HRP20181212T1 - Anti-alfa-v integrinsko protutijelo za liječenje raka prostate - Google Patents
Anti-alfa-v integrinsko protutijelo za liječenje raka prostateInfo
- Publication number
- HRP20181212T1 HRP20181212T1 HRP20181212TT HRP20181212T HRP20181212T1 HR P20181212 T1 HRP20181212 T1 HR P20181212T1 HR P20181212T T HRP20181212T T HR P20181212TT HR P20181212 T HRP20181212 T HR P20181212T HR P20181212 T1 HRP20181212 T1 HR P20181212T1
- Authority
- HR
- Croatia
- Prior art keywords
- prostate cancer
- cancer antibody
- alpha integrin
- integrin
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11001135 | 2011-02-11 | ||
| PCT/EP2012/000548 WO2012107211A1 (en) | 2011-02-11 | 2012-02-07 | Anti-alpha-v integrin antibody for the treatment of prostate cancer |
| EP12702990.8A EP2672994B1 (en) | 2011-02-11 | 2012-02-07 | Anti-alpha-v integrin antibody for the treatment of prostate cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20181212T1 true HRP20181212T1 (hr) | 2018-10-05 |
Family
ID=45569571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20181212TT HRP20181212T1 (hr) | 2011-02-11 | 2012-02-07 | Anti-alfa-v integrinsko protutijelo za liječenje raka prostate |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US9555110B2 (enExample) |
| EP (2) | EP3415162A1 (enExample) |
| JP (2) | JP6320042B2 (enExample) |
| KR (2) | KR101972533B1 (enExample) |
| CN (1) | CN103347540B (enExample) |
| AU (2) | AU2012216145B2 (enExample) |
| CA (1) | CA2827052C (enExample) |
| DK (1) | DK2672994T3 (enExample) |
| EA (1) | EA032117B1 (enExample) |
| ES (1) | ES2683347T3 (enExample) |
| HR (1) | HRP20181212T1 (enExample) |
| HU (1) | HUE037212T2 (enExample) |
| IL (1) | IL227687B (enExample) |
| LT (1) | LT2672994T (enExample) |
| MX (2) | MX352025B (enExample) |
| PL (1) | PL2672994T3 (enExample) |
| PT (1) | PT2672994T (enExample) |
| RS (1) | RS57524B1 (enExample) |
| SG (1) | SG192667A1 (enExample) |
| SI (1) | SI2672994T1 (enExample) |
| TR (1) | TR201810294T4 (enExample) |
| WO (1) | WO2012107211A1 (enExample) |
| ZA (1) | ZA201306807B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012107211A1 (en) | 2011-02-11 | 2012-08-16 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of prostate cancer |
| ES2897782T3 (es) * | 2014-09-17 | 2022-03-02 | Merck Patent Gmbh | Método de tratamiento de las enfermedades de la metástasis ósea, medicamentos para el tratamiento y método para predecir el resultado clínico del tratamiento de las enfermedades causadas por metástasis ósea |
| WO2016041614A1 (en) | 2014-09-17 | 2016-03-24 | Merck Patent Gmbh | A method of treating solid cancers and/or metastases thereof, medicaments therefore, and a method of predicting the clinical outcome of treating solid cancers and/or metastases thereof |
| HK1254295A1 (zh) | 2015-11-23 | 2019-07-19 | 默克专利股份有限公司 | 用於治疗纤维化和/或纤维化病症的抗-αＶ整合素抗体 |
| WO2017088974A2 (en) * | 2015-11-23 | 2017-06-01 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders |
| EP4637731A1 (en) | 2022-12-21 | 2025-10-29 | Gilead Sciences, Inc. | Combination therapy for treating cancer |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK281143B6 (sk) | 1991-03-06 | 2000-12-11 | Merck Patent Gesellschaft Mit Beschr�Nkter Haftung | Chimérická monoklonálna protilátka, expresné vektory a farmaceutický prostriedok |
| US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| DE69531187T2 (de) | 1994-12-20 | 2004-04-22 | Merck Patent Gmbh | Monoklonaler Antikörper gegen das Alpha-V-Integrin |
| DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| WO1998052976A1 (en) | 1997-05-21 | 1998-11-26 | Biovation Limited | Method for the production of non-immunogenic proteins |
| DE19842415A1 (de) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
| EP1051432B1 (en) | 1998-12-08 | 2007-01-24 | Biovation Limited | Method for reducing immunogenicity of proteins |
| US7163681B2 (en) * | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| AU2002256624B2 (en) | 2001-02-19 | 2007-12-06 | Merck Patent Gmbh | Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity |
| DE10163459A1 (de) | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
| EP1575516B1 (en) | 2002-11-26 | 2012-05-30 | Abbott Biotherapeutics Corp. | Chimeric and humanized antibodies to alpha5 beta1 integrin that modulate angiogenesis |
| US8147832B2 (en) | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
| RU2390353C2 (ru) | 2004-02-12 | 2010-05-27 | Мерк Патент Гмбх | Высококонцентрированные жидкие композиции анти-egfr антител |
| KR20060002667A (ko) | 2004-07-03 | 2006-01-09 | 삼성전자주식회사 | 디스크 댐퍼와 디스크 프로텍터를 구비한 하드 디스크드라이브 |
| US8202465B2 (en) | 2004-11-03 | 2012-06-19 | Honeywell International Inc. | Preferential curing technique in compression molding of fiber reinforced composites |
| US20070025889A1 (en) | 2005-07-28 | 2007-02-01 | Pcbu Business Services, Inc. | Reactors, reactor assemblies and production processes |
| DE102005062440B4 (de) | 2005-12-27 | 2011-02-24 | Lts Lohmann Therapie-Systeme Ag | Proteinbasiertes Trägersystem zur Resistenzüberwindung von Tumorzellen |
| EP2270050B1 (en) | 2005-12-30 | 2013-06-05 | Merck Patent GmbH | Anti-CD19 antibodies with reduced immunogenicity |
| AU2007207465B2 (en) | 2006-01-18 | 2012-12-06 | Merck Patent Gmbh | Specific therapy using integrin ligands for treating cancer |
| US8715718B2 (en) | 2006-07-14 | 2014-05-06 | Rutgers, The State University Of New Jersey | Extracellular matrix production from nanoscale substrate |
| EP2526967A1 (en) * | 2007-07-17 | 2012-11-28 | Merck Patent GmbH | Engineered anti-alpha v-integrin hybrid antibodies |
| US20110177155A1 (en) | 2007-08-21 | 2011-07-21 | Immune Disease Institute, Inc. | Methods of delivery of agents to leukocytes and endothelial cells |
| CA2747937C (en) | 2008-12-23 | 2019-02-26 | Merck Patent Gmbh | Biomarkers for inhibitors with anti-angiogenic activity |
| EA032728B1 (ru) | 2009-08-19 | 2019-07-31 | Мерк Патент Гмбх | Антитела для выявления комплексов интегрина в ffpe материале |
| AU2010318323A1 (en) | 2009-11-13 | 2012-06-28 | Merck Patent Gmbh | Anti integrin antibodies linked to nanoparticles loaded with chemotherapeutic agents |
| WO2011162933A1 (en) * | 2010-06-04 | 2011-12-29 | Immunogen, Inc. | Anti-integrin immunoconjugate dosing regimens |
| WO2012107211A1 (en) | 2011-02-11 | 2012-08-16 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of prostate cancer |
| JP6035716B2 (ja) | 2011-08-26 | 2016-11-30 | ソニー株式会社 | 情報処理システム及び情報処理方法 |
| WO2014143383A1 (en) | 2013-03-13 | 2014-09-18 | Agilent Technologies, Inc. | Transposome tethered to a gene delivery vehicle |
| CA2923145C (en) | 2013-09-05 | 2025-09-16 | Amgen Inc. | MOLECULES CONTAINING FCS AND EXHIBITING PREDICTABLE, UNIFORM AND REPRODUCIBLE GLYCOFORM PROFILES |
-
2012
- 2012-02-07 WO PCT/EP2012/000548 patent/WO2012107211A1/en not_active Ceased
- 2012-02-07 CN CN201280008336.1A patent/CN103347540B/zh not_active Expired - Fee Related
- 2012-02-07 US US13/984,669 patent/US9555110B2/en active Active
- 2012-02-07 CA CA2827052A patent/CA2827052C/en active Active
- 2012-02-07 HU HUE12702990A patent/HUE037212T2/hu unknown
- 2012-02-07 PL PL12702990T patent/PL2672994T3/pl unknown
- 2012-02-07 KR KR1020137023946A patent/KR101972533B1/ko not_active Expired - Fee Related
- 2012-02-07 PT PT12702990T patent/PT2672994T/pt unknown
- 2012-02-07 JP JP2013552879A patent/JP6320042B2/ja not_active Expired - Fee Related
- 2012-02-07 ES ES12702990.8T patent/ES2683347T3/es active Active
- 2012-02-07 EA EA201391147A patent/EA032117B1/ru not_active IP Right Cessation
- 2012-02-07 HR HRP20181212TT patent/HRP20181212T1/hr unknown
- 2012-02-07 MX MX2013009062A patent/MX352025B/es active IP Right Grant
- 2012-02-07 AU AU2012216145A patent/AU2012216145B2/en not_active Ceased
- 2012-02-07 MX MX2017014184A patent/MX385144B/es unknown
- 2012-02-07 TR TR2018/10294T patent/TR201810294T4/tr unknown
- 2012-02-07 SG SG2013060140A patent/SG192667A1/en unknown
- 2012-02-07 EP EP18170936.1A patent/EP3415162A1/en not_active Withdrawn
- 2012-02-07 RS RS20180926A patent/RS57524B1/sr unknown
- 2012-02-07 DK DK12702990.8T patent/DK2672994T3/en active
- 2012-02-07 LT LTEP12702990.8T patent/LT2672994T/lt unknown
- 2012-02-07 KR KR1020197011392A patent/KR102103701B1/ko not_active Expired - Fee Related
- 2012-02-07 SI SI201231356T patent/SI2672994T1/sl unknown
- 2012-02-07 EP EP12702990.8A patent/EP2672994B1/en active Active
-
2013
- 2013-07-29 IL IL227687A patent/IL227687B/en active IP Right Grant
- 2013-09-10 ZA ZA2013/06807A patent/ZA201306807B/en unknown
-
2016
- 2016-12-26 JP JP2016250652A patent/JP6488273B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-09 US US15/401,971 patent/US20170218070A1/en not_active Abandoned
- 2017-02-14 AU AU2017200998A patent/AU2017200998B2/en not_active Ceased
-
2019
- 2019-01-25 US US16/258,289 patent/US20190263913A1/en not_active Abandoned
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