SG11201908660RA - N-substituted indole derivatives - Google Patents

N-substituted indole derivatives

Info

Publication number
SG11201908660RA
SG11201908660RA SG11201908660RA SG11201908660RA SG 11201908660R A SG11201908660R A SG 11201908660RA SG 11201908660R A SG11201908660R A SG 11201908660RA SG 11201908660R A SG11201908660R A SG 11201908660RA
Authority
SG
Singapore
Prior art keywords
idorsia
hegenheimermattweg
allschwil
international
pharmaceuticals
Prior art date
Application number
Other languages
English (en)
Inventor
Heinz Fretz
Isabelle Lyothier
Julien Pothier
Sylvia Richard-Bildstein
Thierry Sifferlen
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of SG11201908660RA publication Critical patent/SG11201908660RA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201908660R 2017-05-18 2018-05-17 N-substituted indole derivatives SG11201908660RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017062008 2017-05-18
PCT/EP2018/062865 WO2018210995A1 (en) 2017-05-18 2018-05-17 N-substituted indole derivatives

Publications (1)

Publication Number Publication Date
SG11201908660RA true SG11201908660RA (en) 2019-10-30

Family

ID=62186481

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201908660R SG11201908660RA (en) 2017-05-18 2018-05-17 N-substituted indole derivatives

Country Status (32)

Country Link
US (2) US20200069686A1 (es)
EP (1) EP3625224B1 (es)
JP (1) JP7065117B2 (es)
KR (1) KR102650756B1 (es)
CN (1) CN110621666A (es)
AR (1) AR111806A1 (es)
AU (1) AU2018269667B2 (es)
BR (1) BR112019024114A2 (es)
CA (1) CA3063637A1 (es)
CL (1) CL2019003257A1 (es)
CO (1) CO2019010804A2 (es)
CR (1) CR20190567A (es)
CY (1) CY1124528T1 (es)
DK (1) DK3625224T3 (es)
EA (1) EA039630B1 (es)
ES (1) ES2894124T3 (es)
HR (1) HRP20211532T1 (es)
HU (1) HUE056406T2 (es)
IL (1) IL270616B (es)
LT (1) LT3625224T (es)
MA (1) MA49127B1 (es)
MX (1) MX2019013639A (es)
PE (1) PE20191787A1 (es)
PH (1) PH12019502562A1 (es)
PL (1) PL3625224T3 (es)
PT (1) PT3625224T (es)
RS (1) RS62441B1 (es)
SG (1) SG11201908660RA (es)
SI (1) SI3625224T1 (es)
TW (1) TWI768043B (es)
UA (1) UA124748C2 (es)
WO (1) WO2018210995A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
CA3060394A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as pge2 receptor modulators
WO2018210987A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as pge2 receptor modulators
US11446298B2 (en) 2017-05-18 2022-09-20 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
HUE056080T2 (hu) 2017-05-18 2022-01-28 Idorsia Pharmaceuticals Ltd Fenilszármazékok mint PGE2 receptor modulátorok
WO2021060281A1 (ja) * 2019-09-24 2021-04-01 Agc株式会社 プロスタグランジンe2レセプターep2/ep4デュアルアンタゴニスト
WO2021205367A1 (en) * 2020-04-08 2021-10-14 Askat Inc. Use of ep4 receptor antagonists for the treatment of liver cancer, melanoma, lymphoma and leukemia
JPWO2022102731A1 (es) 2020-11-13 2022-05-19

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE395058T1 (de) 2000-03-24 2008-05-15 Asterand Uk Ltd Verwendung von prostanoid-ep4-rezeptor- antagonisten zur behandlung von kopfschmerzen und nachweisverfahren für solche antagonisten
HN2001000224A (es) 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
GB0031302D0 (en) 2000-12-21 2001-01-31 Glaxo Group Ltd Napthalene derivatives
GB0031295D0 (en) 2000-12-21 2001-01-31 Glaxo Group Ltd Naphthalene derivatives
GB0103269D0 (en) 2001-02-09 2001-03-28 Glaxo Group Ltd Napthalene derivatives
JP2005532291A (ja) 2002-04-12 2005-10-27 ファイザー株式会社 抗炎症薬および鎮痛薬としてのピラゾール化合物
EP1494667A1 (en) 2002-04-12 2005-01-12 Pfizer Japan Inc. Imidazole compounds as anti-inflammatory and analgesic agents
CA2485485A1 (en) 2002-05-23 2003-12-04 Theratechnologies Inc. Antagonistic peptides of prostaglandin e2 receptor subtype ep4
PT1603893E (pt) 2003-01-29 2008-08-21 Asterand Uk Ltd Antagonistas dos receptores ep4
MXPA06002001A (es) * 2003-08-26 2006-06-20 Teijin Pharma Ltd Derivados pirrolopirimidinona.
KR100747401B1 (ko) 2003-09-03 2007-08-08 화이자 인코포레이티드 프로스타글란딘 e2 길항제로서의 페닐 또는 피리딜 아미드 화합물
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
JP4054368B2 (ja) 2004-05-04 2008-02-27 ファイザー株式会社 置換メチルアリール又はヘテロアリールアミド化合物
EA200601830A1 (ru) 2004-05-04 2007-04-27 Пфайзер Инк. Ортозамещённые арильные или гетероарильные амидные соединения
HN2005000795A (es) 2004-10-15 2010-08-19 Aventis Pharma Inc Pirimidinas como antagonistas del receptor de prostaglandina d2
CA2608214C (en) 2005-05-19 2013-08-20 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists
WO2006128129A2 (en) 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating cancer
CA2648729A1 (en) 2006-04-24 2007-11-01 Merck Frosst Canada Ltd. Indole amide derivatives as ep4 receptor antagonists
CA2654811A1 (en) 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Indoline amide derivatives as ep4 receptor ligands
WO2008008059A1 (en) 2006-07-12 2008-01-17 Locus Pharmaceuticals, Inc. Anti-cancer agents ans uses thereof
AR061974A1 (es) 2006-07-14 2008-08-10 Novartis Ag Derivados de pirimidina como inhibidores de alk, composiciones farmaceuticas y procesos de obtencion
CA2660133C (en) 2006-08-11 2015-10-27 Merck Frosst Canada Ltd. Thiophenecarboxamide derivatives as ep4 receptor ligands
WO2008039882A1 (en) 2006-09-30 2008-04-03 Sanofi-Aventis U.S. Llc A combination of niacin and a prostaglandin d2 receptor antagonist
US8158671B2 (en) 2007-02-26 2012-04-17 Merck Canada Inc. Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists
EP2141147A1 (en) 2007-03-26 2010-01-06 Astellas Pharma Inc. Ornithine derivative
CN101636385B (zh) 2007-03-26 2012-09-05 默克弗罗斯特加拿大有限公司 作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物
EP2014657A1 (de) * 2007-06-21 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Diaminopyrimidine als Modulatoren des EP2-Rezeptors
EP2460787A1 (en) 2007-07-03 2012-06-06 Astellas Pharma Inc. Amide compounds and their use as PGE2 antagonists.
PT2565191E (pt) 2008-05-14 2014-12-04 Astellas Pharma Inc Derivados do ácido 4-(indol-7- ilcarbonilaminometil)ciclo-hexanocarboxílico como antagonistas de receptores ep4, úteis no tratamento de insuficiência renal crónica ou de nefropatia diabética
JP5536773B2 (ja) 2008-08-14 2014-07-02 ベータ・ファーマ・カナダ・インコーポレイテッド Ep4受容体アンタゴニストとしてのヘテロ環式アミド誘導体
CN102164942B (zh) 2008-09-19 2017-02-15 生物科技研究有限公司 三萜系化合物及其使用的方法
JP2012503605A (ja) 2008-09-25 2012-02-09 メルク カナダ インコーポレイテッド Ep4受容体アンタゴニストとしてのベータ−カルボリンスルホニルウレア誘導体
CN103003264B (zh) 2010-05-21 2014-08-06 切米利亚股份公司 嘧啶衍生物
BR112013002484B1 (pt) 2010-09-21 2021-10-13 Eisai R&D Management Co. , Ltd. Composto, composição farmacêutica, e, usos de um composto
ES2537017T3 (es) 2010-09-29 2015-06-01 Nb Health Laboratory Co. Ltd. Anticuerpo dirigido contra el receptor EP4 de la prostaglandina E2 humano
US8828987B2 (en) 2010-12-10 2014-09-09 Rottapharm Biotech S.R.L. Pyridine amide derivatives as EP4 receptor antagonists
WO2012103071A2 (en) 2011-01-25 2012-08-02 Eisai R&D Management Co., Ltd. Compounds and compositions
EP2688883B1 (en) 2011-03-24 2016-05-18 Noviga Research AB Pyrimidine derivatives
IN2014CN00719A (es) 2011-07-04 2015-04-03 Rottapharm Spa
EP2554662A1 (en) 2011-08-05 2013-02-06 M Maria Pia Cosma Methods of treatment of retinal degeneration diseases
US20150004175A1 (en) 2011-12-13 2015-01-01 Yale University Compositions and Methods for Reducing CTL Exhaustion
NZ731797A (en) 2012-04-24 2018-08-31 Vertex Pharma Dna-pk inhibitors
AR091429A1 (es) 2012-06-29 2015-02-04 Lilly Co Eli Compuestos de fenoxietil piperidina
TWI572597B (zh) 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基-苯甲酸化合物
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
EP2765128A1 (en) 2013-02-07 2014-08-13 Almirall, S.A. Substituted benzamides with activity towards EP4 receptors
TW201443004A (zh) 2013-02-15 2014-11-16 Lilly Co Eli 苯氧基乙氧基化合物
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫-1h-異喹啉化合物
NO3009426T3 (es) 2013-06-12 2018-09-29
WO2015034820A1 (en) 2013-09-04 2015-03-12 Bristol-Myers Squibb Company Compounds useful as immunomodulators
SG11201601682RA (en) 2013-09-06 2016-04-28 Aurigene Discovery Tech Ltd 1,2,4-oxadiazole derivatives as immunomodulators
WO2015044900A1 (en) 2013-09-27 2015-04-02 Aurigene Discovery Technologies Limited Therapeutic immunomodulating compounds
RS57306B1 (sr) 2013-10-17 2018-08-31 Vertex Pharma Inhibitori dnk-pk
CA2928593A1 (en) 2013-12-17 2015-06-25 Eli Lilly And Company Phenoxyethyl cyclic amine derivatives and their activity as ep4 receptor modulators
ES2727329T3 (es) 2013-12-17 2019-10-15 Lilly Co Eli Compuestos de ácido dimetilbenzoico
TW201607943A (zh) 2013-12-19 2016-03-01 拜耳製藥公司 作為ep4配體之新穎苯并咪唑衍生物
TW201623277A (zh) 2014-03-26 2016-07-01 安斯泰來製藥股份有限公司 醯胺化合物
EP3134085A1 (en) 2014-05-23 2017-03-01 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of cancer
WO2016021742A1 (en) 2014-08-07 2016-02-11 Takeda Pharmaceutical Company Limited Heterocyclic compounds as ep4 receptor antagonists
WO2016054807A1 (en) * 2014-10-10 2016-04-14 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
MX2017009037A (es) 2015-01-09 2017-10-04 Ono Pharmaceutical Co Compuestos espiro triciclicos.
EP3325490B1 (en) 2015-07-23 2019-12-18 Takeda Pharmaceutical Company Limited 1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists
BR112018007664B1 (pt) 2015-10-16 2023-12-19 Eisai R&D Management Co., Ltd Compostos antagonistas de ep4, composição compreendendo o composto e uso dos mesmos para tratar câncer

Also Published As

Publication number Publication date
JP7065117B2 (ja) 2022-05-11
MA49127B1 (fr) 2022-05-31
PT3625224T (pt) 2021-10-06
WO2018210995A1 (en) 2018-11-22
SI3625224T1 (sl) 2021-11-30
PL3625224T3 (pl) 2022-01-10
CO2019010804A2 (es) 2019-10-09
CL2019003257A1 (es) 2020-03-27
AR111806A1 (es) 2019-08-21
UA124748C2 (uk) 2021-11-10
ES2894124T3 (es) 2022-02-11
HRP20211532T1 (hr) 2022-01-07
IL270616B (en) 2022-01-01
HUE056406T2 (hu) 2022-02-28
AU2018269667B2 (en) 2022-02-03
EP3625224A1 (en) 2020-03-25
LT3625224T (lt) 2021-10-25
KR20200006589A (ko) 2020-01-20
TW201900637A (zh) 2019-01-01
BR112019024114A2 (pt) 2020-06-02
CR20190567A (es) 2020-02-10
EA201992679A1 (ru) 2020-05-06
KR102650756B1 (ko) 2024-03-22
CA3063637A1 (en) 2018-11-22
JP2020520359A (ja) 2020-07-09
MA49127A (fr) 2021-05-26
PH12019502562A1 (en) 2020-07-20
US20230165859A1 (en) 2023-06-01
TWI768043B (zh) 2022-06-21
CN110621666A (zh) 2019-12-27
CY1124528T1 (el) 2022-07-22
EP3625224B1 (en) 2021-08-04
US20200069686A1 (en) 2020-03-05
RS62441B1 (sr) 2021-11-30
MX2019013639A (es) 2020-01-21
AU2018269667A1 (en) 2019-10-24
EA039630B1 (ru) 2022-02-18
DK3625224T3 (da) 2021-11-08
PE20191787A1 (es) 2019-12-24

Similar Documents

Publication Publication Date Title
SG11201908660RA (en) N-substituted indole derivatives
SG11201900633XA (en) Piperidine cxcr7 receptor modulators
SG11201908729UA (en) Phenyl derivatives as pge2 receptor modulators
SG11201803627XA (en) N-substituted indole derivatives as pge2 receptor modulators
SG11201908097YA (en) Pyrimidine derivatives as pge2 receptor modulators
SG11201906763RA (en) Pyrrolo [1,2-b] pyridazine derivatives
SG11201810600WA (en) Fxr (nr1h4) modulating compounds
SG11201907604UA (en) Crystalline forms of the 4-pyrimidinesulfamide derivative aprocitentan
SG11201900844UA (en) Amino pyrimidine ssao inhibitors
SG11201804170RA (en) Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders
SG11201805940QA (en) Benzopyrazole compounds and analogues thereof
SG11201810628XA (en) Nasal pharmaceutical compositions with a porous excipient
SG11201810177VA (en) Pet-imaging immunomodulators
SG11201907032RA (en) Amino pyrimidine compounds useful as ssao inhibitors
SG11201808237UA (en) Substituted indole compound derivatives as dengue viral replication inhibitors
SG11201906436VA (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
SG11201808566WA (en) Polymorphic form of n-{6-(2-hydroxypropan-2-yl)-2-[2-(methylsulphonyl)ethyl]-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide
SG11201908977SA (en) Niraparib formulations
SG11201906959RA (en) Aryl hydrocarbon receptor (ahr) modulator compounds
SG11201901558VA (en) Pth compounds with low peak-to-trough ratios
SG11201900558RA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201909680UA (en) Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds
SG11201806393QA (en) Use of gabaa receptor modulators for treatment of itch
SG11201906767XA (en) Estrogen receptor modulators
SG11201806480UA (en) Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer