ES2117950A1 - Nuevos compuestos que bloquean la biosientesis de posporilcolina y su uso como segundo mensajero en proliferacion celular. - Google Patents
Nuevos compuestos que bloquean la biosientesis de posporilcolina y su uso como segundo mensajero en proliferacion celular.Info
- Publication number
- ES2117950A1 ES2117950A1 ES09601893A ES9601893A ES2117950A1 ES 2117950 A1 ES2117950 A1 ES 2117950A1 ES 09601893 A ES09601893 A ES 09601893A ES 9601893 A ES9601893 A ES 9601893A ES 2117950 A1 ES2117950 A1 ES 2117950A1
- Authority
- ES
- Spain
- Prior art keywords
- selective
- antiviral
- antifungic
- phosphorilcholine
- antiparasite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION ESTA RELACIONADA CON EL DISEÑO, SINTESIS Y ACTIVIDAD BIOLOGICA DE DOS NUEVAS ESTRATEGIAS PARA ABORDAR EL DESARROLLO DE COMPUESTOS QUE PRESENTEN ACTIVIDADES SELECTIVAS COMO ANTICANCEROSOS, ANTIVIRALES, ANTIPARASITARIOS Y ANTIFUNGICOS. AQUI SE DESCRIBE LA UTILIZACION DE LA INHIBICION DE LA BIOSINTESIS DE FOSFORILCOLINA Y DE SU ACCION MITOGENICA COMO UNA NUEVA ESTRATEGIA PARA EL TRATAMIENTO DE TUMORES Y DE ENFERMEDADES PARASITARIAS O PRODUCIDAS POR VIRUS Y HONGOS EN ANIMALES Y EN HUMANOS. LOS COMPUESTOS QUE SE DESCRIBEN PERTENECEN A LAS FAMILIAS ESTRUCTURALES QUE HAN DEMOSTRADO ACTIVIDAD ANTITUMORAL, ANTIPARASITARIA Y ANTIFUNGICA, QUE DEBEN SER CONSIDERADOS Y PROTEGIDOS COMO COMPUESTOS DIRECTAMENTE UTILIZADOS EN EL TRATAMIENTO DE ESTAS ENFERMEDADES EN ANIMALES Y HUMANOS. FINALMENTE, SE DESCRIBEN Y PROTEGEN TAMBIEN LOS METODOS SINTETICOS DE TODOS LOS COMPUESTOS DESCRITOS.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9601893A ES2117950B1 (es) | 1996-08-02 | 1996-08-02 | Nuevos compuestos que bloquean la biosintesis de fosforilcolina y su uso como segundo mensajero en proliferacion celular. |
PCT/ES1997/000205 WO1998005644A1 (es) | 1996-08-02 | 1997-08-01 | Nuevos compuestos con actividad selectiva antitumoral, antiviral, antiparasitaria y antifungica que bloquean la biosintesis de fosforilcolina mediante inhibicion selectiva de colina quinasa intracelular o su utilizacion como segundo mensajero en proliferacion celular |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9601893A ES2117950B1 (es) | 1996-08-02 | 1996-08-02 | Nuevos compuestos que bloquean la biosintesis de fosforilcolina y su uso como segundo mensajero en proliferacion celular. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2117950A1 true ES2117950A1 (es) | 1998-08-16 |
ES2117950B1 ES2117950B1 (es) | 1999-09-16 |
Family
ID=8295957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9601893A Expired - Fee Related ES2117950B1 (es) | 1996-08-02 | 1996-08-02 | Nuevos compuestos que bloquean la biosintesis de fosforilcolina y su uso como segundo mensajero en proliferacion celular. |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2117950B1 (es) |
WO (1) | WO1998005644A1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2085386A2 (en) | 2004-01-14 | 2009-08-05 | Consejo Superior De Investigaciones Científicas | Pyridinium and quinolinium derivatives as Choline kinase inhibitors |
US8586613B2 (en) | 2004-01-14 | 2013-11-19 | Universidad De Granada | Pyridinium and quinolinium derivatives |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0927035A4 (en) * | 1996-09-13 | 2002-11-13 | Merck & Co Inc | THROMBIN INHIBITORS |
AU5518899A (en) * | 1998-08-28 | 2000-03-21 | Consejo Superior De Investigaciones Cientificas | System for screening compounds with antitumoral, antiviral, antiparasitic and antifungal activity |
ES2148092B1 (es) * | 1998-08-28 | 2001-04-16 | Consejo Superior Investigacion | Sistema de identificacion ("screening") de compuestos con actividad antitumoral, antiviral, antiparasitaria y antifungica. |
JP4659183B2 (ja) * | 2000-07-21 | 2011-03-30 | 富士フイルム株式会社 | 脂肪族置換アミノピリジニウム誘導体 |
ES2277568B1 (es) | 2005-12-30 | 2008-04-01 | Consejo Superior De Investigaciones Cientificas | Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias. |
US20100068302A1 (en) * | 2008-09-17 | 2010-03-18 | Traslational Cancer Drugs Pharma, S.L. | Methods and compositions for the treatment of cancer |
US20110212994A1 (en) | 2009-06-26 | 2011-09-01 | Brian Clem | Small Molecule Choline Kinase Inhibitors, Screening Assays, and Methods for Safe and Effective Treatment of Neoplastic Disorders |
CN103814026A (zh) * | 2011-09-22 | 2014-05-21 | 沃泰克斯药物股份有限公司 | 可用作胆碱激酶抑制剂的化合物 |
CN102516164B (zh) * | 2011-12-09 | 2013-09-04 | 中国科学院成都生物研究所 | 1,2-二芳基-5-取代吡啶盐化合物及其制备方法和用途 |
US9796679B2 (en) * | 2014-02-11 | 2017-10-24 | Trustees Of Dartmouth College | Type 4 prepilin peptidase inhibitors and methods of use |
WO2019034172A1 (zh) * | 2017-08-18 | 2019-02-21 | 上海轶诺药业有限公司 | 一种具有pd-l1抑制活性的化合物、其制备方法及用途 |
-
1996
- 1996-08-02 ES ES9601893A patent/ES2117950B1/es not_active Expired - Fee Related
-
1997
- 1997-08-01 WO PCT/ES1997/000205 patent/WO1998005644A1/es active Application Filing
Non-Patent Citations (1)
Title |
---|
SZENDEY, G.R. Anticholinesterase-Aktivitõt. Chemische Modelluntersuchungen, Arzeim.-Forsch. (Drug Res.) 22, n‘ 10, pßginas 1746-1748, (1972) * Tabla 2, compuestos VII,VIII; tabla 3, compuesto XI; tabla 4, compuestos XV,XVI,XVII,XVIII; tabla 7; sumario * * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2085386A2 (en) | 2004-01-14 | 2009-08-05 | Consejo Superior De Investigaciones Científicas | Pyridinium and quinolinium derivatives as Choline kinase inhibitors |
CN1910153B (zh) * | 2004-01-14 | 2010-05-26 | 康斯乔最高科学研究公司 | 吡啶和喹啉衍生物 |
US7781458B2 (en) | 2004-01-14 | 2010-08-24 | Consejo Superior De Investigaciones Cientificas | Derivatives of pyridine and quinoline |
US8586613B2 (en) | 2004-01-14 | 2013-11-19 | Universidad De Granada | Pyridinium and quinolinium derivatives |
Also Published As
Publication number | Publication date |
---|---|
WO1998005644A1 (es) | 1998-02-12 |
ES2117950B1 (es) | 1999-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19980816 Kind code of ref document: A1 Effective date: 19980816 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20161125 |