HK1252692A1 - 治療或者預防蛋白質構象病的方法 - Google Patents

治療或者預防蛋白質構象病的方法

Info

Publication number
HK1252692A1
HK1252692A1 HK18112000.3A HK18112000A HK1252692A1 HK 1252692 A1 HK1252692 A1 HK 1252692A1 HK 18112000 A HK18112000 A HK 18112000A HK 1252692 A1 HK1252692 A1 HK 1252692A1
Authority
HK
Hong Kong
Prior art keywords
proteopathy
treating
preventing
methods
Prior art date
Application number
HK18112000.3A
Other languages
English (en)
Inventor
David Saperstein
Original Assignee
Usher Iii Initiative Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usher Iii Initiative Inc filed Critical Usher Iii Initiative Inc
Publication of HK1252692A1 publication Critical patent/HK1252692A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
HK18112000.3A 2015-06-11 2018-09-18 治療或者預防蛋白質構象病的方法 HK1252692A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562174338P 2015-06-11 2015-06-11
US201562174332P 2015-06-11 2015-06-11

Publications (1)

Publication Number Publication Date
HK1252692A1 true HK1252692A1 (zh) 2019-05-31

Family

ID=57503990

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18112000.3A HK1252692A1 (zh) 2015-06-11 2018-09-18 治療或者預防蛋白質構象病的方法

Country Status (11)

Country Link
US (1) US20180099974A1 (zh)
EP (1) EP3307742B1 (zh)
JP (3) JP6924155B2 (zh)
AU (1) AU2016274956A1 (zh)
CA (1) CA2986785A1 (zh)
ES (1) ES2924433T3 (zh)
HK (1) HK1252692A1 (zh)
IL (1) IL256109A (zh)
MX (1) MX2017016114A (zh)
WO (1) WO2016201266A1 (zh)
ZA (1) ZA201708082B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012249801B2 (en) 2011-04-25 2016-05-19 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome
US9227976B2 (en) 2012-10-25 2016-01-05 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
WO2018213211A1 (en) * 2017-05-15 2018-11-22 The Regents Of The University Of Michigan Pyrrolo[2,3-c]pyridines and related analogs as lsd-1 inhibitors
CN111171019A (zh) * 2018-11-13 2020-05-19 上海轶诺药业有限公司 一类五元并六元杂环化合物及其作为蛋白受体激酶抑制剂的用途
MX2021005875A (es) * 2018-11-20 2021-09-23 Univ Georgetown Composiciones y métodos para el tratamiento de trastornos neurodegenerativos, miodegenerativos y de almacenamiento lisosómico.
CN113840602A (zh) * 2019-03-15 2021-12-24 斯基霍克疗法公司 用于校正异常剪接的组合物和方法
IL299695A (en) * 2020-07-09 2023-03-01 Usher Iii Initiative Inc Treatment of cancer, inflammatory diseases and autoimmune diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5893614B2 (ja) * 2010-06-24 2016-03-23 アルファベータ・エービーＡｌｐｈａＢｅｔａ ＡＢ アルツハイマー病および家族性認知症の治療のための化合物および方法
AU2012249801B2 (en) 2011-04-25 2016-05-19 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome
WO2012177997A1 (en) 2011-06-22 2012-12-27 The General Hospital Corporation Treatment of proteinopathies
US8765762B2 (en) * 2012-10-25 2014-07-01 Usher III, Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degerative diseases and hearing loss associated with usher syndrome
US9227976B2 (en) 2012-10-25 2016-01-05 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome

Also Published As

Publication number Publication date
EP3307742B1 (en) 2022-05-18
JP2023071887A (ja) 2023-05-23
EP3307742A4 (en) 2019-03-06
MX2017016114A (es) 2018-04-11
JP2018521026A (ja) 2018-08-02
US20180099974A1 (en) 2018-04-12
JP2021178849A (ja) 2021-11-18
EP3307742A1 (en) 2018-04-18
ES2924433T3 (es) 2022-10-06
JP6924155B2 (ja) 2021-08-25
WO2016201266A1 (en) 2016-12-15
CA2986785A1 (en) 2016-12-15
ZA201708082B (en) 2021-03-31
IL256109A (en) 2018-02-28
AU2016274956A1 (en) 2017-12-14

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