SG55152A1 - Hepatitis b virus surface proteins with reduced host carbohydrate content - Google Patents

Hepatitis b virus surface proteins with reduced host carbohydrate content

Info

Publication number
SG55152A1
SG55152A1 SG1996008131A SG1996008131A SG55152A1 SG 55152 A1 SG55152 A1 SG 55152A1 SG 1996008131 A SG1996008131 A SG 1996008131A SG 1996008131 A SG1996008131 A SG 1996008131A SG 55152 A1 SG55152 A1 SG 55152A1
Authority
SG
Singapore
Prior art keywords
hbv
surface proteins
hepatitis
carbohydrate content
particles
Prior art date
Application number
SG1996008131A
Other languages
English (en)
Inventor
Peter J Kniskern
Arpi Hagopian
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SG55152A1 publication Critical patent/SG55152A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
SG1996008131A 1991-04-29 1992-04-29 Hepatitis b virus surface proteins with reduced host carbohydrate content SG55152A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69292491A 1991-04-29 1991-04-29

Publications (1)

Publication Number Publication Date
SG55152A1 true SG55152A1 (en) 1998-12-21

Family

ID=24782605

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996008131A SG55152A1 (en) 1991-04-29 1992-04-29 Hepatitis b virus surface proteins with reduced host carbohydrate content

Country Status (25)

Country Link
US (1) US5614384A (pl)
EP (1) EP0516286B1 (pl)
JP (1) JP2637877B2 (pl)
KR (1) KR920019373A (pl)
CN (1) CN1067680A (pl)
AT (1) ATE215987T1 (pl)
AU (1) AU650530B2 (pl)
BG (1) BG61700B1 (pl)
CA (1) CA2067290A1 (pl)
CZ (1) CZ282769B6 (pl)
DE (1) DE69232541D1 (pl)
FI (1) FI934650A (pl)
HU (1) HUT69149A (pl)
IE (1) IE921385A1 (pl)
IL (1) IL101651A0 (pl)
LT (1) LT3367B (pl)
MX (1) MX9201970A (pl)
NO (1) NO933897L (pl)
NZ (1) NZ242487A (pl)
PL (1) PL171485B1 (pl)
SG (1) SG55152A1 (pl)
SK (1) SK118193A3 (pl)
WO (1) WO1992019741A1 (pl)
YU (1) YU45492A (pl)
ZA (1) ZA923069B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533263A3 (en) * 1991-09-20 1994-06-08 Merck & Co Inc A multivalent hepatitis b virus vaccine
WO1995031558A1 (en) * 1994-05-16 1995-11-23 Merck & Co., Inc. Process for producing hbv surface proteins
US6300065B1 (en) * 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6696251B1 (en) * 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
JP2002532116A (ja) * 1998-12-23 2002-10-02 メルク エンド カムパニー インコーポレーテッド 改良された組換えｂ型肝炎表面抗原
KR100604994B1 (ko) 2004-01-30 2006-07-26 한국생명공학연구원 알파1,6-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자 및 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법
CN111187720A (zh) * 2019-12-27 2020-05-22 深圳康泰生物制品股份有限公司 表达肠道病毒71型抗原的重组汉逊酵母的细胞破碎方法及其在制备手足口病疫苗中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803164A (en) * 1981-08-31 1989-02-07 Genentech, Inc. Preparation of hepatitis b surface antigen in yeast
US4707542A (en) * 1983-08-22 1987-11-17 Merck & Co., Inc. Immunogenic HbsAg derived from transformed yeast
US4816564A (en) * 1986-01-31 1989-03-28 Merck & Co., Inc. Method for producing hepatitis B virus proteins in yeast
GB8613388D0 (en) * 1986-06-03 1986-07-09 Delta Biotechnology Ltd Induction of galactose regulated gene expression in yeast
DE3719213C1 (de) * 1987-06-09 1988-05-19 Daimler Benz Ag Bodennahe mehrpolige Stromversorgung fuer spurfuehrbare,gummibereifte,elektrisch antreibbare Fahrzeuge
US4963483A (en) * 1987-10-13 1990-10-16 Merck & Co., Inc. Method for producing hepatitis B virus proteins in yeast
DE3887082T2 (de) * 1987-10-29 1994-04-28 Zymogenetics Inc Verfahren zur Regulierung der Proteinglycosylierung.
US5135854A (en) * 1987-10-29 1992-08-04 Zymogenetics, Inc. Methods of regulating protein glycosylation
GB8726953D0 (en) * 1987-11-18 1987-12-23 Delta Biotechnology Ltd Yeast expression system
NZ229260A (en) * 1988-06-03 1994-02-25 Merck & Co Inc Hepatitis b virus, expression cassette for pre-s domain, host cells and
DK0414374T3 (da) * 1989-07-25 1998-03-09 Smithkline Beecham Biolog Hidtil ukendte antigener og fremgangsmåder til fremstilling deraf
CA2022108A1 (en) * 1989-07-31 1991-02-01 Cheryl A. Schulman Enhanced growth and expression of heterologous proteins in recombinant hosts containing mutations in cell wall and/or plasma membrane biosynthesis
CA2022109A1 (en) * 1989-07-31 1991-02-01 Cheryl A. Schulman Enhanced expression of heterologous proteins in recombinant hosts in a non-growth media
EP0431679B1 (en) * 1989-12-05 1994-10-19 Merck & Co. Inc. Method of stabilizing recombinant hepatitis B virus surface proteins from yeast
IL101653A0 (en) * 1991-04-29 1992-12-30 Merck & Co Inc Multiple hepatitis b virus surface proteins which form particles

Also Published As

Publication number Publication date
MX9201970A (es) 1992-11-01
IL101651A0 (en) 1992-12-30
ATE215987T1 (de) 2002-04-15
FI934650A0 (fi) 1993-10-21
EP0516286B1 (en) 2002-04-10
CZ227193A3 (en) 1994-04-13
CZ282769B6 (cs) 1997-10-15
EP0516286A1 (en) 1992-12-02
NO933897D0 (no) 1993-10-28
FI934650A (fi) 1993-10-21
NO933897L (no) 1993-10-28
JPH06141872A (ja) 1994-05-24
BG98187A (bg) 1994-06-30
WO1992019741A1 (en) 1992-11-12
LTIP462A (en) 1994-10-25
NZ242487A (en) 1994-07-26
AU650530B2 (en) 1994-06-23
LT3367B (en) 1995-08-25
AU1522292A (en) 1993-03-11
ZA923069B (en) 1992-12-30
CA2067290A1 (en) 1992-10-30
IE921385A1 (en) 1992-11-04
US5614384A (en) 1997-03-25
JP2637877B2 (ja) 1997-08-06
BG61700B1 (bg) 1998-03-31
CN1067680A (zh) 1993-01-06
YU45492A (sh) 1994-06-10
DE69232541D1 (de) 2002-05-16
PL171485B1 (pl) 1997-05-30
HU9303064D0 (en) 1994-03-28
SK118193A3 (en) 1994-03-09
KR920019373A (ko) 1992-11-19
HUT69149A (en) 1995-08-28

Similar Documents

Publication Publication Date Title
LU91388I2 (en) Papillomavirus (humain types 16,18).
HU9202753D0 (en) Process for producing recombinant avain poxvirus and vaccine comprising same
AU4884085A (en) Oral vaccines comprising live recombinant adenoviruses
SG55152A1 (en) Hepatitis b virus surface proteins with reduced host carbohydrate content
ATE243755T1 (de) Rekombinente adenoviren-impfstoffe
AU2403188A (en) Infectious bovine rhinotracheitis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
YU45292A (sh) Različiti površinski proteini hepatitis b virusa koji obrazuju čestice
CA2116355A1 (en) Infectious bovine rhinotracheitis virus mutants and vaccines
EP0344864A3 (en) Method for producing nonhyperglycosylated hepatitis b virus protein
CA2105277A1 (en) Genetically engineered vaccine strain
EP0288198A3 (en) Production of peptide
RU93058279A (ru) Система экспрессии, белок, вакцина, реагент
DK257887A (da) Fremgangsmaade til fremstilling af hbcag i gaer og plasmid til brug ved udoevelse af fremgangsmaaden
ES2074965A1 (es) Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen.
EP0485347A3 (en) Recombinant hepatitis delta antigen, process for the purification and use thereof
Perez et al. Synthesis and secretion of the hepatitis B surface antigen in mammalian cells.
Tron Hepatitis B virus recombinant vaccines: achievement and progress
YU30495A (sh) Postupak za dobijanje hbv površinskih proteina
CA2558659A1 (en) Genetically engineered canary poxvirus-based vaccine strain