SG11202000840YA - Cellular models of and therapies for ocular diseases - Google Patents

Cellular models of and therapies for ocular diseases

Info

Publication number
SG11202000840YA
SG11202000840YA SG11202000840YA SG11202000840YA SG11202000840YA SG 11202000840Y A SG11202000840Y A SG 11202000840YA SG 11202000840Y A SG11202000840Y A SG 11202000840YA SG 11202000840Y A SG11202000840Y A SG 11202000840YA SG 11202000840Y A SG11202000840Y A SG 11202000840YA
Authority
SG
Singapore
Prior art keywords
therapies
ocular diseases
cellular models
models
cellular
Prior art date
Application number
SG11202000840YA
Other languages
English (en)
Inventor
Richard R Yang
Stephen Tsang
Original Assignee
Reflection Biotechnologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65232366&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11202000840Y(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Reflection Biotechnologies Ltd filed Critical Reflection Biotechnologies Ltd
Publication of SG11202000840YA publication Critical patent/SG11202000840YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
SG11202000840YA 2017-07-31 2018-07-31 Cellular models of and therapies for ocular diseases SG11202000840YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762539473P 2017-07-31 2017-07-31
PCT/IB2018/055755 WO2019025984A1 (en) 2017-07-31 2018-07-31 CELLULAR MODELS AND THERAPIES FOR OCULAR DISEASES

Publications (1)

Publication Number Publication Date
SG11202000840YA true SG11202000840YA (en) 2020-02-27

Family

ID=65232366

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202000840YA SG11202000840YA (en) 2017-07-31 2018-07-31 Cellular models of and therapies for ocular diseases

Country Status (14)

Country Link
US (1) US20200255859A1 (zh)
EP (1) EP3662066B1 (zh)
JP (2) JP7448953B2 (zh)
KR (1) KR20200036912A (zh)
CN (1) CN111630170A (zh)
AU (1) AU2018311504A1 (zh)
BR (1) BR112020001940A2 (zh)
CA (1) CA3071769A1 (zh)
IL (1) IL272339B2 (zh)
MX (1) MX2020001340A (zh)
NZ (1) NZ761655A (zh)
SG (1) SG11202000840YA (zh)
TW (1) TWI820034B (zh)
WO (1) WO2019025984A1 (zh)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
GB201508026D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Capsid
WO2019006418A2 (en) 2017-06-30 2019-01-03 Intima Bioscience, Inc. ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
CN114900773A (zh) 2017-12-14 2022-08-12 弗洛设计声能学公司 声泳系统及其操作方法、控制声换能器及声学系统的方法
KR102465067B1 (ko) * 2018-02-15 2022-11-10 시그마-알드리치 컴퍼니., 엘엘씨 진핵 게놈 변형을 위한 조작된 cas9 시스템
BR112020020266A2 (pt) 2018-04-03 2021-01-19 Stridebio, Inc. Vetores de vírus com evasão de anticorpos
AU2019255708A1 (en) 2018-04-17 2020-11-26 Ascidian Therapeutics, Inc. Trans-splicing molecules
AU2020221274B2 (en) 2019-02-15 2024-02-08 Sigma-Aldrich Co. Llc. Crispr/Cas fusion proteins and systems
MX2021010149A (es) * 2019-02-25 2021-09-14 Novartis Ag Composiciones y metodos para tratar la distrofia cristalina de bietti.
US20220154211A1 (en) * 2019-02-25 2022-05-19 Novartis Ag Compositions and methods to treat bietti crystalline dystrophy
CA3131919A1 (en) * 2019-02-28 2020-09-03 Regeneron Pharmaceuticals, Inc. Adeno-associated virus vectors for the delivery of therapeutics
CA3133453A1 (en) 2019-03-21 2020-09-24 Daniel Mccoy Recombinant adeno-associated virus vectors
CN109979539B (zh) * 2019-04-10 2020-10-02 电子科技大学 基因序列优化方法、装置及数据处理终端
AU2020328511A1 (en) 2019-08-09 2022-03-03 Nutcracker Therapeutics, Inc. Methods and apparatuses for manufacturing for removing material from a therapeutic composition
JP2022546236A (ja) * 2019-08-14 2022-11-04 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． 遺伝子治療のためのａａｖカプシドバリアント
CN110684737B (zh) * 2019-08-29 2021-06-18 中山大学中山眼科中心 一种rpe65基因突变患者的诱导多能干细胞
BR112022006530A2 (pt) * 2019-10-17 2022-07-05 Stridebio Inc Vetores virais adenoassociados para o tratamento da doença de niemann-pick tipo c
US20240131185A1 (en) * 2019-10-17 2024-04-25 Stridebio, Inc. Aav transfer cassette
WO2021114662A1 (zh) * 2019-12-09 2021-06-17 北京大学第三医院（北京大学第三临床医学院） CYP4V2和RdCVF在制备药物中的用途
JP2023513208A (ja) * 2020-02-07 2023-03-30 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク 神経変性の発症を遅延させるかまたは神経変性を処置するためのメタボロームのリプログラミング
CN111349148A (zh) * 2020-03-13 2020-06-30 辉大(上海)生物科技有限公司 一种腺相关病毒载体及其用途
CN113106124B (zh) * 2020-06-09 2022-09-23 北京中因科技有限公司 表达cyp4v2的aav载体及其用途
CN111500635B (zh) * 2020-07-02 2020-10-09 北京大学第三医院（北京大学第三临床医学院） 一种包含携带核酸分子的载体的试剂盒
EP4185335A1 (en) * 2020-07-21 2023-05-31 Frontera Therapeutics, Inc. Compositions and methods for the treatment of ocular diseases
RU2741092C1 (ru) * 2020-07-23 2021-01-22 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кузбасская государственная сельскохозяйственная академия" Генетическая конструкция для получения устойчивых к вирусу лейкоза эмбрионов крупного рогатого скота
CN111849998A (zh) * 2020-07-29 2020-10-30 武汉纽福斯生物科技有限公司 编码人卵黄状黄斑病蛋白1的核酸分子及其应用
WO2022021149A1 (zh) * 2020-07-29 2022-02-03 北京中因科技有限公司 Aav介导的rpgr x连锁视网膜变性的基因编辑治疗
CN111826378B (zh) * 2020-08-05 2022-05-27 武汉纽福斯生物科技有限公司 一种编码人受体酪氨酸激酶Mer的核苷酸序列及其应用
CN111733174B (zh) * 2020-08-07 2021-02-09 北京大学第三医院（北京大学第三临床医学院） 一种分离的核酸分子及其用途
CN113166763B (zh) * 2020-09-24 2022-03-15 北京中因科技有限公司 靶向cyp4v2基因突变位点的核酸分子及其用途
CN113015804B (zh) * 2020-10-13 2022-05-17 北京中因科技有限公司 用于治疗结晶样视网膜变性的核酸分子及其用途
RU2749459C1 (ru) * 2020-11-10 2021-06-11 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Универсальный интеграционный вектор pVEAL и рекомбинантная плазмида pVEAL-15742, обеспечивающая синтез и секрецию scFv-Fc антител ADI-15742 против вируса Эбола в клетках млекопитающих и полученная с использованием вектора pVEAL
WO2022140551A1 (en) * 2020-12-23 2022-06-30 The Schepens Eye Research Institute, Inc. Methods and compositions for the treatment of corneal endothelium disorders
CN112852871A (zh) * 2021-01-15 2021-05-28 西南大学 高效编辑家蚕基因组的Cas9系统及其应用
GB202104611D0 (en) * 2021-03-31 2021-05-12 Univ Oxford Innovation Ltd Gene therapy for retinal disease
CN113318230B (zh) * 2021-06-11 2022-08-26 上海交通大学医学院附属第九人民医院 Optineurin在眼部黑色素瘤诊治中的应用
KR20240052746A (ko) * 2021-07-14 2024-04-23 메이라지티엑스 유케이 Ii 리미티드 Kcnv2 유전자 요법
EP4370663A1 (en) * 2021-07-15 2024-05-22 Shanghai Vitalgen Biopharma Co., Ltd. Recombinant adeno-associated viral vectors for treating bietti crystalline dystrophy
WO2023140837A1 (en) * 2022-01-19 2023-07-27 Massachusetts Eye And Ear Infirmary Optimized aav-based vaccine
US20230100367A1 (en) * 2021-08-24 2023-03-30 National Yang Ming Chiao Tung University Methods of treating cdgsh iron sulfur domain 2 insufficiency-associated disorders
CN114381465B (zh) * 2021-12-22 2024-01-16 苏州诺洁贝生物技术有限公司 优化的cyp4v2基因及其用途
WO2023147058A2 (en) * 2022-01-27 2023-08-03 Asklepios Biopharmaceutical, Inc. Compositions for treating neurological disease
KR20240000814A (ko) * 2022-06-24 2024-01-03 연세대학교 산학협력단 망막색소상피에 특이적으로 작동하는 CRISPR/Cas 복합체를 유효성분으로 포함하는 망막질환 치료용 약학조성물
WO2024092086A1 (en) * 2022-10-26 2024-05-02 The Trustees Of The University Of Pennsylvania Compositions and methods for regenerating corneal endothelium
CN116738352B (zh) * 2023-08-14 2023-12-22 武汉大学人民医院（湖北省人民医院） 视网膜血管阻塞疾病的视杆细胞异常分类方法及装置

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5792751A (en) 1992-04-13 1998-08-11 Baylor College Of Medicine Tranformation of cells associated with fluid spaces
US6093570A (en) 1995-06-07 2000-07-25 The University Of North Carolina At Chapel Hill Helper virus-free AAV production
IL128736A0 (en) 1996-09-06 2000-01-31 Univ Pennsylvania Methods using cre-lox for production of recombinant adeno-associated viruses
US6114148C1 (en) 1996-09-20 2012-05-01 Gen Hospital Corp High level expression of proteins
CA2304983A1 (en) 1997-09-24 1999-04-01 The Regents Of The University Of California Non-primate lentiviral vectors and packaging systems
US6106826A (en) 1997-12-17 2000-08-22 Wisconsin Alumni Research Foundation Replication competent, avirulent Herpes simplex virus as a vector for neural and ocular gene therapy
US7122181B2 (en) 2000-12-19 2006-10-17 Research Development Foundation Lentiviral vector-mediated gene transfer and uses thereof
US7144870B2 (en) 2002-02-15 2006-12-05 Research Development Foundation Hyaluronic acid mediated adenoviral transduction
WO2004023973A2 (en) * 2002-09-12 2004-03-25 Incyte Corporation Molecules for diagnostics and therapeutics
US8326547B2 (en) 2009-10-07 2012-12-04 Nanjingjinsirui Science & Technology Biology Corp. Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm
US20120108651A1 (en) * 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
MX362866B (es) 2012-05-25 2019-02-20 Univ California Metodos y composiciones para la modificacion de adn objetivo dirigida por arn y para la modulacion de la transcripcion dirigida por arn.
EP2692868A1 (en) * 2012-08-02 2014-02-05 Universitat Autònoma De Barcelona Adeno-associated viral (AAV) vectors useful for transducing adipose tissue
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US8993233B2 (en) 2012-12-12 2015-03-31 The Broad Institute Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
AU2013359212B2 (en) 2012-12-12 2017-01-19 Massachusetts Institute Of Technology Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
EP2954051B1 (en) * 2013-02-08 2019-03-27 The Trustees Of The University Of Pennsylvania Modified aav8 capsid for gene transfer for retinal therapies
CN103374575B (zh) * 2013-04-16 2015-01-07 中国人民解放军第三军医大学第一附属医院 Cyp4v2基因突变体及其应用
CN103374574B (zh) * 2013-04-16 2015-01-07 中国人民解放军第三军医大学第一附属医院 Cyp4v2基因突变体及其应用
EP3561062A1 (en) 2013-09-13 2019-10-30 California Institute of Technology Selective recovery
CN103468820B (zh) * 2013-09-27 2015-06-10 中国人民解放军第三军医大学 检测cyp4v2基因常见突变的试剂盒
TN2016000220A1 (en) * 2013-12-06 2017-10-06 Ct Hospitalier Universitaire Montpellier Methods and pharmaceutical compositions for expressing a polynucleotide of interest in the retinal pigment epithelium of a subject.
CN104745592B (zh) * 2013-12-31 2020-02-21 第三军医大学第一附属医院 Cyp4v2基因突变体及其应用
CN104745594B (zh) * 2013-12-31 2019-10-25 中国人民解放军第三军医大学第一附属医院 Cyp4v2基因突变体及其应用
CN104745591B (zh) * 2013-12-31 2020-04-03 中国人民解放军第三军医大学第一附属医院 Cyp4v2基因突变体及其应用
JP6734853B2 (ja) * 2014-12-18 2020-08-05 ソルボンヌ・ユニヴェルシテＳｏｒｂｏｎｎｅ Ｕｎｉｖｅｒｓｉｔｅ 網膜変性処置のためのｏｔｘ２過剰発現トランスジェニック網膜色素上皮細胞
CA2985223A1 (en) 2015-05-07 2016-11-10 Massachusetts Eye And Ear Infirmary Methods of delivering an agent to the eye
GB201519086D0 (en) * 2015-10-28 2015-12-09 Syncona Partners Llp Gene Therapy
WO2017191274A2 (en) * 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein

Also Published As

Publication number Publication date
NZ761655A (en) 2024-03-22
IL272339B1 (en) 2024-01-01
IL272339A (en) 2020-03-31
TWI820034B (zh) 2023-11-01
JP7448953B2 (ja) 2024-03-13
BR112020001940A2 (pt) 2020-08-18
TW201920679A (zh) 2019-06-01
WO2019025984A1 (en) 2019-02-07
IL272339B2 (en) 2024-05-01
CA3071769A1 (en) 2019-02-07
US20200255859A1 (en) 2020-08-13
JP2021500917A (ja) 2021-01-14
KR20200036912A (ko) 2020-04-07
EP3662066B1 (en) 2024-06-05
EP3662066A1 (en) 2020-06-10
AU2018311504A1 (en) 2020-03-12
MX2020001340A (es) 2020-08-31
CN111630170A (zh) 2020-09-04
JP2024059813A (ja) 2024-05-01
EP3662066A4 (en) 2021-06-23

Similar Documents

Publication Publication Date Title
IL272339A (en) Cellular models and treatments for eye diseases
HRP20190117T1 (hr) iRNK TERAPIJA ZA LIJEČENJE BOLESTI OKA
EP3177732A4 (en) Compositions and methods for the treatment of ophthalmic diseases and conditions
EP3390634A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE DISEASES
IL246791A0 (en) Compositions and methods for treating eye diseases
IL269074A (en) Proteins that bind anti-TIGIT antigens and methods of using them
EP3240612A4 (en) Methods of treating retinal diseases
SG11201708114SA (en) Ophthalmic compositions and methods of use therefor
EP3125971A4 (en) Internal body cavity therapeutic applicators and methods for using them
IL268357A (en) Photoreceptor cells for the treatment of retinal diseases
ZA201906213B (en) Compounds and methods for the treatment of parasitic diseases
EP3503903A4 (en) ASCAROSIDE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
IL269363A (en) Methods for measuring medical effects of treating retinal diseases
EP3515444A4 (en) COMPOSITION FOR TREATING EYE DISEASES AND METHOD FOR USE AND PRODUCTION
IL266720A (en) Proteins that bind against gitr antigens and methods of using them
EP3472181A4 (en) METHOD FOR DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES
EP3713553A4 (en) COMPOSITIONS AND METHODS OF TREATMENT OF EYE DISEASES
IL269698B (en) Methods for preventing or treating eye diseases
HK1255691A1 (zh) 對疾病進行組織學診斷和治療的方法
HK1219654A1 (zh) 用於治療眼科疾病和病症的方法
IL259381B (en) Miravegron for the treatment of retinal diseases
PL3515409T3 (pl) Kompleks i kompozycje do leczenia chorób okulistycznych i dermatologicznych
EP3402511A4 (en) COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES
PL3151666T3 (pl) Modele zwierzęce angiogenezy rogówki oraz chorób rozstrzeniowych rogówki, sposoby wytwarzania i sposoby ich zastosowania
SG11202005278PA (en) Compounds for treating eye diseases and methods thereof