DK1663291T3 - Rekombinante lubricinmolekyler og anvendelser deraf - Google Patents

Rekombinante lubricinmolekyler og anvendelser deraf

Info

Publication number
DK1663291T3
DK1663291T3 DK04781229.2T DK04781229T DK1663291T3 DK 1663291 T3 DK1663291 T3 DK 1663291T3 DK 04781229 T DK04781229 T DK 04781229T DK 1663291 T3 DK1663291 T3 DK 1663291T3
Authority
DK
Denmark
Prior art keywords
recombinant lubricin
lubricin molecules
molecules
recombinant
lubricin
Prior art date
Application number
DK04781229.2T
Other languages
English (en)
Inventor
Carl Ralph Flannery
Christopher John Corcoran
Bethany Annis Freeman
Lisa Anne Racie
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Application granted granted Critical
Publication of DK1663291T3 publication Critical patent/DK1663291T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK04781229.2T 2003-08-14 2004-08-13 Rekombinante lubricinmolekyler og anvendelser deraf DK1663291T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49574103P 2003-08-14 2003-08-14
PCT/US2004/026508 WO2005016130A2 (en) 2003-08-14 2004-08-13 Recombinant lubricin molecules and uses thereof

Publications (1)

Publication Number Publication Date
DK1663291T3 true DK1663291T3 (da) 2012-07-02

Family

ID=34193342

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04781229.2T DK1663291T3 (da) 2003-08-14 2004-08-13 Rekombinante lubricinmolekyler og anvendelser deraf

Country Status (21)

Country Link
US (6) US7642236B2 (da)
EP (1) EP1663291B1 (da)
JP (1) JP2007502122A (da)
KR (1) KR101078202B1 (da)
CN (2) CN1867350A (da)
AU (2) AU2004264970B2 (da)
BR (1) BRPI0413553A (da)
CR (1) CR8204A (da)
DK (1) DK1663291T3 (da)
EC (1) ECSP066364A (da)
ES (1) ES2388970T3 (da)
HK (1) HK1089110A1 (da)
IL (2) IL173258A (da)
MX (1) MXPA06001658A (da)
NO (1) NO20060475L (da)
NZ (1) NZ545021A (da)
RU (2) RU2376313C2 (da)
SG (1) SG145724A1 (da)
UA (1) UA91818C2 (da)
WO (1) WO2005016130A2 (da)
ZA (1) ZA200601291B (da)

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* Cited by examiner, † Cited by third party
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US6743774B1 (en) * 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
WO2006012492A2 (en) * 2004-07-23 2006-02-02 Mucosal Therapeutics Llc Compositions and methods for viscosupplementation
US20090068247A1 (en) * 2007-09-12 2009-03-12 Mucosal Therapeutics Biocompatible devices coated with a tribonectin and methods for their production
US20090104148A1 (en) * 2007-09-18 2009-04-23 Jay Gregory D Treatment and prevention of joint disease
US8506944B2 (en) * 2008-05-07 2013-08-13 The Regents Of The University Of California Replenishment and enrichment of ocular surface lubrication
PL2285364T3 (pl) * 2008-05-07 2015-04-30 Univ California Terapeutyczne uzupełnienie i wzbogacenie smarowania powierzchni oka
CN102438645A (zh) * 2009-01-13 2012-05-02 卢布里斯有限责任公司 阴道上皮界面润滑的治疗调节
US9730865B2 (en) 2009-05-22 2017-08-15 Lubris, Llc Application and uses of PRG4 and therapeutic modulation thereof
EP2525805B1 (en) * 2010-01-19 2017-03-15 Lubris LLC Oral care compositions and methods
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
US20130116186A1 (en) * 2011-10-04 2013-05-09 Rhode Island Hospital, A Lifespan Partner Lubricin injections to maintain cartilage health
ES2802878T3 (es) 2013-01-25 2021-01-21 Baylor College Medicine Un sistema de administración y expresión de terapia génica adenoviral dependiente de linfocitos T colaboradores
US20150010606A1 (en) * 2013-07-08 2015-01-08 Arthrex, Inc. Intra-articular injection and implant attachment of molecule consisting of lubricin and extracellular superoxide dismutase or hyaluronic acid and extracellular superoxide dismutase
EP3057451A4 (en) * 2013-10-16 2017-06-21 Ensisheim Partners LLC Protein-specific formulations
US9982027B2 (en) * 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
US10500250B2 (en) * 2013-11-26 2019-12-10 Lubris Llc Compositions and methods for inhibiting intercellular interactions
TN2017000270A1 (en) 2015-01-26 2018-10-19 Lubris Llc Use of prg4 as an anti-inflammatory agent
JP7058603B2 (ja) 2016-01-13 2022-04-22 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 哺乳動物の変形性関節症及び関連する関節症状の治療に有用なｈａｓ２及びルブリシンを含む骨保護遺伝子を発現する組換えａａｖベクター
WO2017132376A1 (en) 2016-01-27 2017-08-03 Just Biotherapeutics, Inc. Hybrid promoter and uses thereof
AU2019290206A1 (en) * 2018-06-21 2021-01-07 Lubris Llc Lubricin for use in wound healing
US20220127318A1 (en) * 2019-01-15 2022-04-28 Cornell University Recombinant lubricins, and compositions and methods for using the same
KR20220145361A (ko) * 2020-02-24 2022-10-28 노파르티스 아게 재조합적으로 생성된 폴리펩타이드의 정제
IT202000022636A1 (it) 2020-09-25 2022-03-25 Ente Ospedaliero Specializzato In Gastroenterologia Istituto Nazionale Di Ricovero E Cura A Caratter “terapia di combinazione di sorafenib e/o regorafenib con la proteina ricombinante umana proteoglicano-4 per il trattamento dell'epatocarcinoma”

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US2734862A (en) * 1956-02-14 Synthetic casein fiber elastic grease
US2487377A (en) * 1948-04-17 1949-11-08 Socony Vacuum Oil Co Inc Lubricant
US2878184A (en) * 1953-12-29 1959-03-17 Rockwell Mfg Co Hydrocarbon resistant glycerol base lubricant
AR207237A1 (es) * 1974-02-25 1976-09-22 Thomas A Procedimiento para obtener extractos biologicos estables liofilizados solubles constituidos por complejos proteicos termorresistentes
US4438100A (en) * 1980-04-25 1984-03-20 A/S Orthana Kemisk Fabrik Sterilized preserved, stable mucine-containing solutions
US5403592A (en) * 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
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US7001881B1 (en) * 1999-04-23 2006-02-21 Rhode Island Hospital Tribonectins
US6960562B2 (en) * 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
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Also Published As

Publication number Publication date
US7893029B2 (en) 2011-02-22
US20070191268A1 (en) 2007-08-16
IL173258A (en) 2010-12-30
IL199528A (en) 2013-03-24
MXPA06001658A (es) 2006-04-28
US7642236B2 (en) 2010-01-05
EP1663291B1 (en) 2012-06-06
KR101078202B1 (ko) 2011-11-01
JP2007502122A (ja) 2007-02-08
US20130196930A1 (en) 2013-08-01
AU2010201537B2 (en) 2012-02-23
US8420793B2 (en) 2013-04-16
SG145724A1 (en) 2008-09-29
IL199528A0 (en) 2011-08-01
ECSP066364A (es) 2006-08-30
CR8204A (es) 2007-10-01
AU2010201537A1 (en) 2010-05-06
AU2004264970B2 (en) 2010-02-11
US20110189731A1 (en) 2011-08-04
EP1663291A4 (en) 2009-08-05
WO2005016130A2 (en) 2005-02-24
ES2388970T3 (es) 2012-10-22
EP1663291A2 (en) 2006-06-07
NO20060475L (no) 2006-03-13
US7897571B2 (en) 2011-03-01
RU2006107925A (ru) 2006-07-27
IL173258A0 (en) 2006-06-11
HK1089110A1 (en) 2006-11-24
RU2009130434A (ru) 2011-02-20
UA91818C2 (ru) 2010-09-10
KR20060072124A (ko) 2006-06-27
US20150343019A1 (en) 2015-12-03
RU2376313C2 (ru) 2009-12-20
US20100080848A1 (en) 2010-04-01
CN1867350A (zh) 2006-11-22
ZA200601291B (en) 2010-08-25
US20100074935A1 (en) 2010-03-25
AU2004264970A1 (en) 2005-02-24
BRPI0413553A (pt) 2006-10-17
CN102924584A (zh) 2013-02-13
NZ545021A (en) 2009-03-31
WO2005016130A3 (en) 2006-02-02
US8987205B2 (en) 2015-03-24

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