SI0971901T1 - Phthalazinones - Google Patents
PhthalazinonesInfo
- Publication number
- SI0971901T1 SI0971901T1 SI9830396T SI9830396T SI0971901T1 SI 0971901 T1 SI0971901 T1 SI 0971901T1 SI 9830396 T SI9830396 T SI 9830396T SI 9830396 T SI9830396 T SI 9830396T SI 0971901 T1 SI0971901 T1 SI 0971901T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pct
- date jul
- sec
- pub
- phthalazinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Lubricants (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97100488 | 1997-01-15 | ||
| PCT/EP1998/000124 WO1998031674A1 (fr) | 1997-01-15 | 1998-01-12 | Phthalazinones |
| EP98901959A EP0971901B1 (fr) | 1997-01-15 | 1998-01-12 | Phthalazinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI0971901T1 true SI0971901T1 (en) | 2003-10-31 |
Family
ID=8226366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9830396T SI0971901T1 (en) | 1997-01-15 | 1998-01-12 | Phthalazinones |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6103718A (fr) |
| EP (1) | EP0971901B1 (fr) |
| JP (1) | JP2001508078A (fr) |
| KR (1) | KR20000070150A (fr) |
| CN (1) | CN1127487C (fr) |
| AT (1) | ATE233247T1 (fr) |
| AU (1) | AU735934B2 (fr) |
| BR (1) | BR9806752A (fr) |
| CA (1) | CA2276455C (fr) |
| CY (1) | CY2446B1 (fr) |
| CZ (1) | CZ293815B6 (fr) |
| DE (1) | DE69811645T2 (fr) |
| DK (1) | DK0971901T3 (fr) |
| EA (1) | EA002764B1 (fr) |
| EE (1) | EE03968B1 (fr) |
| ES (1) | ES2193508T3 (fr) |
| HK (1) | HK1024692A1 (fr) |
| HU (1) | HUP0001541A3 (fr) |
| IL (1) | IL130659A (fr) |
| NO (1) | NO313137B1 (fr) |
| NZ (1) | NZ336573A (fr) |
| PL (1) | PL189418B1 (fr) |
| PT (1) | PT971901E (fr) |
| SI (1) | SI0971901T1 (fr) |
| SK (1) | SK283270B6 (fr) |
| TR (1) | TR199901653T2 (fr) |
| WO (1) | WO1998031674A1 (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2224628T3 (es) * | 1998-03-14 | 2005-03-01 | Altana Pharma Ag | Inhibidores de pde iii/iv a base de ftalazinonas. |
| PT1212089E (pt) | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | Combinacao sinergica de roflumilast e salmeterol |
| WO2001019818A1 (fr) * | 1999-09-14 | 2001-03-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Derives de phthalazinone utilises comme inhibiteurs de pd3/4 |
| ATE374189T1 (de) | 1999-10-25 | 2007-10-15 | Nycomed Gmbh | Phthalazinon-derivate als pde 4 hemmer |
| IL148807A0 (en) | 1999-10-25 | 2002-09-12 | Byk Gulden Lomberg Chem Fab | Tetrahydrothiopyran derivatives and pharmaceutical compositions containing the same |
| PL358057A1 (en) | 2000-06-05 | 2004-08-09 | Altana Pharma Ag | Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors |
| US20040224316A1 (en) * | 2000-08-10 | 2004-11-11 | Tully Timothy P. | Augmented cognitive training |
| US7868015B2 (en) * | 2000-08-10 | 2011-01-11 | Cold Spring Harbor Laboratory | Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit |
| EE05386B1 (et) * | 2001-02-15 | 2011-02-15 | ALTANA�Pharma�AG | Ftalasinoon-piperidinoderivaadid,ÁnendeÁkasutamineÁjaÁravim |
| CA2445233A1 (fr) | 2001-04-25 | 2002-10-31 | Altana Pharma Ag | Phtalazinones |
| EP1385838A1 (fr) * | 2001-04-25 | 2004-02-04 | ALTANA Pharma AG | Derives piperazines et leur utilisation en tant qu'inhibiteurs de pde4 |
| BR0307780A (pt) | 2002-02-19 | 2004-12-28 | Ono Pharmaceutical Co | Compostos derivados de piridazina fundida e medicamentos contendo os compostos como o ingrediente ativo |
| WO2004018449A1 (fr) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Derives de piperidine utilises comme inhibiteurs de la phospodiesterase-4 (pde4) |
| WO2004018450A1 (fr) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Derives de n-oxyde de piperidine |
| WO2004018457A1 (fr) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-phthalazones a substitution pyrrolidinedione utilises comme inhibiteurs de la phosphodiesterase-4 (pde4) |
| US20060167001A1 (en) * | 2002-08-10 | 2006-07-27 | Sterk Jan G | Pyridazinone-derivatives as pde4 inhibitors |
| WO2004098633A1 (fr) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprenant un inhibiteur de la pde-4 et un antagoniste du tnf-alpha |
| CN1823051B (zh) * | 2003-07-14 | 2010-07-07 | 宇部兴产株式会社 | 4-氨基四氢吡喃化合物及其酸盐的制造方法、其合成中间体及其制造方法 |
| JP4778449B2 (ja) * | 2004-02-04 | 2011-09-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての２−（ピペリジン−４−イル）−４，５−ジヒドロ−２ｈ−ピリダジン−３−オン誘導体 |
| EP1716123A1 (fr) * | 2004-02-04 | 2006-11-02 | Altana Pharma AG | Derives de pyridazinone utiles comme inhibiteurs de pde4 |
| RU2007143049A (ru) * | 2005-04-21 | 2009-05-27 | Ниппон Синяку Ко., Лтд. (Jp) | Производное фталазинона и содержащая его фармацевтическая композиция |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| EP2258358A3 (fr) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenèse avec un inhibiteur de l'acetylcholinestérase |
| EP1940389A2 (fr) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| ES2374337T3 (es) * | 2007-05-16 | 2012-02-15 | Nycomed Gmbh | Derivados de pirazolona como inhibidores de pde4. |
| AR074318A1 (es) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| WO2010099217A1 (fr) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine |
| BR112013031791A2 (pt) * | 2011-06-17 | 2017-01-31 | Takeda Gmbh | derivados de ftalazinona-pirrolopirimidinacarboxamida |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| CA2906008C (fr) | 2013-03-13 | 2019-07-09 | Flatley Discovery Lab, Llc | Composes de pyridazinone et procedes pour le traitement de fibrose kystique |
| US20150050626A1 (en) * | 2013-03-15 | 2015-02-19 | Dart Neuroscience, Llc | Systems, Methods, and Software for Improving Cognitive and Motor Abilities |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2845456A1 (de) * | 1978-10-19 | 1980-08-14 | Merck Patent Gmbh | 6-arylpyridazin-3-one und verfahren zu ihrer herstellung |
| DE69332762T2 (de) * | 1992-12-02 | 2003-08-14 | Pfizer Inc., New York | Cathecoldiether als selektive pde iv hemmungsmittel |
| EP0634404A1 (fr) * | 1993-07-13 | 1995-01-18 | Rhone Poulenc Agriculture Ltd. | Dérivés de phtalazine et leur utilisation comme pesticides |
| HU219864B (hu) * | 1994-08-09 | 2001-08-28 | Eisai Co., Ltd. | cGMP-PDE inhibitor kondenzált piridazinszármazékok és alkalmazásuk |
-
1998
- 1998-01-12 AT AT98901959T patent/ATE233247T1/de not_active IP Right Cessation
- 1998-01-12 EA EA199900620A patent/EA002764B1/ru not_active IP Right Cessation
- 1998-01-12 PL PL98334561A patent/PL189418B1/pl not_active IP Right Cessation
- 1998-01-12 ES ES98901959T patent/ES2193508T3/es not_active Expired - Lifetime
- 1998-01-12 BR BR9806752-4A patent/BR9806752A/pt active Search and Examination
- 1998-01-12 AU AU58629/98A patent/AU735934B2/en not_active Ceased
- 1998-01-12 TR TR1999/01653T patent/TR199901653T2/xx unknown
- 1998-01-12 DK DK98901959T patent/DK0971901T3/da active
- 1998-01-12 PT PT98901959T patent/PT971901E/pt unknown
- 1998-01-12 CZ CZ19992533A patent/CZ293815B6/cs not_active IP Right Cessation
- 1998-01-12 SI SI9830396T patent/SI0971901T1/xx unknown
- 1998-01-12 EE EEP199900274A patent/EE03968B1/xx not_active IP Right Cessation
- 1998-01-12 CN CN98803169A patent/CN1127487C/zh not_active Expired - Fee Related
- 1998-01-12 SK SK951-99A patent/SK283270B6/sk unknown
- 1998-01-12 IL IL13065998A patent/IL130659A/en not_active IP Right Cessation
- 1998-01-12 HU HU0001541A patent/HUP0001541A3/hu unknown
- 1998-01-12 NZ NZ336573A patent/NZ336573A/xx unknown
- 1998-01-12 KR KR1019997006376A patent/KR20000070150A/ko not_active Application Discontinuation
- 1998-01-12 EP EP98901959A patent/EP0971901B1/fr not_active Expired - Lifetime
- 1998-01-12 JP JP53363598A patent/JP2001508078A/ja not_active Ceased
- 1998-01-12 CA CA002276455A patent/CA2276455C/fr not_active Expired - Fee Related
- 1998-01-12 DE DE69811645T patent/DE69811645T2/de not_active Expired - Fee Related
- 1998-01-12 WO PCT/EP1998/000124 patent/WO1998031674A1/fr not_active Application Discontinuation
- 1998-01-12 US US09/341,135 patent/US6103718A/en not_active Expired - Fee Related
-
1999
- 1999-07-02 NO NO19993301A patent/NO313137B1/no unknown
-
2000
- 2000-06-30 HK HK00103993A patent/HK1024692A1/xx not_active IP Right Cessation
-
2004
- 2004-08-11 CY CY0400064A patent/CY2446B1/xx unknown
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