ZA200607024B - Novel inhibitors of chymase - Google Patents
Novel inhibitors of chymaseInfo
- Publication number
- ZA200607024B ZA200607024B ZA200607024A ZA200607024A ZA200607024B ZA 200607024 B ZA200607024 B ZA 200607024B ZA 200607024 A ZA200607024 A ZA 200607024A ZA 200607024 A ZA200607024 A ZA 200607024A ZA 200607024 B ZA200607024 B ZA 200607024B
- Authority
- ZA
- South Africa
- Prior art keywords
- chymase
- novel inhibitors
- inhibitors
- novel
- Prior art date
Links
- 102000003858 Chymases Human genes 0.000 title 1
- 108090000227 Chymases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
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- Cardiology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53866304P | 2004-01-23 | 2004-01-23 |
Publications (1)
Publication Number | Publication Date |
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ZA200607024B true ZA200607024B (en) | 2010-02-24 |
Family
ID=34826001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200607024A ZA200607024B (en) | 2004-01-23 | 2006-08-22 | Novel inhibitors of chymase |
Country Status (24)
Country | Link |
---|---|
US (2) | US7459444B2 (ja) |
EP (1) | EP1716160B1 (ja) |
JP (1) | JP5022711B2 (ja) |
KR (1) | KR101182143B1 (ja) |
CN (2) | CN101863923B (ja) |
AR (1) | AR047448A1 (ja) |
AT (1) | ATE493421T1 (ja) |
AU (1) | AU2005207856B2 (ja) |
BR (1) | BRPI0507052A (ja) |
CA (1) | CA2554205C (ja) |
CR (1) | CR8563A (ja) |
DE (1) | DE602005025600D1 (ja) |
EA (1) | EA011745B1 (ja) |
EC (1) | ECSP066721A (ja) |
ES (1) | ES2357013T3 (ja) |
HK (1) | HK1148753A1 (ja) |
IL (1) | IL177037A (ja) |
MX (1) | MXPA06008375A (ja) |
NO (1) | NO20063647L (ja) |
NZ (1) | NZ548684A (ja) |
SG (1) | SG149880A1 (ja) |
TW (1) | TW200539881A (ja) |
WO (1) | WO2005073214A2 (ja) |
ZA (1) | ZA200607024B (ja) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100048513A1 (en) | 2008-08-20 | 2010-02-25 | Hawkins Michael J | Novel inhibitors of chymase |
WO2006059801A1 (ja) | 2004-12-02 | 2006-06-08 | Asubio Pharma Co., Ltd. | 7員環化合物並びにその製造法および医薬用途 |
MX2008009105A (es) * | 2006-01-12 | 2008-09-26 | Janssen Pharmaceutica Nv | Procesamiento del inhibidor de proteasa de leucocitos de secrecion (slpi) por quimasa. |
US8629281B2 (en) | 2011-01-14 | 2014-01-14 | Janssen Pharmaceutica, Nv | Cold menthol receptor-1 antagonists |
JP5404388B2 (ja) * | 2006-05-10 | 2014-01-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 冷メントール受容体−1拮抗薬 |
MX2008015196A (es) | 2006-05-31 | 2008-12-15 | Asubio Pharma Co Ltd | Compuesto de anillo de 7 miembros, proceso para producir el mismo, y su uso medico. |
US8193214B2 (en) | 2006-10-06 | 2012-06-05 | Boehringer Ingelheim International Gmbh | Chymase inhibitors |
US7872044B2 (en) | 2006-10-18 | 2011-01-18 | Janssen Pharmaceutica Nv | Inhibitors of chymase |
PE20081463A1 (es) * | 2006-10-20 | 2008-10-18 | Janssen Pharmaceutica Nv | Formas salinas de compuestos de benzotienilo sustituido |
US20080287398A1 (en) * | 2007-05-02 | 2008-11-20 | Colburn Raymond W | Cold menthol receptor-1 antagonists |
KR20100090686A (ko) * | 2007-10-16 | 2010-08-16 | 얀센 파마슈티카 엔.브이. | 포스폰산 및 포스핀산 화합물의 합성 방법 |
WO2009102384A2 (en) * | 2007-12-21 | 2009-08-20 | Molecular Insight Pharmaceuticals, Inc. | Radiolabeled derivatives of potent chymase inhibitors |
FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
US8263785B2 (en) | 2008-10-29 | 2012-09-11 | Janssen Pharmaceutica N.V. | Process for the preparation of chymase modulators |
JP5587914B2 (ja) | 2009-01-30 | 2014-09-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キマーゼ阻害剤として有用なアザキナゾリンジオン |
JP5690286B2 (ja) * | 2009-03-04 | 2015-03-25 | イデニク プハルマセウティカルス,インコーポレイテッド | ホスホチオフェン及びホスホチアゾールhcvポリメラーゼ阻害剤 |
TWI501962B (zh) | 2009-12-25 | 2015-10-01 | Daiichi Sankyo Co Ltd | 7-membered ring compounds and their pharmaceutical use |
US8558011B2 (en) | 2010-08-31 | 2013-10-15 | Janssen Pharmaceutica, Nv | Cold menthol receptor-1 antagonists |
CN106467515B (zh) * | 2015-08-18 | 2019-09-24 | 宁波洞密生物科技有限公司 | 一类6-吡啶苯并咪唑吲哚衍生物及其制备方法与医药领域的应用 |
CN107573263B (zh) * | 2017-08-14 | 2020-04-07 | 大连理工大学 | 一种ω-取代缩二脲类化合物的合成方法 |
CN108383875B (zh) * | 2018-03-22 | 2020-04-28 | 昆明学院 | 一种银催化的3-膦酰甲基吲哚啉及制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1399089A (en) | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Carboxylic acids and derivatives thereof |
FR2713637B1 (fr) | 1993-12-15 | 1996-01-05 | Cird Galderma | Nouveaux composés bi-aromatiques dérivés d'amide, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
US5508273A (en) * | 1993-12-30 | 1996-04-16 | Ortho Pharmaceutical Corporation | Substituted phosphonic acids and derivatives useful in treating bone wasting diseases |
JP4009460B2 (ja) * | 2000-03-14 | 2007-11-14 | アクテリオン ファマシューティカルズ リミテッド | 1,2,3,4−テトラヒドロイソキノリン誘導体 |
US6852734B2 (en) * | 2000-05-02 | 2005-02-08 | Meiji Seika Kaisha, Ltd. | Indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof |
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2005
- 2005-01-18 DE DE602005025600T patent/DE602005025600D1/de active Active
- 2005-01-18 SG SG200900530-7A patent/SG149880A1/en unknown
- 2005-01-18 CN CN2010101356941A patent/CN101863923B/zh not_active Expired - Fee Related
- 2005-01-18 BR BRPI0507052-0A patent/BRPI0507052A/pt not_active IP Right Cessation
- 2005-01-18 MX MXPA06008375A patent/MXPA06008375A/es unknown
- 2005-01-18 ES ES05711644T patent/ES2357013T3/es active Active
- 2005-01-18 KR KR1020067016876A patent/KR101182143B1/ko not_active IP Right Cessation
- 2005-01-18 AT AT05711644T patent/ATE493421T1/de not_active IP Right Cessation
- 2005-01-18 CN CN2005800088933A patent/CN1934120B/zh not_active Expired - Fee Related
- 2005-01-18 EP EP05711644A patent/EP1716160B1/en active Active
- 2005-01-18 AU AU2005207856A patent/AU2005207856B2/en not_active Ceased
- 2005-01-18 NZ NZ548684A patent/NZ548684A/en unknown
- 2005-01-18 EA EA200601358A patent/EA011745B1/ru not_active IP Right Cessation
- 2005-01-18 WO PCT/US2005/001659 patent/WO2005073214A2/en active Application Filing
- 2005-01-18 JP JP2006551228A patent/JP5022711B2/ja not_active Expired - Fee Related
- 2005-01-18 US US11/037,938 patent/US7459444B2/en not_active Expired - Fee Related
- 2005-01-18 CA CA2554205A patent/CA2554205C/en not_active Expired - Fee Related
- 2005-01-21 AR ARP050100230A patent/AR047448A1/es not_active Application Discontinuation
- 2005-01-24 TW TW094101958A patent/TW200539881A/zh unknown
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2006
- 2006-07-21 EC EC2006006721A patent/ECSP066721A/es unknown
- 2006-07-23 IL IL177037A patent/IL177037A/en not_active IP Right Cessation
- 2006-08-11 NO NO20063647A patent/NO20063647L/no not_active Application Discontinuation
- 2006-08-14 CR CR8563A patent/CR8563A/es unknown
- 2006-08-22 ZA ZA200607024A patent/ZA200607024B/xx unknown
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2008
- 2008-08-20 US US12/229,077 patent/US20090036409A1/en not_active Abandoned
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2011
- 2011-03-23 HK HK11102953.8A patent/HK1148753A1/xx not_active IP Right Cessation
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