SI2198007T1 - Farmacevtski sestavki, ki vsebujejo toksoide Clostridium difficile A in B - Google Patents
Farmacevtski sestavki, ki vsebujejo toksoide Clostridium difficile A in B Download PDFInfo
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- SI2198007T1 SI2198007T1 SI200831906T SI200831906T SI2198007T1 SI 2198007 T1 SI2198007 T1 SI 2198007T1 SI 200831906 T SI200831906 T SI 200831906T SI 200831906 T SI200831906 T SI 200831906T SI 2198007 T1 SI2198007 T1 SI 2198007T1
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- composition
- sodium
- clostridium difficile
- toxoid
- sucrose
- Prior art date
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- 241000193163 Clostridioides difficile Species 0.000 title claims abstract 18
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 239000000203 mixture Substances 0.000 claims abstract 29
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 12
- 238000004220 aggregation Methods 0.000 claims abstract 5
- 230000002776 aggregation Effects 0.000 claims abstract 5
- 238000000034 method Methods 0.000 claims abstract 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 11
- 229930006000 Sucrose Natural products 0.000 claims 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 11
- 239000005720 sucrose Substances 0.000 claims 11
- 239000001509 sodium citrate Substances 0.000 claims 9
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims 8
- 239000000872 buffer Substances 0.000 claims 6
- 239000001508 potassium citrate Substances 0.000 claims 6
- 229960002635 potassium citrate Drugs 0.000 claims 6
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims 6
- 235000011082 potassium citrates Nutrition 0.000 claims 6
- 229910052708 sodium Inorganic materials 0.000 claims 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 3
- 239000008057 potassium phosphate buffer Substances 0.000 claims 3
- 235000011009 potassium phosphates Nutrition 0.000 claims 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 3
- 239000001488 sodium phosphate Substances 0.000 claims 3
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 3
- 239000012064 sodium phosphate buffer Substances 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- -1 aluminum compound Chemical class 0.000 claims 2
- XFTWUNOVBCHBJR-UHFFFAOYSA-N Aspergillomarasmine A Chemical compound OC(=O)C(N)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O XFTWUNOVBCHBJR-UHFFFAOYSA-N 0.000 claims 1
- 101000963974 Hydrophis stokesii Alpha-elapitoxin-Ast2b Proteins 0.000 claims 1
- 101000964025 Naja naja Long neurotoxin 3 Proteins 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000005187 foaming Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 239000003053 toxin Substances 0.000 abstract 2
- 231100000765 toxin Toxicity 0.000 abstract 2
- 108700012359 toxins Proteins 0.000 abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (16)
- Farmacevtski sestavki, ki vsebujejo toksoide Clostridium difficile A in B Patentni zahtevki1. Sestavek, ki vsebuje toksoid Clostridium difficile in farmacevtsko sprejemljive ekscipiente, ki vsebujejo: (a) pufer izbran izmed pufra natrijevega ali kalijevega citrata in pufra natrijevega ali kalijevega fosfata; in (b) sukrozo, kjer farmacevtsko sprejemljivi ekscipienti povečajo termično stabilnost toksoida in/ali zmanjšajo ali odložijo agregacijo toksoida, v primerjavi s sestavkom, ki ne vsebuje omenjenih farmacevtsko sprejemljivih ekscipientov.
- 2. Sestavek po zahtevku 1, ki nadalje vsebuje formaldehid v koncentraciji od 0.001% do 0.020%.
- 3. Sestavek po zahtevku 1 ali 2, kjer: (a) omenjeni farmacevtsko sprejemljivi ekscipienti zmanjšajo ali odložijo agregacijo toksoida za 50% ali več, v primeijavi s sestavkom, ki ne vsebuje omenjenih farmacevtsko sprejemljivih ekscipientov; ali (b) omenjeni farmacevtsko sprejemljivi ekscipienti povečajo termično stabilnost toksoida za 0.5°C ali več, v primerjavi s sestavkom, ki ne vsebuje omenjenih farmacevtsko sprejemljivih ekscipientov.
- 4. Sestavek po kateremkoli zahtevku od 1 do 3, kjer sestavek vsebuje toksoid toksinov C. difficile A in B.
- 5. Sestavek po zahtevku 4, kjer: (a) so toksoidi A in B prisotni v sestavku v razmerju 5:1 (A:B) do 1:5 (A:B); ali (b) so toksoidi A in B prisotni v sestavku v razmerju 3:1 do 3:2 ali 1:1 (A:B).
- 6. Sestavek po kateremkoli zahtevku od 1 do 5, kjer je sestavek farmacevtski sestavek.
- 7. Sestavek po kateremkoli zahtevku od 1 do 6, ki nadalje vsebuje adjuvans.
- 8. Sestavek po zahtevku 7, kjer adjuvans vsebuje aluminijevo spojino, neobvezno, kjer je aluminijeva spojina, spojina aluminijevega hidroksida.
- 9. Sestavek po kateremkoli zahtevku od 1 do 8, kjer je sestavek: (a) v tekoči obliki; ali (b) v obliki suhega praška, liofiliziran, sušen z zamrzovanjem, sušen s pršenjem ali sušen s penjenjem.
- 10. Sestavek po kateremkoli zahtevku od 1 do 9, kjer: (a) je citratni pufer natrijev citrat; ali (b) je fosfatni pufer natrijev fosfat.
- 11. Sestavek po kateremkoli zahtevku od 1 do 9, kjer sestavek vsebuje: (a) toksoide Clostridium difficile A in B, 5-100 mM natrijevega ali kalijevega citrata, 2-20% sukroze in <0.020% formaldehida, pH 5.5-8.5; (b) toksoide Clostridium difficile A in B, 10-30 mM natrijevega ali kalijevega citrata, 2-10% sukroze in <0.020% formaldehida, pH 6.5-8.0; (c) toksoide Clostridium difficile A in B, 20 mM natrijevega citrata, 5% sukroze in 0.016% formaldehida, pH 7.5; (d) toksoide Clostridium difficile A in B, 5-100 mM natrijevega ali kalijevega fosfata, 2- 20% sukroze in <0.020% formaldehida, pH 5.5-8.5; (e) toksoide Clostridium difficile A in B, 10-30 mM natrijevega ali kalijevega fosfata, 2- 10% sukroze in <0.020% formaldehida, pH 6.5-8.0; ali (f) toksoide Clostridium difficile A in B, 20 mM kalijevega fosfata, 5% sukroze in 0.016% formaldehida, pH 7.5.
- 12. Sestavek po kateremkoli zahtevku od 1 do 9, kjer je sestavek v liofilizirani obliki in vsebuje: (a) toksoide Clostridium difficile A in B, 10-30 mM natrijevega ali kalijevega citrata, 2-10% sukroze in <0.020% formaldehida, pH 6.5-8.0; ali (b) toksoide Clostridium difficile A in B, 20 mM natrijevega citrata, 5% sukroze in 0.016% formaldehida, pH 7.5.
- 13. Postopek izdelave sestavka, ki vsebuje toksoid Clostridium difficile in farmacevtsko sprejemljiv ekscipiente, ki vsebujejo: (a) pufer izbran izmed pufra natrijevega ali kalijevega citrata in pufra natrijevega ali kalijevega fosfata; in (b) sukrozo, kjer omenjeni farmacevtsko sprejemljivi ekscipienti povečajo termično stabilnost toksoida in/ali zmanjšajo ali odložijo agregacijo toksoida, v primerjavi s sestavkom, ki ne vsebuje omenjenih farmacevtsko sprejemljivih ekscipientov, kjer postopek obsega zagotavljanje toksoida Clostridium difficile in mešanje omenjenega toksoida Clostridium difficile z omenjenimi farmacevtsko sprejemljivimi ekscipienti.
- 14. Sestavek po kateremkoli zahtevku od 1 do 12, za uporabo v postopku preventive ali zdravljenja okužbe s C. difficile ali bolezni v subjektu.
- 15. Uporaba kombinacije: (a) pufra izbranega izmed pufra natrijevega ali kalijevega citrata in pufra natrijevega ali kalijevega fosfata; in (b) sukroze, za povečanje termične stabilnosti in/ali zmanjšanje ali zavlačevanja agregacija toksoida, Clostridium difficile in vitro. ' ' * **» 4
- 16. Uporaba po zahtevku 15, kjer sta omenjeni komponenti (a) in (b) zagotovljeni v sestavku, kjer je omenjeni sestavek kot je opisano v kateremkoli zahtevku od 1 do 12.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97249607P | 2007-09-14 | 2007-09-14 | |
| PCT/US2008/010767 WO2009035707A1 (en) | 2007-09-14 | 2008-09-15 | Pharmaceutical compositions containing clostridium difficile toxoids a and b |
| EP08830210.4A EP2198007B1 (en) | 2007-09-14 | 2008-09-15 | Pharmaceutical compositions containing clostridium difficile toxoids a and b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2198007T1 true SI2198007T1 (sl) | 2018-04-30 |
Family
ID=40452372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200831906T SI2198007T1 (sl) | 2007-09-14 | 2008-09-15 | Farmacevtski sestavki, ki vsebujejo toksoide Clostridium difficile A in B |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9320790B2 (sl) |
| EP (2) | EP2198007B1 (sl) |
| JP (3) | JP5503543B2 (sl) |
| KR (2) | KR101679812B1 (sl) |
| CN (2) | CN101855336B (sl) |
| AU (1) | AU2008299885C1 (sl) |
| BR (1) | BRPI0816790A8 (sl) |
| CA (1) | CA2699435A1 (sl) |
| CY (1) | CY1119979T1 (sl) |
| DK (1) | DK2198007T3 (sl) |
| ES (1) | ES2657485T3 (sl) |
| HR (1) | HRP20180054T1 (sl) |
| HU (1) | HUE037932T2 (sl) |
| IL (1) | IL204366A (sl) |
| MX (1) | MX2010002815A (sl) |
| NO (1) | NO2198007T3 (sl) |
| PL (1) | PL2198007T3 (sl) |
| PT (1) | PT2198007T (sl) |
| RU (1) | RU2550271C2 (sl) |
| SI (1) | SI2198007T1 (sl) |
| WO (1) | WO2009035707A1 (sl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2198007T1 (sl) | 2007-09-14 | 2018-04-30 | Sanofi Pasteur Biologics, Llc | Farmacevtski sestavki, ki vsebujejo toksoide Clostridium difficile A in B |
| BR112014004896B1 (pt) | 2010-09-03 | 2023-02-14 | Valneva Usa, Inc. | Polipepttdeo isolado de proteínas de toxina a e toxina b de c. difficile e usos do mesmo |
| GB201105981D0 (en) * | 2011-04-08 | 2011-05-18 | Glaxosmithkline Biolog Sa | Novel process |
| PE20141029A1 (es) * | 2011-04-22 | 2014-09-04 | Wyeth Llc | Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos |
| KR101135486B1 (ko) * | 2011-05-25 | 2012-04-13 | 함종욱 | 보툴리눔 에이형 독소의 액상제품 |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| CN104903349B (zh) | 2012-11-08 | 2018-10-19 | 十一生物治疗股份有限公司 | Il-6拮抗剂及其应用 |
| JP6290918B2 (ja) | 2012-12-05 | 2018-03-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
| AP2015008733A0 (en) | 2013-03-14 | 2015-09-30 | Takeda Vaccines Inc | Compositions and methods for live, attenuated alphavirus formulations |
| JP2016519671A (ja) | 2013-03-15 | 2016-07-07 | サノフィ パストゥール インコーポレイテッド | トキソイド、組成物および関連方法 |
| AU2014228956A1 (en) | 2013-03-15 | 2015-10-08 | Sanofi Pasteur, Inc. | Toxoid, compositions and related methods |
| CA2915279A1 (en) | 2013-06-14 | 2014-12-18 | Sanofi Pasteur Inc. | Compositions and methods of immunizing against c. difficile |
| WO2014204303A2 (en) | 2013-06-17 | 2014-12-24 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport | Methods for the prevention of aggregation of viral components |
| US9930893B2 (en) * | 2014-02-10 | 2018-04-03 | The Johns Hopkins University | Inhibitors of DXP synthase and methods of use thereof |
| US11142571B2 (en) | 2014-11-07 | 2021-10-12 | Sesen Bio, Inc. | IL-6 antibodies |
| KR20180011784A (ko) | 2015-05-15 | 2018-02-02 | 사노피 파스퇴르 인코포레이티드 | 클로스트리듐 디피실에 대한 면역화 방법 |
| BE1023343B1 (nl) * | 2015-05-20 | 2017-02-09 | Mycartis Nv | Opslagbuffer |
| CA3012350A1 (en) * | 2016-02-23 | 2017-08-31 | Sesen Bio, Inc. | Il-6 antagonist formulations and uses thereof |
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