SG64336A1 - Process for large scale preparation of 2'3'-didehydro-2',3' dideoxynucleosides - Google Patents

Process for large scale preparation of 2'3'-didehydro-2',3' dideoxynucleosides

Info

Publication number
SG64336A1
SG64336A1 SG1996005651A SG1996005651A SG64336A1 SG 64336 A1 SG64336 A1 SG 64336A1 SG 1996005651 A SG1996005651 A SG 1996005651A SG 1996005651 A SG1996005651 A SG 1996005651A SG 64336 A1 SG64336 A1 SG 64336A1
Authority
SG
Singapore
Prior art keywords
didehydro
large scale
dideoxynucleosides
scale preparation
improved process
Prior art date
Application number
SG1996005651A
Other languages
English (en)
Inventor
Paul M Skonezny
Emerich Eisenreich
Derron R Stark
Brenda T Boyhan
Stephen R Baker
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG64336A1 publication Critical patent/SG64336A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG1996005651A 1993-11-15 1994-11-03 Process for large scale preparation of 2'3'-didehydro-2',3' dideoxynucleosides SG64336A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15215593A 1993-11-15 1993-11-15
US15277893A 1993-11-15 1993-11-15
US08/309,636 US5539099A (en) 1993-11-15 1994-09-23 Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides

Publications (1)

Publication Number Publication Date
SG64336A1 true SG64336A1 (en) 1999-04-27

Family

ID=27387202

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996005651A SG64336A1 (en) 1993-11-15 1994-11-03 Process for large scale preparation of 2'3'-didehydro-2',3' dideoxynucleosides

Country Status (19)

Country Link
US (1) US5539099A (fr)
EP (1) EP0653435B1 (fr)
JP (1) JP3884779B2 (fr)
KR (1) KR100329524B1 (fr)
CN (2) CN1043646C (fr)
AT (1) ATE148707T1 (fr)
AU (1) AU686249B2 (fr)
CA (1) CA2135853C (fr)
CY (1) CY2046B1 (fr)
DE (1) DE69401698T2 (fr)
DK (1) DK0653435T3 (fr)
ES (1) ES2098884T3 (fr)
FI (1) FI105402B (fr)
GR (1) GR3023305T3 (fr)
HK (1) HK116997A (fr)
HU (1) HU221012B1 (fr)
IL (1) IL111570A (fr)
SG (1) SG64336A1 (fr)
TW (1) TW399060B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US6625641B1 (en) * 1996-06-03 2003-09-23 Sun Microsystems, Inc. Method and apparatus for providing client support without installation of server software
CN1054132C (zh) * 1998-01-05 2000-07-05 华东理工大学 一种从混合物中分离胸苷的方法
US6635753B1 (en) 1998-09-30 2003-10-21 Brantford Chemicals Inc. Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
AU2001285197A1 (en) * 2000-09-06 2002-03-22 Bristol-Myers Squibb Company Stavudine polymorphic form 1 process
IL157478A0 (en) 2001-03-01 2004-03-28 Pharmasset Ltd Method for the synthesis of 2', 3'-didehydronucleosides
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
WO2007099389A1 (fr) * 2005-07-11 2007-09-07 Aurobindo Pharma Limited Nouveau procédé amélioré de fabrication de stavudine de forme i
US8026356B2 (en) * 2005-11-28 2011-09-27 Matrix Laboratories, Ltd. Process for the large scale production of Stavudine
CN101029068B (zh) * 2007-04-09 2010-06-23 陆咏 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法
CN102766182B (zh) * 2011-05-06 2015-03-04 江苏苏利精细化工股份有限公司 一种通过糖基转移反应合成二脱氧核苷的方法及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904770A (en) * 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides

Also Published As

Publication number Publication date
KR950014131A (ko) 1995-06-15
HU221012B1 (hu) 2002-07-29
US5539099A (en) 1996-07-23
CA2135853C (fr) 2006-01-03
FI945322A (fi) 1995-05-16
CN1107856A (zh) 1995-09-06
EP0653435B1 (fr) 1997-02-05
JPH07196682A (ja) 1995-08-01
DE69401698T2 (de) 1997-09-11
CN1069648C (zh) 2001-08-15
HUT69171A (en) 1995-08-28
CN1215057A (zh) 1999-04-28
GR3023305T3 (en) 1997-08-29
CA2135853A1 (fr) 1995-05-16
ES2098884T3 (es) 1997-05-01
IL111570A (en) 2001-07-24
CY2046B1 (en) 1998-04-30
ATE148707T1 (de) 1997-02-15
JP3884779B2 (ja) 2007-02-21
AU686249B2 (en) 1998-02-05
TW399060B (en) 2000-07-21
FI945322A0 (fi) 1994-11-11
HK116997A (en) 1997-09-05
DK0653435T3 (da) 1997-07-14
AU7880394A (en) 1995-06-01
KR100329524B1 (ko) 2002-11-23
CN1043646C (zh) 1999-06-16
HU9403256D0 (en) 1995-01-30
FI105402B (fi) 2000-08-15
EP0653435A1 (fr) 1995-05-17
IL111570A0 (en) 1995-01-24
DE69401698D1 (de) 1997-03-20

Similar Documents

Publication Publication Date Title
SG64336A1 (en) Process for large scale preparation of 2'3'-didehydro-2',3' dideoxynucleosides
TW254946B (fr)
FI945323A (fi) 5-metyyliuridiinimenetelmä 2',3'-didehydro-3'-deoksitymidiinin (d4T) laajamittaista valmistusta varten
DK0494665T3 (da) Fremgangsmåde til fremstilling af 6,12-dihydro-6-hydroxy-cannabidiol og anvendelse deraf til fremstilling af transdelta-9-tetrahydrocannabinol
HUT52043A (en) Process for producing intermediates for producing substituted indolinon derivatives
EP0152965A3 (en) Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxy-menthyl)-purines and certain derivatives
FR2701027B1 (fr) Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.
MX9700331A (es) Proceso mejorado para r(+)1,2,3,6-tetrahidro-4-fenil-1-[(3-fenil-3-ciclohexen-1-il)metil]pirid ina, un agente del sistema nervioso central.
PT91253A (pt) Processo de sintese "in vitro" de um acido ribonucleico infeccioso
JPS6460396A (en) Production of 2'-deoxycytidine
CA2006665A1 (fr) Methode de purification du 1,2-dinicotinamidopropane
HUT46648A (en) Process for producing (pentafluoro-phenyl-methyl)-2,2-dimethyl-3-formyl-cyclopropane-carboxylate
JPS6422894A (en) Nulceosides
PT88606A (pt) Processo para a seleccao de microorganismos por meio de um vector plasmidico contendo um gene de sensibilidade a estreptomicina
NZ223910A (en) 2',3'-dideoxynucleosides, process for their production and intermediates therefor
JPS6463591A (en) Novel production of 5-fluorouridine and derivative thereof
JPS6419086A (en) Production of saccharide derivative