ES2098884T3 - Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-2',3'-didesoxinucleosidos. - Google Patents

Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-2',3'-didesoxinucleosidos.

Info

Publication number
ES2098884T3
ES2098884T3 ES94402483T ES94402483T ES2098884T3 ES 2098884 T3 ES2098884 T3 ES 2098884T3 ES 94402483 T ES94402483 T ES 94402483T ES 94402483 T ES94402483 T ES 94402483T ES 2098884 T3 ES2098884 T3 ES 2098884T3
Authority
ES
Spain
Prior art keywords
didesoxinucleosides
dideshidro
preparation procedure
scale preparation
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94402483T
Other languages
English (en)
Inventor
Paul M Skonezny
Emerich Eisenreich
Derron R Stark
Brenda T Boyhan
Stephen R Baker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2098884T3 publication Critical patent/ES2098884T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTA UN PROCESO MEJORADO ADECUADO PARA LA PRODUCCION A GRAN ESCALA DE 2'',3''-DIDESHIDRO-3''-DESOXITIMIDINA (D4T) Y ANALOGOS PARECIDOS. CON EL PROCESO MEJORADO SE OBTIENE D4T EN GRAN CALIDAD Y PUREZA SIN EL USO DE REACCIONES NI REACTIVOS PELIGROSOS Y SE CONSIGUEN MUCHAS MEJORAS IMPORTANTES EN EL PROCESO A GRAN ESCALA INCLUIDO UN NUEVO PASO DE PURIFICACION QUE CONSISTE EN AISLAR UN SOLVATO DE D4T (POR) N-METILPIRROLIDINONA.
ES94402483T 1993-11-15 1994-11-03 Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-2',3'-didesoxinucleosidos. Expired - Lifetime ES2098884T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15215593A 1993-11-15 1993-11-15
US15277893A 1993-11-15 1993-11-15
US08/309,636 US5539099A (en) 1993-11-15 1994-09-23 Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides

Publications (1)

Publication Number Publication Date
ES2098884T3 true ES2098884T3 (es) 1997-05-01

Family

ID=27387202

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94402483T Expired - Lifetime ES2098884T3 (es) 1993-11-15 1994-11-03 Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-2',3'-didesoxinucleosidos.

Country Status (19)

Country Link
US (1) US5539099A (es)
EP (1) EP0653435B1 (es)
JP (1) JP3884779B2 (es)
KR (1) KR100329524B1 (es)
CN (2) CN1043646C (es)
AT (1) ATE148707T1 (es)
AU (1) AU686249B2 (es)
CA (1) CA2135853C (es)
CY (1) CY2046B1 (es)
DE (1) DE69401698T2 (es)
DK (1) DK0653435T3 (es)
ES (1) ES2098884T3 (es)
FI (1) FI105402B (es)
GR (1) GR3023305T3 (es)
HK (1) HK116997A (es)
HU (1) HU221012B1 (es)
IL (1) IL111570A (es)
SG (1) SG64336A1 (es)
TW (1) TW399060B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US6625641B1 (en) * 1996-06-03 2003-09-23 Sun Microsystems, Inc. Method and apparatus for providing client support without installation of server software
CN1054132C (zh) * 1998-01-05 2000-07-05 华东理工大学 一种从混合物中分离胸苷的方法
US6635753B1 (en) 1998-09-30 2003-10-21 Brantford Chemicals Inc. Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
AU2001285197A1 (en) * 2000-09-06 2002-03-22 Bristol-Myers Squibb Company Stavudine polymorphic form 1 process
CN1505635A (zh) 2001-03-01 2004-06-16 2′,3′-二脱氧-2＇,3＇-二脱氢核苷的合成方法
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
WO2007099389A1 (en) * 2005-07-11 2007-09-07 Aurobindo Pharma Limited A new improved process for the preparation of stavudine form i
WO2007060689A2 (en) * 2005-11-28 2007-05-31 Matrix Laboratories Ltd Process for the large scale production of stavudine
CN101029068B (zh) * 2007-04-09 2010-06-23 陆咏 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法
CN102766182B (zh) * 2011-05-06 2015-03-04 江苏苏利精细化工股份有限公司 一种通过糖基转移反应合成二脱氧核苷的方法及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904770A (en) * 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides

Also Published As

Publication number Publication date
EP0653435B1 (en) 1997-02-05
CY2046B1 (en) 1998-04-30
DE69401698T2 (de) 1997-09-11
CN1215057A (zh) 1999-04-28
US5539099A (en) 1996-07-23
AU7880394A (en) 1995-06-01
AU686249B2 (en) 1998-02-05
HUT69171A (en) 1995-08-28
ATE148707T1 (de) 1997-02-15
CN1107856A (zh) 1995-09-06
JP3884779B2 (ja) 2007-02-21
IL111570A0 (en) 1995-01-24
GR3023305T3 (en) 1997-08-29
JPH07196682A (ja) 1995-08-01
CN1069648C (zh) 2001-08-15
CA2135853A1 (en) 1995-05-16
DE69401698D1 (de) 1997-03-20
EP0653435A1 (en) 1995-05-17
CN1043646C (zh) 1999-06-16
IL111570A (en) 2001-07-24
HU221012B1 (hu) 2002-07-29
HU9403256D0 (en) 1995-01-30
FI105402B (fi) 2000-08-15
FI945322A0 (fi) 1994-11-11
SG64336A1 (en) 1999-04-27
HK116997A (en) 1997-09-05
KR100329524B1 (ko) 2002-11-23
FI945322A (fi) 1995-05-16
KR950014131A (ko) 1995-06-15
DK0653435T3 (da) 1997-07-14
TW399060B (en) 2000-07-21
CA2135853C (en) 2006-01-03

Similar Documents

Publication Publication Date Title
ES2093905T3 (es) Nuevo procedimiento para la obtencion de derivados de la n4-acil-5'-desoxi-5-fluorocitidina.
ES2098884T3 (es) Procedimiento para la preparacion a gran escala de 2',3'-dideshidro-2',3'-didesoxinucleosidos.
FI945323A (fi) 5-metyyliuridiinimenetelmä 2',3'-didehydro-3'-deoksitymidiinin (d4T) laajamittaista valmistusta varten
DK0494665T3 (da) Fremgangsmåde til fremstilling af 6,12-dihydro-6-hydroxy-cannabidiol og anvendelse deraf til fremstilling af transdelta-9-tetrahydrocannabinol
MX9202404A (es) Proceso para la sintesis diastereoselectiva de nucleosidos
ES2149157T3 (es) Nuevo procedimiento para la preparacion de nucleotidos.
FI882919A0 (fi) Foerfarande.
FR2701027B1 (fr) Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.
PT817784E (pt) Processo para a sintese de nucleosidos analogos
ES2102358T3 (es) Procedimiento mejorado para la preparacion de derivados cefamicos y sus intermediarios.
DE59603757D1 (de) Verfahren zur Herstellung von kristallinem O-Isopropylisoharnstoff-hydrochlorid
PT91253A (pt) Processo de sintese "in vitro" de um acido ribonucleico infeccioso
HUT46648A (en) Process for producing (pentafluoro-phenyl-methyl)-2,2-dimethyl-3-formyl-cyclopropane-carboxylate

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 653435

Country of ref document: ES