CN101321868A - 通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性 - Google Patents

通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性 Download PDF

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Publication number
CN101321868A
CN101321868A CNA2006800429468A CN200680042946A CN101321868A CN 101321868 A CN101321868 A CN 101321868A CN A2006800429468 A CNA2006800429468 A CN A2006800429468A CN 200680042946 A CN200680042946 A CN 200680042946A CN 101321868 A CN101321868 A CN 101321868A
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China
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sense strand
modified
nucleotide
sugar
sirna
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CNA2006800429468A
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Chinese (zh)
Inventor
E·尤尔曼
M·朱尔克
J·沃尔莫
C·舍特
M·韦伯
I·安迪奥
S·皮施
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Qiagen GmbH
Coley Pharmaceutical GmbH
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Qiagen GmbH
Coley Pharmaceutical GmbH
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CNA2006800429468A 2005-09-16 2006-09-15 通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性 Pending CN101321868A (zh)

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US71759705P 2005-09-16 2005-09-16
US60/717,597 2005-09-16

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CN101321868A true CN101321868A (zh) 2008-12-10

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CNA2006800429468A Pending CN101321868A (zh) 2005-09-16 2006-09-15 通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性

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US (1) US20090306177A1 (enExample)
EP (1) EP1924692A2 (enExample)
JP (1) JP2009508842A (enExample)
KR (1) KR20080047463A (enExample)
CN (1) CN101321868A (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108977446A (zh) * 2011-11-18 2018-12-11 阿尔尼拉姆医药品有限公司 修饰的RNAi试剂
CN114945669A (zh) * 2019-11-06 2022-08-26 阿尔尼拉姆医药品有限公司 肝外递送

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US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
ES2272069T3 (es) 1998-05-22 2007-04-16 Ottawa Health Research Institute Metodos y productos para inducir inmunidad en mucosas.
US7585847B2 (en) 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
ATE440618T1 (de) 2000-06-22 2009-09-15 Univ Iowa Res Found Kombination von cpg und antikírpern gegen cd19, cd20,cd22 oder cd40 zur prävention oder behandlung von krebs.
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US20090306177A1 (en) 2009-12-10
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