213652T3 (pl) 2015-04-30
EP1838298A4 (en) 2009-03-04
PT2213652E (pt) 2015-01-02
ES2526655T3 (es) 2015-01-14
US20060269473A1 (en) 2006-11-30
BRPI0516408B1 (pt) 2021-03-23
DK2213652T3 (en) 2015-01-26
CA2591534C (en) 2013-08-06
LU92647I2 (fr) 2015-11-03
WO2006066104A3 (en) 2006-08-03
EP2213652B1 (en) 2014-10-22
FR15C0012I1 (enExample) 2015-03-20
EP1841465A2 (en) 2007-10-10
FR15C0012I2 (fr) 2015-11-20
WO2006066104A2 (en) 2006-06-22
EA200701299A1 (ru) 2007-12-28
IL206091A (en) 2013-08-29
BE2015C015I2 (enExample) 2025-04-29
HUS1500014I1 (hu) 2016-11-28
NL300719I2 (enExample) 2015-12-29
LTC2213652I2 (lt) 2016-12-27
NO339195B1 (no) 2016-11-14
JP2008524243A (ja) 2008-07-10
NO20073650L (no) 2007-09-14
US7807135B2 (en) 2010-10-05
KR20070093427A (ko) 2007-09-18
NZ555942A (en) 2011-01-28
SG194363A1 (en) 2013-11-29
BRPI0516408B8 (pt) 2021-05-25
EP2213652A1 (en) 2010-08-04
US8465726B2 (en) 2013-06-18
US20100266500A1 (en) 2010-10-21
EP1841465A4 (en) 2009-04-01
KR101321619B1 (ko) 2013-10-30
NL300719I1 (enExample) 2015-12-29
EP1838298A2 (en) 2007-10-03
CA2591534A1 (en) 2006-06-22
AU2005316421A1 (en) 2006-06-22
IL183946A (en) 2011-08-31
BRPI0516408A (pt) 2008-09-02
AU2005316421B2 (en) 2012-04-05
MX2007007380A (es) 2007-10-11
JP5128956B2 (ja) 2013-01-23

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