SI1951661T1 - Antagonisti glukagonskega receptorja priprava interapevtske uporabe - Google Patents

Antagonisti glukagonskega receptorja priprava interapevtske uporabe

Info

Publication number
SI1951661T1
SI1951661T1 SI200631430T SI200631430T SI1951661T1 SI 1951661 T1 SI1951661 T1 SI 1951661T1 SI 200631430 T SI200631430 T SI 200631430T SI 200631430 T SI200631430 T SI 200631430T SI 1951661 T1 SI1951661 T1 SI 1951661T1
Authority
SI
Slovenia
Prior art keywords
preparation
receptor antagonists
therapeutic uses
glucagon receptor
glucagon
Prior art date
Application number
SI200631430T
Other languages
English (en)
Inventor
Scott Eugene Conner
Jianke Li
Guoxin Zhu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SI1951661T1 publication Critical patent/SI1951661T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
SI200631430T 2005-11-17 2006-11-07 Antagonisti glukagonskega receptorja priprava interapevtske uporabe SI1951661T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73762705P 2005-11-17 2005-11-17
EP06850109A EP1951661B1 (en) 2005-11-17 2006-11-07 Glucagon receptor antagonists, preparation and therapeutic uses
PCT/US2006/060586 WO2007106181A2 (en) 2005-11-17 2006-11-07 Glucagon receptor antagonists, preparation and therapeutic uses

Publications (1)

Publication Number Publication Date
SI1951661T1 true SI1951661T1 (sl) 2012-11-30

Family

ID=38474434

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631430T SI1951661T1 (sl) 2005-11-17 2006-11-07 Antagonisti glukagonskega receptorja priprava interapevtske uporabe

Country Status (14)

Country Link
US (1) US7696248B2 (sl)
EP (1) EP1951661B1 (sl)
JP (1) JP5107253B2 (sl)
CN (1) CN101309895B (sl)
AU (1) AU2006340002B2 (sl)
BR (1) BRPI0618349A2 (sl)
CA (1) CA2629348C (sl)
CY (1) CY1113159T1 (sl)
DK (1) DK1951661T3 (sl)
ES (1) ES2391109T3 (sl)
PL (1) PL1951661T3 (sl)
PT (1) PT1951661E (sl)
SI (1) SI1951661T1 (sl)
WO (1) WO2007106181A2 (sl)

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KR100835496B1 (ko) * 2004-06-14 2008-06-09 일라이 릴리 앤드 캄파니 글루카곤 수용체 길항제, 제법 및 치료 용도
KR20150008922A (ko) 2007-02-09 2015-01-23 메타베이시스 테라퓨틱스, 인크. 글루카곤 수용체의 길항제
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2009220615B2 (en) * 2008-03-05 2013-12-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
PT2799428T (pt) 2008-08-13 2017-02-17 Metabasis Therapeutics Inc Antagonistas de glicagina
AU2009298617A1 (en) 2008-10-03 2010-04-08 Schering Corporation Spiro-imidazolone derivatives as glucagon receptor antagonists
PE20100443A1 (es) * 2009-02-06 2010-06-25 Takeda Pharmaceutical Derivados del acido fenil-carbonil-amino-propanoico como antagonistas del glucagon
EP2480077B1 (en) 2009-09-22 2015-02-18 Merck Sharp & Dohme Corp. Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012085745A1 (en) 2010-12-23 2012-06-28 Pfizer Inc. Glucagon receptor modulators
PT2673260T (pt) 2011-02-08 2016-10-24 Pfizer Modulador do recetor de glucagon
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012162409A1 (en) * 2011-05-23 2012-11-29 Janssen Pharmaceutica Nv Biphenyl derivatives useful as glucagon receptor antagonists
PL2714661T3 (pl) * 2011-05-23 2016-03-31 Janssen Pharmaceutica Nv Pochodne kwasu pikolinamidopropanowego przydatne jako antagoniści receptora glukagonu
EP2734503B1 (en) 2011-07-22 2015-09-16 Pfizer Inc. Quinolinyl glucagon receptor modulators
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN104350040B (zh) * 2012-03-29 2016-06-01 武田药品工业株式会社 芳环化合物
WO2015066252A1 (en) 2013-11-04 2015-05-07 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions thereof, and methods of use
EP3154956A4 (en) 2014-06-12 2018-01-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists
JP2016052300A (ja) * 2014-09-03 2016-04-14 日立化成株式会社 生体物質捕獲システム
JP2021513564A (ja) 2018-02-13 2021-05-27 リガンド・ファーマシューティカルズ・インコーポレイテッド グルカゴン受容体拮抗薬

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GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
KR20020014797A (ko) * 1999-05-17 2002-02-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 글루카곤 길항제/역 아고니스트
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
JP2005511683A (ja) 2001-12-03 2005-04-28 ノボ　ノルディスク　アクティーゼルスカブ 新規なグルカゴンアンタゴニスト
JP2006500325A (ja) 2002-06-27 2006-01-05 ノボ　ノルディスク　アクティーゼルスカブ 新規なグルカゴンアンタゴニスト
AU2003291959A1 (en) 2002-12-20 2004-07-14 Novo Nordisk A/S Novel glucagon antagonists
WO2006102067A1 (en) 2005-03-21 2006-09-28 Merck & Co., Inc. Substituted aryl and heteroaryl derivatives

Also Published As

Publication number Publication date
CA2629348A1 (en) 2007-09-20
AU2006340002B2 (en) 2011-12-22
AU2006340002A1 (en) 2007-09-20
JP5107253B2 (ja) 2012-12-26
JP2009519226A (ja) 2009-05-14
BRPI0618349A2 (pt) 2011-08-23
CY1113159T1 (el) 2016-04-13
DK1951661T3 (da) 2012-09-03
EP1951661A2 (en) 2008-08-06
ES2391109T3 (es) 2012-11-21
WO2007106181A3 (en) 2007-12-06
WO2007106181A2 (en) 2007-09-20
CN101309895B (zh) 2012-10-03
US20080300308A1 (en) 2008-12-04
CN101309895A (zh) 2008-11-19
US7696248B2 (en) 2010-04-13
CA2629348C (en) 2013-08-13
EP1951661B1 (en) 2012-08-08
PT1951661E (pt) 2012-09-19
PL1951661T3 (pl) 2012-12-31

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