SI1937687T1 - 7-(2-(4-(6-FLUORO-3-METIL-1,2-BENZISOKSAZOL-5-IL)-1-PIPERAZINIL)ETIL)2 -(1-PROPINIL)-7h-PIRAZOLO-(4,3-e)-(1,2,4)-TRIAZOLO-(1,5-c)-PIRIMIDIN -5-AMIN - Google Patents
7-(2-(4-(6-FLUORO-3-METIL-1,2-BENZISOKSAZOL-5-IL)-1-PIPERAZINIL)ETIL)2 -(1-PROPINIL)-7h-PIRAZOLO-(4,3-e)-(1,2,4)-TRIAZOLO-(1,5-c)-PIRIMIDIN -5-AMINInfo
- Publication number
- SI1937687T1 SI1937687T1 SI200631017T SI200631017T SI1937687T1 SI 1937687 T1 SI1937687 T1 SI 1937687T1 SI 200631017 T SI200631017 T SI 200631017T SI 200631017 T SI200631017 T SI 200631017T SI 1937687 T1 SI1937687 T1 SI 1937687T1
- Authority
- SI
- Slovenia
- Prior art keywords
- åethyl
- benzisoxazol
- triazolo
- pyrazolo
- pyrimidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72002705P | 2005-09-23 | 2005-09-23 | |
| EP06804036A EP1937687B1 (en) | 2005-09-23 | 2006-09-21 | 7-[2-[4-(6-FLUORO-3-METHYL-1,2-BENZISOXAZOL-5-YL)-1-PIPERAZINYL]ETHYL]2-(1-PROPYNYL)-7H-PYRAZOLO-[4,3-e]-[1,2,4]-TRIAZOLO-[1,5-c]-PYRIMIDIN-5 AMINE |
| PCT/US2006/037003 WO2007038284A1 (en) | 2005-09-23 | 2006-09-21 | 7-[2-[4-(6-FLUORO-3-METHYL-1,2-BENZISOXAZOL-5-YL)-1-PIPERAZINYL]ETHYL]-2-(1-PROPYNYL)-7H-PYRAZOLO-[4,3-e]-[1,2,4]-TRIAZOLO-[1,5-c]-PYRIMIDIN-5 AMINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1937687T1 true SI1937687T1 (sl) | 2011-07-29 |
Family
ID=37487759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200631017T SI1937687T1 (sl) | 2005-09-23 | 2006-09-21 | 7-(2-(4-(6-FLUORO-3-METIL-1,2-BENZISOKSAZOL-5-IL)-1-PIPERAZINIL)ETIL)2 -(1-PROPINIL)-7h-PIRAZOLO-(4,3-e)-(1,2,4)-TRIAZOLO-(1,5-c)-PIRIMIDIN -5-AMIN |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7572802B2 (sl) |
| EP (1) | EP1937687B1 (sl) |
| JP (1) | JP4808779B2 (sl) |
| KR (1) | KR101396614B1 (sl) |
| CN (2) | CN102716131B (sl) |
| AR (1) | AR056080A1 (sl) |
| AT (1) | ATE503759T1 (sl) |
| AU (1) | AU2006294633B8 (sl) |
| BR (1) | BRPI0616264B8 (sl) |
| CA (1) | CA2623047C (sl) |
| CY (1) | CY1111921T1 (sl) |
| DE (1) | DE602006021042D1 (sl) |
| DK (1) | DK1937687T3 (sl) |
| EC (1) | ECSP088297A (sl) |
| ES (1) | ES2361856T3 (sl) |
| HK (1) | HK1119681A1 (sl) |
| HR (1) | HRP20110466T1 (sl) |
| IL (1) | IL190275A (sl) |
| MY (1) | MY146429A (sl) |
| NO (1) | NO341760B1 (sl) |
| NZ (1) | NZ566737A (sl) |
| PE (1) | PE20070521A1 (sl) |
| PL (1) | PL1937687T3 (sl) |
| PT (1) | PT1937687E (sl) |
| RS (1) | RS51702B (sl) |
| RU (1) | RU2417997C2 (sl) |
| SG (1) | SG165419A1 (sl) |
| SI (1) | SI1937687T1 (sl) |
| TW (1) | TWI335329B (sl) |
| WO (1) | WO2007038284A1 (sl) |
| ZA (1) | ZA200802550B (sl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ527142A (en) | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
| US7691869B2 (en) | 2007-03-30 | 2010-04-06 | King Pharmaceuticals Research And Development, Inc. | Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity |
| US8859566B2 (en) | 2009-03-13 | 2014-10-14 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds |
| US8598343B2 (en) | 2009-08-07 | 2013-12-03 | Merck Sharp & Dohme Corp. | Process for preparing a 2-alkynyl substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine |
| WO2011101861A1 (en) | 2010-01-29 | 2011-08-25 | Msn Laboratories Limited | Process for preparation of dpp-iv inhibitors |
| CA2812378C (en) * | 2010-09-24 | 2016-11-29 | Advinus Therapeutics Limited | Fused tricyclic compounds as adenosine receptor antagonist |
| WO2012135083A1 (en) * | 2011-03-31 | 2012-10-04 | Merck Sharp & Dohme Corp. | METABOLITES OF 7-(2-(4-(6-FLUORO-3-METHYLBENZO[d]ISOXAZOL-5-YL)PIPERAZIN-1-YL)ETHYL)-2-(PROP-1-YNYL)-7H-PYRAZOLO[4,3-e][1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-5-AMINE AND THEIR UTILITY AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| WO2014101113A1 (en) * | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Piperazine-substituted 7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| WO2014101120A1 (en) | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| WO2014128882A1 (ja) * | 2013-02-21 | 2014-08-28 | 医療法人 和楽会 | 不安うつ病の治療薬 |
| WO2015027431A1 (en) | 2013-08-29 | 2015-03-05 | Merck Sharp & Dohme Corp. | 2,2-difluorodioxolo a2a receptor antagonists |
| CN111943890B (zh) | 2014-11-03 | 2023-10-31 | 艾欧米制药有限公司 | 药用化合物 |
| WO2016089796A1 (en) * | 2014-12-04 | 2016-06-09 | Merck Sharp & Dohme Corp. | Formulation inhibiting effects of low acid environment |
| CN106543095B (zh) * | 2016-09-23 | 2019-03-05 | 江苏大学 | 一种基于2-羟基苯乙酮肟及其衍生物一锅制备苯并异噁唑的方法 |
| WO2019118313A1 (en) | 2017-12-13 | 2019-06-20 | Merck Sharp & Dohme Corp. | Imidazo [1,2-c] quinazolin-5-amine compounds with a2a antagonist properties |
| CN110742893B (zh) * | 2018-07-23 | 2024-04-05 | 百济神州(北京)生物科技有限公司 | A2a受体拮抗剂治疗癌症的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE462170B (sv) | 1987-10-27 | 1990-05-14 | Aahlstrom Corp | Avlaegsnande av loesta och kolloidala makromolekylaera organiska aemnen ur effluenter |
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| ATE208199T1 (de) * | 1993-07-27 | 2001-11-15 | Kyowa Hakko Kogyo Kk | Arzneimittel gegen parkinsonsche krankheit |
| IT1275420B (it) | 1995-06-02 | 1997-08-05 | Schering Plough S P A | Metodo per misurare l'affinita' di legame al recettore a2a dell'adenosina di componenti di interesse farmacologico mediante l'uso del ligando triziato (3h)-sch 58261 |
| IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
| KR100520907B1 (ko) | 2000-05-26 | 2005-10-11 | 쉐링 코포레이션 | 아데노신 Ａ2ａ수용체 길항제 |
| GB0100624D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
| KR100687954B1 (ko) | 2001-10-15 | 2007-02-27 | 쉐링 코포레이션 | 아데노신 Ａ2ａ 수용체 길항제로서의이미다조（4,3-ｅ）-1,2,4-트리아졸로（1,5-ｃ） 피리미딘 |
| US7414058B2 (en) | 2002-12-19 | 2008-08-19 | Schering Corporation | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| BRPI0409787B8 (pt) * | 2003-04-23 | 2021-05-25 | Merck Sharp & Dohme | antagonistas receptores da 2-alquinil- e 2-alquenil-pirazol-[4,3-e]-1,2,4-triazol-[1,5-c]-pirimidina adenosina a2a |
| ES2342082T3 (es) | 2004-04-21 | 2010-07-01 | Schering Corporation | Antagonistas de receptores a2a de adenosina de pirazolo(4,3-e)-1,2,4-triazolo(1,5-c)pirimidina. |
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2006
- 2006-09-20 AR ARP060104110A patent/AR056080A1/es active IP Right Grant
- 2006-09-20 PE PE2006001140A patent/PE20070521A1/es active IP Right Grant
- 2006-09-21 US US11/525,065 patent/US7572802B2/en active Active
- 2006-09-21 CN CN201110394181.7A patent/CN102716131B/zh not_active Expired - Fee Related
- 2006-09-21 SG SG201006970-6A patent/SG165419A1/en unknown
- 2006-09-21 PL PL06804036T patent/PL1937687T3/pl unknown
- 2006-09-21 WO PCT/US2006/037003 patent/WO2007038284A1/en active Application Filing
- 2006-09-21 CN CN2006800352004A patent/CN101273045B/zh not_active Expired - Fee Related
- 2006-09-21 RS RS20110262A patent/RS51702B/en unknown
- 2006-09-21 PT PT06804036T patent/PT1937687E/pt unknown
- 2006-09-21 ES ES06804036T patent/ES2361856T3/es active Active
- 2006-09-21 NZ NZ566737A patent/NZ566737A/en not_active IP Right Cessation
- 2006-09-21 JP JP2008532422A patent/JP4808779B2/ja not_active Expired - Fee Related
- 2006-09-21 AU AU2006294633A patent/AU2006294633B8/en not_active Ceased
- 2006-09-21 MY MYPI20080750A patent/MY146429A/en unknown
- 2006-09-21 SI SI200631017T patent/SI1937687T1/sl unknown
- 2006-09-21 DE DE602006021042T patent/DE602006021042D1/de active Active
- 2006-09-21 BR BRPI0616264A patent/BRPI0616264B8/pt not_active IP Right Cessation
- 2006-09-21 KR KR1020087007052A patent/KR101396614B1/ko active IP Right Grant
- 2006-09-21 AT AT06804036T patent/ATE503759T1/de active
- 2006-09-21 CA CA2623047A patent/CA2623047C/en not_active Expired - Fee Related
- 2006-09-21 DK DK06804036.9T patent/DK1937687T3/da active
- 2006-09-21 EP EP06804036A patent/EP1937687B1/en active Active
- 2006-09-21 RU RU2008115239/04A patent/RU2417997C2/ru active
- 2006-09-21 TW TW095134895A patent/TWI335329B/zh not_active IP Right Cessation
-
2008
- 2008-03-18 IL IL190275A patent/IL190275A/en active IP Right Grant
- 2008-03-19 ZA ZA200802550A patent/ZA200802550B/xx unknown
- 2008-03-19 EC EC2008008297A patent/ECSP088297A/es unknown
- 2008-04-22 NO NO20081924A patent/NO341760B1/no not_active IP Right Cessation
- 2008-10-24 HK HK08111733.1A patent/HK1119681A1/xx not_active IP Right Cessation
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2009
- 2009-07-06 US US12/498,013 patent/US8389532B2/en active Active
-
2011
- 2011-06-20 HR HR20110466T patent/HRP20110466T1/hr unknown
- 2011-06-28 CY CY20111100618T patent/CY1111921T1/el unknown
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