NO20081924L - 7-[2-[4-(6-fluor-3-metyl-1,2-benzisoksazol-5-yl)-1-pipera-zinyl]etyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-e]-[1,2,4]-triazolo-[1,5-c]-pyrimidin-5-amin - Google Patents

7-[2-[4-(6-fluor-3-metyl-1,2-benzisoksazol-5-yl)-1-pipera-zinyl]etyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-e]-[1,2,4]-triazolo-[1,5-c]-pyrimidin-5-amin

Info

Publication number
NO20081924L
NO20081924L NO20081924A NO20081924A NO20081924L NO 20081924 L NO20081924 L NO 20081924L NO 20081924 A NO20081924 A NO 20081924A NO 20081924 A NO20081924 A NO 20081924A NO 20081924 L NO20081924 L NO 20081924L
Authority
NO
Norway
Prior art keywords
zinyl
benzisoxazol
triazolo
pyrazolo
propynyl
Prior art date
Application number
NO20081924A
Other languages
English (en)
Other versions
NO341760B1 (no
Inventor
Samuel Chackalamannil
Craig D Boyle
Unmesh G Shah
Jean E Lachowicz
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37487759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081924(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20081924L publication Critical patent/NO20081924L/no
Publication of NO341760B1 publication Critical patent/NO341760B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Forbindelsen med strukturformel I, eller et farmasøytisk akseptabelt salt derav, er beskrevet, så vel som dens anvendelse ved behandling av sentralnervesystemsykdommer, i særdeleshet Parkinsons sykdom, ekstrapyramidalt syndrom, urolig leggsyndrom og oppmerksomhetssvekket hyperaktivitetsforstyrrelse, farmasøytiske preparater omfattende den, og kombinasjoner med andre midler. (I)
NO20081924A 2005-09-23 2008-04-22 7-[2-[4-(6-fluor-3-metyl-1,2-benzisoksazol-5-yl)-1-piperazinyl]etyl]-2-(1-propynyl)-7Hpyrazolo-[ 4,3-e]-[1,2,4]-triazolo-[1,5-c]-pyrimidin-5-amin, eller et farmasøytisk akseptabelt salt derav, farmasøytiske preparater derav, samt dets anvendelse ved behandling av sentralnervesystemsykdommer. NO341760B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72002705P 2005-09-23 2005-09-23
PCT/US2006/037003 WO2007038284A1 (en) 2005-09-23 2006-09-21 7-[2-[4-(6-FLUORO-3-METHYL-1,2-BENZISOXAZOL-5-YL)-1-PIPERAZINYL]ETHYL]-2-(1-PROPYNYL)-7H-PYRAZOLO-[4,3-e]-[1,2,4]-TRIAZOLO-[1,5-c]-PYRIMIDIN-5 AMINE

Publications (2)

Publication Number Publication Date
NO20081924L true NO20081924L (no) 2008-05-22
NO341760B1 NO341760B1 (no) 2018-01-15

Family

ID=37487759

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081924A NO341760B1 (no) 2005-09-23 2008-04-22 7-[2-[4-(6-fluor-3-metyl-1,2-benzisoksazol-5-yl)-1-piperazinyl]etyl]-2-(1-propynyl)-7Hpyrazolo-[ 4,3-e]-[1,2,4]-triazolo-[1,5-c]-pyrimidin-5-amin, eller et farmasøytisk akseptabelt salt derav, farmasøytiske preparater derav, samt dets anvendelse ved behandling av sentralnervesystemsykdommer.

Country Status (31)

Country Link
US (2) US7572802B2 (no)
EP (1) EP1937687B1 (no)
JP (1) JP4808779B2 (no)
KR (1) KR101396614B1 (no)
CN (2) CN101273045B (no)
AR (1) AR056080A1 (no)
AT (1) ATE503759T1 (no)
AU (1) AU2006294633B8 (no)
BR (1) BRPI0616264B8 (no)
CA (1) CA2623047C (no)
CY (1) CY1111921T1 (no)
DE (1) DE602006021042D1 (no)
DK (1) DK1937687T3 (no)
EC (1) ECSP088297A (no)
ES (1) ES2361856T3 (no)
HK (1) HK1119681A1 (no)
HR (1) HRP20110466T1 (no)
IL (1) IL190275A (no)
MY (1) MY146429A (no)
NO (1) NO341760B1 (no)
NZ (1) NZ566737A (no)
PE (1) PE20070521A1 (no)
PL (1) PL1937687T3 (no)
PT (1) PT1937687E (no)
RS (1) RS51702B (no)
RU (1) RU2417997C2 (no)
SG (1) SG165419A1 (no)
SI (1) SI1937687T1 (no)
TW (1) TWI335329B (no)
WO (1) WO2007038284A1 (no)
ZA (1) ZA200802550B (no)

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NZ527142A (en) 2003-07-23 2006-03-31 Douglas Pharmaceuticals Ltd A stable suspension formulation
US7691869B2 (en) 2007-03-30 2010-04-06 King Pharmaceuticals Research And Development, Inc. Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity
AU2010222289B2 (en) 2009-03-13 2013-07-11 Advinus Therapeutics Private Limited Substituted fused pyrimidine compounds
US8598343B2 (en) 2009-08-07 2013-12-03 Merck Sharp & Dohme Corp. Process for preparing a 2-alkynyl substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
US9006177B2 (en) * 2010-09-24 2015-04-14 Advinus Therapeutics Limited Fused tricyclic compounds as adenosine receptor antagonist
WO2012135083A1 (en) * 2011-03-31 2012-10-04 Merck Sharp & Dohme Corp. METABOLITES OF 7-(2-(4-(6-FLUORO-3-METHYLBENZO[d]ISOXAZOL-5-YL)PIPERAZIN-1-YL)ETHYL)-2-(PROP-1-YNYL)-7H-PYRAZOLO[4,3-e][1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-5-AMINE AND THEIR UTILITY AS ADENOSINE A2a RECEPTOR ANTAGONISTS
WO2014101113A1 (en) * 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Piperazine-substituted 7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
JPWO2014128882A1 (ja) * 2013-02-21 2017-02-02 医療法人 和楽会 不安うつ病の治療薬
WO2015027431A1 (en) 2013-08-29 2015-03-05 Merck Sharp & Dohme Corp. 2,2-difluorodioxolo a2a receptor antagonists
AU2015341913B2 (en) 2014-11-03 2020-07-16 Iomet Pharma Ltd Pharmaceutical compound
EP3227299B1 (en) 2014-12-04 2021-05-26 Merck Sharp & Dohme Corp. Formulation inhibiting effects of low acid environment
CN106543095B (zh) * 2016-09-23 2019-03-05 江苏大学 一种基于2-羟基苯乙酮肟及其衍生物一锅制备苯并异噁唑的方法
WO2019118313A1 (en) 2017-12-13 2019-06-20 Merck Sharp & Dohme Corp. Imidazo [1,2-c] quinazolin-5-amine compounds with a2a antagonist properties
CN110742893B (zh) * 2018-07-23 2024-04-05 百济神州(北京)生物科技有限公司 A2a受体拮抗剂治疗癌症的方法

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SE462170B (sv) 1987-10-27 1990-05-14 Aahlstrom Corp Avlaegsnande av loesta och kolloidala makromolekylaera organiska aemnen ur effluenter
IT1264901B1 (it) 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
CA2144330A1 (en) 1993-07-27 1995-02-09 Fumio Suzuki A therapeutic agent for parkinson's disease
IT1275420B (it) 1995-06-02 1997-08-05 Schering Plough S P A Metodo per misurare l'affinita' di legame al recettore a2a dell'adenosina di componenti di interesse farmacologico mediante l'uso del ligando triziato (3h)-sch 58261
IT1277392B1 (it) 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
IT1291372B1 (it) 1997-05-21 1999-01-07 Schering Plough S P A Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
TWI288137B (en) 2000-05-26 2007-10-11 Schering Corp Adenosine A2a receptor antagonists
GB0100624D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds VII
MXPA04003474A (es) 2001-10-15 2004-07-30 Schering Corp Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pirimidinas como antagonistas del receptor de adenosina a2a.
CN101310724A (zh) * 2002-12-19 2008-11-26 先灵公司 腺苷A2a受体拮抗剂的应用
PT1622912E (pt) * 2003-04-23 2009-08-17 Schering Corp Antagonistas 2-alcinil- e 2-alcenilpirazolo-[4,3-b]-1,2,4- triazolo-[1,5-c]-pirimidina do receptor a2a da adenosina
ES2342082T3 (es) 2004-04-21 2010-07-01 Schering Corporation Antagonistas de receptores a2a de adenosina de pirazolo(4,3-e)-1,2,4-triazolo(1,5-c)pirimidina.

Also Published As

Publication number Publication date
TWI335329B (en) 2011-01-01
HK1119681A1 (en) 2009-03-13
CN101273045B (zh) 2012-02-01
ECSP088297A (es) 2008-04-28
CN102716131B (zh) 2014-04-23
BRPI0616264B1 (pt) 2020-12-22
BRPI0616264A2 (pt) 2011-06-14
AU2006294633A8 (en) 2012-03-29
PE20070521A1 (es) 2007-07-13
SI1937687T1 (sl) 2011-07-29
CA2623047A1 (en) 2007-04-05
US8389532B2 (en) 2013-03-05
CA2623047C (en) 2013-04-23
KR101396614B1 (ko) 2014-05-16
NO341760B1 (no) 2018-01-15
DE602006021042D1 (de) 2011-05-12
TW200730531A (en) 2007-08-16
US20070072867A1 (en) 2007-03-29
NZ566737A (en) 2011-09-30
CY1111921T1 (el) 2015-11-04
PL1937687T3 (pl) 2011-09-30
MY146429A (en) 2012-08-15
ES2361856T3 (es) 2011-06-22
KR20080047423A (ko) 2008-05-28
WO2007038284A1 (en) 2007-04-05
IL190275A (en) 2014-06-30
SG165419A1 (en) 2010-10-28
RU2417997C2 (ru) 2011-05-10
CN102716131A (zh) 2012-10-10
EP1937687A1 (en) 2008-07-02
AU2006294633B8 (en) 2012-03-29
US7572802B2 (en) 2009-08-11
PT1937687E (pt) 2011-06-01
AR056080A1 (es) 2007-09-19
ZA200802550B (en) 2009-06-24
RU2008115239A (ru) 2009-10-27
CN101273045A (zh) 2008-09-24
IL190275A0 (en) 2009-09-22
ATE503759T1 (de) 2011-04-15
JP4808779B2 (ja) 2011-11-02
AU2006294633A1 (en) 2007-04-05
US20090270432A1 (en) 2009-10-29
HRP20110466T1 (hr) 2011-08-31
BRPI0616264B8 (pt) 2021-05-25
RS51702B (en) 2011-10-31
EP1937687B1 (en) 2011-03-30
JP2009509959A (ja) 2009-03-12
DK1937687T3 (da) 2011-07-18
AU2006294633B2 (en) 2012-03-01

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Owner name: MERCK SHARP AND DOHME CORP, US

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