SG165394A1 - Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification - Google Patents
Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modificationInfo
- Publication number
- SG165394A1 SG165394A1 SG201006744-5A SG2010067445A SG165394A1 SG 165394 A1 SG165394 A1 SG 165394A1 SG 2010067445 A SG2010067445 A SG 2010067445A SG 165394 A1 SG165394 A1 SG 165394A1
- Authority
- SG
- Singapore
- Prior art keywords
- sirna
- ribonucleic acid
- short interfering
- modulation
- interfering ribonucleic
- Prior art date
Links
- 238000012986 modification Methods 0.000 title abstract 3
- 230000004048 modification Effects 0.000 title abstract 3
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- 230000002452 interceptive effect Effects 0.000 title abstract 2
- 229920002477 rna polymer Polymers 0.000 title abstract 2
- 108020004459 Small interfering RNA Proteins 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 108091081021 Sense strand Proteins 0.000 abstract 1
- 230000037440 gene silencing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
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- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
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- Wood Science & Technology (AREA)
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- Communicable Diseases (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71759705P | 2005-09-16 | 2005-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG165394A1 true SG165394A1 (en) | 2010-10-28 |
Family
ID=37865319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG201006744-5A SG165394A1 (en) | 2005-09-16 | 2006-09-15 | Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090306177A1 (enExample) |
| EP (1) | EP1924692A2 (enExample) |
| JP (1) | JP2009508842A (enExample) |
| KR (1) | KR20080047463A (enExample) |
| CN (1) | CN101321868A (enExample) |
| AU (1) | AU2006290435A1 (enExample) |
| BR (1) | BRPI0616069A2 (enExample) |
| CA (1) | CA2622761A1 (enExample) |
| EA (1) | EA013375B1 (enExample) |
| IL (1) | IL190154A0 (enExample) |
| SG (1) | SG165394A1 (enExample) |
| WO (1) | WO2007031877A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| DE69932717T2 (de) | 1998-05-22 | 2007-08-09 | Ottawa Health Research Institute, Ottawa | Methoden und produkte zur induzierung mukosaler immunität |
| US7585847B2 (en) | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| CA2410371C (en) | 2000-06-22 | 2015-11-17 | University Of Iowa Research Foundation | Methods for enhancing antibody-induced cell lysis and treating cancer |
| ES2543710T3 (es) | 2002-04-04 | 2015-08-21 | Zoetis Belgium S.A. | Oligorribonucleótidos inmunoestimulantes que contienen G y U |
| US7605138B2 (en) | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7576066B2 (en) | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7569553B2 (en) | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| DK2241325T3 (da) | 2002-10-29 | 2012-04-10 | Coley Pharm Group Inc | Anvendelse af CPG-oligonukleotider til behandling af Hepatitis Cvirusinfektion |
| AU2003300919A1 (en) | 2002-12-11 | 2004-06-30 | Coley Pharmaceutical Gmbh | 5' cpg nucleic acids and methods of use |
| BRPI0411514A (pt) * | 2003-06-20 | 2006-08-01 | Coley Pharm Gmbh | antagonistas de receptor toll-like de molécula pequena |
| EA008741B1 (ru) | 2003-10-30 | 2007-08-31 | Коли Фармасьютикал Гмбх | Аналоги олигонуклеотидов с-класса с улучшенной иммуностимулирующей эффективностью |
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- 2006-09-15 JP JP2008530660A patent/JP2009508842A/ja active Pending
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- 2006-09-15 EA EA200800838A patent/EA013375B1/ru not_active IP Right Cessation
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| EP1924692A2 (en) | 2008-05-28 |
| JP2009508842A (ja) | 2009-03-05 |
| EA013375B1 (ru) | 2010-04-30 |
| CN101321868A (zh) | 2008-12-10 |
| CA2622761A1 (en) | 2007-03-22 |
| WO2007031877A3 (en) | 2007-08-30 |
| BRPI0616069A2 (pt) | 2011-06-07 |
| US20090306177A1 (en) | 2009-12-10 |
| EA200800838A1 (ru) | 2008-08-29 |
| IL190154A0 (en) | 2008-08-07 |
| AU2006290435A1 (en) | 2007-03-22 |
| KR20080047463A (ko) | 2008-05-28 |
| WO2007031877A2 (en) | 2007-03-22 |
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