EE200100184A - Uudsed asendatud indolinoonid inhibeeriva toimegamitmesugustele kinaasidele ja tsükliin/CDK kompleksidele - Google Patents

Uudsed asendatud indolinoonid inhibeeriva toimegamitmesugustele kinaasidele ja tsükliin/CDK kompleksidele

Info

Publication number
EE200100184A
EE200100184A EEP200100184A EEP200100184A EE200100184A EE 200100184 A EE200100184 A EE 200100184A EE P200100184 A EEP200100184 A EE P200100184A EE P200100184 A EEP200100184 A EE P200100184A EE 200100184 A EE200100184 A EE 200100184A
Authority
EE
Estonia
Prior art keywords
kinases
cyclin
variety
inhibitory activity
novel substituted
Prior art date
Application number
EEP200100184A
Other languages
English (en)
Estonian (et)
Inventor
Walter Rainer
Grell Wolfgang
Heckel Armin
Himmelsbach Frank
Eberlein Wolfgang
Roth Gerald
C. A. Van Meel Jacobus
Redemann Norbert
Spevak Walter
Tontsch-Grunt Ulrike
von R�den Thomas
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19844003A external-priority patent/DE19844003A1/de
Priority claimed from DE19937496A external-priority patent/DE19937496A1/de
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of EE200100184A publication Critical patent/EE200100184A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200100184A 1998-09-25 1999-09-22 Uudsed asendatud indolinoonid inhibeeriva toimegamitmesugustele kinaasidele ja tsükliin/CDK kompleksidele EE200100184A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19844003A DE19844003A1 (de) 1998-09-25 1998-09-25 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19937496A DE19937496A1 (de) 1999-08-07 1999-08-07 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/007040 WO2000018734A1 (fr) 1998-09-25 1999-09-22 Nouvelles indolinones substituees a effet inhibiteur sur differentes kinases et differents complexes cycline/cdk

Publications (1)

Publication Number Publication Date
EE200100184A true EE200100184A (et) 2002-08-15

Family

ID=26049076

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100184A EE200100184A (et) 1998-09-25 1999-09-22 Uudsed asendatud indolinoonid inhibeeriva toimegamitmesugustele kinaasidele ja tsükliin/CDK kompleksidele

Country Status (28)

Country Link
US (1) US6855710B2 (fr)
EP (1) EP1115704B1 (fr)
JP (1) JP2002525356A (fr)
KR (1) KR20010085841A (fr)
CN (1) CN1319090A (fr)
AT (1) ATE243195T1 (fr)
AU (1) AU763361B2 (fr)
BG (1) BG105327A (fr)
BR (1) BR9914065A (fr)
CA (1) CA2342622A1 (fr)
DE (1) DE59906030D1 (fr)
DK (1) DK1115704T3 (fr)
EA (1) EA200100320A1 (fr)
EE (1) EE200100184A (fr)
ES (1) ES2196860T3 (fr)
HR (1) HRP20010216A2 (fr)
HU (1) HUP0104973A3 (fr)
ID (1) ID27757A (fr)
IL (1) IL141622A0 (fr)
NO (1) NO20011477D0 (fr)
NZ (1) NZ510845A (fr)
PL (1) PL346898A1 (fr)
PT (1) PT1115704E (fr)
SI (1) SI1115704T1 (fr)
SK (1) SK4032001A3 (fr)
TR (1) TR200100854T2 (fr)
WO (1) WO2000018734A1 (fr)
YU (1) YU21301A (fr)

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GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
CA2461812C (fr) * 2001-09-27 2011-09-20 Allergan, Inc. L'utilisation de 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones en tant qu'inhibiteurs de kinases
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
MXPA04009329A (es) 2002-03-26 2005-01-25 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y usos de los mismos.
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
US7514468B2 (en) 2002-07-23 2009-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
DE10233366A1 (de) * 2002-07-23 2004-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
PE20040701A1 (es) * 2002-07-23 2004-11-30 Boehringer Ingelheim Pharma Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos
DE10237423A1 (de) * 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
US20040204458A1 (en) 2002-08-16 2004-10-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of Lck inhibitors for treatment of immunologic diseases
RS20050174A (en) * 2002-08-29 2007-06-04 Boehringer Ingelheim Pharmaceuticals Inc., -3(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
US7148249B2 (en) * 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
DE602004017884D1 (de) 2003-10-03 2009-01-02 Boehringer Ingelheim Pharma Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren
KR101165863B1 (ko) 2004-03-11 2012-07-13 액테리온 파마슈티칼 리미티드 인돌-1-일-아세트산 유도체
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20061155A1 (es) * 2004-12-24 2006-12-16 Boehringer Ingelheim Int Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
US7741361B2 (en) 2004-12-27 2010-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CA2605688A1 (fr) 2005-04-28 2006-11-02 Boehringer Ingelheim International Gmbh Composes pour le traitement des maladies inflammatoiresflammatoires
WO2008070507A2 (fr) 2006-12-06 2008-06-12 Boehringer Ingelheim International Gmbh Substances mimétiques de glucocorticoïde, procédés de préparation de celles-ci, compositions pharmaceutiques et utilisations de celles-ci
RU2482877C2 (ru) * 2006-12-11 2013-05-27 Дженентек, Инк. Композиции и способы для лечения опухоли
CN101273991B (zh) * 2007-03-28 2010-05-26 广东同德药业有限公司 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用
NZ585799A (en) * 2007-12-03 2012-04-27 Boehringer Ingelheim Int Process for the manufacture of an indolinone derivative in particular 3-z-[1-(4-(n-((4-methyl-piperazin-1-yl)-methylcarbonyl)-n-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone
UY31506A1 (es) 2007-12-03 2009-08-03 Derivados de indolinona y procedimiento para su preparacion
DK2238108T3 (da) * 2008-01-25 2012-10-15 Boehringer Ingelheim Int Saltformer af et 6-fluor-1,2-dihydro-2-oxo-3h-indol-3-yliden-derivat, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende de samme
AU2009256289A1 (en) 2008-06-06 2009-12-10 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
TW201011002A (en) 2008-07-29 2010-03-16 Boehringer Ingelheim Int New compounds
JPWO2013137371A1 (ja) * 2012-03-15 2015-08-03 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
CN103664737A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
WO2019152977A2 (fr) 2018-02-05 2019-08-08 Bio-Rad Laboratories, Inc. Résine de chromatographie ayant un ligand mode mixte échange anionique/hydrophobe
CN114957084B (zh) * 2022-01-21 2023-05-09 九江学院 一种吲哚酮类化合物及其制备方法和应用

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GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease

Also Published As

Publication number Publication date
US6855710B2 (en) 2005-02-15
CN1319090A (zh) 2001-10-24
DE59906030D1 (de) 2003-07-24
ID27757A (id) 2001-04-26
BR9914065A (pt) 2001-06-19
AU6086399A (en) 2000-04-17
SK4032001A3 (en) 2001-11-06
HRP20010216A2 (en) 2002-04-30
JP2002525356A (ja) 2002-08-13
EP1115704A1 (fr) 2001-07-18
ES2196860T3 (es) 2003-12-16
IL141622A0 (en) 2002-03-10
SI1115704T1 (en) 2003-12-31
YU21301A (sh) 2003-04-30
TR200100854T2 (tr) 2001-12-21
PL346898A1 (en) 2002-03-11
EP1115704B1 (fr) 2003-06-18
PT1115704E (pt) 2003-11-28
HUP0104973A3 (en) 2002-06-28
BG105327A (en) 2001-12-29
WO2000018734A1 (fr) 2000-04-06
NO20011477L (no) 2001-03-22
CA2342622A1 (fr) 2000-04-06
KR20010085841A (ko) 2001-09-07
US20040058978A1 (en) 2004-03-25
HUP0104973A2 (hu) 2002-04-29
AU763361B2 (en) 2003-07-17
NZ510845A (en) 2003-10-31
NO20011477D0 (no) 2001-03-22
EA200100320A1 (ru) 2001-10-22
ATE243195T1 (de) 2003-07-15
DK1115704T3 (da) 2003-09-29

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