CA2622761A1 - Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification - Google Patents

Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification Download PDF

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Publication number
CA2622761A1
CA2622761A1 CA002622761A CA2622761A CA2622761A1 CA 2622761 A1 CA2622761 A1 CA 2622761A1 CA 002622761 A CA002622761 A CA 002622761A CA 2622761 A CA2622761 A CA 2622761A CA 2622761 A1 CA2622761 A1 CA 2622761A1
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Canada
Prior art keywords
modification
sense strand
sugar
sirna
modified nucleotide
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Abandoned
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CA002622761A
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English (en)
French (fr)
Inventor
Eugen Uhlmann
Marion Jurk
Jorg Vollmer
Christian Schetter
Martin Weber
Ioanna Andreou
Stefan Pitsch
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Qiagen GmbH
Coley Pharmaceutical GmbH
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Individual
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Publication of CA2622761A1 publication Critical patent/CA2622761A1/en
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CA002622761A 2005-09-16 2006-09-15 Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification Abandoned CA2622761A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71759705P 2005-09-16 2005-09-16
US60/717,597 2005-09-16
PCT/IB2006/003356 WO2007031877A2 (en) 2005-09-16 2006-09-15 Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification

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CA2622761A1 true CA2622761A1 (en) 2007-03-22

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CA002622761A Abandoned CA2622761A1 (en) 2005-09-16 2006-09-15 Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification

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US (1) US20090306177A1 (enExample)
EP (1) EP1924692A2 (enExample)
JP (1) JP2009508842A (enExample)
KR (1) KR20080047463A (enExample)
CN (1) CN101321868A (enExample)
AU (1) AU2006290435A1 (enExample)
BR (1) BRPI0616069A2 (enExample)
CA (1) CA2622761A1 (enExample)
EA (1) EA013375B1 (enExample)
IL (1) IL190154A0 (enExample)
SG (1) SG165394A1 (enExample)
WO (1) WO2007031877A2 (enExample)

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US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
IL139813A0 (en) 1998-05-22 2002-02-10 Loeb Health Res Inst At The Ot Methods and products for inducing mucosal immunity
US7585847B2 (en) 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
DE60139689D1 (de) 2000-06-22 2009-10-08 Univ Iowa Res Found Kombination von CpG und Antikörpern gegen CD19,CD20,CD22 oder CD40 zur Prävention oder Behandlung von Krebs.
ES2734652T3 (es) 2002-04-04 2019-12-11 Zoetis Belgium S A Oligorribonucleótidos inmunoestimulantes que contienen G y U
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
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