DK0738715T3 - Arylalkyl-pyridazinoner. - Google Patents

Arylalkyl-pyridazinoner.

Info

Publication number
DK0738715T3
DK0738715T3 DK96105702T DK96105702T DK0738715T3 DK 0738715 T3 DK0738715 T3 DK 0738715T3 DK 96105702 T DK96105702 T DK 96105702T DK 96105702 T DK96105702 T DK 96105702T DK 0738715 T3 DK0738715 T3 DK 0738715T3
Authority
DK
Denmark
Prior art keywords
cooa
substd
halo
opt
alkyl
Prior art date
Application number
DK96105702T
Other languages
English (en)
Inventor
Rochus Dr Jonas
Michael Dr Wolf
Norbert Dr Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0738715T3 publication Critical patent/DK0738715T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
DK96105702T 1995-04-20 1996-04-11 Arylalkyl-pyridazinoner. DK0738715T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19514568A DE19514568A1 (de) 1995-04-20 1995-04-20 Arylalkyl-pyridazinone

Publications (1)

Publication Number Publication Date
DK0738715T3 true DK0738715T3 (da) 2003-05-26

Family

ID=7759974

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96105702T DK0738715T3 (da) 1995-04-20 1996-04-11 Arylalkyl-pyridazinoner.

Country Status (21)

Country Link
US (2) US6399611B1 (da)
EP (1) EP0738715B1 (da)
JP (1) JP4005157B2 (da)
KR (1) KR100428879B1 (da)
CN (1) CN1159299C (da)
AT (1) ATE231842T1 (da)
AU (1) AU705025B2 (da)
CA (1) CA2174472C (da)
CZ (1) CZ291868B6 (da)
DE (2) DE19514568A1 (da)
DK (1) DK0738715T3 (da)
ES (1) ES2191070T3 (da)
HU (1) HU226198B1 (da)
NO (1) NO307931B1 (da)
PT (1) PT738715E (da)
RU (1) RU2159236C2 (da)
SI (1) SI0738715T1 (da)
SK (1) SK284167B6 (da)
TW (1) TW475927B (da)
UA (1) UA43853C2 (da)
ZA (1) ZA963154B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
JP4017214B2 (ja) * 1996-06-11 2007-12-05 興和創薬株式会社 ５−フェニル−３−ピリダジノン誘導体
WO1998008828A1 (fr) * 1996-08-27 1998-03-05 Nikken Chemicals Co., Ltd. Derives du 2-phenylmorpholin-5-one et composition pharmaceutique les comprenant
DE19850701A1 (de) 1998-11-04 2000-05-11 Merck Patent Gmbh Benzoylpyridazine
CA2715683A1 (en) 1999-08-21 2001-03-01 Nycomed Gmbh Synergistic combination
DE10064997A1 (de) * 2000-12-23 2002-06-27 Merck Patent Gmbh Benzoylpyridazine
WO2002072103A1 (en) * 2001-02-12 2002-09-19 Merck Patent Gmbh Use of type 4 phosphodiesterase inhibitors in myocardial diseases
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
ES2427930T3 (es) * 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
WO2002094321A1 (fr) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Compositions favorisant la guérison d'une fracture osseuse
DE10150517A1 (de) * 2001-10-12 2003-04-17 Merck Patent Gmbh Verwendung von Phosphodiesterase IV-Inhibitoren
EP1463509A1 (en) * 2001-10-31 2004-10-06 MERCK PATENT GmbH Type 4 phosphodiesterase inhibitors and uses thereof
US7074959B2 (en) * 2002-08-01 2006-07-11 New Mexico Highlands University Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces
AU2004226353A1 (en) 2003-04-01 2004-10-14 Laboratoires Serono Sa Inhibitors of phosphodiesterases in infertility
JP4778449B2 (ja) * 2004-02-04 2011-09-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−（ピペリジン−４−イル）−４，５−ジヒドロ−２ｈ−ピリダジン−３−オン誘導体
EP1716123A1 (en) * 2004-02-04 2006-11-02 Altana Pharma AG Pyridazinone derivatives and their use as pde4 inhibitors
EP2094662B1 (en) * 2006-12-14 2012-04-11 Astellas Pharma Inc. Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents
US8466198B2 (en) * 2008-09-02 2013-06-18 Bruce Kneller Compositions comprising creatine salts and methods of use thereof
ES2567779T3 (es) * 2009-08-26 2016-04-26 Jeffrey M. Golini Composición farmacéutica o nutracéutica
AU2017232906B2 (en) 2016-03-16 2022-03-31 H. Lee Moffitt Cancer Center & Research Institute, Inc. Small molecules against cereblon to enhance effector T cell function
SG11202012464WA (en) 2018-07-11 2021-01-28 H Lee Moffitt Cancer Center And Research Institute Inc Dimeric immuno-modulatory compounds against cereblon-based mechanisms

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1604863A (da) * 1967-11-22 1972-04-17
US3975388A (en) * 1971-02-22 1976-08-17 Bdh Pharmaceuticals Limited Pyridazinones
DE2845456A1 (de) 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
US4397854A (en) * 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
NZ208107A (en) * 1983-05-11 1986-12-05 Byk Gulden Lomberg Chem Fab 6-aryl-3(2h)-pyridazinones and pharmaceutical compositions
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー ４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
EP0412814A3 (en) * 1989-08-10 1991-07-24 Glaxo Inc. Pyridazinones having cardiotonic and beta blocking activity
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
JP2806192B2 (ja) * 1992-11-02 1998-09-30 日本曹達株式会社 血小板凝集抑制剤
DE19502699A1 (de) 1995-01-28 1996-08-01 Merck Patent Gmbh Arylalkyl-thiadiazinone

Also Published As

Publication number Publication date
HUP9601034A3 (en) 1999-03-01
TW475927B (en) 2002-02-11
KR100428879B1 (ko) 2004-07-15
DE19514568A1 (de) 1996-10-24
KR960037662A (ko) 1996-11-19
EP0738715A2 (de) 1996-10-23
AU705025B2 (en) 1999-05-13
NO961578D0 (no) 1996-04-19
CN1159299C (zh) 2004-07-28
UA43853C2 (uk) 2002-01-15
SI0738715T1 (en) 2003-10-31
CN1142493A (zh) 1997-02-12
JPH08291145A (ja) 1996-11-05
SK284167B6 (sk) 2004-10-05
EP0738715B1 (de) 2003-01-29
ZA963154B (en) 1996-12-06
CA2174472A1 (en) 1996-10-21
CZ291868B6 (cs) 2003-06-18
US6531473B2 (en) 2003-03-11
HU9601034D0 (en) 1996-06-28
SK48796A3 (en) 1997-02-05
HUP9601034A2 (en) 1996-12-30
PT738715E (pt) 2003-06-30
EP0738715A3 (de) 1998-06-17
CA2174472C (en) 2008-10-21
ATE231842T1 (de) 2003-02-15
AU5071196A (en) 1996-10-31
ES2191070T3 (es) 2003-09-01
HU226198B1 (en) 2008-06-30
NO307931B1 (no) 2000-06-19
RU2159236C2 (ru) 2000-11-20
US20020111356A1 (en) 2002-08-15
NO961578L (no) 1996-10-21
CZ113296A3 (en) 1996-11-13
US6399611B1 (en) 2002-06-04
JP4005157B2 (ja) 2007-11-07
DE59610081D1 (de) 2003-03-06

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