JPS6460396A - Production of 2'-deoxycytidine - Google Patents
Production of 2'-deoxycytidineInfo
- Publication number
- JPS6460396A JPS6460396A JP62214783A JP21478387A JPS6460396A JP S6460396 A JPS6460396 A JP S6460396A JP 62214783 A JP62214783 A JP 62214783A JP 21478387 A JP21478387 A JP 21478387A JP S6460396 A JPS6460396 A JP S6460396A
- Authority
- JP
- Japan
- Prior art keywords
- deoxycytidine
- deoxyribose
- cytosine
- phosphoric acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE:To obtain 2'-deoxycytidine useful as a raw material for 2',3'- dideoxycytidine known as a remedy for AIDS, in high efficiency, by reacting 2'-deoxyribose-1-phosphoric acid or its salt with cytosine in the presence of a specific microorganism. CONSTITUTION:2'-Deoxyribonucleoside (2'-deoxyadenosine, etc.) or 2'- deoxyribose-1-phosphoric acid present in the hydrolyzed product of DNA (excluding 2'-deoxycytidine) is made to react with cytosine in an aqueous medium containing a microbial strain belonging to Achromobacter genus, Aeromonas genus, etc., and capable of producing 2'-deoxycytidine from cytosine and 2'- deoxyribose-1-phosphoric acid or its salt, e.g. Achromobacter viscosus ATCC-12448.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62214783A JPH0789948B2 (en) | 1987-08-28 | 1987-08-28 | 2 ▲ '▼ -Method for producing deoxycytidine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62214783A JPH0789948B2 (en) | 1987-08-28 | 1987-08-28 | 2 ▲ '▼ -Method for producing deoxycytidine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6460396A true JPS6460396A (en) | 1989-03-07 |
JPH0789948B2 JPH0789948B2 (en) | 1995-10-04 |
Family
ID=16661464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62214783A Expired - Lifetime JPH0789948B2 (en) | 1987-08-28 | 1987-08-28 | 2 ▲ '▼ -Method for producing deoxycytidine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0789948B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6777208B2 (en) | 2000-10-25 | 2004-08-17 | Ajinomoto Co., Inc. | Method for producing 2′ -deoxyribonucleoside |
US7629457B2 (en) | 2001-05-01 | 2009-12-08 | Mitsui Chemicals, Inc. | Method for producing cytosine nucleoside compounds |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56102794A (en) * | 1979-05-01 | 1981-08-17 | Ajinomoto Co Inc | Preparation of pyrimidine ribonucleosides and pyrimidine deoxyribonucleosides |
-
1987
- 1987-08-28 JP JP62214783A patent/JPH0789948B2/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56102794A (en) * | 1979-05-01 | 1981-08-17 | Ajinomoto Co Inc | Preparation of pyrimidine ribonucleosides and pyrimidine deoxyribonucleosides |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6777208B2 (en) | 2000-10-25 | 2004-08-17 | Ajinomoto Co., Inc. | Method for producing 2′ -deoxyribonucleoside |
US7223589B2 (en) | 2000-10-25 | 2007-05-29 | Ajinomoto Co., Inc. | Bacterium for the production of 2′-deoxyribonucleoside |
US7629457B2 (en) | 2001-05-01 | 2009-12-08 | Mitsui Chemicals, Inc. | Method for producing cytosine nucleoside compounds |
Also Published As
Publication number | Publication date |
---|---|
JPH0789948B2 (en) | 1995-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EXPY | Cancellation because of completion of term |