SI0738715T1 - Arylalkyl-pyridazinones - Google Patents

Arylalkyl-pyridazinones

Info

Publication number
SI0738715T1
SI0738715T1 SI9630593T SI9630593T SI0738715T1 SI 0738715 T1 SI0738715 T1 SI 0738715T1 SI 9630593 T SI9630593 T SI 9630593T SI 9630593 T SI9630593 T SI 9630593T SI 0738715 T1 SI0738715 T1 SI 0738715T1
Authority
SI
Slovenia
Prior art keywords
cooa
substd
halo
opt
alkyl
Prior art date
Application number
SI9630593T
Other languages
English (en)
Slovenian (sl)
Inventor
Rochus Dr. Jonas
Michael Dr. Wolf
Norbert Dr. Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SI0738715T1 publication Critical patent/SI0738715T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI9630593T 1995-04-20 1996-04-11 Arylalkyl-pyridazinones SI0738715T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19514568A DE19514568A1 (de) 1995-04-20 1995-04-20 Arylalkyl-pyridazinone
EP96105702A EP0738715B1 (de) 1995-04-20 1996-04-11 Arylalkyl-pyridazinone

Publications (1)

Publication Number Publication Date
SI0738715T1 true SI0738715T1 (en) 2003-10-31

Family

ID=7759974

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630593T SI0738715T1 (en) 1995-04-20 1996-04-11 Arylalkyl-pyridazinones

Country Status (21)

Country Link
US (2) US6399611B1 (no)
EP (1) EP0738715B1 (no)
JP (1) JP4005157B2 (no)
KR (1) KR100428879B1 (no)
CN (1) CN1159299C (no)
AT (1) ATE231842T1 (no)
AU (1) AU705025B2 (no)
CA (1) CA2174472C (no)
CZ (1) CZ291868B6 (no)
DE (2) DE19514568A1 (no)
DK (1) DK0738715T3 (no)
ES (1) ES2191070T3 (no)
HU (1) HU226198B1 (no)
NO (1) NO307931B1 (no)
PT (1) PT738715E (no)
RU (1) RU2159236C2 (no)
SI (1) SI0738715T1 (no)
SK (1) SK284167B6 (no)
TW (1) TW475927B (no)
UA (1) UA43853C2 (no)
ZA (1) ZA963154B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
JP4017214B2 (ja) * 1996-06-11 2007-12-05 興和創薬株式会社 ５−フェニル−３−ピリダジノン誘導体
EP0924204A4 (en) * 1996-08-27 2002-10-23 Nikken Chemicals Co Ltd 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
DE19850701A1 (de) 1998-11-04 2000-05-11 Merck Patent Gmbh Benzoylpyridazine
PT1212089E (pt) 1999-08-21 2006-08-31 Altana Pharma Ag Combinacao sinergica de roflumilast e salmeterol
DE10064997A1 (de) * 2000-12-23 2002-06-27 Merck Patent Gmbh Benzoylpyridazine
EP1368035A1 (en) * 2001-02-12 2003-12-10 MERCK PATENT GmbH Use of type 4 phosphodiesterase inhibitors in myocardial diseases
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
MXPA03010679A (es) 2001-05-23 2004-03-02 Tanabe Seiyaku Co Una composicion para acelerar la cicatrizacion de fractura osea.
CA2447618A1 (en) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. A composition for regenerative treatment of cartilage disease
DE10150517A1 (de) * 2001-10-12 2003-04-17 Merck Patent Gmbh Verwendung von Phosphodiesterase IV-Inhibitoren
EP1463509A1 (en) * 2001-10-31 2004-10-06 MERCK PATENT GmbH Type 4 phosphodiesterase inhibitors and uses thereof
US7074959B2 (en) * 2002-08-01 2006-07-11 New Mexico Highlands University Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
JP4778449B2 (ja) 2004-02-04 2011-09-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−（ピペリジン−４−イル）−４，５−ジヒドロ−２ｈ−ピリダジン−３−オン誘導体
EP1716123A1 (en) * 2004-02-04 2006-11-02 Altana Pharma AG Pyridazinone derivatives and their use as pde4 inhibitors
EP2094662B1 (en) * 2006-12-14 2012-04-11 Astellas Pharma Inc. Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents
US8466198B2 (en) * 2008-09-02 2013-06-18 Bruce Kneller Compositions comprising creatine salts and methods of use thereof
EP3001912A1 (en) * 2009-08-26 2016-04-06 Jeffrey M. Golini Pharmaceutical or nutraceutical composition
CN109153644B (zh) 2016-03-16 2022-10-21 H·李·莫菲特癌症中心研究有限公司 用以增强效应t细胞功能的针对cereblon的小分子
BR112021000395A2 (pt) 2018-07-11 2021-04-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Compostos imunomoduladores diméricos contra mecanismos baseados em cereblon

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1604863A (no) * 1967-11-22 1972-04-17
US3975388A (en) * 1971-02-22 1976-08-17 Bdh Pharmaceuticals Limited Pyridazinones
DE2845456A1 (de) 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
US4397854A (en) * 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
PT78566B (de) * 1983-05-11 1986-07-17 Byk Gulden Lomberg Chem Fab Pyridazinone ihre herstellung und verwendung pyridazinone enthaltende arzneimittel
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー ４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
CA2023026A1 (en) * 1989-08-10 1991-02-11 Thomas N. Wheeler Pyridazinones having cardiotonic and beta blocking activity
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
JP2806192B2 (ja) * 1992-11-02 1998-09-30 日本曹達株式会社 血小板凝集抑制剤
DE19502699A1 (de) * 1995-01-28 1996-08-01 Merck Patent Gmbh Arylalkyl-thiadiazinone

Also Published As

Publication number Publication date
ATE231842T1 (de) 2003-02-15
ZA963154B (en) 1996-12-06
HU9601034D0 (en) 1996-06-28
TW475927B (en) 2002-02-11
NO961578L (no) 1996-10-21
AU5071196A (en) 1996-10-31
SK284167B6 (sk) 2004-10-05
PT738715E (pt) 2003-06-30
EP0738715B1 (de) 2003-01-29
US6531473B2 (en) 2003-03-11
KR960037662A (ko) 1996-11-19
CZ113296A3 (en) 1996-11-13
UA43853C2 (uk) 2002-01-15
CA2174472C (en) 2008-10-21
HU226198B1 (en) 2008-06-30
CN1159299C (zh) 2004-07-28
SK48796A3 (en) 1997-02-05
EP0738715A3 (de) 1998-06-17
JPH08291145A (ja) 1996-11-05
CZ291868B6 (cs) 2003-06-18
DK0738715T3 (da) 2003-05-26
RU2159236C2 (ru) 2000-11-20
DE59610081D1 (de) 2003-03-06
EP0738715A2 (de) 1996-10-23
NO307931B1 (no) 2000-06-19
HUP9601034A3 (en) 1999-03-01
DE19514568A1 (de) 1996-10-24
JP4005157B2 (ja) 2007-11-07
HUP9601034A2 (en) 1996-12-30
AU705025B2 (en) 1999-05-13
KR100428879B1 (ko) 2004-07-15
US6399611B1 (en) 2002-06-04
CN1142493A (zh) 1997-02-12
CA2174472A1 (en) 1996-10-21
NO961578D0 (no) 1996-04-19
US20020111356A1 (en) 2002-08-15
ES2191070T3 (es) 2003-09-01

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