SI20305A - Kristali natrijeve soli pravastatina - Google Patents

Kristali natrijeve soli pravastatina Download PDF

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Publication number
SI20305A
SI20305A SI9900191A SI9900191A SI20305A SI 20305 A SI20305 A SI 20305A SI 9900191 A SI9900191 A SI 9900191A SI 9900191 A SI9900191 A SI 9900191A SI 20305 A SI20305 A SI 20305A
Authority
SI
Slovenia
Prior art keywords
sodium salt
pravastatin sodium
pravastatin
ethyl acetate
crystals
Prior art date
Application number
SI9900191A
Other languages
English (en)
Slovenian (sl)
Inventor
Zlatko Pflaum
Original Assignee
LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20432515&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI20305(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. filed Critical LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.
Priority to SI9900191A priority Critical patent/SI20305A/sl
Priority to US10/049,093 priority patent/US7078558B1/en
Priority to SI200030653T priority patent/SI1200385T2/sl
Priority to DE60017568T priority patent/DE60017568T2/de
Priority to PCT/IB2000/001103 priority patent/WO2001010813A1/en
Priority to NZ516685A priority patent/NZ516685A/en
Priority to IL14805000A priority patent/IL148050A0/xx
Priority to YU5402A priority patent/YU5402A/sh
Priority to PL00365850A priority patent/PL365850A1/xx
Priority to KR1020077015051A priority patent/KR20070086847A/ko
Priority to DK00946239T priority patent/DK1200385T3/da
Priority to PT00946239T priority patent/PT1200385E/pt
Priority to CA002379335A priority patent/CA2379335A1/en
Priority to CNB008113653A priority patent/CN1205172C/zh
Priority to RU2002102862/04A priority patent/RU2247711C2/ru
Priority to SK174-2002A priority patent/SK1742002A3/sk
Priority to ES00946239T priority patent/ES2235911T5/es
Priority to AU60109/00A priority patent/AU782143B2/en
Priority to KR1020027001231A priority patent/KR100766928B1/ko
Priority to HU0202536A priority patent/HUP0202536A3/hu
Priority to JP2001515281A priority patent/JP2003506424A/ja
Priority to CZ2002414A priority patent/CZ2002414A3/cs
Priority to EP00946239A priority patent/EP1200385B2/de
Priority to AT00946239T priority patent/ATE287389T1/de
Publication of SI20305A publication Critical patent/SI20305A/sl
Priority to ZA200200437A priority patent/ZA200200437B/en
Priority to HR20020106A priority patent/HRP20020106A2/hr
Priority to BG106389A priority patent/BG65368B1/bg
Priority to IL148050A priority patent/IL148050A/en
Priority to US10/408,012 priority patent/US6740775B1/en
Priority to US11/400,872 priority patent/US20060183929A1/en
Priority to IL187261A priority patent/IL187261A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI9900191A 1998-09-18 1999-08-06 Kristali natrijeve soli pravastatina SI20305A (sl)

Priority Applications (31)

Application Number Priority Date Filing Date Title
SI9900191A SI20305A (sl) 1999-08-06 1999-08-06 Kristali natrijeve soli pravastatina
SI200030653T SI1200385T2 (sl) 1999-08-06 2000-08-04 Kristali natrijeve soli pravastatina
RU2002102862/04A RU2247711C2 (ru) 1999-08-06 2000-08-04 Кристаллическая форма натриевой соли правастатина
AU60109/00A AU782143B2 (en) 1998-09-18 2000-08-04 Crystals of the sodium salt of pravastatin
SK174-2002A SK1742002A3 (en) 1999-08-06 2000-08-04 Crystals of the sodium salt of pravastatin
PCT/IB2000/001103 WO2001010813A1 (en) 1999-08-06 2000-08-04 Crystals of the sodium salt of pravastatin
NZ516685A NZ516685A (en) 1999-08-06 2000-08-04 Crystals of the sodium salt of pravastatin
IL14805000A IL148050A0 (en) 1999-08-06 2000-08-04 Crystals of the sodium salt of pravastatin
YU5402A YU5402A (sh) 1999-08-06 2000-08-04 Kristali natrijumove soli pravastatina
PL00365850A PL365850A1 (en) 1999-08-06 2000-08-04 Crystals of the sodium salt of pravastatin
KR1020077015051A KR20070086847A (ko) 1999-08-06 2000-08-04 결정형의 프라바스타틴 소듐염
DK00946239T DK1200385T3 (da) 1999-08-06 2000-08-04 Krystaller af natriumsalt af pravastatin
PT00946239T PT1200385E (pt) 1999-08-06 2000-08-04 Cristais do sal de sodio de pravastatina
CA002379335A CA2379335A1 (en) 1999-08-06 2000-08-04 Crystals of the sodium salt of pravastatin
CNB008113653A CN1205172C (zh) 1999-08-06 2000-08-04 普伐他汀钠盐晶体
US10/049,093 US7078558B1 (en) 1999-08-06 2000-08-04 Crystals of the sodium salt of pravastatin
DE60017568T DE60017568T2 (de) 1999-08-06 2000-08-04 Kristalle des natriumsalzes von pravastatin
AT00946239T ATE287389T1 (de) 1999-08-06 2000-08-04 Kristalle des natriumsalzes von pravastatin
ES00946239T ES2235911T5 (es) 1999-08-06 2000-08-04 Procedimiento para la preparación de cristales de la sal sódica de pravastatina.
KR1020027001231A KR100766928B1 (ko) 1999-08-06 2000-08-04 결정형의 프라바스타틴 소듐염
HU0202536A HUP0202536A3 (en) 1999-08-06 2000-08-04 Crystals of the sodium salt of pravastatin
JP2001515281A JP2003506424A (ja) 1999-08-06 2000-08-04 プラバスタチンナトリウムの結晶
CZ2002414A CZ2002414A3 (cs) 1999-08-06 2000-08-04 Krystaly sodné soli pravastatinu
EP00946239A EP1200385B2 (de) 1999-08-06 2000-08-04 Verfahren zur herstellung von kristallen des natriumsalzes von pravastatin
ZA200200437A ZA200200437B (en) 1999-08-06 2002-01-17 Crystals of the sodium salt of pravastatin.
HR20020106A HRP20020106A2 (en) 1999-08-06 2002-02-04 Crystals of the sodium salt of pravastatin
BG106389A BG65368B1 (bg) 1999-08-06 2002-02-05 Кристали на натриевата сол на правастатин
IL148050A IL148050A (en) 1999-08-06 2002-02-06 Crystals of pravastatin sodium salt
US10/408,012 US6740775B1 (en) 1999-08-06 2003-04-04 Crystalline sodium salt of pravastatin
US11/400,872 US20060183929A1 (en) 1999-08-06 2006-04-10 Crystals of the sodium salt of pravastatin
IL187261A IL187261A0 (en) 1999-08-06 2007-11-08 Crystals of the sodium salt of pravastatin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9900191A SI20305A (sl) 1999-08-06 1999-08-06 Kristali natrijeve soli pravastatina

Publications (1)

Publication Number Publication Date
SI20305A true SI20305A (sl) 2001-02-28

Family

ID=20432515

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9900191A SI20305A (sl) 1998-09-18 1999-08-06 Kristali natrijeve soli pravastatina
SI200030653T SI1200385T2 (sl) 1999-08-06 2000-08-04 Kristali natrijeve soli pravastatina

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200030653T SI1200385T2 (sl) 1999-08-06 2000-08-04 Kristali natrijeve soli pravastatina

Country Status (24)

Country Link
US (3) US7078558B1 (de)
EP (1) EP1200385B2 (de)
JP (1) JP2003506424A (de)
KR (2) KR100766928B1 (de)
CN (1) CN1205172C (de)
AT (1) ATE287389T1 (de)
BG (1) BG65368B1 (de)
CA (1) CA2379335A1 (de)
CZ (1) CZ2002414A3 (de)
DE (1) DE60017568T2 (de)
DK (1) DK1200385T3 (de)
ES (1) ES2235911T5 (de)
HR (1) HRP20020106A2 (de)
HU (1) HUP0202536A3 (de)
IL (3) IL148050A0 (de)
NZ (1) NZ516685A (de)
PL (1) PL365850A1 (de)
PT (1) PT1200385E (de)
RU (1) RU2247711C2 (de)
SI (2) SI20305A (de)
SK (1) SK1742002A3 (de)
WO (1) WO2001010813A1 (de)
YU (1) YU5402A (de)
ZA (1) ZA200200437B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20070A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
SK8312002A3 (en) * 1999-12-14 2003-05-02 Biogal Gyogyszergyar Novel forms of pravastatin sodium
JP2002121172A (ja) * 2000-10-16 2002-04-23 Sankyo Co Ltd プラバスタチン又はその薬理上許容される塩の精製方法
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
HUP0500074A3 (en) 2002-03-18 2005-07-28 Biocon Ltd Bangalore Amorphous hmg-coa reductase inhibitors of desired particle size and process for producing them
US20060275219A1 (en) * 2003-06-10 2006-12-07 Taisho Pharmaceutical Co., Ltd. Radial spherical crystallization product, process for producing the same, and dry powder preparation containing the crystallization product
CN1293874C (zh) * 2003-08-18 2007-01-10 李朝晖 以洛伐他汀盐为主要活性成分的中药红曲及其制剂
EP2033636A1 (de) 2003-11-24 2009-03-11 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Verfahren zur Reinigung von Pravastatin
US20080242725A1 (en) * 2004-03-01 2008-10-02 Janez Kerc Pharmaceutical Composition
US20090149533A1 (en) * 2004-08-06 2009-06-11 Transform Pharmaceuticals, Inc. Novel fenofibrate formulations and related methods of treatment
US20090042979A1 (en) * 2004-08-06 2009-02-12 Transform Pharmaceuticals Inc. Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
NZ552389A (en) 2004-08-06 2009-05-31 Transform Pharmaceuticals Inc Statin pharmaceutical compositions and related methods of treatment
MX2007009229A (es) * 2005-02-09 2007-09-25 Teva Gyogyszergyar Zartkoruen Metodos para realizar pravastatina de sodio.
JP4895510B2 (ja) * 2005-02-23 2012-03-14 株式会社トクヤマ バリオールアミンの製造方法
JP4813841B2 (ja) * 2005-07-25 2011-11-09 キユーピー株式会社 プラバスタチンナトリウムの製造方法
WO2009148709A1 (en) * 2008-04-16 2009-12-10 University Of Utah Research Foundation Pharmacological targeting of vascular malformations
CN101348476B (zh) * 2008-09-05 2011-05-11 丽珠集团新北江制药股份有限公司 一种制备4,5,6,7-四氢普伐他汀及其钠盐的方法和固体结晶形式
CN101648867B (zh) * 2009-09-04 2012-07-11 天津大学 一种普伐他汀钠晶型及其制备方法和应用
EP2343054A1 (de) 2010-01-04 2011-07-13 LEK Pharmaceuticals d.d. Pellets und Mikroteilchen von Pravastatin-Natrium und Verfahren zu deren Herstellung
CN102533893A (zh) * 2010-12-09 2012-07-04 浙江海正药业股份有限公司 一种制备莫那可林j的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS572240A (en) * 1980-06-06 1982-01-07 Sankyo Co Ltd Ml-236b derivative
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
CA2040865C (en) 1990-05-15 2002-07-23 James L. Bergey Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor
KR100210482B1 (ko) * 1997-04-10 1999-07-15 김종인 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법
US6098031A (en) 1998-03-05 2000-08-01 Gsi Lumonics, Inc. Versatile method and system for high speed, 3D imaging of microscopic targets
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
SI20070A (sl) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
PT1154979E (pt) * 1999-02-03 2005-08-31 Inst Drug Res Ltd Processo microbiano para a preparacao da pravastatina
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin

Also Published As

Publication number Publication date
HUP0202536A2 (hu) 2003-01-28
BG65368B1 (bg) 2008-04-30
DE60017568T2 (de) 2006-03-30
ES2235911T3 (es) 2005-07-16
DK1200385T3 (da) 2005-05-23
WO2001010813A1 (en) 2001-02-15
IL187261A0 (en) 2008-02-09
CA2379335A1 (en) 2001-02-15
PT1200385E (pt) 2005-04-29
HRP20020106A2 (en) 2003-04-30
US20060183929A1 (en) 2006-08-17
JP2003506424A (ja) 2003-02-18
NZ516685A (en) 2004-01-30
IL148050A0 (en) 2002-09-12
IL148050A (en) 2008-11-03
ZA200200437B (en) 2003-03-26
RU2247711C2 (ru) 2005-03-10
EP1200385A1 (de) 2002-05-02
SI1200385T2 (sl) 2012-02-29
US7078558B1 (en) 2006-07-18
BG106389A (en) 2002-09-30
EP1200385B1 (de) 2005-01-19
KR20070086847A (ko) 2007-08-27
PL365850A1 (en) 2005-01-10
US6740775B1 (en) 2004-05-25
HUP0202536A3 (en) 2003-04-28
SK1742002A3 (en) 2002-06-04
CN1368948A (zh) 2002-09-11
CN1205172C (zh) 2005-06-08
ATE287389T1 (de) 2005-02-15
CZ2002414A3 (cs) 2002-07-17
DE60017568D1 (de) 2005-02-24
KR20020025204A (ko) 2002-04-03
YU5402A (sh) 2005-03-15
ES2235911T5 (es) 2012-02-27
EP1200385B2 (de) 2011-09-21
SI1200385T1 (en) 2005-08-31
KR100766928B1 (ko) 2007-10-17

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