SG91796A1 - N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use - Google Patents

N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use

Info

Publication number
SG91796A1
SG91796A1 SG9702412A SG1997002412A SG91796A1 SG 91796 A1 SG91796 A1 SG 91796A1 SG 9702412 A SG9702412 A SG 9702412A SG 1997002412 A SG1997002412 A SG 1997002412A SG 91796 A1 SG91796 A1 SG 91796A1
Authority
SG
Singapore
Prior art keywords
thiazol
aryl
sulphonamide derivatives
sulphonamide
derivatives
Prior art date
Application number
SG9702412A
Other languages
English (en)
Inventor
Cesura Andrea
Rover Stephan
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG91796A1 publication Critical patent/SG91796A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
SG9702412A 1996-07-19 1997-07-09 N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use SG91796A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96111661 1996-07-19

Publications (1)

Publication Number Publication Date
SG91796A1 true SG91796A1 (en) 2002-10-15

Family

ID=8223010

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9702412A SG91796A1 (en) 1996-07-19 1997-07-09 N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use

Country Status (23)

Country Link
US (2) US5877193A (en:Method)
EP (1) EP0819681A3 (en:Method)
JP (1) JP2991679B2 (en:Method)
KR (1) KR100247672B1 (en:Method)
CN (1) CN1176101A (en:Method)
AU (1) AU725496B2 (en:Method)
BR (1) BR9704023A (en:Method)
CA (1) CA2210613A1 (en:Method)
CO (1) CO4900053A1 (en:Method)
CZ (1) CZ227397A3 (en:Method)
HR (1) HRP970393A2 (en:Method)
HU (1) HUP9701193A3 (en:Method)
IL (1) IL121298A (en:Method)
MA (1) MA24273A1 (en:Method)
MX (1) MX9705385A (en:Method)
NO (1) NO973338L (en:Method)
NZ (1) NZ328331A (en:Method)
PE (1) PE91298A1 (en:Method)
PL (1) PL321203A1 (en:Method)
SG (1) SG91796A1 (en:Method)
TR (1) TR199700653A2 (en:Method)
YU (1) YU30297A (en:Method)
ZA (1) ZA976222B (en:Method)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725138D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Thiophenesulfonamide compounds
GB9725141D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Benzenesulfonamide compounds
US6211185B1 (en) 1999-05-05 2001-04-03 Veterinary Pharmacy Corporation Concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution, and a suspending agent
SE0001899D0 (sv) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
NZ538100A (en) * 2000-12-13 2006-07-28 Arqule Inc Heterocyclic sulfonamide inhibitors of beta amyloid production
RS44304A (sr) 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1
US6869970B2 (en) * 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
FR2849599B1 (fr) * 2003-01-07 2006-12-29 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
FR2849598B1 (fr) * 2003-01-07 2006-09-22 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
WO2005054216A1 (ja) * 2003-12-01 2005-06-16 Reverse Proteomics Research Institute Co., Ltd. 新規抗癌剤「スルコキシン」
DK2054397T3 (en) * 2006-08-16 2016-01-18 J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone SMALL MOLECULAR INHIBITORS OF KYNURENIN-3-MONOOXYGENASE
EP2420494B1 (en) 2006-08-16 2014-10-08 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Use of thiadiazole compounds as inhibitors of kynurenine-3-monooxygenase
US8623347B2 (en) * 2008-01-15 2014-01-07 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
WO2009124086A2 (en) * 2008-04-04 2009-10-08 Siga Technologies, Inc. Antibacterial drug for treatment of staphylococcus aureus and other gram-positive bacterial infections
UA103319C2 (en) * 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
CN101602687A (zh) * 2008-06-13 2009-12-16 上海特化医药科技有限公司 6-硝基苯乙酮类化合物、其制备方法及用途
CN106518845B (zh) * 2011-08-30 2019-09-13 Chdi基金会股份有限公司 犬尿氨酸-3-单加氧酶抑制剂、药物组合物及其使用方法
CN102627589A (zh) * 2012-04-05 2012-08-08 天津理工大学 一种两步合成制备4-异丙基苯磺酰氯的方法和工艺
CN102633696A (zh) * 2012-04-05 2012-08-15 天津理工大学 一种两步合成制备对位取代烷基苯磺酰氯的方法和工艺
CN102633695A (zh) * 2012-04-05 2012-08-15 天津理工大学 一种4-异丙基苯磺酰氯的制备方法和工艺
CN102633687B (zh) * 2012-04-05 2016-06-08 天津瑞岭化工有限公司 一种对位取代烷基苯磺酰氯的制备方法和工艺
JP6469009B2 (ja) * 2012-09-21 2019-02-13 ロード アイランド ホスピタル がん処置用β−ヒドロキシラーゼ阻害剤
ES3022639T3 (en) 2016-05-20 2025-05-28 Xenon Pharmaceuticals Inc Benzenesulfonamide compounds and their use as therapeutic agents
MX2019006697A (es) 2016-12-09 2019-08-16 Xenon Pharmaceuticals Inc Compuestos de bencenosulfonamida y su uso como agentes terapeuticos.
WO2019241533A1 (en) 2018-06-13 2019-12-19 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
WO2020047312A1 (en) 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
BR112021000209A2 (pt) 2018-08-31 2021-08-24 Xenon Pharmaceuticals Inc. Compostos de sulfonamida substituída por heteroarila e seu uso como agentes terapêuticos
CN113164419A (zh) * 2018-09-07 2021-07-23 皮克医疗公司 Eif4e抑制剂和其用途
CN114516807B (zh) * 2022-02-24 2023-11-17 南京大学 一种含硝基多取代芳香二胺单体及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0569193A1 (en) * 1992-05-06 1993-11-10 E.R. SQUIBB & SONS, INC. N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists
WO1994027979A1 (en) * 1993-05-20 1994-12-08 Immunopharmaceutics, Inc. Sulfonamides and derivatives thereof that modulate the activity of endothelin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016650A1 (en) * 1994-11-29 1996-06-06 Hisamitsu Pharmaceutical Co., Inc. Antibacterial or bactericide comprising 2-aminothiazole derivative and salts thereof
GB9702194D0 (en) * 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0569193A1 (en) * 1992-05-06 1993-11-10 E.R. SQUIBB & SONS, INC. N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists
WO1994027979A1 (en) * 1993-05-20 1994-12-08 Immunopharmaceutics, Inc. Sulfonamides and derivatives thereof that modulate the activity of endothelin

Also Published As

Publication number Publication date
KR980008228A (ko) 1998-04-30
US5877193A (en) 1999-03-02
YU30297A (sh) 2000-10-30
HUP9701193A3 (en) 2000-08-28
AU2875297A (en) 1998-01-29
EP0819681A2 (de) 1998-01-21
KR100247672B1 (ko) 2000-04-01
HUP9701193A2 (hu) 1999-02-01
CN1176101A (zh) 1998-03-18
JP2991679B2 (ja) 1999-12-20
NZ328331A (en) 1999-05-28
PL321203A1 (en) 1998-02-02
NO973338D0 (no) 1997-07-18
HU9701193D0 (en) 1997-09-29
NO973338L (no) 1998-01-20
TR199700653A2 (xx) 1998-02-21
IL121298A (en) 2001-03-19
PE91298A1 (es) 1998-12-31
AU725496B2 (en) 2000-10-12
MA24273A1 (fr) 1998-04-01
BR9704023A (pt) 1998-11-17
EP0819681A3 (de) 1998-02-04
CO4900053A1 (es) 2000-03-27
HRP970393A2 (en) 1998-04-30
JPH1067761A (ja) 1998-03-10
ZA976222B (en) 1998-01-19
IL121298A0 (en) 1998-01-04
US5958910A (en) 1999-09-28
MX9705385A (es) 1998-04-30
CZ227397A3 (cs) 1998-02-18
CA2210613A1 (en) 1998-01-19

Similar Documents

Publication Publication Date Title
SG91796A1 (en) N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use
ZA9711141B (en) Novel ketobenzamides and their use
HUP0000369A3 (en) 3-thiocarbamoylpyrazole derivatives and their use as pesticides
IL120125A0 (en) Substituted oxazolidinones their preparation and their use
HRP970349B1 (en) Sulfonamides and their use
IL128800A0 (en) 4-Heteroylpyrazol derivatives and the use thereof as herbicides
IL120124A0 (en) Heteroaryl-oxazolidinones their preparation and use
IL114795A0 (en) N-benzylindole- and benmzopyrazole derivatives their preparation and use
HRP970225A2 (en) Benzofuryl derivatives and their use
EP0788489A4 (en) HETEROCYCLIC COMPOUNDS AND THEIR USE
ZA975591B (en) New amidino derivatives and their use as thrombininhibitors
IL126476A0 (en) Aminoisoquinolines and aminothienopyridine derivatives and their use as anti-inflammatory agents
HUP9700446A3 (en) Oilsuspension-concentrate and using thereof
IL126968A0 (en) Alkylaminobenzothiazole and benzoxazole derivatives
ZA974830B (en) Triazine derivatives and their use
ZA978876B (en) Oxazolone derivatives and their use
IL127068A0 (en) Substituted benzamide derivatives and their use as anticonvulsants
HUP0001781A3 (en) Substituted pyrazolyl-pyrazole derivatives and their use as herbicides
AU3085895A (en) N-phenylated amide and urea derivatives
PL331523A1 (en) Azolotrizines and azolopyrimidines
HUP0001792A3 (en) Dibenzo-oxazepine and-dioxepine derivatives and their use as anti-tumor agents
IL123535A0 (en) Benzoxazindione derivatives and their use
AU1724697A (en) Novel aminophenol derivatives and their use
IL118629A0 (en) N-Substituted cis-N-propenyl-acetemides their preparation and use
GB9417969D0 (en) Alkaloids and derivatives thereof