JPS6463591A - Novel production of 5-fluorouridine and derivative thereof - Google Patents
Novel production of 5-fluorouridine and derivative thereofInfo
- Publication number
- JPS6463591A JPS6463591A JP62220022A JP22002287A JPS6463591A JP S6463591 A JPS6463591 A JP S6463591A JP 62220022 A JP62220022 A JP 62220022A JP 22002287 A JP22002287 A JP 22002287A JP S6463591 A JPS6463591 A JP S6463591A
- Authority
- JP
- Japan
- Prior art keywords
- groups
- saccharide
- fluorouracil
- protecting groups
- subjected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE:To obtain the titled compound useful as an intermediate for DNA synthesis inhibitor and carcinostatic agent in high yield, by subjecting a specific nucleoside and 5-fluorouracil to exchange reaction in the presence of a Lewis acid catalyst. CONSTITUTION:A nucleoside having groups (preferably guanine groups or hypoxanthine groups) exchangeable with 5-fluorouracil groups in a base part and protecting groups (preferably protecting groups in the saccharide part are acyl groups and the protecting groups in the saccharide and base parts are silyl or acyl groups) in the saccharide and base parts and 5-fluorouracil are subjected to exchange reaction in the presence of a Lewis acid catalyst (preferably anhydrous stannic chloride). The protecting groups in the saccharide part, as necessary, are then subjected to eliminating reaction to afford the aimed compound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62220022A JPS6463591A (en) | 1987-09-02 | 1987-09-02 | Novel production of 5-fluorouridine and derivative thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62220022A JPS6463591A (en) | 1987-09-02 | 1987-09-02 | Novel production of 5-fluorouridine and derivative thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6463591A true JPS6463591A (en) | 1989-03-09 |
Family
ID=16744706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62220022A Pending JPS6463591A (en) | 1987-09-02 | 1987-09-02 | Novel production of 5-fluorouridine and derivative thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6463591A (en) |
-
1987
- 1987-09-02 JP JP62220022A patent/JPS6463591A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lim et al. | Synthesis of “9-deazaadenosine”; a new cytotoxic C-nucleoside isostere of adenosine | |
| US5773423A (en) | A3 adenosine receptor agonists | |
| AU737902B2 (en) | Anti-viral pyrimidine nucleoside analogues | |
| Shuto et al. | New neplanocin analogs. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents | |
| Mikhailopulo et al. | Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro-and 2'-azido-3'-fluoro-2', 3'-dideoxy-D-ribofuranosides of natural heterocyclic bases | |
| Waga et al. | Synthesis and biological evaluation of 4′-C-methyl nucleosides | |
| HU912253D0 (en) | Process for the production of purinyl-phosphonic acid derivatives | |
| JPH05112595A (en) | Adenosine kinase inhibitor | |
| CHU et al. | Nucleosides. CXXXV.: Synthesis of some 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purines and their biological activities | |
| AzUMA et al. | Transnucleosidation: an improved method for transglycosylation from pyrimidines to purines | |
| EP0152965A3 (en) | Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxy-menthyl)-purines and certain derivatives | |
| IE904070A1 (en) | Deoxyfluoronucleoside process | |
| Van Aerschot et al. | Synthesis and antiviral activity evaluation of 3′-fluoro-3′-deoxyribonucleosides: broad-spectrum antiviral activity of 3′-fluoro-3′-deoxyadenosine | |
| Gosselin et al. | Systematic synthesis and biological evaluation of. alpha.-and. beta.-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases | |
| CA2135853A1 (en) | Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides | |
| US3014900A (en) | Process for the preparation of ketosidopurines | |
| Hutchinson et al. | New potent and selective A1 adenosine receptor agonists | |
| US3213082A (en) | Cobamide derivatives | |
| Elliott et al. | Analogs of 8-azaguanosine | |
| Minakawa et al. | Nucleosides and nucleotides. 116. Convenient syntheses of 3-deazaadenosine, 3-deazaguanosine, and 3-deazainosine via ring closure of 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide or-carbonitrile | |
| Herdewijn et al. | synthesis of 9-(3-azido-2, 3-dideoxy-β-D-erythro-pentofuranosyl)-2, 6-diaminopurine (AzddDAP) | |
| JPS6463591A (en) | Novel production of 5-fluorouridine and derivative thereof | |
| WO1991004033A1 (en) | 2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents | |
| SEELA et al. | 8-Aza-7-deaza-2', 3'-dideoxyadenosine: synthesis and conversion into allopurinol 2', 3'-dideoxyribofuranoside | |
| Rosemeyer et al. | 2′, 3′‐Dideoxy‐3′‐fluorotubercidin and Related Dideoxyribonucleosides:. Synthesis via a 2′‐deoxy‐3′‐oxoribofuranoside intermediate and conformation studies |