PL1951661T3 - Antagoniści receptora glukagonu, wytwarzanie i terapeutyczne zastosowania - Google Patents
Antagoniści receptora glukagonu, wytwarzanie i terapeutyczne zastosowaniaInfo
- Publication number
- PL1951661T3 PL1951661T3 PL06850109T PL06850109T PL1951661T3 PL 1951661 T3 PL1951661 T3 PL 1951661T3 PL 06850109 T PL06850109 T PL 06850109T PL 06850109 T PL06850109 T PL 06850109T PL 1951661 T3 PL1951661 T3 PL 1951661T3
- Authority
- PL
- Poland
- Prior art keywords
- preparation
- receptor antagonists
- therapeutic uses
- glucagon receptor
- glucagon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73762705P | 2005-11-17 | 2005-11-17 | |
PCT/US2006/060586 WO2007106181A2 (en) | 2005-11-17 | 2006-11-07 | Glucagon receptor antagonists, preparation and therapeutic uses |
EP06850109A EP1951661B1 (en) | 2005-11-17 | 2006-11-07 | Glucagon receptor antagonists, preparation and therapeutic uses |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1951661T3 true PL1951661T3 (pl) | 2012-12-31 |
Family
ID=38474434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL06850109T PL1951661T3 (pl) | 2005-11-17 | 2006-11-07 | Antagoniści receptora glukagonu, wytwarzanie i terapeutyczne zastosowania |
Country Status (14)
Country | Link |
---|---|
US (1) | US7696248B2 (pl) |
EP (1) | EP1951661B1 (pl) |
JP (1) | JP5107253B2 (pl) |
CN (1) | CN101309895B (pl) |
AU (1) | AU2006340002B2 (pl) |
BR (1) | BRPI0618349A2 (pl) |
CA (1) | CA2629348C (pl) |
CY (1) | CY1113159T1 (pl) |
DK (1) | DK1951661T3 (pl) |
ES (1) | ES2391109T3 (pl) |
PL (1) | PL1951661T3 (pl) |
PT (1) | PT1951661E (pl) |
SI (1) | SI1951661T1 (pl) |
WO (1) | WO2007106181A2 (pl) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ551015A (en) * | 2004-06-14 | 2010-07-30 | Lilly Co Eli | Glucagon receptor antagonists, preparation and therapeutic uses |
KR20200123866A (ko) | 2007-02-09 | 2020-10-30 | 메타베이시스 테라퓨틱스, 인크. | 글루카곤 수용체의 길항제 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AU2009220615B2 (en) * | 2008-03-05 | 2013-12-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
PT2799428T (pt) | 2008-08-13 | 2017-02-17 | Metabasis Therapeutics Inc | Antagonistas de glicagina |
AR073412A1 (es) | 2008-10-03 | 2010-11-03 | Schering Corp | Derivados de espiro imidazolona como antagonistas del receptor glucagon y composiciones que los comprende. |
CL2009001796A1 (es) * | 2009-02-06 | 2011-09-16 | Takeda Pharmaceuticals Co | Compuestos derivados de heteroarilo-(benceno/heteroarilo) fusionados con actividad antagonista de glucagon; composicion farmaceutica; y su uso para suprimir la produccion de azucar y para la terapia o el tratamiento de la diabetes. |
EP2480077B1 (en) | 2009-09-22 | 2015-02-18 | Merck Sharp & Dohme Corp. | Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
SG191040A1 (en) * | 2010-12-23 | 2013-08-30 | Pfizer | Glucagon receptor modulators |
WO2012107850A1 (en) * | 2011-02-08 | 2012-08-16 | Pfizer Inc. | Glucagon receptor modulator |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
CN103547563B (zh) * | 2011-05-23 | 2016-03-23 | 詹森药业有限公司 | 可用作胰高血糖素受体拮抗剂的联苯基衍生物 |
PT2714661E (pt) * | 2011-05-23 | 2016-01-22 | Janssen Pharmaceutica Nv | Derivados de ácido picolinamido propanóico úteis como antagonistas do recetor de glucagona |
EP2734503B1 (en) * | 2011-07-22 | 2015-09-16 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
JPWO2013147026A1 (ja) * | 2012-03-29 | 2015-12-14 | 武田薬品工業株式会社 | 芳香環化合物 |
WO2015066252A1 (en) | 2013-11-04 | 2015-05-07 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
JP2016052300A (ja) * | 2014-09-03 | 2016-04-14 | 日立化成株式会社 | 生体物質捕獲システム |
WO2019160940A1 (en) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9420557D0 (en) * | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
CA2373892A1 (en) * | 1999-05-17 | 2000-11-23 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
WO2003048109A1 (en) | 2001-12-03 | 2003-06-12 | Novo Nordisk A/S | Novel glucagon antagonists |
US6881746B2 (en) * | 2001-12-03 | 2005-04-19 | Novo Nordick A/S | Glucagon antagonists/inverse agonists |
AU2003233780A1 (en) | 2002-06-27 | 2004-01-19 | Novo Nordisk A/S | Novel glucagon antagonists/inverse agonists |
WO2004056763A2 (en) | 2002-12-20 | 2004-07-08 | Novo Nordisk A/S | Novel glucagon antagonists |
EP1863755A1 (en) | 2005-03-21 | 2007-12-12 | Merck & Co., Inc. | Substituted aryl and heteroaryl derivatives |
-
2006
- 2006-11-07 CA CA2629348A patent/CA2629348C/en not_active Expired - Fee Related
- 2006-11-07 CN CN2006800429010A patent/CN101309895B/zh active Active
- 2006-11-07 ES ES06850109T patent/ES2391109T3/es active Active
- 2006-11-07 PL PL06850109T patent/PL1951661T3/pl unknown
- 2006-11-07 DK DK06850109.7T patent/DK1951661T3/da active
- 2006-11-07 BR BRPI0618349-2A patent/BRPI0618349A2/pt not_active IP Right Cessation
- 2006-11-07 PT PT06850109T patent/PT1951661E/pt unknown
- 2006-11-07 EP EP06850109A patent/EP1951661B1/en active Active
- 2006-11-07 US US12/093,054 patent/US7696248B2/en active Active
- 2006-11-07 WO PCT/US2006/060586 patent/WO2007106181A2/en active Application Filing
- 2006-11-07 SI SI200631430T patent/SI1951661T1/sl unknown
- 2006-11-07 JP JP2008541446A patent/JP5107253B2/ja active Active
- 2006-11-07 AU AU2006340002A patent/AU2006340002B2/en not_active Ceased
-
2012
- 2012-09-28 CY CY20121100902T patent/CY1113159T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20080300308A1 (en) | 2008-12-04 |
PT1951661E (pt) | 2012-09-19 |
CN101309895B (zh) | 2012-10-03 |
AU2006340002B2 (en) | 2011-12-22 |
CA2629348C (en) | 2013-08-13 |
BRPI0618349A2 (pt) | 2011-08-23 |
CY1113159T1 (el) | 2016-04-13 |
EP1951661A2 (en) | 2008-08-06 |
WO2007106181A3 (en) | 2007-12-06 |
JP5107253B2 (ja) | 2012-12-26 |
EP1951661B1 (en) | 2012-08-08 |
CA2629348A1 (en) | 2007-09-20 |
US7696248B2 (en) | 2010-04-13 |
CN101309895A (zh) | 2008-11-19 |
AU2006340002A1 (en) | 2007-09-20 |
SI1951661T1 (sl) | 2012-11-30 |
WO2007106181A2 (en) | 2007-09-20 |
DK1951661T3 (da) | 2012-09-03 |
ES2391109T3 (es) | 2012-11-21 |
JP2009519226A (ja) | 2009-05-14 |
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