SG149880A1 - Novel inhibitors of chymase - Google Patents

Novel inhibitors of chymase

Info

Publication number
SG149880A1
SG149880A1 SG200900530-7A SG2009005307A SG149880A1 SG 149880 A1 SG149880 A1 SG 149880A1 SG 2009005307 A SG2009005307 A SG 2009005307A SG 149880 A1 SG149880 A1 SG 149880A1
Authority
SG
Singapore
Prior art keywords
chymase
novel inhibitors
methods
intermediates
derivatives
Prior art date
Application number
SG200900530-7A
Other languages
English (en)
Inventor
Michael J Hawkins
Michael N Greco
Eugene Powell
Bruce E Maryanoff
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG149880A1 publication Critical patent/SG149880A1/en

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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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SG200900530-7A 2004-01-23 2005-01-18 Novel inhibitors of chymase SG149880A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53866304P 2004-01-23 2004-01-23

Publications (1)

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SG149880A1 true SG149880A1 (en) 2009-02-27

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SG200900530-7A SG149880A1 (en) 2004-01-23 2005-01-18 Novel inhibitors of chymase

Country Status (24)

Country Link
US (2) US7459444B2 (ja)
EP (1) EP1716160B1 (ja)
JP (1) JP5022711B2 (ja)
KR (1) KR101182143B1 (ja)
CN (2) CN101863923B (ja)
AR (1) AR047448A1 (ja)
AT (1) ATE493421T1 (ja)
AU (1) AU2005207856B2 (ja)
BR (1) BRPI0507052A (ja)
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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100048513A1 (en) 2008-08-20 2010-02-25 Hawkins Michael J Novel inhibitors of chymase
WO2006059801A1 (ja) 2004-12-02 2006-06-08 Asubio Pharma Co., Ltd. ７員環化合物並びにその製造法および医薬用途
MX2008009105A (es) * 2006-01-12 2008-09-26 Janssen Pharmaceutica Nv Procesamiento del inhibidor de proteasa de leucocitos de secrecion (slpi) por quimasa.
US8629281B2 (en) 2011-01-14 2014-01-14 Janssen Pharmaceutica, Nv Cold menthol receptor-1 antagonists
JP5404388B2 (ja) * 2006-05-10 2014-01-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 冷メントール受容体−１拮抗薬
MX2008015196A (es) 2006-05-31 2008-12-15 Asubio Pharma Co Ltd Compuesto de anillo de 7 miembros, proceso para producir el mismo, y su uso medico.
US8193214B2 (en) 2006-10-06 2012-06-05 Boehringer Ingelheim International Gmbh Chymase inhibitors
US7872044B2 (en) 2006-10-18 2011-01-18 Janssen Pharmaceutica Nv Inhibitors of chymase
PE20081463A1 (es) * 2006-10-20 2008-10-18 Janssen Pharmaceutica Nv Formas salinas de compuestos de benzotienilo sustituido
US20080287398A1 (en) * 2007-05-02 2008-11-20 Colburn Raymond W Cold menthol receptor-1 antagonists
KR20100090686A (ko) * 2007-10-16 2010-08-16 얀센 파마슈티카 엔.브이. 포스폰산 및 포스핀산 화합물의 합성 방법
WO2009102384A2 (en) * 2007-12-21 2009-08-20 Molecular Insight Pharmaceuticals, Inc. Radiolabeled derivatives of potent chymase inhibitors
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
US8263785B2 (en) 2008-10-29 2012-09-11 Janssen Pharmaceutica N.V. Process for the preparation of chymase modulators
JP5587914B2 (ja) 2009-01-30 2014-09-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング キマーゼ阻害剤として有用なアザキナゾリンジオン
JP5690286B2 (ja) * 2009-03-04 2015-03-25 イデニク プハルマセウティカルス，インコーポレイテッド ホスホチオフェン及びホスホチアゾールｈｃｖポリメラーゼ阻害剤
TWI501962B (zh) 2009-12-25 2015-10-01 Daiichi Sankyo Co Ltd 7-membered ring compounds and their pharmaceutical use
US8558011B2 (en) 2010-08-31 2013-10-15 Janssen Pharmaceutica, Nv Cold menthol receptor-1 antagonists
CN106467515B (zh) * 2015-08-18 2019-09-24 宁波洞密生物科技有限公司 一类6-吡啶苯并咪唑吲哚衍生物及其制备方法与医药领域的应用
CN107573263B (zh) * 2017-08-14 2020-04-07 大连理工大学 一种ω-取代缩二脲类化合物的合成方法
CN108383875B (zh) * 2018-03-22 2020-04-28 昆明学院 一种银催化的3-膦酰甲基吲哚啉及制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399089A (en) 1971-05-14 1975-06-25 Glaxo Lab Ltd Carboxylic acids and derivatives thereof
FR2713637B1 (fr) 1993-12-15 1996-01-05 Cird Galderma Nouveaux composés bi-aromatiques dérivés d'amide, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US5508273A (en) * 1993-12-30 1996-04-16 Ortho Pharmaceutical Corporation Substituted phosphonic acids and derivatives useful in treating bone wasting diseases
JP4009460B2 (ja) * 2000-03-14 2007-11-14 アクテリオン ファマシューティカルズ リミテッド １，２，３，４−テトラヒドロイソキノリン誘導体
US6852734B2 (en) * 2000-05-02 2005-02-08 Meiji Seika Kaisha, Ltd. Indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof

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MXPA06008375A (es) 2007-03-21
AU2005207856A1 (en) 2005-08-11
AU2005207856B2 (en) 2011-07-14
JP2007518807A (ja) 2007-07-12
EP1716160B1 (en) 2010-12-29
KR101182143B1 (ko) 2012-09-13
US20050176769A1 (en) 2005-08-11
NO20063647L (no) 2006-10-19
HK1148753A1 (en) 2011-09-16
ATE493421T1 (de) 2011-01-15
AR047448A1 (es) 2006-01-18
IL177037A (en) 2013-05-30
KR20060129401A (ko) 2006-12-15
EP1716160A2 (en) 2006-11-02
ZA200607024B (en) 2010-02-24
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CR8563A (es) 2009-01-14
IL177037A0 (en) 2006-12-10
CN101863923A (zh) 2010-10-20
CA2554205C (en) 2013-08-27
CA2554205A1 (en) 2005-08-11
WO2005073214A3 (en) 2005-10-20
ECSP066721A (es) 2006-10-31
CN1934120A (zh) 2007-03-21
US7459444B2 (en) 2008-12-02
CN1934120B (zh) 2010-05-26
EA200601358A1 (ru) 2007-02-27
EA011745B1 (ru) 2009-06-30
ES2357013T3 (es) 2011-04-15
US20090036409A1 (en) 2009-02-05
BRPI0507052A (pt) 2007-06-12
DE602005025600D1 (de) 2011-02-10
TW200539881A (en) 2005-12-16
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WO2005073214A2 (en) 2005-08-11

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