SG11202010767SA - Methods of treating hemophilia a - Google Patents

Methods of treating hemophilia a

Info

Publication number
SG11202010767SA
SG11202010767SA SG11202010767SA SG11202010767SA SG11202010767SA SG 11202010767S A SG11202010767S A SG 11202010767SA SG 11202010767S A SG11202010767S A SG 11202010767SA SG 11202010767S A SG11202010767S A SG 11202010767SA SG 11202010767S A SG11202010767S A SG 11202010767SA
Authority
SG
Singapore
Prior art keywords
methods
treating hemophilia
hemophilia
treating
Prior art date
Application number
SG11202010767SA
Other languages
English (en)
Inventor
Alison Innes
Suresh Katragadda
Kara Rice
Dan Rudin
Chhabra Ekta Seth
Nancy Wong
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of SG11202010767SA publication Critical patent/SG11202010767SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
SG11202010767SA 2018-05-18 2019-05-17 Methods of treating hemophilia a SG11202010767SA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862673670P 2018-05-18 2018-05-18
US201862712880P 2018-07-31 2018-07-31
US201862773785P 2018-11-30 2018-11-30
US201962801576P 2019-02-05 2019-02-05
PCT/US2019/032956 WO2019222682A1 (fr) 2018-05-18 2019-05-17 Procédés de traitement de l'hémophilie a

Publications (1)

Publication Number Publication Date
SG11202010767SA true SG11202010767SA (en) 2020-11-27

Family

ID=67002363

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202010767SA SG11202010767SA (en) 2018-05-18 2019-05-17 Methods of treating hemophilia a

Country Status (13)

Country Link
EP (1) EP3793588A1 (fr)
JP (2) JP2021523878A (fr)
KR (1) KR20210020030A (fr)
CN (1) CN112512555A (fr)
AU (1) AU2019270184A1 (fr)
BR (1) BR112020022164A2 (fr)
CA (1) CA3099049A1 (fr)
CO (1) CO2020014566A2 (fr)
MA (1) MA52630A (fr)
MX (1) MX2020012397A (fr)
SG (1) SG11202010767SA (fr)
TW (1) TW202015723A (fr)
WO (1) WO2019222682A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021257899A1 (fr) * 2020-06-19 2021-12-23 Bioverativ Therapeutics Inc. Procédés de traitement de l'hémophilie a et outils pharmacocinétiques de population pour déterminer des traitements et leurs utilisations
TW202317178A (zh) * 2021-06-23 2023-05-01 美商百歐維拉提夫治療公司 因子ⅷ嵌合蛋白的配製品及其用途
IL311969A (en) * 2021-10-15 2024-06-01 Bioverativ Therapeutics Inc Formulations of factor VIII chimeric proteins and uses thereof
WO2023172893A2 (fr) * 2022-03-08 2023-09-14 Bioverativ Therapeutics Inc. Procédés de traitement de l'hémophilie a

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KR102665348B1 (ko) 2014-08-13 2024-05-16 더 칠드런스 호스피탈 오브 필라델피아 지혈 장애의 치료를 위한 변이체 인자 viii의 패키징 및 발현을 위한 개선된 발현 카세트
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AU2016266627A1 (en) 2015-05-22 2018-01-18 CSL Behring Lengnau AG Truncated von Willebrand Factor polypeptides for treating hemophilia
EP3400238B1 (fr) 2016-01-07 2021-05-19 CSL Behring Lengnau AG Facteur de von willebrand muté
DK3400002T3 (da) 2016-01-07 2022-04-11 CSL Behring Lengnau AG Muteret, trunkeret von willebrand faktor
EP3476937A4 (fr) 2016-06-24 2019-12-04 Mogam Institute for Biomedical Research Protéine chimère comprenant les facteurs fviii et vwf, et utilisation de celle-ci
AU2017358865A1 (en) 2016-11-11 2019-05-09 CSL Behring Lengnau AG Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
MA46968A (fr) 2016-12-02 2019-10-09 Bioverativ Therapeutics Inc Procédés d'induction de tolérance immunitaire à des facteurs de coagulation

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MA52630A (fr) 2021-05-26
EP3793588A1 (fr) 2021-03-24
BR112020022164A2 (pt) 2021-02-02
US20190375822A1 (en) 2019-12-12
WO2019222682A1 (fr) 2019-11-21
KR20210020030A (ko) 2021-02-23
CO2020014566A2 (es) 2020-12-10
AU2019270184A1 (en) 2020-11-26
CN112512555A (zh) 2021-03-16
JP2023101713A (ja) 2023-07-21
TW202015723A (zh) 2020-05-01
JP2021523878A (ja) 2021-09-09
MX2020012397A (es) 2021-04-12

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