LT3367B - Hepatitis b virus surface proteins with reduced host carbohydrate content - Google Patents

Hepatitis b virus surface proteins with reduced host carbohydrate content Download PDF

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Publication number
LT3367B
LT3367B LTIP462A LTIP462A LT3367B LT 3367 B LT3367 B LT 3367B LT IP462 A LTIP462 A LT IP462A LT IP462 A LTIP462 A LT IP462A LT 3367 B LT3367 B LT 3367B
Authority
LT
Lithuania
Prior art keywords
hbv
yeast
hbsag
protein
hepatitis
Prior art date
Application number
LTIP462A
Other languages
English (en)
Lithuanian (lt)
Inventor
Peter J Kniskern
Arpi Hapogian
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of LTIP462A publication Critical patent/LTIP462A/xx
Publication of LT3367B publication Critical patent/LT3367B/lt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
LTIP462A 1991-04-29 1993-03-30 Hepatitis b virus surface proteins with reduced host carbohydrate content LT3367B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69292491A 1991-04-29 1991-04-29

Publications (2)

Publication Number Publication Date
LTIP462A LTIP462A (en) 1994-10-25
LT3367B true LT3367B (en) 1995-08-25

Family

ID=24782605

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP462A LT3367B (en) 1991-04-29 1993-03-30 Hepatitis b virus surface proteins with reduced host carbohydrate content

Country Status (25)

Country Link
US (1) US5614384A (pl)
EP (1) EP0516286B1 (pl)
JP (1) JP2637877B2 (pl)
KR (1) KR920019373A (pl)
CN (1) CN1067680A (pl)
AT (1) ATE215987T1 (pl)
AU (1) AU650530B2 (pl)
BG (1) BG61700B1 (pl)
CA (1) CA2067290A1 (pl)
CZ (1) CZ282769B6 (pl)
DE (1) DE69232541D1 (pl)
FI (1) FI934650A0 (pl)
HU (1) HUT69149A (pl)
IE (1) IE921385A1 (pl)
IL (1) IL101651A0 (pl)
LT (1) LT3367B (pl)
MX (1) MX9201970A (pl)
NO (1) NO933897L (pl)
NZ (1) NZ242487A (pl)
PL (1) PL171485B1 (pl)
SG (1) SG55152A1 (pl)
SK (1) SK118193A3 (pl)
WO (1) WO1992019741A1 (pl)
YU (1) YU45492A (pl)
ZA (1) ZA923069B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533263A3 (en) * 1991-09-20 1994-06-08 Merck & Co Inc A multivalent hepatitis b virus vaccine
YU30495A (sh) * 1994-05-16 1997-12-05 Merck & Co. Inc. Postupak za dobijanje hbv površinskih proteina
US6300065B1 (en) * 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6696251B1 (en) * 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
WO2000037104A1 (en) * 1998-12-23 2000-06-29 Merck & Co., Inc. Improved recombinant hepatitis b surface antigen
KR100604994B1 (ko) * 2004-01-30 2006-07-26 한국생명공학연구원 알파1,6-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자 및 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법
CN111187720A (zh) * 2019-12-27 2020-05-22 深圳康泰生物制品股份有限公司 表达肠道病毒71型抗原的重组汉逊酵母的细胞破碎方法及其在制备手足口病疫苗中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803164A (en) * 1981-08-31 1989-02-07 Genentech, Inc. Preparation of hepatitis b surface antigen in yeast
US4707542A (en) * 1983-08-22 1987-11-17 Merck & Co., Inc. Immunogenic HbsAg derived from transformed yeast
US4816564A (en) * 1986-01-31 1989-03-28 Merck & Co., Inc. Method for producing hepatitis B virus proteins in yeast
GB8613388D0 (en) * 1986-06-03 1986-07-09 Delta Biotechnology Ltd Induction of galactose regulated gene expression in yeast
DE3719213C1 (de) * 1987-06-09 1988-05-19 Daimler Benz Ag Bodennahe mehrpolige Stromversorgung fuer spurfuehrbare,gummibereifte,elektrisch antreibbare Fahrzeuge
US4963483A (en) * 1987-10-13 1990-10-16 Merck & Co., Inc. Method for producing hepatitis B virus proteins in yeast
DE3887082T2 (de) * 1987-10-29 1994-04-28 Zymogenetics Inc Verfahren zur Regulierung der Proteinglycosylierung.
US5135854A (en) * 1987-10-29 1992-08-04 Zymogenetics, Inc. Methods of regulating protein glycosylation
GB8726953D0 (en) * 1987-11-18 1987-12-23 Delta Biotechnology Ltd Yeast expression system
NZ229260A (en) * 1988-06-03 1994-02-25 Merck & Co Inc Hepatitis b virus, expression cassette for pre-s domain, host cells and
EP0414374B1 (en) * 1989-07-25 1997-10-08 Smithkline Biologicals S.A. Novel antigens and methods for their preparation
CA2022109A1 (en) * 1989-07-31 1991-02-01 Cheryl A. Schulman Enhanced expression of heterologous proteins in recombinant hosts in a non-growth media
CA2022108A1 (en) * 1989-07-31 1991-02-01 Cheryl A. Schulman Enhanced growth and expression of heterologous proteins in recombinant hosts containing mutations in cell wall and/or plasma membrane biosynthesis
DE69013471T2 (de) * 1989-12-05 1995-03-30 Merck & Co Inc Methode zur Stabilisierung von rekombinanten Hepatitis-B-Virus-Oberflächenproteinen aus Hefe.
IL101653A0 (en) * 1991-04-29 1992-12-30 Merck & Co Inc Multiple hepatitis b virus surface proteins which form particles

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
BALLOU L, COHEN RE, BALLOU CE: "Saccharomyces cerevisiae mutants that make mannoproteins with a truncated carbohydrate outer chain", J BIOL CHEM., 1980, pages 5986 - 5991, XP055325194
BALLOU L. ET AL.: "A mutation that prevents glucosylation of the lipid-linked oligosaccharide precursor leads to underglycosylation of secreted yeast invertase", PROC NATL ACAD SCI U S A., 1986, pages 3081 - 3085
BITTER ET AL.: "Expression of interferon-gamma from hybrid yeast GPD promoters containing upstream regulatory sequences from the GAL1-GAL10 intergenic region", GENE, 1984, pages 263 - 274
EDITED BY CHRISTIAN M. METALLO: "Methods in Enzymology", pages: 1990
HANSSON ET AL.: "Sites that bind polymerized albumin on hepatitis B surface antigen particles: detection by radioimmunoassay", INFECT. IMMUNOL., 1979, pages 125 - 130
HEERMANN KH ET AL.: "Large surface proteins of hepatitis B virus containing the pre-s sequence", J. VIROL., 1984, pages 396 - 402, XP001053577
HOLLAND JP AND HOLLAND MJ: "Structural comparison of two nontandemly repeated yest glyceraldehyde-3P dehydrogenase genes", J. BIOL. CHEM., 1980, pages 2596 - 2605, XP001319016
KNISKERN P.J. ET AL.: "A candidate vaccine for hepatitis B containing the complete viral surface protein", HEPATOLOGY, 1988, pages 82 - 87
KNISKERN PJ ET AL.: "Unusually high-level expression of a foreign gene (hepatitis B virus core antigen) in Saccharomyces cerevisiae", GENE, 1986, pages 135 - 141, XP001313309
KUKURUZINSKA MA, BERGH ML, JACKSON BJ: "Protein glycosylation in yeast.", ANNU REV BIOCHEM., 1987, pages 915 - 944
LOWRY ET AL.: "Protein measurement with the Folin phenol reagent", J. BIOL. CHEM., 1951, pages 265 - 275, XP000196391
MACHIDA ET AL.: "A polypeptide containing 55 amino acid residues coded by the preS region coded by hepatitis B virus", GASTROENTEROLOGY, 1984, pages 910 - 918
STEVENS ET AL.: "Yeast-recombinant hepatitis B vaccine. Efficacy with hepatitis B immune globulin in prevention of perinatal hepatitis B virus transmission", JAMA, 1987, pages 2612 - 2616
STIBBE W, GERLICH WH.: "Structural relationships between minor and major proteins of hepatitis B surface antigen", J. VIROL., 1983, pages 626 - 628
TSAI ET AL.: "Carbohydrate structure of Sacharomyces cerevisiae mnn9 mannoprotein", J. BIOL. CHEM., 1984, pages 3805 - 3811
VALENZUELA P. ET AL.: "Synthesis and assembly in yeast of hepatitis B surface antigen particles containing the polyalbumin receptor", BIOTECHNOLOGY, 1985, pages 317 - 320
WAMPLER ET AL.: "Multiple chemical forms of hepatitis B surface antigen produced in yeast", PROC. NATL. ACAD. SCI., 1985, pages 6830 - 6834, XP002295841, DOI: doi:10.1073/pnas.82.20.6830

Also Published As

Publication number Publication date
MX9201970A (es) 1992-11-01
CN1067680A (zh) 1993-01-06
FI934650A (fi) 1993-10-21
SG55152A1 (en) 1998-12-21
AU1522292A (en) 1993-03-11
AU650530B2 (en) 1994-06-23
DE69232541D1 (de) 2002-05-16
FI934650A0 (fi) 1993-10-21
EP0516286A1 (en) 1992-12-02
WO1992019741A1 (en) 1992-11-12
ZA923069B (en) 1992-12-30
US5614384A (en) 1997-03-25
SK118193A3 (en) 1994-03-09
NO933897D0 (no) 1993-10-28
HUT69149A (en) 1995-08-28
PL171485B1 (pl) 1997-05-30
JPH06141872A (ja) 1994-05-24
IE921385A1 (en) 1992-11-04
BG98187A (bg) 1994-06-30
YU45492A (sh) 1994-06-10
CA2067290A1 (en) 1992-10-30
LTIP462A (en) 1994-10-25
IL101651A0 (en) 1992-12-30
EP0516286B1 (en) 2002-04-10
KR920019373A (ko) 1992-11-19
HU9303064D0 (en) 1994-03-28
BG61700B1 (bg) 1998-03-31
NZ242487A (en) 1994-07-26
CZ282769B6 (cs) 1997-10-15
CZ227193A3 (en) 1994-04-13
NO933897L (no) 1993-10-28
JP2637877B2 (ja) 1997-08-06
ATE215987T1 (de) 2002-04-15

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Free format text: KNISKERN,PETER J., 841 PATTERSON DRIVE, LANSDALE, PENNSYLVANIA 19446, US, HAGOPIAN,ARPI, 771 HARTLEY DRIVE, LANSDALE, PENNSYLVANIA 19446, US, 19950914

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