HUE037212T2 - Anti-alfa-V integrin ellenanyag prosztatarák kezelésére - Google Patents
Anti-alfa-V integrin ellenanyag prosztatarák kezeléséreInfo
- Publication number
- HUE037212T2 HUE037212T2 HUE12702990A HUE12702990A HUE037212T2 HU E037212 T2 HUE037212 T2 HU E037212T2 HU E12702990 A HUE12702990 A HU E12702990A HU E12702990 A HUE12702990 A HU E12702990A HU E037212 T2 HUE037212 T2 HU E037212T2
- Authority
- HU
- Hungary
- Prior art keywords
- alpha
- prostate cancer
- integrin antibody
- treat prostate
- treat
- Prior art date
Links
- 206010060862 Prostate cancer Diseases 0.000 title 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11001135 | 2011-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE037212T2 true HUE037212T2 (hu) | 2018-08-28 |
Family
ID=45569571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12702990A HUE037212T2 (hu) | 2011-02-11 | 2012-02-07 | Anti-alfa-V integrin ellenanyag prosztatarák kezelésére |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US9555110B2 (enExample) |
| EP (2) | EP2672994B1 (enExample) |
| JP (2) | JP6320042B2 (enExample) |
| KR (2) | KR101972533B1 (enExample) |
| CN (1) | CN103347540B (enExample) |
| AU (2) | AU2012216145B2 (enExample) |
| CA (1) | CA2827052C (enExample) |
| DK (1) | DK2672994T3 (enExample) |
| EA (1) | EA032117B1 (enExample) |
| ES (1) | ES2683347T3 (enExample) |
| HR (1) | HRP20181212T1 (enExample) |
| HU (1) | HUE037212T2 (enExample) |
| IL (1) | IL227687B (enExample) |
| LT (1) | LT2672994T (enExample) |
| MX (2) | MX352025B (enExample) |
| PL (1) | PL2672994T3 (enExample) |
| PT (1) | PT2672994T (enExample) |
| RS (1) | RS57524B1 (enExample) |
| SG (1) | SG192667A1 (enExample) |
| SI (1) | SI2672994T1 (enExample) |
| TR (1) | TR201810294T4 (enExample) |
| WO (1) | WO2012107211A1 (enExample) |
| ZA (1) | ZA201306807B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201810294T4 (tr) | 2011-02-11 | 2018-08-27 | Merck Patent Gmbh | Prostat kanseri tedavisi için anti-alfa-v integrin antikoru. |
| KR20170052690A (ko) | 2014-09-17 | 2017-05-12 | 메르크 파텐트 게엠베하 | 고형암 및/또는 이의 전이 치료 방법, 그에 따른 약제, 및 고형암 및/또는 이의 전이 치료의 임상 결과 예측 방법 |
| ES2897782T3 (es) * | 2014-09-17 | 2022-03-02 | Merck Patent Gmbh | Método de tratamiento de las enfermedades de la metástasis ósea, medicamentos para el tratamiento y método para predecir el resultado clínico del tratamiento de las enfermedades causadas por metástasis ósea |
| US20190144547A1 (en) | 2015-11-23 | 2019-05-16 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders |
| TW201720843A (zh) * | 2015-11-23 | 2017-06-16 | 馬克專利公司 | 用於治療纖維化及／或纖維化病症之抗－αＶ整合素抗體 |
| WO2024137442A1 (en) | 2022-12-21 | 2024-06-27 | Gilead Sciences, Inc. | Combination therapy for treating cancer |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ282603B6 (cs) | 1991-03-06 | 1997-08-13 | Merck Patent Gesellschaft Mit Beschränkter Haftun G | Humanizované a chimerické monoklonální protilátky |
| US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| EP0719859B1 (en) | 1994-12-20 | 2003-07-02 | MERCK PATENT GmbH | Anti-alpha V-integrin monoclonal antibody |
| DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| GB2339430A (en) | 1997-05-21 | 2000-01-26 | Biovation Ltd | Method for the production of non-immunogenic proteins |
| DE19842415A1 (de) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
| DE69934967T2 (de) | 1998-12-08 | 2007-12-06 | Biovation Ltd. | Verfahren zur verminderung der immunogenität von proteinen |
| US7163681B2 (en) * | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| EP1998266A3 (en) | 2001-02-19 | 2009-02-11 | Merck Patent GmbH | Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity |
| DE10163459A1 (de) | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
| NZ540562A (en) | 2002-11-26 | 2008-04-30 | Pdl Biopharma Inc | Therapeutic chimeric and humanized antibodies directed against alpha5beta1 integrin, methods for purification of these antibodies, and their use in treating conditions comprising undesirable tissue angiogenesis |
| US8147832B2 (en) | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
| AU2005211890B2 (en) | 2004-02-12 | 2011-07-28 | Merck Patent Gmbh | Highly concentrated liquid formulations of anti-EGFR antibodies |
| KR20060002667A (ko) | 2004-07-03 | 2006-01-09 | 삼성전자주식회사 | 디스크 댐퍼와 디스크 프로텍터를 구비한 하드 디스크드라이브 |
| US8202465B2 (en) | 2004-11-03 | 2012-06-19 | Honeywell International Inc. | Preferential curing technique in compression molding of fiber reinforced composites |
| US20070025889A1 (en) | 2005-07-28 | 2007-02-01 | Pcbu Business Services, Inc. | Reactors, reactor assemblies and production processes |
| DE102005062440B4 (de) | 2005-12-27 | 2011-02-24 | Lts Lohmann Therapie-Systeme Ag | Proteinbasiertes Trägersystem zur Resistenzüberwindung von Tumorzellen |
| DK2270050T3 (da) | 2005-12-30 | 2013-08-12 | Merck Patent Gmbh | Anti-CD19-antistoffer med nedsat immunogenicitet |
| ES2521679T3 (es) | 2006-01-18 | 2014-11-13 | Merck Patent Gmbh | Terapia específica usando ligandos de integrinas para el tratamiento del cáncer |
| US8715718B2 (en) | 2006-07-14 | 2014-05-06 | Rutgers, The State University Of New Jersey | Extracellular matrix production from nanoscale substrate |
| CA2693863C (en) | 2007-07-17 | 2017-10-03 | Merck Patent Gmbh | Engineered anti-alpha v- integrin hybrid antibodies |
| US20110177155A1 (en) | 2007-08-21 | 2011-07-21 | Immune Disease Institute, Inc. | Methods of delivery of agents to leukocytes and endothelial cells |
| US20120004129A1 (en) | 2008-12-23 | 2012-01-05 | Merck Patent Gmbh | Biomarkers for inhibitors with anti-angiogenic activity |
| CA2771441C (en) | 2009-08-19 | 2016-10-11 | Merck Patent Gmbh | Antibodies for the detection of integrin complexes in ffpe material |
| US20120263739A1 (en) | 2009-11-13 | 2012-10-18 | Merck Patent Gmbh | Anti integrin antibodies linked to nanoparticles loaded with chemotherapeutic agents |
| WO2011162933A1 (en) * | 2010-06-04 | 2011-12-29 | Immunogen, Inc. | Anti-integrin immunoconjugate dosing regimens |
| TR201810294T4 (tr) | 2011-02-11 | 2018-08-27 | Merck Patent Gmbh | Prostat kanseri tedavisi için anti-alfa-v integrin antikoru. |
| JP6035716B2 (ja) | 2011-08-26 | 2016-11-30 | ソニー株式会社 | 情報処理システム及び情報処理方法 |
| WO2014143383A1 (en) | 2013-03-13 | 2014-09-18 | Agilent Technologies, Inc. | Transposome tethered to a gene delivery vehicle |
| EP3041863A4 (en) | 2013-09-05 | 2017-08-16 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
-
2012
- 2012-02-07 TR TR2018/10294T patent/TR201810294T4/tr unknown
- 2012-02-07 CN CN201280008336.1A patent/CN103347540B/zh active Active
- 2012-02-07 US US13/984,669 patent/US9555110B2/en active Active
- 2012-02-07 WO PCT/EP2012/000548 patent/WO2012107211A1/en not_active Ceased
- 2012-02-07 KR KR1020137023946A patent/KR101972533B1/ko not_active Expired - Fee Related
- 2012-02-07 EP EP12702990.8A patent/EP2672994B1/en active Active
- 2012-02-07 HU HUE12702990A patent/HUE037212T2/hu unknown
- 2012-02-07 EA EA201391147A patent/EA032117B1/ru not_active IP Right Cessation
- 2012-02-07 DK DK12702990.8T patent/DK2672994T3/en active
- 2012-02-07 HR HRP20181212TT patent/HRP20181212T1/hr unknown
- 2012-02-07 ES ES12702990.8T patent/ES2683347T3/es active Active
- 2012-02-07 EP EP18170936.1A patent/EP3415162A1/en not_active Withdrawn
- 2012-02-07 MX MX2013009062A patent/MX352025B/es active IP Right Grant
- 2012-02-07 PT PT12702990T patent/PT2672994T/pt unknown
- 2012-02-07 AU AU2012216145A patent/AU2012216145B2/en not_active Ceased
- 2012-02-07 KR KR1020197011392A patent/KR102103701B1/ko not_active Expired - Fee Related
- 2012-02-07 JP JP2013552879A patent/JP6320042B2/ja active Active
- 2012-02-07 SI SI201231356T patent/SI2672994T1/sl unknown
- 2012-02-07 CA CA2827052A patent/CA2827052C/en active Active
- 2012-02-07 MX MX2017014184A patent/MX385144B/es unknown
- 2012-02-07 PL PL12702990T patent/PL2672994T3/pl unknown
- 2012-02-07 LT LTEP12702990.8T patent/LT2672994T/lt unknown
- 2012-02-07 RS RS20180926A patent/RS57524B1/sr unknown
- 2012-02-07 SG SG2013060140A patent/SG192667A1/en unknown
-
2013
- 2013-07-29 IL IL227687A patent/IL227687B/en active IP Right Grant
- 2013-09-10 ZA ZA2013/06807A patent/ZA201306807B/en unknown
-
2016
- 2016-12-26 JP JP2016250652A patent/JP6488273B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-09 US US15/401,971 patent/US20170218070A1/en not_active Abandoned
- 2017-02-14 AU AU2017200998A patent/AU2017200998B2/en not_active Ceased
-
2019
- 2019-01-25 US US16/258,289 patent/US20190263913A1/en not_active Abandoned
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