SI1259507T1 - Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 4r-(3s-hydroxy-1-methyl)piperidinyl)-4h-1-benzopyran-4-one hydrochloride - Google Patents

Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 4r-(3s-hydroxy-1-methyl)piperidinyl)-4h-1-benzopyran-4-one hydrochloride

Info

Publication number
SI1259507T1
SI1259507T1 SI200130201T SI200130201T SI1259507T1 SI 1259507 T1 SI1259507 T1 SI 1259507T1 SI 200130201 T SI200130201 T SI 200130201T SI 200130201 T SI200130201 T SI 200130201T SI 1259507 T1 SI1259507 T1 SI 1259507T1
Authority
SI
Slovenia
Prior art keywords
pseudopolymorph
benzopyran
piperidinyl
chlorophenyl
dihydroxy
Prior art date
Application number
SI200130201T
Other languages
English (en)
Slovenian (sl)
Inventor
Gary L. Bafus
Christine M. Harrison-Bowman
Gary L. Silvey
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of SI1259507T1 publication Critical patent/SI1259507T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Stereophonic System (AREA)
  • Inorganic Insulating Materials (AREA)
  • Pyrane Compounds (AREA)
SI200130201T 2000-01-18 2001-01-08 Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 4r-(3s-hydroxy-1-methyl)piperidinyl)-4h-1-benzopyran-4-one hydrochloride SI1259507T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48471700A 2000-01-18 2000-01-18
EP01900939A EP1259507B1 (en) 2000-01-18 2001-01-08 Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one hydrochloride
PCT/US2001/000519 WO2001053293A1 (en) 2000-01-18 2001-01-08 Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one

Publications (1)

Publication Number Publication Date
SI1259507T1 true SI1259507T1 (en) 2005-02-28

Family

ID=23925305

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130201T SI1259507T1 (en) 2000-01-18 2001-01-08 Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 4r-(3s-hydroxy-1-methyl)piperidinyl)-4h-1-benzopyran-4-one hydrochloride

Country Status (26)

Country Link
EP (1) EP1259507B1 (no)
JP (1) JP2003520797A (no)
KR (1) KR100806464B1 (no)
CN (1) CN1174977C (no)
AT (1) ATE273303T1 (no)
AU (1) AU2001226346A1 (no)
BR (1) BR0107726A (no)
CA (1) CA2397593C (no)
CZ (1) CZ301195B6 (no)
DE (1) DE60104822T2 (no)
DK (1) DK1259507T3 (no)
EA (1) EA005247B1 (no)
ES (1) ES2222332T3 (no)
HU (1) HUP0204126A3 (no)
IL (2) IL150638A0 (no)
MX (1) MXPA02007005A (no)
NO (1) NO322572B1 (no)
NZ (1) NZ520280A (no)
PL (1) PL200696B1 (no)
PT (1) PT1259507E (no)
SI (1) SI1259507T1 (no)
SK (1) SK287404B6 (no)
TR (1) TR200402036T4 (no)
TW (1) TWI284129B (no)
WO (1) WO2001053293A1 (no)
ZA (1) ZA200205639B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109803684B (zh) 2016-08-23 2022-08-23 卫材 R&D 管理有限公司 用于治疗肝细胞癌的组合疗法
KR102517650B1 (ko) 2017-03-16 2023-04-05 에자이 알앤드디 매니지먼트 가부시키가이샤 유방암의 치료를 위한 조합물 요법
EP3903828A4 (en) 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE AND A KINASE INHIBITOR

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164232B (no) * 1986-04-11 1989-02-04 Hoechst India
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs

Also Published As

Publication number Publication date
PL200696B1 (pl) 2009-01-30
IL150638A (en) 2009-06-15
CZ301195B6 (cs) 2009-12-02
CZ20022466A3 (cs) 2002-11-13
PT1259507E (pt) 2004-12-31
ATE273303T1 (de) 2004-08-15
SK10362002A3 (sk) 2003-01-09
TWI284129B (en) 2007-07-21
DK1259507T3 (da) 2004-11-01
NZ520280A (en) 2004-04-30
NO20023386D0 (no) 2002-07-12
PL356165A1 (en) 2004-06-14
CN1395576A (zh) 2003-02-05
CN1174977C (zh) 2004-11-10
JP2003520797A (ja) 2003-07-08
NO322572B1 (no) 2006-10-30
EA200200775A1 (ru) 2002-12-26
CA2397593C (en) 2009-11-10
KR100806464B1 (ko) 2008-02-21
TR200402036T4 (tr) 2004-10-21
DE60104822D1 (de) 2004-09-16
WO2001053293A1 (en) 2001-07-26
BR0107726A (pt) 2002-10-01
MXPA02007005A (es) 2004-09-06
ZA200205639B (en) 2003-10-15
IL150638A0 (en) 2003-02-12
CA2397593A1 (en) 2001-07-26
AU2001226346A1 (en) 2001-07-31
SK287404B6 (sk) 2010-09-07
EP1259507B1 (en) 2004-08-11
HUP0204126A3 (en) 2006-02-28
EA005247B1 (ru) 2004-12-30
EP1259507A1 (en) 2002-11-27
HUP0204126A2 (hu) 2003-04-28
ES2222332T3 (es) 2005-02-01
NO20023386L (no) 2002-09-12
KR20020069361A (ko) 2002-08-30
DE60104822T2 (de) 2005-09-01

Similar Documents

Publication Publication Date Title
AU6397301A (en) Synchronization method
AU2000242834A1 (en) Method and terminal for inputting instructions
AU2002215125A1 (en) Well treatment method
MXPA03005573A (es) Inyector y metodo para la introduccion prolongada de reactivos dentro del plasma.
EP1164965A4 (en) ENDODONTIC INSTRUMENT, INSTRUMENT SHAPE AND MANUFACTURING METHOD
AU2002303283A1 (en) Methods for treating drug addiction
AU4455601A (en) Hole structure and production method for hole structure
PL366059A1 (en) Ion-sensitive, water-dispersible polymers, a method of making same and items using same
AU2002217089A1 (en) Method for producing sulfonamide-substituted imidazotriazinones
AU5749601A (en) Ion-sensitive, water-dispersible polymers composition, a method of making same and items using same
SI1259507T1 (en) Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 4r-(3s-hydroxy-1-methyl)piperidinyl)-4h-1-benzopyran-4-one hydrochloride
AU2002322838A1 (en) Low sensitivity explosive compositions and method for making explosive compositions
AU2002224322A1 (en) Lactam dipeptide and its use in inhibiting beta-amyloid peptiderelease
PT1252155E (pt) Solvato de etanol de (-)-cis-2-(2-clorofenil)-5,7-di-hidroxi-8-[4r-(3s-hidroxi-1-metil)piperidinil]-4h-1-bezopiran-4-ona
AU4732001A (en) Thiepino (3,2-b) dihydropyridines and related compositions and methods
PL347056A1 (en) Novel compounds of heterocycloalkylbezocyclobutane and heterocycloarylbenzocyclobutane, method of obtaining them and pharmacological compositions containming such compounds
AU2001261260A1 (en) Methods for accelerated desensitization of teeth
AU2001270741A1 (en) Steel compositions, method for obtaining same and parts made from same
PL347407A1 (en) Method of obtaining derivatives of 5,6,7,8-tetrahydronaphtalen-2-ole
AU2001254821A1 (en) Method for producing cyclic lactams
AU2001261116A1 (en) Method and compositions for drug discovery
AU2002238690A1 (en) Low-pressure carburising method
AUPQ740300A0 (en) Method of, and apparatus for, forming an article and an article formed by same
AU2001284421A1 (en) Method of determining base sequence
MX9708494A (es) Nuevo proceso para la preparacion de clorhidrato de ropivacaina monohidratada.