SI1115704T1 - Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes - Google Patents
Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexesInfo
- Publication number
- SI1115704T1 SI1115704T1 SI9930391T SI9930391T SI1115704T1 SI 1115704 T1 SI1115704 T1 SI 1115704T1 SI 9930391 T SI9930391 T SI 9930391T SI 9930391 T SI9930391 T SI 9930391T SI 1115704 T1 SI1115704 T1 SI 1115704T1
- Authority
- SI
- Slovenia
- Prior art keywords
- cyclin
- inhibitory effect
- various kinases
- novel substituted
- substituted indolinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844003A DE19844003A1 (de) | 1998-09-25 | 1998-09-25 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19937496A DE19937496A1 (de) | 1999-08-07 | 1999-08-07 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1999/007040 WO2000018734A1 (fr) | 1998-09-25 | 1999-09-22 | Nouvelles indolinones substituees a effet inhibiteur sur differentes kinases et differents complexes cycline/cdk |
| EP99947404A EP1115704B1 (fr) | 1998-09-25 | 1999-09-22 | Nouvelles indolinones substituees a effet inhibiteur sur differentes kinases et differents complexes cycline/cdk |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1115704T1 true SI1115704T1 (en) | 2003-12-31 |
Family
ID=26049076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9930391T SI1115704T1 (en) | 1998-09-25 | 1999-09-22 | Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6855710B2 (fr) |
| EP (1) | EP1115704B1 (fr) |
| JP (1) | JP2002525356A (fr) |
| KR (1) | KR20010085841A (fr) |
| CN (1) | CN1319090A (fr) |
| AT (1) | ATE243195T1 (fr) |
| AU (1) | AU763361B2 (fr) |
| BG (1) | BG105327A (fr) |
| BR (1) | BR9914065A (fr) |
| CA (1) | CA2342622A1 (fr) |
| DE (1) | DE59906030D1 (fr) |
| DK (1) | DK1115704T3 (fr) |
| EA (1) | EA200100320A1 (fr) |
| EE (1) | EE200100184A (fr) |
| ES (1) | ES2196860T3 (fr) |
| HR (1) | HRP20010216A2 (fr) |
| HU (1) | HUP0104973A3 (fr) |
| ID (1) | ID27757A (fr) |
| IL (1) | IL141622A0 (fr) |
| NO (1) | NO20011477L (fr) |
| NZ (1) | NZ510845A (fr) |
| PL (1) | PL346898A1 (fr) |
| PT (1) | PT1115704E (fr) |
| SI (1) | SI1115704T1 (fr) |
| SK (1) | SK4032001A3 (fr) |
| TR (1) | TR200100854T2 (fr) |
| WO (1) | WO2000018734A1 (fr) |
| YU (1) | YU21301A (fr) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6765012B2 (en) * | 2001-09-27 | 2004-07-20 | Allergan, Inc. | 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| PT1490062E (pt) | 2002-03-26 | 2008-01-30 | Boehringer Ingelheim Pharma | Miméticos de glucocorticóides, métodos para a sua preparação, composições farmacêuticas e suas utilizações |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
| PE20040701A1 (es) * | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| US20040097574A1 (en) * | 2002-08-29 | 2004-05-20 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| ATE414701T1 (de) * | 2003-10-03 | 2008-12-15 | Boehringer Ingelheim Pharma | Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren |
| ES2345662T3 (es) | 2004-03-11 | 2010-09-29 | Actelion Pharmaceuticals Ltd. | Derivados de acido indol-1-il-acetico. |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1836166B1 (fr) | 2004-12-27 | 2009-06-17 | Boehringer Ingelheim Pharmaceuticals Inc. | Composes mimetiques glucocorticoides, compositions pharmaceutiques les contenant, et methodes de fabrication et d'utilisation de ceux-ci |
| BRPI0609899A2 (pt) * | 2005-04-28 | 2010-05-11 | Boehringer Ingelheim International Gmbh | compostos para o tratamento de doenças inflamatórias, uso dos mesmos, formulações farmacêuticas, combinações medicamentosas e produtos intermediários |
| BRPI0720131A2 (pt) | 2006-12-06 | 2014-02-04 | Boehringer Ingelheim Int | Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos. |
| US20100086544A1 (en) * | 2006-12-11 | 2010-04-08 | Mass Robert D | Compositions and methods for treating a neoplasm |
| CN101273991B (zh) * | 2007-03-28 | 2010-05-26 | 广东同德药业有限公司 | 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用 |
| RU2525114C2 (ru) * | 2007-12-03 | 2014-08-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ получения производного индолинона |
| PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
| JP2011510032A (ja) * | 2008-01-25 | 2011-03-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ６−フルオロ−１，２−ジヒドロ−２−オキソ−３ｈ−インドール−３−イリデン誘導体の塩形態、それらの製造方法及びそれらを含有する医薬組成物 |
| WO2009149139A1 (fr) | 2008-06-06 | 2009-12-10 | Boehringer Ingelheim International Gmbh | Mimétiques de glucocorticoïdes, leurs procédés de fabrication, des compositions pharmaceutiques et leurs utilisations |
| PE20110213A1 (es) | 2008-07-29 | 2011-04-16 | Boehringer Ingelheim Int | Derivados de indolinona como inhibidores de quinasa |
| JPWO2013137371A1 (ja) * | 2012-03-15 | 2015-08-03 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
| CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
| CN111683976B (zh) | 2018-02-05 | 2022-11-18 | 生物辐射实验室股份有限公司 | 具有阴离子交换-疏水混合模式配体的色谱树脂 |
| CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-09-22 WO PCT/EP1999/007040 patent/WO2000018734A1/fr not_active Application Discontinuation
- 1999-09-22 ID IDW20010688A patent/ID27757A/id unknown
- 1999-09-22 SI SI9930391T patent/SI1115704T1/xx unknown
- 1999-09-22 EA EA200100320A patent/EA200100320A1/ru unknown
- 1999-09-22 AU AU60863/99A patent/AU763361B2/en not_active Ceased
- 1999-09-22 BR BR9914065-9A patent/BR9914065A/pt unknown
- 1999-09-22 DE DE59906030T patent/DE59906030D1/de not_active Expired - Fee Related
- 1999-09-22 DK DK99947404T patent/DK1115704T3/da active
- 1999-09-22 TR TR2001/00854T patent/TR200100854T2/xx unknown
- 1999-09-22 HU HU0104973A patent/HUP0104973A3/hu unknown
- 1999-09-22 EE EEP200100184A patent/EE200100184A/xx unknown
- 1999-09-22 SK SK403-2001A patent/SK4032001A3/sk unknown
- 1999-09-22 JP JP2000572194A patent/JP2002525356A/ja active Pending
- 1999-09-22 AT AT99947404T patent/ATE243195T1/de not_active IP Right Cessation
- 1999-09-22 NZ NZ510845A patent/NZ510845A/en unknown
- 1999-09-22 EP EP99947404A patent/EP1115704B1/fr not_active Expired - Lifetime
- 1999-09-22 IL IL14162299A patent/IL141622A0/xx unknown
- 1999-09-22 ES ES99947404T patent/ES2196860T3/es not_active Expired - Lifetime
- 1999-09-22 CN CN99811297A patent/CN1319090A/zh active Pending
- 1999-09-22 CA CA002342622A patent/CA2342622A1/fr not_active Abandoned
- 1999-09-22 PL PL99346898A patent/PL346898A1/xx not_active Application Discontinuation
- 1999-09-22 YU YU21301A patent/YU21301A/sh unknown
- 1999-09-22 PT PT99947404T patent/PT1115704E/pt unknown
- 1999-09-22 KR KR1020017003773A patent/KR20010085841A/ko not_active Application Discontinuation
-
2001
- 2001-03-09 BG BG105327A patent/BG105327A/xx active Pending
- 2001-03-21 HR HR20010216A patent/HRP20010216A2/hr not_active Application Discontinuation
- 2001-03-22 NO NO20011477A patent/NO20011477L/no not_active Application Discontinuation
-
2003
- 2003-09-19 US US10/666,643 patent/US6855710B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT1115704E (pt) | 2003-11-28 |
| PL346898A1 (en) | 2002-03-11 |
| NZ510845A (en) | 2003-10-31 |
| EP1115704B1 (fr) | 2003-06-18 |
| JP2002525356A (ja) | 2002-08-13 |
| ID27757A (id) | 2001-04-26 |
| WO2000018734A1 (fr) | 2000-04-06 |
| HRP20010216A2 (en) | 2002-04-30 |
| US6855710B2 (en) | 2005-02-15 |
| NO20011477D0 (no) | 2001-03-22 |
| CA2342622A1 (fr) | 2000-04-06 |
| KR20010085841A (ko) | 2001-09-07 |
| CN1319090A (zh) | 2001-10-24 |
| EE200100184A (et) | 2002-08-15 |
| YU21301A (sh) | 2003-04-30 |
| HUP0104973A3 (en) | 2002-06-28 |
| NO20011477L (no) | 2001-03-22 |
| EP1115704A1 (fr) | 2001-07-18 |
| ES2196860T3 (es) | 2003-12-16 |
| US20040058978A1 (en) | 2004-03-25 |
| EA200100320A1 (ru) | 2001-10-22 |
| DE59906030D1 (de) | 2003-07-24 |
| TR200100854T2 (tr) | 2001-12-21 |
| SK4032001A3 (en) | 2001-11-06 |
| ATE243195T1 (de) | 2003-07-15 |
| HUP0104973A2 (hu) | 2002-04-29 |
| BG105327A (en) | 2001-12-29 |
| BR9914065A (pt) | 2001-06-19 |
| IL141622A0 (en) | 2002-03-10 |
| AU6086399A (en) | 2000-04-17 |
| DK1115704T3 (da) | 2003-09-29 |
| AU763361B2 (en) | 2003-07-17 |
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