SG46672A1 - Antiproliferative quinazolines - Google Patents

Antiproliferative quinazolines

Info

Publication number
SG46672A1
SG46672A1 SG1996008023A SG1996008023A SG46672A1 SG 46672 A1 SG46672 A1 SG 46672A1 SG 1996008023 A SG1996008023 A SG 1996008023A SG 1996008023 A SG1996008023 A SG 1996008023A SG 46672 A1 SG46672 A1 SG 46672A1
Authority
SG
Singapore
Prior art keywords
compounds
quinazolines
antiproliferative
thymidylate synthase
enzyme thymidylate
Prior art date
Application number
SG1996008023A
Other languages
English (en)
Inventor
Stephen E Webber
Ted M Bleckman
John Attard
Terence R Jones
Michael D Varney
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of SG46672A1 publication Critical patent/SG46672A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG1996008023A 1992-03-31 1993-03-26 Antiproliferative quinazolines SG46672A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/861,030 US5430148A (en) 1992-03-31 1992-03-31 Antiproliferative quinazolines

Publications (1)

Publication Number Publication Date
SG46672A1 true SG46672A1 (en) 1998-02-20

Family

ID=25334675

Family Applications (2)

Application Number Title Priority Date Filing Date
SG1996008023A SG46672A1 (en) 1992-03-31 1993-03-26 Antiproliferative quinazolines
SG9800739A SG93183A1 (en) 1992-03-31 1996-02-22 Antiproliferative quinazolines

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG9800739A SG93183A1 (en) 1992-03-31 1996-02-22 Antiproliferative quinazolines

Country Status (20)

Country Link
US (3) US5430148A (fr)
EP (1) EP0637300B1 (fr)
JP (1) JP3272357B2 (fr)
KR (1) KR100226114B1 (fr)
AT (1) ATE205197T1 (fr)
AU (1) AU681075B2 (fr)
CA (2) CA2132514C (fr)
DE (1) DE69330715T2 (fr)
DK (1) DK0637300T3 (fr)
ES (1) ES2162818T3 (fr)
FI (1) FI113765B (fr)
HU (1) HU222523B1 (fr)
MD (1) MD1638G2 (fr)
NO (1) NO307829B1 (fr)
NZ (1) NZ251804A (fr)
PT (1) PT637300E (fr)
RU (1) RU2135481C1 (fr)
SG (2) SG46672A1 (fr)
TJ (1) TJ272B (fr)
WO (1) WO1993020055A1 (fr)

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AU2003270015A1 (en) 2002-05-09 2003-12-02 Cytokinetics, Inc. Compounds, compositions, and methods
MXPA04011074A (es) * 2002-05-09 2005-06-08 Cytokinetics Inc Compuestos de pirimidinona, composiciones y metodos.
EP1513820A4 (fr) * 2002-05-23 2006-09-13 Cytokinetics Inc Composes, compositions et procedes
AU2003236527A1 (en) * 2002-06-14 2003-12-31 Cytokinetics, Inc. Compounds, compositions, and methods
US6906205B2 (en) * 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US20080125441A1 (en) * 2002-06-21 2008-05-29 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US7211580B2 (en) * 2002-07-23 2007-05-01 Cytokinetics, Incorporated Compounds, compositions, and methods
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WO2004034972A2 (fr) * 2002-09-30 2004-04-29 Cytokinetics, Inc. Composes, compositions, et procedes
US7232824B2 (en) * 2003-09-30 2007-06-19 Scios, Inc. Quinazoline derivatives as medicaments
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US7439254B2 (en) * 2003-12-08 2008-10-21 Cytokinetics, Inc. Compounds, compositions, and methods
BRPI0606318B8 (pt) * 2005-01-19 2021-05-25 Rigel Pharmaceuticals Inc composto, composição, e, uso de um composto
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CN1303080C (zh) * 2005-07-18 2007-03-07 康辰医药发展有限公司 盐酸洛拉曲克的合成工艺
JO2985B1 (ar) 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
CN101353343B (zh) * 2007-07-27 2012-07-04 上海医药工业研究院 高纯度盐酸诺拉曲塞二水合物的制备方法
US8426430B2 (en) * 2008-06-30 2013-04-23 Hutchison Medipharma Enterprises Limited Quinazoline derivatives
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JP5697685B2 (ja) 2009-12-18 2015-04-08 バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ 三環式抗生物質
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RU2507199C1 (ru) * 2012-09-10 2014-02-20 Владимир Иванович Петров Производные хиназолина, обладающие антидепрессивной, анксиолитической и ноотропной активностью
RU2622638C1 (ru) * 2016-07-14 2017-06-19 Владимир Иванович Петров Производные хиназолин-4(3н)-она, обладающие нейро- и кардиопротекторной активностью
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Also Published As

Publication number Publication date
PT637300E (pt) 2002-01-30
CA2474211C (fr) 2006-10-03
DE69330715T2 (de) 2002-02-14
HU222523B1 (hu) 2003-08-28
DK0637300T3 (da) 2001-12-10
JPH07505395A (ja) 1995-06-15
MD1638F2 (en) 2001-03-31
US5885996A (en) 1999-03-23
NO943629L (no) 1994-09-29
DE69330715D1 (de) 2001-10-11
NO307829B1 (no) 2000-06-05
AU3966493A (en) 1993-11-08
EP0637300B1 (fr) 2001-09-05
FI944525A0 (fi) 1994-09-29
RU94045251A (ru) 1996-07-20
SG93183A1 (en) 2002-12-17
EP0637300A1 (fr) 1995-02-08
CA2474211A1 (fr) 1993-10-14
JP3272357B2 (ja) 2002-04-08
FI944525A (fi) 1994-09-29
ATE205197T1 (de) 2001-09-15
NO943629D0 (no) 1994-09-29
MD1638G2 (ro) 2001-09-30
US5430148A (en) 1995-07-04
AU681075B2 (en) 1997-08-21
ES2162818T3 (es) 2002-01-16
HUT68580A (en) 1995-06-28
KR100226114B1 (ko) 1999-10-15
NZ251804A (en) 1997-06-24
WO1993020055A1 (fr) 1993-10-14
FI113765B (fi) 2004-06-15
RU2135481C1 (ru) 1999-08-27
HU9402799D0 (en) 1994-12-28
CA2132514C (fr) 2004-10-26
TJ272B (en) 2000-10-05
CA2132514A1 (fr) 1993-10-14
US5707992A (en) 1998-01-13

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