SG11202011461TA - Anti-pvrig/anti-tigit bispecific antibodies and methods of use - Google Patents
Anti-pvrig/anti-tigit bispecific antibodies and methods of useInfo
- Publication number
- SG11202011461TA SG11202011461TA SG11202011461TA SG11202011461TA SG11202011461TA SG 11202011461T A SG11202011461T A SG 11202011461TA SG 11202011461T A SG11202011461T A SG 11202011461TA SG 11202011461T A SG11202011461T A SG 11202011461TA SG 11202011461T A SG11202011461T A SG 11202011461TA
- Authority
- SG
- Singapore
- Prior art keywords
- pvrig
- methods
- bispecific antibodies
- tigit bispecific
- tigit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862679703P | 2018-06-01 | 2018-06-01 | |
| US201862773586P | 2018-11-30 | 2018-11-30 | |
| PCT/US2019/035062 WO2019232484A1 (en) | 2018-06-01 | 2019-05-31 | Anti-pvrig/anti-tigit bispecific antibodies and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202011461TA true SG11202011461TA (en) | 2020-12-30 |
Family
ID=67003669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202011461TA SG11202011461TA (en) | 2018-06-01 | 2019-05-31 | Anti-pvrig/anti-tigit bispecific antibodies and methods of use |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20190382477A1 (he) |
| EP (1) | EP3802605A1 (he) |
| JP (1) | JP2021525087A (he) |
| KR (1) | KR20210016448A (he) |
| CN (1) | CN113039202A (he) |
| AU (1) | AU2019276578A1 (he) |
| BR (1) | BR112020024249A2 (he) |
| CA (1) | CA3101019A1 (he) |
| CL (1) | CL2020003127A1 (he) |
| CO (1) | CO2020016619A2 (he) |
| IL (1) | IL279053A (he) |
| MX (1) | MX2020012797A (he) |
| SG (1) | SG11202011461TA (he) |
| WO (1) | WO2019232484A1 (he) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022514702A (ja) | 2018-12-21 | 2022-02-14 | オーエスイー・イミュノセラピューティクス | 二機能性抗ｐｄ－１／ｉｌ－７分子 |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| TW202136287A (zh) | 2019-12-17 | 2021-10-01 | 法商Ｏｓｅ免疫治療公司 | 包含il-7變體之雙官能分子 |
| CA3170025A1 (en) * | 2020-03-13 | 2021-09-16 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pvrig binding protein and its medical uses |
| WO2021224438A1 (en) | 2020-05-07 | 2021-11-11 | Institut Curie | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| BR112022025801A2 (pt) | 2020-06-18 | 2023-10-03 | Hoffmann La Roche | Métodos para tratar um paciente e para tratar um paciente com escc avançado, kit, anticorpo, uso de um anticorpo e uso de um antagonista de ligação |
| TW202216778A (zh) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷 |
| WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
| WO2022148781A1 (en) | 2021-01-05 | 2022-07-14 | Institut Curie | Combination of mcoln activators and immune checkpoint inhibitors |
| WO2022165275A2 (en) * | 2021-01-28 | 2022-08-04 | Compugen Ltd. | Combination therapy with anti-pvrig antibodies formulations and anti-pd-1-antibodies |
| WO2022165266A1 (en) * | 2021-01-28 | 2022-08-04 | Compugen Ltd. | Anti-pvrig antibodies formulations and uses thereof |
| EP4292611A1 (en) * | 2021-02-09 | 2023-12-20 | Shanghai Junshi Biosciences Co., Ltd. | Anti-cd112r antibody and use thereof |
| CA3206413A1 (en) | 2021-02-11 | 2022-08-18 | Pinchas TSUKERMAN | Antibodies against cd112r and uses thereof |
| AU2022253351A1 (en) | 2021-04-09 | 2023-10-12 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
| US20240182572A1 (en) | 2021-04-09 | 2024-06-06 | Ose Immunotherapeutics | Scaffold for bifunctional molecules comprising pd-1 or cd28 and sirp binding domains |
| WO2022258049A1 (en) * | 2021-06-10 | 2022-12-15 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric pvrig |
| TW202320848A (zh) | 2021-07-28 | 2023-06-01 | 美商建南德克公司 | 治療癌症之方法及組成物 |
| AU2022320667A1 (en) * | 2021-07-30 | 2024-03-14 | Shandong Simcere Biopharmaceutical Co., Ltd. | Anti-pvrig/anti-tigit bispecific antibody and application |
| CA3231553A1 (en) * | 2021-09-15 | 2023-03-23 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising anti-pvrig/tigit bispecific antibody |
| TW202328195A (zh) | 2021-09-15 | 2023-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｐｄ－１的蛋白及其醫藥用途 |
| TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗ｔｉｇｉｔ抗體、抗ｃｄ３８抗體及ｐｄ—１軸結合拮抗劑治療血液癌症的方法 |
| CN114057867B (zh) * | 2021-12-14 | 2023-05-12 | 河南联科物联网科技有限公司 | 一种抗减蛋综合征的单克隆抗体及其应用 |
| CN116925222A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗pvrig抗体、其药物组合物及用途 |
| CN116925233A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗tigit-抗pvrig双特异性抗体、其药物组合物及用途 |
| WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
| TW202402325A (zh) * | 2022-06-08 | 2024-01-16 | 大陸商山東先聲生物製藥有限公司 | Pvrig/tigit雙特異性抗體藥物組合物及其用途 |
| WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
| WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
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| UA122395C2 (uk) | 2014-08-19 | 2020-11-10 | Мерк Шарп Енд Доум Корп. | Антитіло проти tigit |
| SG10202006538TA (en) | 2014-12-23 | 2020-08-28 | Bristol Myers Squibb Co | Antibodies to tigit |
| PT3653221T (pt) | 2015-02-19 | 2022-11-08 | Compugen Ltd | Anticorpos anti-pvrig e métodos de utilização |
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| RU2729379C1 (ru) | 2015-10-01 | 2020-08-06 | Потенза Терапевтикс, Инк. | Анти-tigit антигенсвязывающие белки и способы их применения |
| UA125898C2 (uk) | 2016-03-04 | 2022-07-06 | Джн Байосайєнсіз, Ллк | Антитіла до tigit |
| IL263542B1 (he) | 2016-06-14 | 2024-06-01 | Xencor Inc | נוגדנים דו-ספציפיים מעכבי נקודת בקרה אימונולוגית |
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| PT3347379T (pt) | 2016-08-17 | 2020-02-18 | Compugen Ltd | Anticorpos anti-tígitos, anticorpos anti-pvrig e as suas combinações |
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| JP7348072B2 (ja) * | 2017-06-01 | 2023-09-20 | コンピュジェン リミテッド | 三重併用抗体療法 |
-
2019
- 2019-05-31 SG SG11202011461TA patent/SG11202011461TA/en unknown
- 2019-05-31 US US16/428,856 patent/US20190382477A1/en active Pending
- 2019-05-31 BR BR112020024249-7A patent/BR112020024249A2/pt unknown
- 2019-05-31 EP EP19733259.6A patent/EP3802605A1/en active Pending
- 2019-05-31 AU AU2019276578A patent/AU2019276578A1/en active Pending
- 2019-05-31 KR KR1020207038135A patent/KR20210016448A/ko unknown
- 2019-05-31 WO PCT/US2019/035062 patent/WO2019232484A1/en active Application Filing
- 2019-05-31 MX MX2020012797A patent/MX2020012797A/es unknown
- 2019-05-31 CA CA3101019A patent/CA3101019A1/en active Pending
- 2019-05-31 JP JP2020565487A patent/JP2021525087A/ja active Pending
- 2019-05-31 CN CN201980050598.6A patent/CN113039202A/zh active Pending
-
2020
- 2020-11-29 IL IL279053A patent/IL279053A/he unknown
- 2020-12-01 CL CL2020003127A patent/CL2020003127A1/es unknown
- 2020-12-30 CO CONC2020/0016619A patent/CO2020016619A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019276578A1 (en) | 2021-01-14 |
| IL279053A (he) | 2021-01-31 |
| MX2020012797A (es) | 2021-03-25 |
| WO2019232484A1 (en) | 2019-12-05 |
| CN113039202A (zh) | 2021-06-25 |
| JP2021525087A (ja) | 2021-09-24 |
| CA3101019A1 (en) | 2019-12-05 |
| WO2019232484A9 (en) | 2021-05-06 |
| BR112020024249A2 (pt) | 2021-03-02 |
| KR20210016448A (ko) | 2021-02-15 |
| US20190382477A1 (en) | 2019-12-19 |
| CL2020003127A1 (es) | 2021-10-29 |
| EP3802605A1 (en) | 2021-04-14 |
| CO2020016619A2 (es) | 2021-01-18 |
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