SG145724A1 - Recombinant lubricin molecules and uses thereof - Google Patents

Recombinant lubricin molecules and uses thereof

Info

Publication number
SG145724A1
SG145724A1 SG200805896-8A SG2008058968A SG145724A1 SG 145724 A1 SG145724 A1 SG 145724A1 SG 2008058968 A SG2008058968 A SG 2008058968A SG 145724 A1 SG145724 A1 SG 145724A1
Authority
SG
Singapore
Prior art keywords
recombinant lubricin
lubricin molecules
molecules
recombinant
pleura
Prior art date
Application number
SG200805896-8A
Other languages
English (en)
Inventor
Carl Ralph Flannery
Christopher John Corcoran
Bethany Annis Freeman
Lisa Anne Racie
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of SG145724A1 publication Critical patent/SG145724A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
SG200805896-8A 2003-08-14 2004-08-13 Recombinant lubricin molecules and uses thereof SG145724A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49574103P 2003-08-14 2003-08-14

Publications (1)

Publication Number Publication Date
SG145724A1 true SG145724A1 (en) 2008-09-29

Family

ID=34193342

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200805896-8A SG145724A1 (en) 2003-08-14 2004-08-13 Recombinant lubricin molecules and uses thereof

Country Status (21)

Country Link
US (6) US7642236B2 (da)
EP (1) EP1663291B1 (da)
JP (1) JP2007502122A (da)
KR (1) KR101078202B1 (da)
CN (2) CN102924584A (da)
AU (2) AU2004264970B2 (da)
BR (1) BRPI0413553A (da)
CR (1) CR8204A (da)
DK (1) DK1663291T3 (da)
EC (1) ECSP066364A (da)
ES (1) ES2388970T3 (da)
HK (1) HK1089110A1 (da)
IL (2) IL173258A (da)
MX (1) MXPA06001658A (da)
NO (1) NO20060475L (da)
NZ (1) NZ545021A (da)
RU (2) RU2376313C2 (da)
SG (1) SG145724A1 (da)
UA (1) UA91818C2 (da)
WO (1) WO2005016130A2 (da)
ZA (1) ZA200601291B (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743774B1 (en) * 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
WO2006012492A2 (en) * 2004-07-23 2006-02-02 Mucosal Therapeutics Llc Compositions and methods for viscosupplementation
US20090068247A1 (en) * 2007-09-12 2009-03-12 Mucosal Therapeutics Biocompatible devices coated with a tribonectin and methods for their production
US20090104148A1 (en) * 2007-09-18 2009-04-23 Jay Gregory D Treatment and prevention of joint disease
SI2285364T1 (sl) 2008-05-07 2015-03-31 The Regents Of The University Of California Terapevtska regeneracija in obogatitev lubrikacije okularne površine
US8506944B2 (en) * 2008-05-07 2013-08-13 The Regents Of The University Of California Replenishment and enrichment of ocular surface lubrication
CA2749480C (en) * 2009-01-13 2015-03-31 Singularis, Inc. Therapeutic modulation of vaginal epithelium boundary lubrication
CA2762989C (en) 2009-05-22 2021-04-13 Benjamin Sullivan Prg4 for treatment of oral cavity boundary lubrication disorders
ES2627103T3 (es) 2010-01-19 2017-07-26 Lubris Llc Composiciones de cuidado bucal y métodos
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
US20130116186A1 (en) * 2011-10-04 2013-05-09 Rhode Island Hospital, A Lifespan Partner Lubricin injections to maintain cartilage health
PL2948553T3 (pl) 2013-01-25 2020-11-16 Baylor College Of Medicine Adenowirusowy system dostarczania i ekspresji terapii genowej zależny od pomocnika
US20150010606A1 (en) * 2013-07-08 2015-01-08 Arthrex, Inc. Intra-articular injection and implant attachment of molecule consisting of lubricin and extracellular superoxide dismutase or hyaluronic acid and extracellular superoxide dismutase
EP3057451A4 (en) * 2013-10-16 2017-06-21 Ensisheim Partners LLC Protein-specific formulations
WO2015060935A1 (en) * 2013-10-22 2015-04-30 Lubris, Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
ES2913061T3 (es) 2013-11-26 2022-05-31 Lubris Llc Composiciones y métodos para inhibir las interacciones intercelulares
MA53108A (fr) 2015-01-26 2021-05-12 Lubris Llc Utilisation de prg4 comme agent anti-inflammatoire
US20170198263A1 (en) 2016-01-13 2017-07-13 Merial Inc. Recombinant AAV Vectors Expressing Osteoprotective genes, including HAS2 and Lubricin, useful in the Treatment of Osteoarthritis and Related Joint Conditions in Mammals
EP3408397B1 (en) 2016-01-27 2020-07-15 Just-Evotec Biologics, Inc. Hybrid promoter and uses thereof
KR20210024015A (ko) * 2018-06-21 2021-03-04 루브리스 엘엘씨 상처 치유에 사용하기 위한 루브리신
WO2020150390A1 (en) * 2019-01-15 2020-07-23 Cornell University Recombinant mucins, and compositions and methods for using the same
BR112022016481A2 (pt) * 2020-02-24 2022-10-25 Novartis Ag Purificação de polipeptídeos recombinantemente produzidos
IT202000022636A1 (it) 2020-09-25 2022-03-25 Ente Ospedaliero Specializzato In Gastroenterologia Istituto Nazionale Di Ricovero E Cura A Caratter “terapia di combinazione di sorafenib e/o regorafenib con la proteina ricombinante umana proteoglicano-4 per il trattamento dell'epatocarcinoma”

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US2734862A (en) * 1956-02-14 Synthetic casein fiber elastic grease
US2487377A (en) * 1948-04-17 1949-11-08 Socony Vacuum Oil Co Inc Lubricant
US2878184A (en) * 1953-12-29 1959-03-17 Rockwell Mfg Co Hydrocarbon resistant glycerol base lubricant
AR207237A1 (es) * 1974-02-25 1976-09-22 Thomas A Procedimiento para obtener extractos biologicos estables liofilizados solubles constituidos por complejos proteicos termorresistentes
JPS57500562A (da) * 1980-04-25 1982-04-01
US5403592A (en) * 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
GB8803697D0 (en) * 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5260417A (en) * 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
US5326558A (en) * 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
US6433142B1 (en) 1989-08-08 2002-08-13 Genetics Institute, Llc Megakaryocyte stimulating factors
AU652022B2 (en) * 1991-02-12 1994-08-11 C.R. Bard Inc. Injectable medical device
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
CN1107891A (zh) * 1994-03-04 1995-09-06 上海贝特生物技术有限公司 人促巨核细胞生成素及其分离纯化和基因克隆方法及应用
US5515590A (en) * 1994-07-19 1996-05-14 University Of Kentucky Research Foundation Method for reducing the generation of wear particulates from an implant
US5709020A (en) * 1994-07-19 1998-01-20 University Of Kentucky Research Foundation Method for reducing the generation of wear particulates from an implant
US5510122A (en) * 1994-09-28 1996-04-23 The Research Foundation Of State University Of New York Preparation and use of whole saliva
US6960562B2 (en) * 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
US6743774B1 (en) * 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
US7001881B1 (en) * 1999-04-23 2006-02-21 Rhode Island Hospital Tribonectins
WO2001007068A1 (en) 1999-07-23 2001-02-01 Case Western Reserve University Novel methods and reagents for the treatment of osteoarthritis
WO2002062847A2 (en) 2000-12-29 2002-08-15 Glaxo Group Limited Superficial zone protein and methods of making and using same
EP1440981A3 (en) 2003-01-21 2005-11-23 Research Association for Biotechnology Full-length human cdna

Also Published As

Publication number Publication date
RU2376313C2 (ru) 2009-12-20
US20150343019A1 (en) 2015-12-03
IL199528A0 (en) 2011-08-01
BRPI0413553A (pt) 2006-10-17
HK1089110A1 (en) 2006-11-24
US7897571B2 (en) 2011-03-01
WO2005016130A2 (en) 2005-02-24
UA91818C2 (ru) 2010-09-10
CR8204A (es) 2007-10-01
NZ545021A (en) 2009-03-31
KR101078202B1 (ko) 2011-11-01
NO20060475L (no) 2006-03-13
CN102924584A (zh) 2013-02-13
IL173258A (en) 2010-12-30
IL173258A0 (en) 2006-06-11
US20070191268A1 (en) 2007-08-16
ECSP066364A (es) 2006-08-30
RU2006107925A (ru) 2006-07-27
EP1663291A4 (en) 2009-08-05
AU2004264970B2 (en) 2010-02-11
US20110189731A1 (en) 2011-08-04
US8987205B2 (en) 2015-03-24
ZA200601291B (en) 2010-08-25
US20100080848A1 (en) 2010-04-01
US20100074935A1 (en) 2010-03-25
DK1663291T3 (da) 2012-07-02
WO2005016130A3 (en) 2006-02-02
US8420793B2 (en) 2013-04-16
CN1867350A (zh) 2006-11-22
ES2388970T3 (es) 2012-10-22
EP1663291B1 (en) 2012-06-06
MXPA06001658A (es) 2006-04-28
AU2010201537A1 (en) 2010-05-06
US7893029B2 (en) 2011-02-22
AU2010201537B2 (en) 2012-02-23
US20130196930A1 (en) 2013-08-01
IL199528A (en) 2013-03-24
KR20060072124A (ko) 2006-06-27
US7642236B2 (en) 2010-01-05
AU2004264970A1 (en) 2005-02-24
JP2007502122A (ja) 2007-02-08
RU2009130434A (ru) 2011-02-20
EP1663291A2 (en) 2006-06-07

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