SG192667A1 - Anti-alpha-v integrin antibody for the treatment of prostate cancer - Google Patents
Anti-alpha-v integrin antibody for the treatment of prostate cancer Download PDFInfo
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- SG192667A1 SG192667A1 SG2013060140A SG2013060140A SG192667A1 SG 192667 A1 SG192667 A1 SG 192667A1 SG 2013060140 A SG2013060140 A SG 2013060140A SG 2013060140 A SG2013060140 A SG 2013060140A SG 192667 A1 SG192667 A1 SG 192667A1
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- Toxicology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/EP2012/000548 WO2012107211A1 (en) | 2011-02-11 | 2012-02-07 | Anti-alpha-v integrin antibody for the treatment of prostate cancer |
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| SG192667A1 true SG192667A1 (en) | 2013-09-30 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TR201810294T4 (tr) | 2011-02-11 | 2018-08-27 | Merck Patent Gmbh | Prostat kanseri tedavisi için anti-alfa-v integrin antikoru. |
| KR20170052690A (ko) | 2014-09-17 | 2017-05-12 | 메르크 파텐트 게엠베하 | 고형암 및/또는 이의 전이 치료 방법, 그에 따른 약제, 및 고형암 및/또는 이의 전이 치료의 임상 결과 예측 방법 |
| ES2897782T3 (es) * | 2014-09-17 | 2022-03-02 | Merck Patent Gmbh | Método de tratamiento de las enfermedades de la metástasis ósea, medicamentos para el tratamiento y método para predecir el resultado clínico del tratamiento de las enfermedades causadas por metástasis ósea |
| US20190144547A1 (en) | 2015-11-23 | 2019-05-16 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders |
| TW201720843A (zh) * | 2015-11-23 | 2017-06-16 | 馬克專利公司 | 用於治療纖維化及／或纖維化病症之抗－αＶ整合素抗體 |
| WO2024137442A1 (en) | 2022-12-21 | 2024-06-27 | Gilead Sciences, Inc. | Combination therapy for treating cancer |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ282603B6 (cs) | 1991-03-06 | 1997-08-13 | Merck Patent Gesellschaft Mit Beschränkter Haftun G | Humanizované a chimerické monoklonální protilátky |
| US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| EP0719859B1 (en) | 1994-12-20 | 2003-07-02 | MERCK PATENT GmbH | Anti-alpha V-integrin monoclonal antibody |
| DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| GB2339430A (en) | 1997-05-21 | 2000-01-26 | Biovation Ltd | Method for the production of non-immunogenic proteins |
| DE19842415A1 (de) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
| DE69934967T2 (de) | 1998-12-08 | 2007-12-06 | Biovation Ltd. | Verfahren zur verminderung der immunogenität von proteinen |
| US7163681B2 (en) * | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| EP1998266A3 (en) | 2001-02-19 | 2009-02-11 | Merck Patent GmbH | Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity |
| DE10163459A1 (de) | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
| NZ540562A (en) | 2002-11-26 | 2008-04-30 | Pdl Biopharma Inc | Therapeutic chimeric and humanized antibodies directed against alpha5beta1 integrin, methods for purification of these antibodies, and their use in treating conditions comprising undesirable tissue angiogenesis |
| US8147832B2 (en) | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
| AU2005211890B2 (en) | 2004-02-12 | 2011-07-28 | Merck Patent Gmbh | Highly concentrated liquid formulations of anti-EGFR antibodies |
| KR20060002667A (ko) | 2004-07-03 | 2006-01-09 | 삼성전자주식회사 | 디스크 댐퍼와 디스크 프로텍터를 구비한 하드 디스크드라이브 |
| US8202465B2 (en) | 2004-11-03 | 2012-06-19 | Honeywell International Inc. | Preferential curing technique in compression molding of fiber reinforced composites |
| US20070025889A1 (en) | 2005-07-28 | 2007-02-01 | Pcbu Business Services, Inc. | Reactors, reactor assemblies and production processes |
| DE102005062440B4 (de) | 2005-12-27 | 2011-02-24 | Lts Lohmann Therapie-Systeme Ag | Proteinbasiertes Trägersystem zur Resistenzüberwindung von Tumorzellen |
| DK2270050T3 (da) | 2005-12-30 | 2013-08-12 | Merck Patent Gmbh | Anti-CD19-antistoffer med nedsat immunogenicitet |
| ES2521679T3 (es) | 2006-01-18 | 2014-11-13 | Merck Patent Gmbh | Terapia específica usando ligandos de integrinas para el tratamiento del cáncer |
| US8715718B2 (en) | 2006-07-14 | 2014-05-06 | Rutgers, The State University Of New Jersey | Extracellular matrix production from nanoscale substrate |
| CA2693863C (en) | 2007-07-17 | 2017-10-03 | Merck Patent Gmbh | Engineered anti-alpha v- integrin hybrid antibodies |
| US20110177155A1 (en) | 2007-08-21 | 2011-07-21 | Immune Disease Institute, Inc. | Methods of delivery of agents to leukocytes and endothelial cells |
| US20120004129A1 (en) | 2008-12-23 | 2012-01-05 | Merck Patent Gmbh | Biomarkers for inhibitors with anti-angiogenic activity |
| CA2771441C (en) | 2009-08-19 | 2016-10-11 | Merck Patent Gmbh | Antibodies for the detection of integrin complexes in ffpe material |
| US20120263739A1 (en) | 2009-11-13 | 2012-10-18 | Merck Patent Gmbh | Anti integrin antibodies linked to nanoparticles loaded with chemotherapeutic agents |
| WO2011162933A1 (en) * | 2010-06-04 | 2011-12-29 | Immunogen, Inc. | Anti-integrin immunoconjugate dosing regimens |
| TR201810294T4 (tr) | 2011-02-11 | 2018-08-27 | Merck Patent Gmbh | Prostat kanseri tedavisi için anti-alfa-v integrin antikoru. |
| JP6035716B2 (ja) | 2011-08-26 | 2016-11-30 | ソニー株式会社 | 情報処理システム及び情報処理方法 |
| WO2014143383A1 (en) | 2013-03-13 | 2014-09-18 | Agilent Technologies, Inc. | Transposome tethered to a gene delivery vehicle |
| EP3041863A4 (en) | 2013-09-05 | 2017-08-16 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
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2012
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- 2012-02-07 CN CN201280008336.1A patent/CN103347540B/zh active Active
- 2012-02-07 US US13/984,669 patent/US9555110B2/en active Active
- 2012-02-07 WO PCT/EP2012/000548 patent/WO2012107211A1/en not_active Ceased
- 2012-02-07 KR KR1020137023946A patent/KR101972533B1/ko not_active Expired - Fee Related
- 2012-02-07 EP EP12702990.8A patent/EP2672994B1/en active Active
- 2012-02-07 HU HUE12702990A patent/HUE037212T2/hu unknown
- 2012-02-07 EA EA201391147A patent/EA032117B1/ru not_active IP Right Cessation
- 2012-02-07 DK DK12702990.8T patent/DK2672994T3/en active
- 2012-02-07 HR HRP20181212TT patent/HRP20181212T1/hr unknown
- 2012-02-07 ES ES12702990.8T patent/ES2683347T3/es active Active
- 2012-02-07 EP EP18170936.1A patent/EP3415162A1/en not_active Withdrawn
- 2012-02-07 MX MX2013009062A patent/MX352025B/es active IP Right Grant
- 2012-02-07 PT PT12702990T patent/PT2672994T/pt unknown
- 2012-02-07 AU AU2012216145A patent/AU2012216145B2/en not_active Ceased
- 2012-02-07 KR KR1020197011392A patent/KR102103701B1/ko not_active Expired - Fee Related
- 2012-02-07 JP JP2013552879A patent/JP6320042B2/ja active Active
- 2012-02-07 SI SI201231356T patent/SI2672994T1/sl unknown
- 2012-02-07 CA CA2827052A patent/CA2827052C/en active Active
- 2012-02-07 MX MX2017014184A patent/MX385144B/es unknown
- 2012-02-07 PL PL12702990T patent/PL2672994T3/pl unknown
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- 2012-02-07 RS RS20180926A patent/RS57524B1/sr unknown
- 2012-02-07 SG SG2013060140A patent/SG192667A1/en unknown
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2013
- 2013-07-29 IL IL227687A patent/IL227687B/en active IP Right Grant
- 2013-09-10 ZA ZA2013/06807A patent/ZA201306807B/en unknown
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2016
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2017
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- 2017-02-14 AU AU2017200998A patent/AU2017200998B2/en not_active Ceased
-
2019
- 2019-01-25 US US16/258,289 patent/US20190263913A1/en not_active Abandoned
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