SG11202012786RA - Crispr effector system based amplification methods, systems, and diagnostics - Google Patents
Crispr effector system based amplification methods, systems, and diagnosticsInfo
- Publication number
- SG11202012786RA SG11202012786RA SG11202012786RA SG11202012786RA SG11202012786RA SG 11202012786R A SG11202012786R A SG 11202012786RA SG 11202012786R A SG11202012786R A SG 11202012786RA SG 11202012786R A SG11202012786R A SG 11202012786RA SG 11202012786R A SG11202012786R A SG 11202012786RA
- Authority
- SG
- Singapore
- Prior art keywords
- diagnostics
- systems
- system based
- amplification methods
- based amplification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/301—Endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/513—Winding/unwinding enzyme, e.g. helicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/101—Temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/125—Specific component of sample, medium or buffer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690257P | 2018-06-26 | 2018-06-26 | |
| US201862767052P | 2018-11-14 | 2018-11-14 | |
| US201962818650P | 2019-03-14 | 2019-03-14 | |
| PCT/US2019/039167 WO2020006036A1 (en) | 2018-06-26 | 2019-06-26 | Crispr effector system based amplification methods, systems, and diagnostics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012786RA true SG11202012786RA (en) | 2021-01-28 |
Family
ID=67263107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012786RA SG11202012786RA (en) | 2018-06-26 | 2019-06-26 | Crispr effector system based amplification methods, systems, and diagnostics |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210269866A1 (de) |
| EP (1) | EP3814527B1 (de) |
| JP (1) | JP2021528090A (de) |
| KR (1) | KR20210040943A (de) |
| CN (1) | CN112543812A (de) |
| AU (1) | AU2019294630A1 (de) |
| BR (1) | BR112020026306A2 (de) |
| CA (1) | CA3102163A1 (de) |
| IL (1) | IL279065A (de) |
| MX (1) | MX2020013836A (de) |
| SG (1) | SG11202012786RA (de) |
| WO (1) | WO2020006036A1 (de) |
| ZA (1) | ZA202007610B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
| JP7500549B2 (ja) * | 2018-09-20 | 2024-06-17 | インスティテュート オブ ズーオロジー、チャイニーズ アカデミー オブ サイエンシーズ | 核酸を検出する方法 |
| CN111118218B (zh) * | 2020-01-20 | 2024-01-23 | 杭州奥盛仪器有限公司 | 对虾虹彩病毒的CRISPR-Cas12a蛋白酶等温检测引物组、试剂盒及其检测方法 |
| CN113337488B (zh) * | 2020-03-02 | 2024-04-19 | 中国科学院分子细胞科学卓越创新中心 | 一种分离的Cas13蛋白 |
| WO2021188669A1 (en) * | 2020-03-18 | 2021-09-23 | University Of Connecticut | Crispr-cas12a reaction for rapid and highly sensitive isothermal nucleic acid detection |
| US11761031B2 (en) | 2020-05-28 | 2023-09-19 | The Hong Kong University Of Science And Technology | Method for real time monitoring of nucleic acid amplicons mediated by loop oligonucleotide probes |
| WO2021254267A1 (zh) * | 2020-06-16 | 2021-12-23 | 山东舜丰生物科技有限公司 | 利用核酸类似物或碱基修饰物进行靶核酸检测的方法 |
| CN112029838B (zh) * | 2020-07-23 | 2022-07-12 | 东南大学 | 一种用于DNA均相检测的CRISPR/Cas9分型PCR方法及其应用 |
| WO2022104381A1 (en) * | 2020-11-13 | 2022-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | A MINIMAL CRISPRi/a SYSTEM FOR TARGETED GENOME REGULATION |
| CN114507716A (zh) * | 2020-11-16 | 2022-05-17 | 北京迅识科技有限公司 | 检测样品中靶核酸的方法 |
| CN112980924B (zh) * | 2021-02-10 | 2023-07-25 | 华南师范大学 | 一种免扩增的dna单分子定量检测方法、试剂盒和缓冲液 |
| WO2022261308A1 (en) | 2021-06-10 | 2022-12-15 | New England Biolabs, Inc. | An isothermal diagnostic test that utilizes a cas protein and a polymerase |
| WO2022260718A1 (en) * | 2021-06-12 | 2022-12-15 | Lin Shi Lung | Novel replicase cycling reaction (rcr) |
| WO2023287669A2 (en) | 2021-07-12 | 2023-01-19 | Labsimply, Inc. | Nuclease cascade assay |
| EP4373963A2 (de) | 2021-07-21 | 2024-05-29 | Montana State University | Nukleinsäurenachweis mit typ-iii-crispr-komplex |
| CN113584134B (zh) * | 2021-09-06 | 2024-01-30 | 青岛金斯达生物技术有限公司 | 一种基于CRISPR-Cas9的等温核酸检测系统及其方法和应用 |
| WO2023167752A2 (en) * | 2021-12-09 | 2023-09-07 | The Broad Institute, Inc. | Small novel crispr-cas systems and methods of use thereof |
| US20230279375A1 (en) | 2021-12-13 | 2023-09-07 | Labsimply, Inc. | Signal boost cascade assay |
| US11820983B2 (en) | 2021-12-13 | 2023-11-21 | Labsimply, Inc. | Tuning cascade assay kinetics via molecular design |
| CN114410752B (zh) * | 2022-01-24 | 2024-06-25 | 华南师范大学 | 一种基于光控的CRISPR-Cas核酸检测试剂盒及检测方法 |
| GB202214125D0 (en) | 2022-09-27 | 2022-11-09 | Genomic Labs Ltd | Nucleic acid amplification; improved methods |
| US11982677B2 (en) | 2022-10-02 | 2024-05-14 | Vedabio, Inc. | Dimerization screening assays |
| WO2024081156A1 (en) | 2022-10-14 | 2024-04-18 | Vedabio, Inc. | Detection of nucleic acid and non-nucleic acid target molecules |
| WO2024111543A1 (ja) * | 2022-11-25 | 2024-05-30 | 国立研究開発法人理化学研究所 | 標的核酸の検出方法及びキット |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US715640A (en) | 1902-09-10 | 1902-12-09 | Whitney Mfg Company | Clutch mechanism. |
| US5541099A (en) | 1989-08-10 | 1996-07-30 | Life Technologies, Inc. | Cloning and expression of T5 DNA polymerase reduced in 3'-to-5' exonuclease activity |
| US6555349B1 (en) | 1993-01-22 | 2003-04-29 | Cornell Research Foundation, Inc. | Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase |
| DE60324810D1 (de) * | 2002-09-20 | 2009-01-02 | New England Biolabs Inc | HELICASE-ABHuNGIGE AMPLIFIKATION VON NUKLEINSUREN |
| CN100519758C (zh) * | 2002-09-20 | 2009-07-29 | 新英格兰生物实验室公司 | 核酸的解旋酶依赖性扩增 |
| EP2418286A1 (de) * | 2010-08-10 | 2012-02-15 | QIAGEN GmbH | Verbessertes Verfahren zur isothermalen Amplifikation von Nukleinsäuren |
| CN105188767A (zh) | 2012-07-25 | 2015-12-23 | 布罗德研究所有限公司 | 可诱导的dna结合蛋白和基因组干扰工具及其应用 |
| EP3434776A1 (de) | 2012-12-12 | 2019-01-30 | The Broad Institute, Inc. | Verfahren, modelle, systeme und vorrichtungen zur identifikation von zielsequenzen für cas-enzyme oder crispr-cas-systeme für zielsequenzen und förderresultate davon |
| DK2931898T3 (en) | 2012-12-12 | 2016-06-20 | Massachusetts Inst Technology | CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS |
| CA2894668A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas systems and methods for altering expression of gene products in eukaryotic cells |
| DK2921557T3 (en) | 2012-12-12 | 2016-11-07 | Broad Inst Inc | Design of systems, methods and optimized sequence manipulation guide compositions |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| SG10201912327SA (en) | 2012-12-12 | 2020-02-27 | Broad Inst Inc | Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation |
| EP2931899A1 (de) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Funktionale genomik unter verwendung von crispr-cas systemen, zusammensetzungen, verfahren, knockout-bibliotheken und anwendungen davon |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| RU2721275C2 (ru) | 2012-12-12 | 2020-05-18 | Те Брод Инститьют, Инк. | Доставка, конструирование и оптимизация систем, способов и композиций для манипуляции с последовательностями и применения в терапии |
| PL2921557T3 (pl) | 2012-12-12 | 2017-03-31 | Broad Inst Inc | Projektowanie systemów, sposoby i optymalizowane kompozycje kierujące do manipulacji sekwencją |
| US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
| WO2014204729A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components |
| AU2014281027A1 (en) | 2013-06-17 | 2016-01-28 | Massachusetts Institute Of Technology | Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation |
| EP3011033B1 (de) | 2013-06-17 | 2020-02-19 | The Broad Institute, Inc. | Funktionale genomik unter verwendung von crispr-cas-systemen, zusammensetzungen, verfahren, schirme und anwendungen davon |
| CN113425857A (zh) | 2013-06-17 | 2021-09-24 | 布罗德研究所有限公司 | 用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途 |
| JP6625971B2 (ja) | 2013-06-17 | 2019-12-25 | ザ・ブロード・インスティテュート・インコーポレイテッド | 配列操作のためのタンデムガイド系、方法および組成物の送達、エンジニアリングおよび最適化 |
| EP3011035B1 (de) | 2013-06-17 | 2020-05-13 | The Broad Institute, Inc. | Test zur quantitativen bewertung der zielstellenspaltung durch eine oder mehrere crispr-cas führungssequenzen |
| AU2014281030B2 (en) | 2013-06-17 | 2020-07-09 | Massachusetts Institute Of Technology | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells |
| US10655173B2 (en) | 2013-10-18 | 2020-05-19 | The Broad Institute, Inc. | Spatial and cellular mapping of biomolecules in situ by high-throughput sequencing |
| CN111218447A (zh) | 2013-11-07 | 2020-06-02 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| SG10201804976YA (en) | 2013-12-12 | 2018-07-30 | Broad Inst Inc | Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for Genome Editing |
| KR20160089526A (ko) | 2013-12-12 | 2016-07-27 | 더 브로드 인스티튜트, 인코퍼레이티드 | 입자 전달 성분을 이용한 표적 장애 및 질병에 대한 ｃｒｉｓｐｒ-ｃａｓ 시스템 및 조성물의 전달, 이용 및 치료 적용 |
| KR20160097327A (ko) | 2013-12-12 | 2016-08-17 | 더 브로드 인스티튜트, 인코퍼레이티드 | 유전자 산물, 구조 정보 및 유도성 모듈형 ｃａｓ 효소의 발현의 변경을 위한 ｃｒｉｓｐｒ-ｃａｓ 시스템 및 방법 |
| EP4219699A1 (de) | 2013-12-12 | 2023-08-02 | The Broad Institute, Inc. | Konstruktion von systemen, verfahren und optimierten führungszusammensetzungen mit neuen architekturen zur sequenzmanipulation |
| WO2015089364A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Crystal structure of a crispr-cas system, and uses thereof |
| AU2014361784A1 (en) | 2013-12-12 | 2016-06-23 | Massachusetts Institute Of Technology | Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for HBV and viral diseases and disorders |
| CA2932436A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute, Inc. | Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders |
| JP6793547B2 (ja) | 2013-12-12 | 2020-12-02 | ザ・ブロード・インスティテュート・インコーポレイテッド | 最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物 |
| CN107109495B (zh) * | 2014-11-11 | 2021-12-24 | 伊鲁米那股份有限公司 | 使用crispr-cas系统的多核苷酸扩增 |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| WO2016094867A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Protected guide rnas (pgrnas) |
| EP3230452A1 (de) | 2014-12-12 | 2017-10-18 | The Broad Institute Inc. | Totführungen für crispr-transkriptionsfaktoren |
| AU2015369725A1 (en) | 2014-12-24 | 2017-06-29 | Massachusetts Institute Of Technology | CRISPR having or associated with destabilization domains |
| WO2016149661A1 (en) | 2015-03-18 | 2016-09-22 | The Broad Institute, Inc. | Massively parallel on-chip coalescence of microemulsions |
| EP3436575A1 (de) | 2015-06-18 | 2019-02-06 | The Broad Institute Inc. | Neuartige crispr-enzyme und -systeme |
| CA3012631A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| CA3024543A1 (en) | 2015-10-22 | 2017-04-27 | The Broad Institute, Inc. | Type vi-b crispr enzymes and systems |
| WO2017106657A1 (en) | 2015-12-18 | 2017-06-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| JP6914274B2 (ja) | 2016-01-22 | 2021-08-04 | ザ・ブロード・インスティテュート・インコーポレイテッド | Ｃｒｉｓｐｒｃｐｆ１の結晶構造 |
| US20200263190A1 (en) | 2016-04-19 | 2020-08-20 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| AU2017253107B2 (en) | 2016-04-19 | 2023-07-20 | Massachusetts Institute Of Technology | CPF1 complexes with reduced indel activity |
| EP3445848A1 (de) | 2016-04-19 | 2019-02-27 | The Broad Institute, Inc. | Neuartige crispr-enzyme und -systeme |
| CA3028158A1 (en) | 2016-06-17 | 2017-12-21 | The Broad Institute, Inc. | Type vi crispr orthologs and systems |
| WO2018035387A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| WO2018035388A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| JP7228514B2 (ja) | 2016-12-09 | 2023-02-24 | ザ・ブロード・インスティテュート・インコーポレイテッド | Ｃｒｉｓｐｒエフェクターシステムベースの診断法 |
| WO2018170340A1 (en) | 2017-03-15 | 2018-09-20 | The Broad Institute, Inc. | Crispr effector system based diagnostics for virus detection |
| US11739308B2 (en) | 2017-03-15 | 2023-08-29 | The Broad Institute, Inc. | Cas13b orthologues CRISPR enzymes and systems |
| US11104937B2 (en) | 2017-03-15 | 2021-08-31 | The Broad Institute, Inc. | CRISPR effector system based diagnostics |
| US11174515B2 (en) | 2017-03-15 | 2021-11-16 | The Broad Institute, Inc. | CRISPR effector system based diagnostics |
| US11618928B2 (en) | 2017-04-12 | 2023-04-04 | The Broad Institute, Inc. | CRISPR effector system based diagnostics for malaria detection |
| BR112019021378A2 (pt) | 2017-04-12 | 2020-05-05 | Massachusetts Inst Technology | ortólogos de crispr tipo vi inovadores e sistemas |
| US20210121280A1 (en) | 2017-04-16 | 2021-04-29 | Sanford Health | Filter for Stent Retriever and Methods for Use Thereof |
| JP7364472B2 (ja) | 2017-05-18 | 2023-10-18 | ザ・ブロード・インスティテュート・インコーポレイテッド | 標的化された核酸編集のための系、方法、及び組成物 |
| WO2019005866A1 (en) | 2017-06-26 | 2019-01-03 | The Broad Institute, Inc. | NEW TYPE VI CRISPR ORTHOLOGISTS AND ASSOCIATED SYSTEMS |
-
2019
- 2019-06-26 WO PCT/US2019/039167 patent/WO2020006036A1/en active Application Filing
- 2019-06-26 CN CN201980052855.XA patent/CN112543812A/zh active Pending
- 2019-06-26 AU AU2019294630A patent/AU2019294630A1/en active Pending
- 2019-06-26 SG SG11202012786RA patent/SG11202012786RA/en unknown
- 2019-06-26 JP JP2020572975A patent/JP2021528090A/ja active Pending
- 2019-06-26 EP EP19739825.8A patent/EP3814527B1/de active Active
- 2019-06-26 BR BR112020026306-0A patent/BR112020026306A2/pt unknown
- 2019-06-26 US US16/973,061 patent/US20210269866A1/en active Pending
- 2019-06-26 MX MX2020013836A patent/MX2020013836A/es unknown
- 2019-06-26 KR KR1020217001812A patent/KR20210040943A/ko not_active Application Discontinuation
- 2019-06-26 CA CA3102163A patent/CA3102163A1/en active Pending
-
2020
- 2020-11-29 IL IL279065A patent/IL279065A/en unknown
- 2020-12-07 ZA ZA2020/07610A patent/ZA202007610B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL279065A (en) | 2021-01-31 |
| KR20210040943A (ko) | 2021-04-14 |
| BR112020026306A2 (pt) | 2021-03-30 |
| CA3102163A1 (en) | 2020-01-02 |
| US20210269866A1 (en) | 2021-09-02 |
| EP3814527A1 (de) | 2021-05-05 |
| JP2021528090A (ja) | 2021-10-21 |
| ZA202007610B (en) | 2023-06-28 |
| AU2019294630A1 (en) | 2020-12-17 |
| CN112543812A (zh) | 2021-03-23 |
| EP3814527B1 (de) | 2023-02-22 |
| WO2020006036A1 (en) | 2020-01-02 |
| MX2020013836A (es) | 2021-05-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202007610B (en) | Crispr effector system based amplification methods, systems, and diagnostics | |
| IL276349A (en) | Diagnostics based on the CRISPR system | |
| IL273360A (en) | CRISPR-based diagnostics | |
| IL283210A (en) | Droplet diagnostic systems and methods based on the CRISPR system | |
| IL269330A (en) | crispr based diagnostics for virus detection | |
| EP3551753A4 (de) | Auf crispr-effektor-system basierende diagnose | |
| EP3786085A4 (de) | Roboter sowie fördersystem und verfahren | |
| EP3846446A4 (de) | Bilderfassungsvorrichtung, bilderfassungssystem, bilderfassungsverfahren und bilderfassungsprogramm | |
| EP3712853A4 (de) | Verfahren und system zur positionierung und geeigneter roboter | |
| EP3892226A4 (de) | Verfahren und system zur kollisionsvermeidung zwischen mechanischen armen und medizinischer roboter | |
| EP3496573A4 (de) | Haltungsverbesserungsvorrichtung, -system und -verfahren | |
| EP3731437A4 (de) | Topologieverarbeitungsverfahren, -vorrichtung und -system | |
| EP3766753A4 (de) | System zur diagnose von anomalien und verfahren zur diagnose von anomalien | |
| EP3820183A4 (de) | Gruppenerzeugungsverfahren, -vorrichtung und -system | |
| EP3646993A4 (de) | Roboter, kombinationsverfahren davon und roboterkombinationssystem | |
| EP3626401A4 (de) | Steuervorrichtung, robotersteuerverfahren und robotersteuersystem | |
| IL276248A (en) | Hydrogen refueling monitoring system of a vehicle with hydrogen fuel and monitoring method used by the system | |
| EP3774208A4 (de) | Manipulator, system und verfahren zum betrieb davon | |
| EP3624487A4 (de) | Berichterstattungsverfahren, -vorrichtung und -system | |
| EP3904016A4 (de) | Robotersteuerungsvorrichtung, robotersteuerungssystem und robotersteuerungsverfahren | |
| EP3610996A4 (de) | Robotersystem und verfahren zum betrieb davon | |
| IL278963A (en) | Dual NICKASE-based CRISPR amplification preparations, systems and methods | |
| EP3800977A4 (de) | Vorrichtung, systeme und verfahren zur überwachung landwirtschaftlicher operationen | |
| EP3711287A4 (de) | Automatisierte videokonferenzsysteme, steuerungen und verfahren | |
| EP3893486A4 (de) | Bildgebungsvorrichtung, bildgebungssystem und industrieroboter |