SI1525177T1 - Substituirani 1,3-difenilprop-2-en-1-on derivati,priprava in njihova uporaba - Google Patents
Substituirani 1,3-difenilprop-2-en-1-on derivati,priprava in njihova uporabaInfo
- Publication number
- SI1525177T1 SI1525177T1 SI200330864T SI200330864T SI1525177T1 SI 1525177 T1 SI1525177 T1 SI 1525177T1 SI 200330864 T SI200330864 T SI 200330864T SI 200330864 T SI200330864 T SI 200330864T SI 1525177 T1 SI1525177 T1 SI 1525177T1
- Authority
- SI
- Slovenia
- Prior art keywords
- derivatives
- diphenylprop
- substituted
- preparation
- concerns
- Prior art date
Links
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical class C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 title abstract 2
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0208571A FR2841900B1 (fr) | 2002-07-08 | 2002-07-08 | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| PCT/FR2003/002127 WO2004005233A1 (fr) | 2002-07-08 | 2003-07-08 | Derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1525177T1 true SI1525177T1 (sl) | 2007-10-31 |
Family
ID=29725283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200330864T SI1525177T1 (sl) | 2002-07-08 | 2003-07-08 | Substituirani 1,3-difenilprop-2-en-1-on derivati,priprava in njihova uporaba |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7943661B2 (zh) |
| EP (1) | EP1525177B1 (zh) |
| JP (1) | JP4575771B2 (zh) |
| KR (1) | KR100974577B1 (zh) |
| CN (1) | CN100548960C (zh) |
| AT (1) | ATE365703T1 (zh) |
| AU (1) | AU2003264698B2 (zh) |
| BR (1) | BRPI0312398B8 (zh) |
| CA (1) | CA2490986C (zh) |
| CY (1) | CY1108085T1 (zh) |
| DE (1) | DE60314633T2 (zh) |
| DK (1) | DK1525177T3 (zh) |
| EA (1) | EA011090B1 (zh) |
| ES (1) | ES2287528T3 (zh) |
| FR (1) | FR2841900B1 (zh) |
| IL (2) | IL165696A0 (zh) |
| MX (1) | MXPA05000427A (zh) |
| NO (1) | NO329700B1 (zh) |
| NZ (1) | NZ538051A (zh) |
| PL (1) | PL207362B1 (zh) |
| PT (1) | PT1525177E (zh) |
| SI (1) | SI1525177T1 (zh) |
| WO (1) | WO2004005233A1 (zh) |
| ZA (1) | ZA200501082B (zh) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841900B1 (fr) | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| JP2007517841A (ja) * | 2004-01-08 | 2007-07-05 | ジェンフィット | １，３−ジフェニルプロプ−２−エン−１−オン誘導体化合物、その調製方法およびその使用 |
| FR2902789A1 (fr) | 2006-06-21 | 2007-12-28 | Genfit Sa | Derives de 1,3-diphenylpropane substitues, preparations et utilisations |
| US20100285126A1 (en) * | 2007-08-02 | 2010-11-11 | Rahul Dabre | Pharmaceutical compositions of fenofibrate |
| US10722575B2 (en) | 2009-11-26 | 2020-07-28 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
| EP2641596B1 (en) * | 2009-11-26 | 2018-05-02 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
| US9221751B2 (en) | 2009-11-26 | 2015-12-29 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
| WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
| SG185397A1 (en) | 2010-05-17 | 2012-12-28 | Genfit | Improved preparation of chalcone derivatives |
| TWI415600B (zh) * | 2011-08-10 | 2013-11-21 | Univ Kaohsiung Medical | 用於治療動脈粥狀硬化的組合物及其製備方法 |
| AU2012360796B2 (en) | 2011-12-28 | 2017-02-02 | Genfit | 1,3-diphenylpropane derivatives, preparations and uses thereof |
| CN102697757B (zh) * | 2012-05-18 | 2014-06-04 | 广州军区广州总医院 | 对羟基苄叉丙酮在制备预防和/或治疗脑病药物中的应用 |
| EA031718B1 (ru) | 2013-01-18 | 2019-02-28 | Женфит | Лечение фиброза и рака, связанных с тирозинкиназой |
| EP3416629A4 (en) * | 2016-02-16 | 2019-08-07 | CoNCERT Pharmaceuticals, Inc. | DEUTERATED GFT-505 |
| KR102338085B1 (ko) | 2016-03-31 | 2021-12-10 | 장피트 | 담즙울체성 질환의 치료 방법 |
| FR3056908B1 (fr) | 2016-09-30 | 2019-04-19 | Nashpharm | Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie |
| FR3056909B1 (fr) | 2016-09-30 | 2019-04-19 | Nashpharm | Composition comprenant au moins un sel pharmaceutiquement acceptable d'elafibranor soluble en milieux aqueux presentant une absorption intestinale amelioree |
| CA3047098A1 (en) * | 2016-12-16 | 2018-06-21 | Jia Zhou | Inhibitors of bromodomain-containing protein 4 (brd4) |
| WO2018133705A1 (zh) * | 2017-01-22 | 2018-07-26 | 苏州科睿思制药有限公司 | Gft-505的晶型及其制备方法和用途 |
| SG11201906987RA (en) | 2017-02-21 | 2019-09-27 | Genfit | Combination of a ppar agonist with a fxr agonist |
| CN110418641A (zh) | 2017-02-24 | 2019-11-05 | 基恩菲特公司 | 用于组合疗法的药物组合物 |
| WO2018193007A1 (en) | 2017-04-18 | 2018-10-25 | Genfit | Combination comprising a ppar agonist such as elafibranor and an acetyl-coa carboxylase (acc) inhibitor |
| CN108658908B (zh) | 2017-07-31 | 2019-05-10 | 广州必贝特医药技术有限公司 | 1，3-二取代烯酮类化合物及其应用 |
| BR112020002261A2 (pt) | 2017-08-04 | 2020-07-28 | Advitech Advisory And Technologies Sa | processo para a preparação de elafibranor, composto e uso de pelo menos um composto |
| CN111093705A (zh) | 2017-09-13 | 2020-05-01 | 诺华股份有限公司 | 包含fxr激动剂的组合 |
| WO2019099761A1 (en) | 2017-11-16 | 2019-05-23 | Teva Pharmaceuticals International Gmbh | Solid state forms of elafibranor |
| CN111148742B (zh) | 2017-11-30 | 2021-11-16 | 四川科伦博泰生物医药股份有限公司 | 芳香族化合物及其药物组合物和用途 |
| EP3514541A1 (de) * | 2018-01-17 | 2019-07-24 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors |
| WO2019186410A1 (en) * | 2018-03-27 | 2019-10-03 | Lupin Limited | Solid forms of elafibranor and processes thereof |
| EP3830070A1 (en) * | 2018-08-03 | 2021-06-09 | Genfit | Elafibranor salts |
| WO2020039297A1 (en) * | 2018-08-24 | 2020-02-27 | Mankind Pharma Ltd. | Novel compounds and their use in preparation of elafibranor and pharmaceutical acceptable salts thereof |
| WO2020115628A1 (en) * | 2018-12-03 | 2020-06-11 | Mankind Pharma Ltd. | Solid forms of elafibranor and process of preparation thereof |
| CN110156648A (zh) * | 2019-05-30 | 2019-08-23 | 河北科技大学 | 一种Elafibranor中间体的制备方法 |
| CN114630660A (zh) | 2019-10-28 | 2022-06-14 | 基恩菲特公司 | 具有抗氧化特性的联合疗法 |
| CN112824380A (zh) * | 2019-11-21 | 2021-05-21 | 杭州百诚医药科技股份有限公司 | α-氟代查耳酮类衍生物及其应用 |
| CN111138264B (zh) * | 2019-11-29 | 2023-08-04 | 温州医科大学 | 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用 |
| CN113121394B (zh) * | 2019-12-30 | 2022-11-08 | 中国药科大学 | 一种苯氧乙酸类衍生物的制备方法 |
| AU2021219286A1 (en) * | 2020-02-10 | 2022-09-22 | Genfit | Polymorphs of elafibranor |
| CN114901641A (zh) * | 2020-02-28 | 2022-08-12 | 四川科伦博泰生物医药股份有限公司 | 芳香族化合物及其药物组合物和用途 |
| BR112022023368A2 (pt) | 2020-05-18 | 2022-12-20 | Genfit | Elafibranor para o tratamento de colangite esclerosante primária |
| AU2021334117A1 (en) | 2020-08-26 | 2023-04-06 | Genfit | Compositions and methods for the treatment of primary biliary cholangitis |
| CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
| CN114853686B (zh) | 2021-08-23 | 2023-06-20 | 中国药科大学 | 三氮唑酮类化合物及其医药用途 |
| CN115894379A (zh) | 2022-01-20 | 2023-04-04 | 中国药科大学 | 海因类化合物及其医药用途 |
| WO2024184365A1 (en) | 2023-03-06 | 2024-09-12 | Genfit | Solid dosage forms of elafibranor |
| CN118363355B (zh) * | 2024-06-19 | 2024-08-30 | 武汉名实生物医药科技有限责任公司 | 一种产品生产实时监控系统 |
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| US3558612A (en) * | 1968-05-22 | 1971-01-26 | Dow Chemical Co | Substituted phenoxyacetic acids |
| CH593224A5 (zh) * | 1973-10-30 | 1977-11-30 | Taisho Pharmaceutical Co Ltd | |
| US3994955A (en) * | 1975-01-20 | 1976-11-30 | G. D. Searle & Co. | Substituted phenoxydialkylacetic acids and esters |
| JPS5278856A (en) | 1975-12-26 | 1977-07-02 | Taisho Pharmaceut Co Ltd | Preparation of chalcone ethers |
| US4190671A (en) * | 1977-03-17 | 1980-02-26 | Biorex Laboratories Limited | Chalcone derivatives |
| JPS5419947A (en) | 1977-07-16 | 1979-02-15 | Taisho Pharmaceut Co Ltd | Chalcone derivatives |
| GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
| JPS6310720A (ja) | 1986-07-01 | 1988-01-18 | Nippon Kayaku Co Ltd | ５−リポキシゲナ−ゼ阻害剤および抗アレルギ−剤 |
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| DE68915269T2 (de) * | 1988-11-25 | 1994-09-29 | Dainippon Ink & Chemicals | Polyvalentes entzündungshemmendes mittel. |
| JPH0442229A (ja) * | 1990-06-08 | 1992-02-12 | Fujitsu Ltd | レジスト材料およびパターンの形成方法 |
| JPH05255655A (ja) | 1992-03-12 | 1993-10-05 | Kanebo Ltd | 紫外線吸収剤 |
| JPH06122623A (ja) | 1992-10-09 | 1994-05-06 | Minofuaagen Seiyaku Honpo:Goushi | 抗腫瘍剤 |
| US5276058A (en) * | 1993-06-09 | 1994-01-04 | Nippon Hypox Laboratories Incorporated | 3,4-dihydroxychalcone derivatives |
| DE4327365A1 (de) * | 1993-08-14 | 1995-02-16 | Boehringer Mannheim Gmbh | Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| WO1998027970A2 (en) | 1996-12-24 | 1998-07-02 | National Research Council Of Canada | Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals |
| EP0947511A1 (en) | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
| WO2000023073A1 (en) | 1998-10-20 | 2000-04-27 | Korea Institute Of Science And Technology | Bioflavonoids as plasma high density lipoprotein level increasing agent |
| ATE409028T1 (de) * | 2000-01-27 | 2008-10-15 | Takara Bio Inc | Arzneien zur behandlung von nervenerkrankungen |
| US6608101B1 (en) * | 2000-06-20 | 2003-08-19 | Atherogenics, Inc. | 1, 3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders |
| EP1254759B1 (de) | 2001-05-03 | 2009-03-18 | Leister Process Technologies | Düse zum Schweissen von Kunststoffbahnen oder -folien |
| FR2841900B1 (fr) | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| FR2841784B1 (fr) * | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| FR2857361B1 (fr) * | 2003-07-08 | 2005-09-09 | Genfit S A | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
| JP2007517841A (ja) * | 2004-01-08 | 2007-07-05 | ジェンフィット | １，３−ジフェニルプロプ−２−エン−１−オン誘導体化合物、その調製方法およびその使用 |
-
2002
- 2002-07-08 FR FR0208571A patent/FR2841900B1/fr not_active Expired - Fee Related
-
2003
- 2003-07-08 NZ NZ538051A patent/NZ538051A/en not_active IP Right Cessation
- 2003-07-08 BR BRPI0312398A patent/BRPI0312398B8/pt not_active IP Right Cessation
- 2003-07-08 WO PCT/FR2003/002127 patent/WO2004005233A1/fr active IP Right Grant
- 2003-07-08 DE DE60314633T patent/DE60314633T2/de not_active Expired - Lifetime
- 2003-07-08 JP JP2004518890A patent/JP4575771B2/ja not_active Expired - Lifetime
- 2003-07-08 SI SI200330864T patent/SI1525177T1/sl unknown
- 2003-07-08 MX MXPA05000427A patent/MXPA05000427A/es active IP Right Grant
- 2003-07-08 IL IL16569603A patent/IL165696A0/xx unknown
- 2003-07-08 KR KR1020057000349A patent/KR100974577B1/ko active IP Right Grant
- 2003-07-08 PT PT03762749T patent/PT1525177E/pt unknown
- 2003-07-08 AU AU2003264698A patent/AU2003264698B2/en not_active Ceased
- 2003-07-08 AT AT03762749T patent/ATE365703T1/de active
- 2003-07-08 ES ES03762749T patent/ES2287528T3/es not_active Expired - Lifetime
- 2003-07-08 DK DK03762749T patent/DK1525177T3/da active
- 2003-07-08 EP EP03762749A patent/EP1525177B1/fr not_active Expired - Lifetime
- 2003-07-08 EA EA200500169A patent/EA011090B1/ru not_active IP Right Cessation
- 2003-07-08 PL PL372809A patent/PL207362B1/pl unknown
- 2003-07-08 CA CA2490986A patent/CA2490986C/fr not_active Expired - Fee Related
- 2003-07-08 US US10/520,079 patent/US7943661B2/en active Active
- 2003-07-08 CN CNB038163667A patent/CN100548960C/zh not_active Expired - Lifetime
-
2004
- 2004-12-03 NO NO20045301A patent/NO329700B1/no not_active IP Right Cessation
- 2004-12-09 IL IL165696A patent/IL165696A/en active IP Right Grant
-
2005
- 2005-02-07 ZA ZA200501082A patent/ZA200501082B/xx unknown
-
2006
- 2006-07-26 US US11/493,040 patent/US7566737B2/en not_active Expired - Lifetime
-
2007
- 2007-08-03 CY CY20071101040T patent/CY1108085T1/el unknown
-
2011
- 2011-04-11 US US13/083,659 patent/US8058308B2/en not_active Expired - Lifetime
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