BRPI0507052A - inibidores de quìnase - Google Patents
inibidores de quìnaseInfo
- Publication number
- BRPI0507052A BRPI0507052A BRPI0507052-0A BRPI0507052A BRPI0507052A BR PI0507052 A BRPI0507052 A BR PI0507052A BR PI0507052 A BRPI0507052 A BR PI0507052A BR PI0507052 A BRPI0507052 A BR PI0507052A
- Authority
- BR
- Brazil
- Prior art keywords
- kinase inhibitors
- intermediates
- derivatives
- compositions
- compounds
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
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- C—CHEMISTRY; METALLURGY
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
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- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/59—Hydrogenated pyridine rings
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- C07F9/60—Quinoline or hydrogenated quinoline ring systems
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/62—Isoquinoline or hydrogenated isoquinoline ring systems
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- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
- C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
INIBIDORES DE QUìNASE. A presente invenção refere-se a um composto da fórmula (I): a métodos para o preparo desses compostos, composições, intermediários e derivados dos mesmos e a método para o tratamento de distúrbios inflamatórios e mediados por protease de serina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53866304P | 2004-01-23 | 2004-01-23 | |
PCT/US2005/001659 WO2005073214A2 (en) | 2004-01-23 | 2005-01-18 | Novel inhibitors of chymase |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0507052A true BRPI0507052A (pt) | 2007-06-12 |
Family
ID=34826001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507052-0A BRPI0507052A (pt) | 2004-01-23 | 2005-01-18 | inibidores de quìnase |
Country Status (24)
Country | Link |
---|---|
US (2) | US7459444B2 (pt) |
EP (1) | EP1716160B1 (pt) |
JP (1) | JP5022711B2 (pt) |
KR (1) | KR101182143B1 (pt) |
CN (2) | CN1934120B (pt) |
AR (1) | AR047448A1 (pt) |
AT (1) | ATE493421T1 (pt) |
AU (1) | AU2005207856B2 (pt) |
BR (1) | BRPI0507052A (pt) |
CA (1) | CA2554205C (pt) |
CR (1) | CR8563A (pt) |
DE (1) | DE602005025600D1 (pt) |
EA (1) | EA011745B1 (pt) |
EC (1) | ECSP066721A (pt) |
ES (1) | ES2357013T3 (pt) |
HK (1) | HK1148753A1 (pt) |
IL (1) | IL177037A (pt) |
MX (1) | MXPA06008375A (pt) |
NO (1) | NO20063647L (pt) |
NZ (1) | NZ548684A (pt) |
SG (1) | SG149880A1 (pt) |
TW (1) | TW200539881A (pt) |
WO (1) | WO2005073214A2 (pt) |
ZA (1) | ZA200607024B (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US20100048513A1 (en) | 2008-08-20 | 2010-02-25 | Hawkins Michael J | Novel inhibitors of chymase |
AU2005310490B2 (en) | 2004-12-02 | 2012-01-19 | Daiichi Sankyo Company, Limited | 7-membered ring compound, process for producing the same, and medicinal use thereof |
KR20080085093A (ko) * | 2006-01-12 | 2008-09-22 | 얀센 파마슈티카 엔.브이. | 키마아제에 의한 slpi의 프로세싱 |
WO2007134107A2 (en) | 2006-05-10 | 2007-11-22 | Janssen Pharmaceutica N.V. | Cold menthol receptor-1 antagonists |
US8629281B2 (en) | 2011-01-14 | 2014-01-14 | Janssen Pharmaceutica, Nv | Cold menthol receptor-1 antagonists |
CN101495463B (zh) | 2006-05-31 | 2012-08-15 | 第一三共株式会社 | 7-元环化合物、其制备方法和药物用途 |
JP4986249B2 (ja) * | 2006-10-06 | 2012-07-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チマーゼ阻害剤 |
US7872044B2 (en) * | 2006-10-18 | 2011-01-18 | Janssen Pharmaceutica Nv | Inhibitors of chymase |
PE20081463A1 (es) * | 2006-10-20 | 2008-10-18 | Janssen Pharmaceutica Nv | Formas salinas de compuestos de benzotienilo sustituido |
US20080287398A1 (en) * | 2007-05-02 | 2008-11-20 | Colburn Raymond W | Cold menthol receptor-1 antagonists |
TW200932752A (en) * | 2007-10-16 | 2009-08-01 | Janssen Pharmaceutica Nv | Process for synthesizing phosphonic and phosphinic acid compounds |
US20090169475A1 (en) * | 2007-12-21 | 2009-07-02 | Molecular Insight Pharmaceuticals, Inc. | Radiolabeled derivatives of potent chymase inhibitors |
FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
WO2010051372A1 (en) * | 2008-10-29 | 2010-05-06 | Janssen Pharmaceutica Nv | Process for the preparation of chymase modulators |
JP5587914B2 (ja) | 2009-01-30 | 2014-09-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キマーゼ阻害剤として有用なアザキナゾリンジオン |
US8193372B2 (en) * | 2009-03-04 | 2012-06-05 | Idenix Pharmaceuticals, Inc. | Phosphothiophene and phosphothiazole HCV polymerase inhibitors |
NZ600748A (en) * | 2009-12-25 | 2014-06-27 | Daiichi Sankyo Co Ltd | Seven-membered ring compound and pharmaceutical use therefor |
US8558011B2 (en) | 2010-08-31 | 2013-10-15 | Janssen Pharmaceutica, Nv | Cold menthol receptor-1 antagonists |
CN106467515B (zh) * | 2015-08-18 | 2019-09-24 | 宁波洞密生物科技有限公司 | 一类6-吡啶苯并咪唑吲哚衍生物及其制备方法与医药领域的应用 |
CN107573263B (zh) * | 2017-08-14 | 2020-04-07 | 大连理工大学 | 一种ω-取代缩二脲类化合物的合成方法 |
CN108383875B (zh) * | 2018-03-22 | 2020-04-28 | 昆明学院 | 一种银催化的3-膦酰甲基吲哚啉及制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1399089A (en) | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Carboxylic acids and derivatives thereof |
FR2713637B1 (fr) * | 1993-12-15 | 1996-01-05 | Cird Galderma | Nouveaux composés bi-aromatiques dérivés d'amide, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
US5508273A (en) * | 1993-12-30 | 1996-04-16 | Ortho Pharmaceutical Corporation | Substituted phosphonic acids and derivatives useful in treating bone wasting diseases |
PT1274687E (pt) * | 2000-03-14 | 2005-04-29 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetra-hidroisoquinolina |
US6852734B2 (en) * | 2000-05-02 | 2005-02-08 | Meiji Seika Kaisha, Ltd. | Indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof |
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2005
- 2005-01-18 WO PCT/US2005/001659 patent/WO2005073214A2/en active Application Filing
- 2005-01-18 ES ES05711644T patent/ES2357013T3/es active Active
- 2005-01-18 MX MXPA06008375A patent/MXPA06008375A/es unknown
- 2005-01-18 EP EP05711644A patent/EP1716160B1/en active Active
- 2005-01-18 KR KR1020067016876A patent/KR101182143B1/ko not_active IP Right Cessation
- 2005-01-18 BR BRPI0507052-0A patent/BRPI0507052A/pt not_active IP Right Cessation
- 2005-01-18 DE DE602005025600T patent/DE602005025600D1/de active Active
- 2005-01-18 AT AT05711644T patent/ATE493421T1/de not_active IP Right Cessation
- 2005-01-18 NZ NZ548684A patent/NZ548684A/en unknown
- 2005-01-18 AU AU2005207856A patent/AU2005207856B2/en not_active Ceased
- 2005-01-18 EA EA200601358A patent/EA011745B1/ru not_active IP Right Cessation
- 2005-01-18 US US11/037,938 patent/US7459444B2/en not_active Expired - Fee Related
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- 2005-01-18 CN CN2005800088933A patent/CN1934120B/zh not_active Expired - Fee Related
- 2005-01-18 CA CA2554205A patent/CA2554205C/en not_active Expired - Fee Related
- 2005-01-18 JP JP2006551228A patent/JP5022711B2/ja not_active Expired - Fee Related
- 2005-01-18 CN CN2010101356941A patent/CN101863923B/zh not_active Expired - Fee Related
- 2005-01-21 AR ARP050100230A patent/AR047448A1/es not_active Application Discontinuation
- 2005-01-24 TW TW094101958A patent/TW200539881A/zh unknown
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2006
- 2006-07-21 EC EC2006006721A patent/ECSP066721A/es unknown
- 2006-07-23 IL IL177037A patent/IL177037A/en not_active IP Right Cessation
- 2006-08-11 NO NO20063647A patent/NO20063647L/no not_active Application Discontinuation
- 2006-08-14 CR CR8563A patent/CR8563A/es unknown
- 2006-08-22 ZA ZA200607024A patent/ZA200607024B/xx unknown
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2008
- 2008-08-20 US US12/229,077 patent/US20090036409A1/en not_active Abandoned
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2011
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