SG11202106605VA - Compounds that participate in cooperative binding and uses thereof - Google Patents
Compounds that participate in cooperative binding and uses thereofInfo
- Publication number
- SG11202106605VA SG11202106605VA SG11202106605VA SG11202106605VA SG11202106605VA SG 11202106605V A SG11202106605V A SG 11202106605VA SG 11202106605V A SG11202106605V A SG 11202106605VA SG 11202106605V A SG11202106605V A SG 11202106605VA SG 11202106605V A SG11202106605V A SG 11202106605VA
- Authority
- SG
- Singapore
- Prior art keywords
- participate
- compounds
- cooperative binding
- cooperative
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862783816P | 2018-12-21 | 2018-12-21 | |
| US201962894493P | 2019-08-30 | 2019-08-30 | |
| US201962930489P | 2019-11-04 | 2019-11-04 | |
| PCT/US2019/068100 WO2020132597A1 (en) | 2018-12-21 | 2019-12-20 | Compounds that participate in cooperative binding and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202106605VA true SG11202106605VA (en) | 2021-07-29 |
Family
ID=71099011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202106605VA SG11202106605VA (en) | 2018-12-21 | 2019-12-20 | Compounds that participate in cooperative binding and uses thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20200197391A1 (ko) |
| EP (1) | EP3897644A4 (ko) |
| JP (1) | JP2022520154A (ko) |
| KR (1) | KR20210116479A (ko) |
| CN (1) | CN113498342A (ko) |
| AU (1) | AU2019401466A1 (ko) |
| BR (1) | BR112021012057A2 (ko) |
| CA (1) | CA3123869A1 (ko) |
| IL (1) | IL284210A (ko) |
| MX (1) | MX2021007468A (ko) |
| SG (1) | SG11202106605VA (ko) |
| TW (1) | TW202039509A (ko) |
| WO (1) | WO2020132597A1 (ko) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109983001B (zh) | 2016-07-12 | 2023-04-04 | 锐新医药公司 | 作为变构shp2抑制剂的2,5-双取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪 |
| IL296456A (en) | 2017-01-23 | 2022-11-01 | Revolution Medicines Inc | Bicyclics as allosteric shp2 inhibitors |
| BR112019014527A2 (pt) | 2017-01-23 | 2020-02-27 | Revolution Medicines, Inc. | Compostos de piridina como inibidores de shp2 alostéricos |
| AU2018347516A1 (en) | 2017-10-12 | 2020-05-07 | Revolution Medicines, Inc. | Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors |
| SG11202004090YA (en) | 2017-12-15 | 2020-05-28 | Revolution Medicines Inc | Polycyclic compounds as allosteric shp2 inhibitors |
| WO2021091956A1 (en) * | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| EP4054719A1 (en) | 2019-11-04 | 2022-09-14 | Revolution Medicines, Inc. | Ras inhibitors |
| JP2022553857A (ja) | 2019-11-04 | 2022-12-26 | レボリューション メディシンズ インコーポレイテッド | Ｒａｓ阻害剤 |
| US20210322405A1 (en) * | 2020-04-15 | 2021-10-21 | Washington University | Compositions and methods for treating cancer |
| WO2021257736A1 (en) | 2020-06-18 | 2021-12-23 | Revolution Medicines, Inc. | Methods for delaying, preventing, and treating acquired resistance to ras inhibitors |
| IL301062A (en) | 2020-09-03 | 2023-05-01 | Revolution Medicines Inc | Use of SOS1 inhibitors to treat malignancies with SHP2 mutations |
| PE20231207A1 (es) | 2020-09-15 | 2023-08-17 | Revolution Medicines Inc | Derivados indolicos como inhibidores de ras en el tratamiento del cancer |
| JP2023553835A (ja) * | 2020-12-17 | 2023-12-26 | ブロッサムヒル・セラピューティクス・インコーポレイテッド | 大環状化合物およびそれらの使用 |
| WO2022235870A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
| CN117500811A (zh) | 2021-05-05 | 2024-02-02 | 锐新医药公司 | 共价ras抑制剂及其用途 |
| WO2022235864A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors |
| AU2022281343A1 (en) | 2021-05-25 | 2023-11-30 | Revolution Medicines, Inc. | Methods for inhibiting ras |
| WO2022251193A1 (en) * | 2021-05-27 | 2022-12-01 | Mirati Therapeutics, Inc. | Combination therapies |
| WO2023015559A1 (en) * | 2021-08-13 | 2023-02-16 | Nutshell Biotech (Shanghai) Co., Ltd. | Macrocycle compounds as inhibitors of ras |
| AR126854A1 (es) | 2021-08-27 | 2023-11-22 | Hoffmann La Roche | Compuestos macrocíclicos para el tratamiento de cáncer |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| WO2023114954A1 (en) | 2021-12-17 | 2023-06-22 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
| TW202400607A (zh) * | 2022-04-25 | 2024-01-01 | 美商翰森生物有限責任公司 | 環狀化合物、製備方法及其醫藥用途 |
| WO2023232776A1 (en) | 2022-06-01 | 2023-12-07 | F. Hoffmann-La Roche Ag | Haloindole macrocyclic compounds for the treatment of cancer |
| WO2023240263A1 (en) * | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2024060966A1 (zh) * | 2022-09-19 | 2024-03-28 | 杭州阿诺生物医药科技有限公司 | 一种pan-KRAS抑制剂化合物 |
| WO2024067857A1 (zh) * | 2022-09-29 | 2024-04-04 | 南京明德新药研发有限公司 | 大环衍生物及其应用 |
| CN116284045A (zh) * | 2023-05-18 | 2023-06-23 | 西南交通大学 | 一种手性吲哚单元取代的四氢异喹啉化合物及其合成方法 |
| CN116570599B (zh) * | 2023-07-04 | 2023-10-20 | 四川大学华西医院 | Vs6766联合ly3009120的应用及药物组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601852B2 (en) * | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
| ES2907071T3 (es) * | 2011-05-19 | 2022-04-21 | Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio | Compuestos macrocíclicos como inhibidores de proteína quinasas |
| AR091279A1 (es) * | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
-
2019
- 2019-12-20 AU AU2019401466A patent/AU2019401466A1/en active Pending
- 2019-12-20 KR KR1020217022312A patent/KR20210116479A/ko unknown
- 2019-12-20 MX MX2021007468A patent/MX2021007468A/es unknown
- 2019-12-20 JP JP2021535755A patent/JP2022520154A/ja active Pending
- 2019-12-20 WO PCT/US2019/068100 patent/WO2020132597A1/en active Application Filing
- 2019-12-20 TW TW108146857A patent/TW202039509A/zh unknown
- 2019-12-20 EP EP19901393.9A patent/EP3897644A4/en active Pending
- 2019-12-20 CA CA3123869A patent/CA3123869A1/en active Pending
- 2019-12-20 BR BR112021012057-2A patent/BR112021012057A2/pt unknown
- 2019-12-20 CN CN201980092760.0A patent/CN113498342A/zh active Pending
- 2019-12-20 US US16/723,438 patent/US20200197391A1/en not_active Abandoned
- 2019-12-20 SG SG11202106605VA patent/SG11202106605VA/en unknown
-
2021
- 2021-06-20 IL IL284210A patent/IL284210A/en unknown
-
2023
- 2023-03-16 US US18/184,766 patent/US20240139185A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019401466A1 (en) | 2021-07-01 |
| IL284210A (en) | 2021-08-31 |
| BR112021012057A2 (pt) | 2021-10-19 |
| WO2020132597A8 (en) | 2020-07-16 |
| CA3123869A1 (en) | 2020-06-25 |
| KR20210116479A (ko) | 2021-09-27 |
| EP3897644A1 (en) | 2021-10-27 |
| EP3897644A4 (en) | 2022-09-07 |
| JP2022520154A (ja) | 2022-03-29 |
| TW202039509A (zh) | 2020-11-01 |
| US20200197391A1 (en) | 2020-06-25 |
| US20240139185A1 (en) | 2024-05-02 |
| CN113498342A (zh) | 2021-10-12 |
| WO2020132597A1 (en) | 2020-06-25 |
| MX2021007468A (es) | 2021-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL284210A (en) | Compounds participating in sharing relationships and their use | |
| EP3606492A4 (en) | LINKS INVOLVED IN A COOPERATIVE BINDING AND USES THEREOF | |
| EP3247378A4 (en) | Compounds that participate in cooperative binding and uses thereof | |
| IL272524A (en) | CLEC9A binding factors and their use | |
| IL272643A (en) | Binders | |
| IL262241A (en) | Trispecific and/or trivalent binding proteins | |
| SG11202100931QA (en) | Muscle-targeting complexes and uses thereof | |
| EP3247377A4 (en) | Compounds that participate in cooperative binding and uses thereof | |
| HK1245287A1 (zh) | IL13RAα2結合劑和其在癌症治療中的用途 | |
| IL263715A (en) | lag-3 binding organs | |
| ZA201808160B (en) | Bispecific binding proteins and uses thereof | |
| GB201805963D0 (en) | PD-L1 Binding Affirmers and Uses Related Thereto | |
| GB201802201D0 (en) | Binding agents | |
| IL272064A (en) | Binding proteins 1 | |
| EP3565812C0 (en) | TUBULIN-BINDING SUBSTANCES AND THERAPEUTIC USE THEREOF | |
| IL276497A (en) | Fibrolast binders and their use | |
| IL268288A (en) | Binders | |
| IL266516A (en) | An antibody that binds specifically to cd66c and its use | |
| IL291007A (en) | cd8 binding agents and uses thereof | |
| IL284053A (en) | New compounds and their use in therapy | |
| ZA202006103B (en) | Trispecific and/or trivalent binding proteins | |
| PL3430913T3 (pl) | Kompozycja do wiązania mykotoksyn i jej zastosowanie | |
| PL3067402T3 (pl) | Kompozycja spoiwa i jej zastosowanie w płytach z tworzywa drzewnego | |
| IL277158A (en) | Compounds and their uses for the treatment of tumors in a patient | |
| IL267565A (en) | Binding polypeptides and methods for their preparation |